Best Large Grants for Nonprofit Organizations in Wisconsin

The Fiscal Year 2026 National Dam Safety Program focuses on rehabilitating high hazard potential dams that do not meet state safety standards. Funded by FEMA, this initiative aims to protect lives and property by providing federal funds to eligible states, which then pass these funds to non-Federal governmental or nonprofit organizations. Rehabilitation involves repairing, replacing, reconstructing, or removing dams to ensure compliance with safety regulations.

The Morris Animal Foundation is offering Pilot Study Awards focused on reptile and amphibian health and welfare, particularly for chytrid research. These awards aim to fund innovative, proof-of-concept studies that demonstrate a clear understanding of animal health issues and collaboration with stakeholders. Proposals must have a direct impact on wildlife populations and adhere to strict health study policies. The maximum funding is $20,000 for a duration of 12 months, ensuring significant contributions to wildlife health advancements.

The Morris Animal Foundation invites research pre-proposals for the Wildlife Health (Reptile and Amphibian) - First Award, aimed at enhancing the health and welfare of amphibians and reptiles. This initiative focuses on impactful research, particularly in chytrid disease. Eligible applicants include early career researchers with appropriate qualifications and a clear understanding of animal health challenges. Projects should demonstrate collaboration with relevant stakeholders and provide direct benefits to wildlife populations, emphasizing conservation through an animal health perspective.

The Forest Legacy Program (FLP) invites applications for FY2028 funding to safeguard privately owned forest lands through conservation easements or land purchases. This USDA Forest Service initiative collaborates with State agencies to protect vital forest ecosystems threatened by development. Participants can ensure the preservation of traditional forest uses and public benefits such as clean water, wildlife habitats, and recreational opportunities. For more details, visit the USDA Forest Service website.

This funding opportunity from the Patient-Centered Outcomes Research Institute aims to enhance health decision-making through comparative clinical effectiveness research, focusing on critical areas such as cancer, maternal health, and mental health. The initiative encourages robust observational studies that utilize existing data to derive patient-centered insights. Applications must address specific themes approved by PCORI and demonstrate potential benefits to the U.S. healthcare system, thus ensuring relevance and stakeholder engagement in research efforts.

The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by supporting the Centers for Structural Biology of HIV and other Infectious Diseases. This solicitation will support multidisciplinary groups of scientists to determine the 3-dimensional structures of molecules and molecular complexes involved in priority infectious diseases. The effort focuses on exploring biomolecular complexes that can be targeted to make new medicines and tests to prevent or treat infections and improve human health. The centers will drive cutting-edge research and development of structural biology technologies, including high-resolution 3D structural analyses, computational molecular dynamics, functional and mechanistic characterization at the molecular and cellular level, visualization at the atomic level of molecular complexes in cells and tissues, and advanced structure-guided design of molecules to combat infectious diseases. The centers will maximize use of common resources, establish broad collaborations, and mentor future structural biology researchers. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.

The Hazen and Sawyer Scholarship, valued at $10,000, is awarded annually to a graduate-level candidate dedicated to addressing critical challenges in drinking water, water reuse, and water resources. Sponsored by the American Water Works Association (AWWA), this scholarship supports students who are permanent residents of the U.S., Mexico, or Canada. Eligible funds cover tuition, books, and related educational expenses, enhancing the recipient's ability to contribute to the water industry.

The 15 and the Mahomies Foundation Grants aim to enhance the lives of children by supporting health, wellness, and community initiatives. This private foundation seeks to fund 501(c)(3) non-profit organizations, focusing on charitable causes. Grant requests are reviewed quarterly, and applicants must meet eligibility criteria. However, the foundation does not accept applications from individuals or for non-charitable items such as autographs or game tickets.

The Zero Hunger | Zero Waste Foundation Grant supports nonprofit organizations focused on ending hunger and reducing food waste. Since its inception, the foundation has allocated over $59 million to enhance food security through innovative programs and community engagement. Eligible applicants include 501(c)(3) nonprofits addressing critical needs such as food access, nutrition education, and support for vulnerable populations. This initiative aims to create equitable food systems and ensure that no one goes hungry.

The Arthur N. Rupe Foundation Grant focuses on promoting positive social change through scholarly studies, education, and public debate. It supports projects related to caregiving, civil debate, and public policy, aiming to enhance the quality of life in America. The foundation prioritizes specific project funding over general operations and does not support individuals or capital campaigns. Grant inquiries are invited through a letter of inquiry process, ensuring alignment with its mission.

The Richard King Mellon Foundation invites proposals for the RKMF Innovative Wood Products and Value Chains Grant, aimed at fostering innovation in wood products and strengthening value chains. With a focus on rural economic development and environmental conservation, the Foundation supports projects that enhance the use of novel wood materials in the built environment. Eligible initiatives may include product development, market strengthening, and demonstration of new technologies to maximize the benefits of these innovations.

The Elizabeth Furber Scholarship honors the legacy of Elizabeth Furber by providing financial assistance to American Indian and Alaska Native female graduate students. This scholarship supports students pursuing full-time degrees in various fields, including fine arts, music, and creative writing. As a need-based award, it requires applicants to demonstrate Tribal affiliation through a Tribal Eligibility Certificate. This opportunity empowers eligible students to achieve their academic goals.

The Down Syndrome – Aim High Scholarship, offered by The Community Foundation for the Greater Capital Region, empowers students pursuing careers in special education or therapy for individuals with Down Syndrome. This scholarship supports dedicated individuals committed to improving the lives of others through education and professional development. Since 1968, the foundation has focused on enhancing community well-being, making this scholarship a vital resource for aspiring professionals in the field.

The J.R. Simplot Company Foundation Grant supports U.S. non-profit organizations focused on art, education, youth, community, and global food and agriculture. Established in 1929, the foundation is committed to enhancing community welfare through creative cultural endeavors, educational initiatives, health services, and youth programs. Applications are reviewed quarterly, ensuring a timely response to organizations dedicated to making a positive impact in their communities.

The ANR Foundation Postdoctoral Fellowship offers financial support to researchers focusing on arthritis and related autoimmune diseases. This initiative aims to cultivate future leaders in the field by providing fellowships that foster innovative research and exceptional training opportunities. Open to various research areas, including osteoarthritis and lupus, the fellowship seeks to empower physicians to advance their work and make impactful contributions to understanding these conditions.

The Basic Needs Giving Partnership provides single-year grants to support organizations in Northeast Wisconsin that are addressing the root causes of poverty. Their focus is on collaborative initiatives in areas such as early care and education, housing access, mental health, and substance use. By partnering with local communities, they aim to foster equity and enhance economic well-being, while also disrupting systemic barriers that perpetuate poverty.

The Bay Area Lyme Foundation Grant supports innovative research aimed at improving diagnostics and treatments for Lyme disease. With a revised granting schedule, proposals can be submitted year-round, with reviews conducted three times annually. The foundation welcomes applications from universities, hospitals, and independent entities across the U.S., emphasizing the importance of addressing challenges in diagnosing and treating Lyme disease, especially for difficult cases.

The Dr. Bruce D. J. Batt Fellowship in Waterfowl Conservation honors the legacy of Dr. Bruce Batt, a leading figure in waterfowl research. This fellowship offers up to $5,000 annually to graduate students at North American universities conducting vital research on waterfowl and wetlands. Renewable for up to two additional years for PhD students, the fellowship promotes the integration of sound science in conservation efforts, supporting the next generation of waterfowl professionals.

The A Fund for Women Grant, offered by the Madison Community Foundation, aims to empower women and girls in Dane County by supporting projects focused on economic empowerment and education. Eligible 501(c)3 organizations can apply for funding to enhance accessibility to education, promote financial literacy, and advocate for policy changes that support women's rights. The deadline for full applications is June 25, 2025, and multi-year grants may be considered.

The WaterSMART Cooperative Watershed Management Program offers funding to eligible entities for developing local solutions to water management issues. This initiative supports watershed group development, restoration planning, and project design, promoting stakeholder cooperation and improving water reliability. It aligns with key priorities from the Trump administration, addressing complex water challenges and enhancing federal grant oversight. By facilitating these efforts, the program aims to stretch limited water resources and foster collaborative solutions among diverse stakeholders.

The Emergency/Medical Workers Behavioral Health Fund aims to support emergency workers facing trauma and anxiety due to their roles. Established by the HealthWell Foundation, it provides financial assistance for treatment-related costs, including copayments for prescription drugs, counseling, and transportation. In 2024, the Foundation awarded over $1.2 billion to underinsured patients, ensuring no one is denied essential healthcare due to financial barriers. This initiative helps address the critical mental health needs of those who serve on the front lines.

The Stackner Family Foundation Grants support organizations providing essential services to individuals with intellectual and physical disabilities or chronic mental health diagnosis. Applicants must verify their tax-exempt status and focus on the Milwaukee and Waukesha Counties area. This funding opportunity is available once every 12 months, ensuring targeted and effective support for local initiatives that enhance the quality of life for affected individuals.

The Therapeutic Giving program by Johnson & Johnson Innovative Medicine focuses on supporting nonprofit organizations that enhance patient access to treatment in cardiovascular and metabolic health. Applications are encouraged for initiatives that promote education, empower patients, and address healthcare disparities. Eligible organizations must be IRS 501(c)(3) certified, with a preference for programs demonstrating measurable outcomes. The funding period for local organizations extends from January to October 15th, while national organizations can apply in September.

The W. Wesley Eckenfelder Graduate Research Award, administered by the AEESP Foundation, recognizes outstanding graduate students in environmental engineering and science whose research enhances wastewater management knowledge. This prestigious annual award offers a $1,500 honorarium and a plaque for winners, along with a $500 travel stipend for attending the AAEES awards ceremony. Eligible candidates include both Master’s and Ph.D. students who demonstrate exemplary academic performance and innovative research contributions.

The Therapeutic Giving program by Johnson & Johnson Innovative Medicine focuses on enhancing patient access to treatment in cardiovascular and metabolism areas. Nonprofit organizations classified as 501(c)(3) are eligible to apply for funding. The program emphasizes innovative initiatives that address healthcare disparities and improve patient outcomes through education, advocacy, and support services. Applications are evaluated based on design, capacity, and potential impact, with a preference for programs over event-based funding.

The OVW Fiscal Year 2026 Training and Services to End Violence and Abuse Against Individuals with Disabilities and Deaf People Program aims to empower states, local and Tribal governments, and nonprofit organizations to provide crucial training and resources. This initiative focuses on addressing domestic violence, stalking, sexual assault, and caregiver abuse against individuals with disabilities and Deaf individuals, enhancing direct services and support for these vulnerable populations.

The Therapeutic Giving program by Johnson & Johnson Innovative Medicine focuses on Pulmonary Arterial Hypertension and supports nonprofit organizations that enhance patient access to treatment and services. Eligible applicants must be IRS 501(c)(3) certified and prioritize innovative programs with measurable outcomes. Funding is aimed at addressing health disparities and improving patient care through education, advocacy, and direct services. Applications are accepted from January 1 to October 15, with a preference for initiatives over event-based requests.