Best Unrestricted Grants for Nonprofits in Wisconsin

American Brain Foundation

The American Brain Foundation funds research across the spectrum of the brain and nervous system, because it is our best hope for improving treatments, advancing prevention strategies, and discovering cures. Brain diseases, disorders, and injuries are interconnected. When we cure one, we will cure many.

Next Generation Research Grants

The American Brain Foundation’s Next Generation Research Grants (NGRGs) support early career investigators conducting high-quality research aimed at better understanding, treating, and curing brain diseases. These grants are offered in collaboration with disease-focused partner organizations and reflect ABF’s Cure One, Cure Many research philosophy: the belief that breakthroughs in one area of research accelerate progress across many others.

Lawrence M. Brass, MD Clinical Research Training Scholarship in Stroke

This award aims to recognize the importance of good clinical research and to encourage early career investigators in clinical studies related to stroke, vascular neurology, and neurocritical care.

For the purpose of this scholarship, research is defined as “patient-oriented research conducted with human participants, or translational research specifically designed to develop treatments or enhance diagnosis of neurological disease. These areas of research include epidemiologic or behavioral studies, clinical trials, studies of disease mechanisms, the development of new technologies, and health services and outcomes research.” Disease-related studies not directly involving humans or human tissue are also encouraged if the primary goal is the development of therapies, diagnostic tests, or other tools to prevent or mitigate neurological diseases.

The Moody's Community Impact Grant Program supports organizations with tax-exempt status to foster social and economic equality. Established by Moody's Foundation, it prioritizes initiatives that empower underestimated communities and entrepreneurs, driving innovation and ecological restoration. The foundation focuses on inclusive growth, providing resources for small businesses and community resilience. Eligible organizations must be registered charities under U.S. IRS guidelines, while ineligible entities include individuals and those promoting unlawful discrimination.

The Patient-Centered Outcomes Research Institute (PCORI) will announce the Phased Large Awards for Comparative Effectiveness Research on December 2, 2025. This funding aims to support high-quality, patient-centered comparative clinical effectiveness research projects. The initiative encourages applicants to engage with patients and stakeholders to address critical healthcare dilemmas and improve decision-making. Projects should compare established clinical alternatives with evidence of efficacy, targeting vital health issues across diverse populations.

The Mastercard Strive USA 2025 Innovation Fund aims to enhance the financial health of small businesses across the U.S. by providing up to $250,000 in grants to organizations developing innovative solutions. This initiative focuses on addressing challenges such as limited access to financial resources and vulnerability to economic shocks, ultimately fostering resilience and growth within the small business sector.

The ASTRO-LUNGevity Residents/Fellows in Radiation Oncology Seed Grant aims to enhance the research careers of residents and fellows focused on radiation oncology, specifically benefiting lung cancer patients. This initiative supports basic, translational, and clinical research endeavors. With a maximum award amount of $50,000 for one year, it provides essential funding to foster innovative projects that can lead to significant advancements in lung cancer treatment.

The Community Development Block Grant Program for Indian Tribes and Alaska Native Villages aims to foster the development of viable communities by providing funding for housing, living environments, and economic opportunities, primarily benefiting low- and moderate-income individuals. The program is competitive, offering both single-purpose and imminent threat grants to address urgent public health and safety issues, ensuring that tribes can improve their community welfare effectively.

The NMDP Barbara Buchbinder Nurse Research Program Grant supports pediatric BMT nurses conducting research to enhance transplant experiences and outcomes for children. With only 4% of federal funding allocated to childhood cancer, this program, honoring a dedicated nurse, aims to attract new talent to the field. Each selected Buchbinder Scholar receives a $25,000 award to pursue relevant investigations, emphasizing the importance of supportive care in pediatric allogeneic hematopoietic cell transplants.

The SAF Technology Transfer Award honors exceptional contributions to technology transfer in forestry by an SAF member. It recognizes leaders who have significantly impacted forestry practices through innovation and quality work. The award includes a $1,000 honorarium, complimentary registration for the SAF convention, and up to $500 for travel costs. Presented at the SAF national convention, it emphasizes the importance of effective technology transfer for sustainable forest management.

The Alzheimer’s Association's Center for Dementia Respite Innovation Grant (CDRI) supports innovative respite care projects, aiming to improve person-centered dementia care across the U.S. With up to $20 million available over five years, the grant encourages local respite care providers to enhance their services through collaboration and innovative solutions. Recipients will receive training and assistance to ensure their programs are effective and sustainable, addressing the growing need for quality dementia care.

The Single Ventricle Research Fund (SVRF) offers annual grants aimed at enhancing research and care for individuals with single ventricle heart defects. With awards of up to $600,000, the SVRF encourages innovative projects that align with the Additional Ventures Research Roadmap. This initiative not only supports novel treatments but also fosters collaboration across disciplines to address critical challenges in single ventricle heart disease management.

The 1954 Project - Luminary Award seeks visionary nonprofit leaders dedicated to advancing educational equity for Black students. Awardees receive $1 million in funding, leadership development, and networking opportunities. The selection prioritizes leaders demonstrating strategic vision, community commitment, adaptability, and collaborative spirit. Applicants must align with one of three impact areas: Innovation in Teaching and Learning, Diversity in Education, or Pathways to Economic Mobility, ensuring their initiatives foster systemic change and uplift marginalized communities.

The Charles and Joan Hermanowski Family Foundation aims to enhance the lives of children and young adults in the U.S. by providing financial support to 501(c)(3) organizations focused on arts, education, health, and welfare. Grants, capped at $10,000, must be utilized within one year and are not automatically renewable. The foundation seeks to support smaller charities that may not receive broad public backing, thus creating a more significant impact on individual communities.

Single Ventricle Research Fund (SVRF)

Our flagship funding program — the Single Ventricle Research Fund (SVRF) — is an annual research award program that supports foundational studies aimed at improving outcomes for individuals with single ventricle heart disease. By addressing the organ- and multi-organ-level complications and clinical sequelae that drive long-term morbidity and mortality, the SVRF seeks to close critical gaps in understanding and treatment, and accelerate progress toward better, more predictive, and preventative care.

In its sixth cycle, the SVRF welcomes foundational research that is directly relevant to improving outcomes for individuals with single ventricle heart disease.

What Fits

Through the SVRF, Additional Ventures aims to accelerate foundational research that will lead to improved care and new therapeutic opportunities grounded in a mechanistic understanding of single ventricle heart disease.

The 2027 SVRF welcomes research aligned with the focus areas and strategic topics described in the Additional Ventures’ 2026 Research Roadmap. We are particularly interested in proposals that seek to elucidate the mechanisms underlying, prevent, or reverse the interrelated organ- and multi-organ-level sequelae that contribute to long-term morbidity and mortality.

Eligible investigators include postdoctoral fellows or equivalents holding a mentored position. Collaborative proposals will not be accepted through this track.

The 1890 Institution Teaching, Research, and Extension Capacity Building Grants Program aims to enhance the capabilities of eligible institutions by fostering collaboration with federal and non-federal entities. This initiative supports the White House's commitment to promote excellence at Historically Black Colleges and Universities (HBCUs). By strengthening institutional teaching, research, and extension capacities, the program helps ensure that HBCUs can effectively contribute to innovative solutions in education and community development.

The Lotte Lenya Competition, established in 1998 by the Kurt Weill Foundation for Music, honors the legacy of renowned actress Lotte Lenya. This unique contest blends acting and vocal skills, targeting performers aged 19-32 from diverse backgrounds. Celebrating its 25th anniversary in 2023, the competition has increased its prize offerings, with over $1.6 million awarded to more than 800 singers. It's a prestigious platform that has propelled many winners to successful careers in musical theater and opera.

The Mishler Brown Fund Grant, managed by the Community Foundation of Elkhart County, supports nonprofits dedicated to agriculture and historic preservation. Applications are accepted annually from October 1 to December 31, with funds awarded in January. Organizations must have a 501(c)(3) status but do not need to be located in Elkhart County. The fund honors Helen Mishler's legacy by preserving farming heritage, including her family's historic homestead.

The Cancer Prevention and Control Programs aim to enhance cancer outcomes by funding partnerships among national, state, territorial, and tribal organizations. These initiatives focus on evidence-based strategies for cancer surveillance, prevention, and control, specifically targeting breast and cervical cancer screening for underserved populations. Through collaboration, the program seeks to improve clinical services and cancer survivorship, ultimately striving towards the vision of 'All People Free of Cancer' by leveraging resources and community involvement.

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

Catalyzing Innovation through Partnerships

At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.

About this Challenge

This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).

Award Structure and Funding Level

To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:

For technically ambitious or higher-risk, earlier-stage concepts focused on feasibility testing, assay or workflow prototyping, and initial cost-reduction validation. Intended approaches that require focused development to demonstrate viability.

Gilead Sciences

At Gilead, we are relentlessly committed to advancing transformative therapies for the most serious diseases, delivering an exponentially positive impact on health.

For more than three decades, we have combined scientific rigor with a deep sense of purpose to improve health outcomes and reimagine care. Our work spans more than 35 countries with a focus on three therapeutic areas: virology, oncology, and inflammation, where unmet medical needs remain greatest.

From individual patients to whole populations, we’re committed to delivering healthier futures for people and communities worldwide.

Our Mission: To discover, develop and deliver innovative therapeutics for people with life-threatening diseases.

HIV Prevention NOVA 2026

Program Description

Gilead Sciences invites research proposals that advance the evidence base for innovative and scalable models of delivery for long-acting (LA) HIV pre-exposure prophylaxis (PrEP) in the United States.

This Topic of Interest (TOI) is focused on care delivery models implemented in non-traditional settings, defined as clinical and non-clinical environments where PrEP services are not routinely provided. Emphasis is placed on approaches that reflect real-life practice and address gaps in current PrEP delivery infrastructure.

Persistent inequities in PrEP uptake in the U.S. suggest that expanding availability within traditional clinical settings alone is unlikely to reach all populations with unmet PrEP need.1,2 Rigorous implementation studies in non-traditional settings where PrEP services are not routinely provided are needed to evaluate whether these models can reduce access barriers and improve equitable reach among individuals who may benefit from PrEP.2,3,4

The goal of this TOI is to generate practical, decision-relevant evidence that informs how LA PrEP can be implemented, scaled, and sustained in real-life U.S. settings.

About The John A. Hartford Foundation

The John A. Hartford Foundation, based in New York City, is a private, nonpartisan, national philanthropy dedicated to improving the care of older adults. The leader in the field of aging and health, the foundation has three priority areas: creating age-friendly health systems, supporting family caregivers, and improving serious illness and end-of-life care.

Since 1982, The John A. Hartford Foundation has awarded more than $758 million in grants to enhance the health and well-being of older people.

JAHF New Partners Program Call for Proposals:

National Initiatives Advancing Improvements in Care for Older Adults

The John A. Hartford Foundation (JAHF) is entering a new chapter that builds on its work to improve care for older adults and support family caregivers while bringing new organizations, leaders and ideas into its community of grantees and partners.

Through this funding opportunity, JAHF is seeking proposals from organizations that have not previously received a major grant from the foundation.

Proposed initiatives must have a national or multi-site scope and align with at least one of the foundation's three priority areas:

• Age-Friendly Health Systems
• Family Caregiving
• Serious Illness and End-of-Life Care

The Scleroderma-Related Lung Disease— The Debra Lurvey Memorial Research Grant, provided by the National Scleroderma Foundation, aims to support research in scleroderma-related lung disease. With a funding amount of $200,000, the grant encourages established investigators to explore innovative solutions and enhance understanding of this condition, ultimately working towards improving the quality of life for affected individuals and advancing medical knowledge in the field.

The Cynthia and Alan Baran Fine Arts and Music Scholarship Fund, established by passionate artists Cynthia and Alan Baran, aims to support young individuals pursuing their dreams in visual arts and music. This fund, administered by the Community Foundation of Middle Tennessee, offers scholarships to rising college students majoring in Fine Arts or Music, emphasizing the importance of creativity and academic achievement. With a commitment to fostering talent, this initiative empowers future generations to thrive in the arts.

The Bernick's Beverages and Vending Fund Grants aim to support organizations that align with the Bernick family's values, offering up to $150,000 in funding for 8-10 eligible groups. Focus areas include youth education and fitness initiatives, with grants ranging from $5,000 to $40,000. Eligible applicants include 501(c)(3) nonprofits, schools, and government entities within Bernick's operational regions. The foundation seeks innovative programs that foster community engagement and promote healthy lifestyles.

The Residential Curbside Recycling Cart Grant Program, offered by The Recycling Partnership, supports communities in enhancing their recycling efforts through grant funding and technical assistance. It encourages the implementation of cart-based recycling systems, conversion from bins to carts, and expansion of service areas to ensure equitable access. This initiative also includes vital education and outreach support, helping residents improve their recycling habits and ultimately achieve higher recycling rates.

The AISES Indigenous Peoples Education Fund (IPEF) Scholarship offers $5,000 to support Indigenous students pursuing degrees in STEM fields. This scholarship is available to current AISES members who are full-time students and enrolled citizens or descendants of recognized Native American tribes. AISES aims to empower these students, fostering diversity in STEM while recognizing the importance of education as a tool for personal growth and community development.

The IRSS RIFM Special Award for Inhalation Toxicology offers a $500 prize for trainees contributing to inhalation toxicology research. Sponsored by the Society of Toxicology, this award encourages innovative evaluations of inhaled toxicants, exposure science advancements, and risk assessment research. Applicants must submit a one-page summary of their work and a pending abstract for presentation at the SOT Annual Meeting, alongside a mentor's support letter. This award aims to promote excellence in the field.

Alkermes

At Alkermes, we apply our deep neuroscience expertise to develop medicines designed to help people living with complex and difficult-to-treat psychiatric and neurological disorders, including addiction, serious mental illness and sleep disorders. With our portfolio of marketed medicines and investigational pipeline candidates, we seek to make a meaningful difference in the way people manage these chronic diseases. Our patient-inspired science, integrated research strategy, sophisticated development capabilities and specialized commercial infrastructure enable us to pursue the development and commercialization of innovative new medicines, including those for people with conditions that have traditionally been overlooked or stigmatized.

Our greatest strengths at Alkermes are our people and our inherent empathy for patients, families and caregivers. Neurological and psychiatric disorders strike people at the core of who they are and impact many facets of their lives. We work with urgency to develop new treatment options for people living with these conditions.

Pathways APN Research Awards

The Alkermes Pathways Advanced Practice Nurse (APN) Research Awards™ program is designed to empower the advanced practice nursing community by offering funding opportunities that recognize their vital role in evidence-based care and the advancement of mental health research.

The Alkermes Pathways APN Research Awards provide opportunities for individual grants of up to $10,000 per project for licensed psychiatric-mental health nurse practitioners who are actively engaged in clinical, academic, and/or community health settings and are committed to advancing research in schizophrenia or bipolar I disorder.