Best Small Grants for Nonprofits in South Dakota

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA) on Aug. 4, 2026, seeking to fund high-impact, patient-centered comparative clinical effectiveness research (CER) projects. This preannouncement provides potential applicants additional time to identify collaborators; obtain patient and stakeholder input on potential studies; and develop responsive, high-quality applications. 

Patient-centered CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences. 

About PCORI

PCORI funds patient-centered comparative clinical effectiveness research (CER).

Our Mission

PCORI helps people make informed healthcare decisions, and improves healthcare delivery and outcomes, by producing and promoting high-integrity, evidence-based information that comes from research guided by patients, caregivers, and the broader healthcare community.

Broad Pragmatic Studies PCORI Funding

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA), seeking to fund patient-centered comparative clinical effectiveness research (CER) projects. 

Research Initiative Highlights

CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences.

Special Areas of Emphasis

For Cycle 2 2026, PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAE) within the BPS funding opportunity. The purpose of identifying these SAEs is to encourage submissions to these areas, rather than limiting submissions to these topics. Applicants addressing one of the below SAEs should identify the area that is best associated with their research approach:  

• Addressing Obesity
• Diabetes Prevention, Care and Treatment
• Management of Urogynecological and Pelvic Pain
• Pain Management for Individuals Living With Sickle Cell Disease

In PCORI-funded research, patients and other research partners are expected to meaningfully contribute their lived experience or professional expertise to ensure studies are patient-centered, relevant and useful for healthcare decision making. Applicants must address PCORI’s Foundational Expectations for Partnerships in Research — an evidence-based framework supported by tools and resources to guide effective engagement strategies. Applicants are also strongly encouraged to consider the inclusion of a broad range of patient-centered burdens and economic outcomes. 

Broad Pragmatic Studies PFA: Category 1, Category 2 and Category 3 Study Specifications

PCORI will commit up to $120 million in direct costs through this funding opportunity. This funding opportunity contains three categories for funding:

• Category 1: Category 1 will support research projects with direct costs up to and including $5 million.

• Category 2: Category 2 will support research projects with direct costs greater than $5 million and up to a maximum of $12 million. Applications for funding under Category 2 will be required to provide additional information in the Letter of Intent (LOI) and application to justify the size and scope of the proposed research projects and to explain how additional funds are necessary with respect to the scale, scope and complexity of personnel and material resources needed to address the research question.

• Category 3: Category 3 will support research projects with direct costs up to $12 million that utilize PCORnet® to conduct observational studies and/or pragmatic trials that are national in scale. Category 3 PCORnet Studies® must include two or more Clinical Research Networks and share study progress, performance metrics and best practices with the network to promote continuous learning and improvement. PCORnet Studies® will leverage the PCORnet Common Data Model® as appropriate. Additional details about Category 3 can be found on the PCORI website.  

The Great American Cleanup Grants, offered by Keep America Beautiful, aim to enhance community beautification and environmental efforts across the U.S. This initiative encourages KAB affiliates to remove litter, plant greenery, and restore public spaces, contributing to the larger goal of cleaning up 25 billion pieces of litter by 2026. With cash grants available, this program fosters collaboration among communities, promoting sustainable practices and a cleaner, greener future for all.

The Ethnic Minorities and Women’s Internship Grant supports entry-level athletics administrative positions for one academic year, promoting diversity in NCAA Division II. It provides $30,000 for intern salaries and $3,000 for professional development, benefiting six schools annually from a total budget of $180,000. Eligible applicants must be active NCAA members, with a focus on enhancing ethnic minority and gender representation in athletics administration. This initiative encourages professional growth and compliance in diverse environments.

The US Department of Health & Human Services, through the NIH, invites applications for innovative approaches to implement SBIRT/P for addressing alcohol, tobacco, and other drug use in adults facing health disparities. This funding opportunity encourages research that tests screening, brief interventions, and referrals for treatment or prevention services. Applications are due on specified deadlines from February 2024 through March 2027, fostering collaboration with healthcare and community partners to enhance public health outcomes.

The Dale Lokke Law Enforcement Scholarship, managed by the Sioux Falls Area Community Foundation, offers financial assistance to graduating seniors from Minnehaha County high schools. This scholarship aims to support students planning to attend accredited four-year colleges in South Dakota while promoting involvement in community activities and addressing financial needs. With over $500,000 awarded annually, it helps students pursue their educational goals and career aspirations.

The Region 4 Professional Development Awards for 2025-2026 foster the growth of health information access and data science skills among network members. This funding supports diverse projects such as workshops, conferences, and educational activities aimed at enhancing the professional capacity of individuals affiliated with NNLM Region 4. By encouraging proposals that address the needs of underrepresented communities, the awards aim to improve health information services and access across the region.

The First Interstate BancSystem Foundation focuses on strengthening communities by providing grants primarily to nonprofits assisting low- and moderate-income individuals. In 2023, they awarded $9.2 million across their footprint, emphasizing projects with significant community impact. Grants are recommended by local First Interstate Bank branches and are evaluated based on the nonprofit's leadership, financial stability, and community benefit. Areas of ineligibility include individual projects and those that do not demonstrate a substantial community impact.

The Rupert Dunklau Foundation Grant supports organizations with 501(c)(3) status, focusing on Lutheran Higher Education, Health and Human Care, and Faith Strengthening. Since its establishment in 1968, the foundation has aimed to provide financial resources to ministries within the Lutheran tradition, particularly in Nebraska and surrounding states. Eligible projects must align with the foundation's mission to promote the welfare of mankind through educational and health initiatives.

The Marvin R. and Pearl E. Patterson Family Fund Scholarship, offered by the Grand Haven Area Community Foundation, supports students aspiring to study graphic or fine arts, as well as those interested in environmental sciences. Open to high school graduates from the Tri-Cities area, this scholarship considers leadership, community involvement, and academic achievements, although financial need is not a requirement. Applicants must provide transcripts and relevant documents to qualify for this opportunity.

The Growing Tribal Economies Through Forest Market Innovations grant program, initiated by First Nations Development Institute, aims to empower Tribes and Alaska Native Villages to engage in emerging markets that enhance forest health and resilience. With funding of $200,000 to $500,000 per grant, this initiative supports projects focusing on sustainability, innovation, and traditional knowledge. Eligible applicants are encouraged to develop forest products, certifications, and practices that contribute positively to biodiversity and ecosystem management.

The Asian Cultural Council's Individual Fellowship provides artists, scholars, and arts professionals from Asia and the United States with opportunities for self-directed cultural exchange and research in unfamiliar regions. This program supports activities such as interviews, workshops, and archival research, fostering cultural immersion and collaboration. With a funding limit of $35,000, the fellowship encourages innovative proposals that enhance creative perspectives and relationships among peers, while also ensuring strong eligibility criteria for applicants.

The Asian Cultural Council's New York Fellowship offers a transformative six-month program for artists, scholars, and arts professionals from Asia. Participants engage deeply with New York City's vibrant cultural landscape, attending performances, exhibitions, and workshops while building networks with local communities. This unique opportunity fosters peer-learning and individual artistic development, encouraging fellows to incorporate their experiences into their practices and contribute to their home cultures. The fellowship emphasizes exploration, exchange, and support, culminating in a rich cultural immersion.

The Bush Fellowship empowers individuals across various sectors to amplify their leadership and drive community change. Offering up to $150,000 over two years, it supports personal growth and networking for selected Fellows. Applicants must be at least 24 years old and residents of specific states or Native nations. The program is competitive, with over 600 applications in recent years. It emphasizes equitable leadership and a commitment to making impactful changes within communities.

South Dakota Department of Health

The South Dakota Department of Health (SD DOH) strives to promote, protect, and improve the health of all South Dakotans with information, licensing, and more.

Cardiovascular Disease Prevention and Treatment Funding

The South Dakota Department of Health is pleased to announce a funding opportunity, the Cardiovascular Disease Prevention and Treatment funding. This funding opportunity is intended to support strategies that have a focus on prevention, treatment and/or management of cardiovascular disease. The facilities awarded funding through this opportunity will receive funds and technical assistance to create and expand sustainable programs to help link resources that support self-management and lifestyle changes to address those at increased risk for CVD with a focus on hypertension management.

The South Dakota Department of Health (SD DOH) Heart Disease and Stroke Prevention Program (HDSPP) is offering funding to meet one or both of the following priorities: Priority 1: Self-Measured Blood Pressure (SMBP) Program; and Priority 2: Care Coordination Program.

Priority 1: Self-Measured Blood pressure (SMBP) Program

Self-Measured Blood Pressure (SMBP) Program supports the implementation and expansion of Self-Measured Blood Pressure Monitoring programs through partnerships with local healthcare facilities and clinics. These programs are designed to help individuals with hypertension manage their condition effectively by monitoring their blood pressure at home in conjunction with clinical support.

The ReFED Catalytic Grant Fund, managed by Refed Inc., supports innovative solutions to minimize food waste and reduce methane emissions, a cost-effective strategy for climate action. This fund prioritizes initiatives that enhance food recycling and improve supply chain efficiency in the beef and dairy sectors. By focusing on proven methods, the grant aims to accelerate impactful changes in the food system, ultimately fostering sustainable practices and collaborative efforts to combat food waste.

The Tobacco Prevention & Cessation RFA aims to support community-driven initiatives that promote tobacco-free lifestyles in South Dakota. With a focus on collaboration among local organizations, this funding opportunity seeks to implement strategies outlined in the SD-TCP State Plan, which emphasizes long-term changes to reduce tobacco-related health issues. By fostering partnerships and investing in impactful projects, the RFA is dedicated to decreasing the prevalence of tobacco use and its associated harms in the state.

Entergy’s Open Grants Program aims to enhance community well-being through funding initiatives in arts, education, social services, and community improvement. The program prioritizes support for organizations that serve diverse populations, including children and low-income communities. Eligible entities must have 501(c)(3) status or equivalent nonprofit recognition. Applications should be submitted three months in advance, allowing ample time for review. Entergy focuses on projects that foster self-sufficiency and enrich local neighborhoods.

The Grand Haven Offshore Challenge Scholarship, offered by the Grand Haven Area Community Foundation, supports students pursuing studies in natural resources, including fisheries and wildlife. This scholarship is available for applicants attending any public or private college or university. The fund was established to honor community contributions towards environmental preservation and is awarded based on academic merit and financial need. Apply once for all scholarships you may qualify for to streamline your application process.

Community Finance Initiative 

Advancing the financial resilience of low-income households across the U.S.

This model enables us to engage and support a broad range of organizations across the globe to tackle some of the most pressing social issues of our time.

The Citi Foundation’s 2026 Community Finance Initiative commits $35 million to support programming that bolsters the financial stability, strength and safety of low-income households in the U.S.

Focus Areas

The Foundation seeks to support organizations advancing low-income household financial resilience in the United States across three focus areas:

Stabilize: Programs that help low-income households to build financial skills and confidence to manage daily finances and navigate financial stress.

• Financial coaching on budgeting, credit, debt reduction and savings strategies.
• Digital tools offering personalized financial guidance and product navigation.
• Assistance with public benefits and social safety net programs.

Strengthen: Programs that help low-income households build and repair credit, as well as short- and long-term financial assets.

• Financial products or services for credit building and credit repair.
• Initiatives to increase savings, including emergency funds.
• Support for homeownership, including readiness, preservation and long-term stability (e.g., first-time buyer assistance, preventing displacement and support systems for aging in place resources).

Safeguard: Programs that protect low-income household financial security by preventing and addressing financial losses.

• Education and support for the safe and confident use of digital financial tools.
• Fraud and scam awareness, prevention and recovery initiatives, including protection from identity theft.
• Interventions to help households recover from major financial shocks (e.g., healthcare costs, extended family care, job transitions or natural disasters).

Funding Opportunity

The Foundation plans to award 70 $500,000 (USD) grants (to be disbursed over two years) totaling $35 million to community organizations working in select communities where Citi has a presence.

The grants will be restricted and are anticipated to be disbursed in two annual payments in 2026 and 2027. Proposed projects should be for a term of 24 months, starting no sooner than August 1, 2026 and ending no later than December 31, 2028.

The Osmann Family Native American Scholarship supports South Dakota high school seniors who are enrolled members of a Native American tribe. Managed by the Sioux Falls Area Community Foundation, this scholarship is aimed at students planning to attend a four-year college or technical school in the state. Eligible candidates must maintain a minimum GPA of 2.5 and demonstrate commitment to academic success and community involvement. The scholarship is renewable for up to three additional years, providing crucial financial support for education.

Background

Transportation Alternatives (TA) is a program that uses federal transportation funds, designated by Congress, for specific activities that enhance the inter-modal transportation system and provide safe alternative transportation options. TA encompasses a variety of smaller-scale non-motorized transportation projects such as pedestrian and bicycle facilities, recreational trails, safe routes to school projects, community improvements such as historic preservation and vegetation management, and environmental mitigation related to storm water and habitat connectivity.

Approximately $8 Million is available through a competitive project selection process administered by the South Department of Transportation (SDDOT) Office of Project Development. Projects may be limited to $600,000 depending on annual funding allowance. The minimum for infrastructure projects will be $50,000. There is no minimum for non-infrastructure projects. Minimum local match required is 18.05%.

The Elam Baer and Janis Clay Epilepsy Scholarship, administered by Scholarship America, aims to eliminate financial barriers for students with epilepsy. This scholarship is open to residents of Minnesota, North Dakota, South Dakota, Wisconsin, or Iowa, who are high school seniors or current college students. Applicants must maintain a minimum GPA of 2.5 and plan to enroll in accredited institutions. The program reflects a commitment to accessibility and support for underrepresented students.

Alfred & Julia Bucher Education Trust

To provide financial support to graduates of Hyde and Hand counties attending a South Dakota institution of higher learning or the seminary.

About Us

We come to work every day because we believe in the power of possibility.

We believe the Sioux Falls area is a great place to live, work, and play. We also believe we have a responsibility to help preserve and sustain what’s good here, and to champion ideas and movements that have the potential to make our community even better.

We believe that meaningful and important social impact comes from thinking outside the box and having the courage to dream big dreams.

We believe strongly in the power and purpose of philanthropy. To us, philanthropy is more than just gifts and grants — philanthropy is thinking about how we can leverage financial, intellectual and human capital to help create a stronger, more vibrant community.

Finally, we believe philanthropy challenges us all to consider two important questions about our future – questions that drive and inspire our work every day: If we don't join together to build a better tomorrow, who will? And if not now, when?

Supporting Area Students

We’re proud to award more than 70 competitive scholarships to deserving students each year. 

Whether you’re preparing to graduate from high school, wrapping up a general equivalency diploma, or working toward your undergraduate or graduate degree, the Sioux Falls Area Community Foundation is proud to partner with passionate donors to administer a wide variety of competitive scholarships to help you achieve your educational goals.

Siouxland Chapter CFMA Scholarship

Awarded to graduating seniors of high schools in South Dakota.

Our Work:

The Citi Foundation commits $20 million to help nonprofit housing developers overcome financial and operational barriers to building and preserving affordable housing in the U.S.

Apply for Funding

Citi Foundation primarily provides funding through open Requests for Proposals (RFP). This model enables us to engage and support a broad range of organizations across the globe to tackle some of the most pressing social issues of our time. Each RFP launched is accompanied by detailed information on goals, selection criteria and relevant application deadlines.

Housing Affordability

Citi's Blueprint for Housing Opportunity

Recognized as the number one affordable housing lender in the U.S. by Affordable Housing Finance magazine, Citi knows increasing supply is essential to addressing housing affordability — one of the defining economic challenges of our time. That’s why we are putting our capital, community impact and expertise toward helping more Americans access housing they can truly afford.

The ASP Conservation Small Grants program is dedicated to supporting primate conservation efforts. It invites proposals for conservation research or related projects, including education, with awards up to $3500. This initiative encourages ASP members, especially those in habitat countries, to submit impactful projects that contribute to broader conservation goals. The program emphasizes funding for local salaries, research supplies, and educational materials, ensuring the sustainability of primate conservation efforts.