Best Seed Grants for Nonprofits in South Dakota

The Childhood Asthma in Urban Settings Clinical Research Network (CAUSE) aims to enhance asthma prevention and treatment in economically disadvantaged pediatric populations. Funded by the NIH, CAUSE supports multi-site clinical studies to identify innovative strategies and treatment targets for asthma. Utilizing systems biology, the network seeks to discover specific disease endotypes suitable for new therapeutic approaches, addressing the high burden of asthma in urban settings.

The Lois Lenski Covey Foundation offers the Bookmobile Grant to promote literacy among underserved children. Grants range from $500 to $3,000 specifically for purchasing books for youth from preschool to grade 8. Eligible organizations include 501(c)(3) nonprofits and public libraries that operate lending bookmobiles. The Foundation aims to ensure access to quality literature, fostering a love of reading in disadvantaged communities while addressing their limited book budgets.

The Clinical Data, Safety and Statistical Centers (CDSSC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance clinical research through comprehensive support. This includes statistical analysis, protocol development, and oversight of safety monitoring in studies related to asthma, autoimmune diseases, and transplantation. By coordinating these efforts, the program seeks to facilitate impactful research outcomes and improve public health outcomes through informed data-driven decisions.

The Asthma and Allergic Diseases Cooperative Research Centers (AADCRC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance research on asthma and related allergic diseases. This initiative fosters multi-center, multidisciplinary research to explore disease mechanisms and treatment responses. By promoting clinical trials and observational studies, the AADCRC seeks to advance understanding and improve interventions for conditions such as asthma and food allergies, ultimately benefiting public health.

This grant focuses on implementing research to identify effective combinations of community-clinical linkage strategies aimed at diabetes prevention and management. It addresses the challenges faced by Federally Qualified Health Centers and safety-net clinics, emphasizing the need for coordinated approaches. The study will explore factors influencing the adoption and integration of these strategies, ultimately aiming to develop practical evidence and best practices that enhance diabetes care in primary settings.

The AAFP Foundation offers Family Medicine Chapter Engagement Grants to support the philanthropic initiatives of its constituent chapters. Each chapter or chapter foundation can receive $750 to highlight programs focused on Student/Resident education, Member Outreach, or Public Health. This initiative not only showcases the impactful work being done at the chapter level but also aids in fundraising efforts, fostering stronger community connections and improving health outcomes.

The Innovation Grants to Nurture Initial Translational Efforts (IGNITE) program, supported by the National Institutes of Health, aims to fund pharmacodynamic and pharmacokinetic studies. These studies will assess the biological activity of therapeutic agents, including small molecules and biologics, for diseases prioritized by participating institutes. The initiative emphasizes the development of non-opioid analgesics with minimal addiction risks. Although applications are not currently solicited, this notice encourages potential applicants to prepare collaborative projects.

The Manning Family Foundation offers Health and Life Sciences Research Grants to support innovative research aimed at finding effective treatments and cures for diseases like diabetes and macular degeneration. Since 2003, they have funded 501(c)(3) nonprofits that contribute to these fields, emphasizing entrepreneurialism and impactful research. Applications are accepted on a rolling basis, with awards given three times a year, fostering advancements in health and community well-being.

Shaw's Foundation Grants support nonprofit organizations that enhance community well-being, focusing on hunger, youth education, and health. Eligible organizations must be 501(c)(3) certified and serve specific regions like California and Hawaii. An employee sponsor is mandatory for applications in these areas. The grant review process typically takes about eight weeks, and the foundation prioritizes collaborations with local partners to maximize community impact.

The Native American Research Centers for Health (NARCH) program supports federally-recognized American Indian and Alaska Native Tribes and organizations in advancing health-related research. It aims to enhance research careers and infrastructure through a competitive application process. Funded by the US Dept. of Health & Human Services, this initiative invites eligible entities to apply, ensuring that only high-quality proposals undergo peer review for potential funding.

Angel Post Deployment Test Program

Through a collaborative partnership with UNCF, XYZ Corporation has established a scholarship program to help STEM students get on the fast track to a rewarding career. In addition to direct financial support, Intel-sponsored scholarships offer the benefits of exposure to potential job opportunities, networking with fellow scholars, insight to other Intel scholarships, research, training opportunities, and access to Intel mentors offering support on technical, non-technical, cultural, and dissertation-related needs.

The Steven C. Leuthold Family Foundation Grants support 501(c)(3) non-profits in areas such as land conservation, environmental protection, human services, and animal welfare. Founded in 1991 by philanthropist Steven C. Leuthold, the foundation prioritizes organizations that align with its giving preferences. Applications are due by June 30, 2025, with grants distributed by December 2025. Note that incomplete applications will not be accepted.

The Skyler James Wenger Scholarship, established in 2012 in memory of Skyler, a 14-year-old who tragically lost his life, supports graduating seniors from Cedar Cliff or Red Land High School. Eligible applicants must plan to attend college or trade school, come from a single-parent household, be athletes, and demonstrate financial need. This one-time award aims to honor Skyler's legacy by helping deserving students achieve their educational goals.

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is launching a Notice of Funding Opportunity (NOFO) under the NIH HEAL initiative to enhance research on joint health and pain. This initiative aims to refine the understanding of joint tissues and pain mechanisms, expand clinical phenotyping, and support preclinical testing of novel therapies. Collaborations among experts in neurobiology, pain science, and rheumatic diseases are encouraged to foster innovative solutions for joint pain management.

The Lynn E. Poffenberger Memorial Scholarship Fund, established by the Middle Paxton Lions Club, honors the legacy of Mr. Poffenberger by providing annual scholarships to two graduating seniors. Eligible applicants must reside in Middle Paxton Township or Dauphin Borough, demonstrate financial need, and show active community involvement. This one-time scholarship aims to support deserving students in their educational pursuits, reflecting the values of service and commitment to the community.

The Douglas W. Pfautz Memorial Scholarship Fund honors a dedicated community servant and family man, Doug Pfautz. Sponsored by the Rotary Club of Elizabethtown, this scholarship supports high school seniors from the Elizabethtown Area School District who demonstrate good moral character and a commitment to community service. Applicants must maintain good academic standing and plan to pursue further education. This one-time award encourages students to embody the Rotary motto of 'Service Above Self', continuing Doug's legacy of service.

The JADE Learning Electrical Technologies Scholarship supports students enrolled in North Carolina technical or occupational schools focused on electrical systems technologies. Eligible candidates include undergraduates, graduates, and apprentices who demonstrate financial need and strong academic performance. The scholarship application requires careful attention to specific donor-defined eligibility criteria. Applications open on December 16, 2025, and close on March 3, 2026, with preference given to those pursuing a two-year associate’s degree.

The 'Repurposing Research for Chicago - Track 1 – Health Equity' grant, offered by Cures Within Reach, aims to fund clinical repurposing trials addressing health disparities among underrepresented populations. With a budget of up to $100,000, it encourages trials led by underrepresented researchers or focusing on women's health. The initiative seeks to enhance the quality of life in the Chicagoland area through effective and innovative medical solutions, fostering collaboration across diverse stakeholder groups.

Community Foundation of the Endless Mountains

Our mission at the Community Foundation of the Endless Mountains is to improve the region’s quality of life through the power of philanthropy. We do this by offering individuals, families, and businesses the most effective charitable giving tools available in the marketplace today. Founded in 1998, the Community Foundation of the Endless Mountains is honored to work with hundreds of donors, nonprofits, advisors, and civic leaders to achieve dreams for making the Endless Mountains region of Northeastern Pennsylvania an even better place to live for everyone.

Scholarships

Many generous individuals, families, and businesses have established scholarship funds to provide support to graduates in our region. Scholarships are available to graduating high school seniors.

Lawrence & Phyllis DeWolfe Scholarship

Established by the family and friends of Mr. and Mrs. Lawrence DeWolfe to provide college scholarships to graduating seniors from Blue Ridge, Lackawanna Trail, and Mountain View school districts who will major in agriculture, education, a STEM field or law enforcement.

Community Foundation of the Endless Mountains

Our mission at the Community Foundation of the Endless Mountains is to improve the region’s quality of life through the power of philanthropy. We do this by offering individuals, families, and businesses the most effective charitable giving tools available in the marketplace today. Founded in 1998, the Community Foundation of the Endless Mountains is honored to work with hundreds of donors, nonprofits, advisors, and civic leaders to achieve dreams for making the Endless Mountains region of Northeastern Pennsylvania an even better place to live for everyone.

Scholarships

Many generous individuals, families, and businesses have established scholarship funds to provide support to graduates in our region. Scholarships are available to graduating high school seniors.

Cody Albert Memorial Scholarship

Established by Dale and Linda Albert in memory of their son Cody to provide a college scholarship to students from Susquehanna County who will major in the Visual Arts, Psychology, or Physical Therapy and who have overcome anxiety, depression, or other adversity.

The Eash-Potter Scholarship supports LGBTQ youth in central Pennsylvania, honoring Melinda Eash and Sharon Potter's legacy. It is available to graduating high school seniors from specific counties who demonstrate commitment to enhancing the community climate for LGBTQ+ individuals. Financial need is a consideration, and the scholarship is a one-time award. Students of color, transgender individuals, and children of LGBTQ+ parents are particularly encouraged to apply, promoting diversity and inclusion within the scholarship program.

The Pediatric Oncology Student Training (POST) Program Grant, offered by Alex’s Lemonade Stand Foundation, aims to foster the next generation of pediatric oncology researchers. This summer internship provides undergraduate, graduate, and medical students with hands-on research experience in a supportive environment, focusing on diversity and inclusion. Grants will specifically support students from underrepresented communities in the scientific workforce, enabling impactful research and mentorship opportunities to advance pediatric cancer care.

The Woman's National Farm and Garden Association (WNF&GA) Scholarship supports graduate students pursuing careers in conservation and natural resource management. This annual scholarship aims to continue the legacy of conservationists dedicated to protecting our planet's resources. Eligible candidates must demonstrate a strong commitment to environmental stewardship through their academic and community involvement. However, WNF&GA members and their immediate families are excluded from eligibility. The scholarship is a vital resource for future leaders in conservation.

The Bureau of Land Management's Plant Conservation and Restoration Program (PCRP) aims to enhance the native seed supply chain, crucial for restoring resilient public lands. By collaborating with various partners, PCRP seeks to improve rangeland health, restore wildlife habitats, and create job opportunities. In 2026, the focus will be on local seed collections, supporting farmers entering the native seed market, and developing innovative technologies to ensure effective restoration outcomes and ecological resilience.

The Disaster Grants Program by LSC provides vital funding to organizations aiding survivors of government-declared emergencies. It empowers legal aid groups to deliver essential services to low-income disaster survivors, ensuring access to legal assistance during crises. The program also educates communities on disaster legal services and prepares them for future emergencies, enhancing resilience and response capabilities. By supporting various grant types, the initiative addresses immediate needs and fosters long-term recovery strategies.

The Sophie Kosiorek Scholarship, provided by the Erie Community Foundation, awards $800,000 in scholarships to over 500 deserving students annually. This scholarship specifically supports a four-year member of the Seneca High School girls basketball team, recognizing the positive attitude and strong team ethic exemplified by Sophie. Eligible applicants must maintain a GPA of 3.0 or higher, ensuring that the scholarship supports both athletic and academic excellence.

The Kowalik Family Christopher Gott Memorial Scholarship, offered by the Erie Community Foundation, aims to support a high school senior from the City of Erie who embodies Christopher Gott's passion for learning and skill development. In 2023, the foundation provided over $800,000 in scholarships to more than 500 students pursuing further education. This scholarship honors Christopher, a devoted nurse and classical guitarist, who epitomized the spirit of continuous personal growth.