Best Large Grants for Nonprofit Organizations in Virginia

The Sensata Foundation, established in 2017, is a 501(c)(3) nonprofit supporting community development and STEM education across the U.S. With a focus on improving access to STEM resources and empowering youth, the Foundation partners with nonprofits to address food insecurity, homelessness, and environmental sustainability. By fostering community partnerships and providing financial support, Sensata Foundation aims to inspire future leaders and enhance the quality of life for all, particularly in underserved areas.

The Williamsburg Health Foundation (WHF) offers the Responsive Grant to enhance health in Greater Williamsburg. This private foundation supports nonprofit organizations and government agencies focused on improving opportunities for uninsured and underinsured populations. Priority is given to proposals that align with WHF's mission, demonstrate collaboration, and create stronger health systems. For more details, visit their Strategic Plan online.

The Community Grants for Educational Success aim to enhance educational achievement for underperforming children and youth in South Hampton Roads. By supporting innovative programs, the grant focuses on preparing students for kindergarten, preventing dropouts, and facilitating transitions to higher education. The initiative emphasizes the importance of education in fostering economic development and personal prosperity, aiming for measurable outcomes like improved graduation rates and increased enrollment in post-secondary education.

The Rheum for Kids: Pediatric Skin and Joint Grant, offered by the Arthritis National Research Foundation, is aimed at early-career researchers focused on pediatric joint and skin diseases. This grant provides funding of up to $50,000 for one year to support innovative research projects. It encourages applications from diverse fields to advance the understanding and treatment of rheumatic diseases in children, fostering new insights and potential breakthroughs in pediatric healthcare.

The HEAL Initiative aims to combat the opioid crisis through action-oriented research that enhances the translation of addiction epidemiology, prevention, treatment, and recovery services into practice. It prioritizes scalable, evidence-based approaches targeting various levels, including individual and community. The initiative supports a range of methods for research deployment, emphasizing collaboration between researchers and decision-makers to improve outcomes for those affected by addiction and related chronic pain.

The Michael R. Priddy Music Scholarship, offered by the Central Kentucky Community Foundation, aims to support graduating high school seniors from Hardin County Schools, specifically Elizabethtown and LaRue County High Schools. This scholarship is intended for students who have demonstrated involvement in classical orchestra or music performance, or who plan to pursue music studies, thereby fostering musical education in the community.

The Plymale Foundation Grant, established by Robert E. Plymale in 1963 and now part of the Greater Lynchburg Community Foundation, supports 501(c)(3) organizations in Campbell County and surrounding areas. With approximately $40,000 available annually, grants typically range from $1,000 to $15,000, focusing on social welfare, healthcare, education, and children's needs. The foundation emphasizes funding special projects rather than operating expenses or capital projects.

About the Williamsburg Health Foundation 

The Williamsburg Health Foundation (WHF) is an independent private foundation dedicated to improving the health and well-being of those who live in Greater Williamsburg.

The Foundation is focused on strengthening the healthcare safety-net for uninsured and underinsured individuals and supports programs and activities that target behavioral and social risk factors that influence health throughout the life span.

WHF awards grants to nonprofit organizations as well as local and state government agencies that serve residents in our service area of the City of Williamsburg, James City County, and York County.

Grantmaking

With the goal of enhancing health in Greater Williamsburg, WHF is interested in evidence-based, promising, or previously successful approaches, and new ideas. WHF welcomes proposals from eligible entities that prioritize positive outcomes for populations with low incomes and target one or more of these underlying factors affecting lifelong health and well-being:

• Access to care: Availability, affordability, and quality of health-related services.
• Economic Advancement: Financial literacy and capability to access essential resources.
• Healthy Living: A way of living that lowers the risk of being seriously ill. 

Grant Priorities

As the Foundation’s funds are finite and the good work of nonprofit organizations and others is limitless, we have established the funding priorities outlined in the grantmaking guidelines. Priority consideration is given to proposals which:

• Align with the Foundation’s vision, mission, overarching goal, and strategies.
• Impact the health of economically disadvantaged individuals, including those who are uninsured and underinsured.
• Demonstrate collaboration, defined as aligning work among partners.

Unsolicited Grants/Proposals

The Foundation accepts unsolicited proposals through three grant cycles annually. 

Applying for an Unsolicited Grant requires the submission of WHF’s online grant application. WHF has two separate Unsolicited Grant applications: 1) project/program proposals and 2) capital project proposals.

Both applications require organizations to identify the need, target population, strategy for addressing the need, and alignment of the proposed request with WHF’s strategic plan and funding strategies.

Capital Project Proposals

Support of projects related to the construction, expansion, renovation of buildings and the acquisition of land. (Please note, capital grants are considered during the third grant cycle of the year, and the ability to support such projects varies by year. Even when capital project requests are strategically aligned, the ability to fund capital requests of this type may be limited by the grants budget and programmatic requests that year.) 

While the capital project application does not require submission of the WHF Program Budget Packet, the application itself requires budgetary information specific to the capital project.

The AWWA Scholarship Program, administered by the American Water Works Association, offers a $5,000 scholarship to graduate-level students pursuing careers in the water industry. Recognizing the vital role of future professionals, AWWA aims to support education in water supply and wastewater management through this scholarship initiative. Founded in 1886, American Water is the largest U.S. investor-owned water utility, emphasizing the importance of investing in education for sustainable water solutions.

What We Do

At the North Carolina Community Foundation, we bring together generous people and connect them to causes and organizations they care about.

Our mission is to inspire North Carolinians to make lasting and meaningful contributions to their communities.

Our Philanthropic Network

We believe in the power of permanent philanthropy to strengthen our communities and people. By stewarding and growing donors’ gifts, our philanthropic network makes a powerful impact through robust grants and scholarships programs.

Geraldine Mayo Beveridge Scholarship Endowment

About Geraldine Mayo Beveridge

Geraldine “Gerry” Mayo Beveridge taught school in Carteret County for 40 years. She was a Home Economics teacher and thought of her students as her children; she and husband “Captain David” had none of their own. Gerry would discreetly provide classroom supplies and clothing items for students in need. She quietly contributed money toward college for capable students who couldn’t afford it.

Gerry’s concern for students continued after retirement. As a member of the Carteret County Retired School Personnel (CCRSP), Gerry convinced members of the importance of awarding a scholarship to a graduating senior in each high school – East Carteret, West Carteret, and later, Croatan. To raise money, she organized bake sales and brought plants and canned foods to sell to members. The scholarships, though small, were a great effort for members and were greatly appreciated by recipients.

Gerry left a considerable sum of money to CCRSP with the expectation that it be managed well and used for scholarships. Today, the Geraldine Mayo Beveridge Scholarship is awarded to qualifying graduating seniors who want to teach Vocational Education, now called Career and Technical Education.

Gerry’s passion for her students and her love of education continues through this scholarship. She was an amazing educator whose philanthropy will last in perpetuity.

The NIDCD Cooperative Agreement for Clinical Trials in Communication Disorders (U01) aims to support clinical trials that evaluate interventions for communication disorders. This funding opportunity encourages collaboration between NIDCD Project Scientists and investigators, focusing on trials that require FDA oversight, establish efficacy, or pose risks of harm. By fostering well-designed studies, the NIDCD seeks to advance treatment and prevention strategies in the field of communication disorders.

The Ballyshannon Fund Grant supports educational initiatives that enhance public understanding of the economic significance of agricultural and forestry sectors in Central Virginia. To be eligible, organizations must possess 501(c)(3) status or be governmental entities, focusing on local projects. Notably, it does not fund capital campaigns, endowments, individuals, or physical infrastructure projects. First-time applicants should submit a Letter of Intent by February 15, while returning applicants must provide a full proposal.

Just One More Grant aims to transform lives by providing financial support to individuals and nonprofit organizations in the U.S. who are overcoming challenges like mental health issues, drug misuse, and educational barriers. The foundation encourages applications from those committed to personal growth and community support. Though current grants are paused for nonprofits, interested individuals with actionable plans are invited to apply. More information and past winners can be found on their website.

The SCALE initiative aims to combat injury, violence, overdose, and suicide, the leading causes of morbidity and mortality among individuals aged 0-44. By enhancing implementation and outreach, this funding opportunity seeks to empower organizations to implement effective prevention strategies, especially in underserved communities, including tribal areas. The program encourages collaboration and continuous improvement to achieve sustainable reductions in these critical public health issues.

The Comcast NBCUniversal Foundation offers Local Impact Grants to nonprofit organizations in 11 markets, providing $225,000 to support local programs addressing community issues. Eligible organizations must be 501(c)(3) nonprofits with a revenue exceeding $100,000 and must operate in one of the specified television markets. The grants aim to empower youth through education, promote diverse storytelling, and enhance community engagement. This initiative underscores Comcast's commitment to fostering inclusion and equitable opportunities for underserved communities.

The Special Emphasis Limited Project Grant from the American Society of Colon and Rectal Surgeons aims to address health disparities in colorectal surgery. It focuses on improving care for racial/ethnic minorities, women, LGBTQ+ populations, and individuals with disabilities. Proposals should concentrate on patient-oriented interventions and may explore quality improvement, access to services, and enhancing workforce diversity. Funding of up to $20,000 is available for innovative projects that promote equity in colorectal healthcare.

The Kars4Kids Small Grant Program aims to support educational initiatives globally, impacting the lives of children. This program welcomes applications from IRS-recognized nonprofit organizations focused on youth development, mentorship, and education. Grants typically range from $500 to $2,000, depending on mission alignment and available funds. Kars4Kids, a national Jewish nonprofit, is dedicated to nurturing productive community members through educational and mentoring opportunities.

The NIDDK High Risk Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34 Clinical Trial Optional) supports innovative, hypothesis-driven clinical studies with a focus on diseases relevant to NIDDK. This initiative facilitates early peer review and assessment of study designs while providing essential support for operational documents. Applicants are encouraged to consult with NIDDK staff before submission to enhance the chances of success.

Native Forward awards are allocated based on the financial aid information provided by the institution’s Financial Aid Office. Awards can vary, ranging from $100 to $30,000 per academic year.

Native Forward Scholars Fund members of federally and state-recognized Tribes as well as first and second-generation descendants. However, Native Forward Scholars Fund scholarship opportunities have different Tribal eligibility requirements and can be determined by submitting a Tribal Eligibility Certificate.

Hillman Barnett Adkins Endowed Fund Scholarship

The Hillman Barnett Adkins Endowed Fund is provided in honor of members of the Hillman, Barnett, and Adkins families. The purpose of the Hillman Barnett Adkins Endowed Fund is to provide financial assistance to eligible American Indian and Alaska Native vocational, undergraduate, and graduate students enrolled at an accredited not-for-profit college/university, vocational school, or Tribally controlled college or university (TCU) and pursuing degrees with a focus in Fine Arts (studio arts), Performing Arts (music, drama, musical theater, dance), Creative Writing, Art History, Visual Communication, Photography, Culinary Arts, Film (Cinematography, Screenwriting), or Fashion Design & Jewelry Design.

This opportunity is a merit-based award.

The NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Required) invites applications for high-risk clinical trials that involve multiple centers and aim to change clinical practice or public health. Applicants are encouraged to submit Letters of Intent 30 days before the proposal deadline, with various deadlines set from February 2025 to October 2026. Planning activities must be completed before submission, and consultation with NIDDK staff is advised.

The NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) support small businesses in conducting clinical trials for NIH-funded projects. This initiative encourages partnerships with investors to assist in the commercialization of innovations in neurological disorders. Applicants must submit a comprehensive Commercialization Plan detailing anticipated funding. The program aims to promote effective transitions from research to market, enhancing the development of drugs, devices, and therapies for neurological conditions.

The Basil O'Connor Starter Scholar Research Awards, offered by March of Dimes, support emerging researchers in maternal and child health. With a $150,000 grant over two years, the program prioritizes projects addressing preterm birth and health equity. Eligible applicants must be within four to nine years of completing their clinical training or terminal degree, holding a tenure-track position. This initiative aims to foster impactful research that enhances clinical treatments for serious maternal and newborn health conditions.

The Spencer T. and Ann W. Olin Foundation Wetlands and Waterfowl Research Fellowship supports graduate students in North America conducting research on waterfowl or wetland biology. The fellowship, offering up to $9,500 annually, emphasizes applicant qualifications, research proposal soundness, originality, and potential contributions to conservation efforts. This competitive opportunity is renewable for up to two additional years for PhD students and once for Masters students, pending satisfactory progress reports.

Funding Innovative Research

Cannonball Kids’ cancer Foundation (CKc) prioritizes funding clinical trials, research that is nearing translation to a clinical trial, and young investigator grants.

Grants funded by CKc must be innovative and provide better quality of life or symptom relief than current treatments. 

When possible, CKc will prioritize funding research:

• with a focus on cancers that are under-funded or under-researched,
• with a focus on patient populations who are traditionally underserved.

When possible, CKc will prioritize funding researchers of diverse backgrounds.

For CKc, “innovation” means the invention or application of novel methods or treatments, specifically treatments that have fewer side-effects than standard care, increase a child’s quality of life, and/or create an option for care where there otherwise were few or none (either on primary diagnosis, relapse, or for recalcitrant cancers).

Research Grants

Grant Program: Young Investigator

$100,000 over 3 years

• PI must hold an academic appointment at the instructor level or higher
• PI must be within 5 years of completing a training fellowship in Pediatric Hematology/Oncology or a closely related discipline that has direct clinical contact with pediatric cancer patients
• Research must be within 2-3 years to translation to a clinical trial or already associated with a clinical trial

• Evidence of Mentor's commitment to the PI's career development plan
• Translational potential

The Eco-Living Fund Grant, managed by the Charlottesville Area Community Foundation, seeks to promote sustainable living through projects that encourage zero-footprint and net-positive practices. Eligible applicants include tax-exempt organizations and government agencies within the foundation's service area. Grants support initiatives that demonstrate measurable outcomes in resource conservation and community engagement. The fund aims for projects that not only enhance environmental sustainability but can also serve as models for broader change, potentially saving costs for participants.

The Lynde and Harry Bradley Foundation Grant supports organizations dedicated to preserving American exceptionalism through a commitment to individual liberty, free markets, and civic responsibility. It prioritizes proposals from 501(c)(3) organizations that promote informed citizenship and strong communities. With ongoing acceptance of Letters of Inquiry, the Foundation seeks to empower initiatives that align with its principles of limited government and the rule of law, fostering a rich community culture.

Many Hands Grants has awarded over $2.5 million since 2004 to support local nonprofits focused on women, children, and families in need throughout the Washington, DC area. The organization offers four grants annually, including a $100,000 Impact Grant and three Partner Grants. The funding is unrestricted and aims to enhance the operational capacity of grantees, enabling them to better serve their communities in areas such as economic empowerment, education, health, and housing.