Intellectual and Developmental Disabilities Grants

The Lawrence Foundation is a private family foundation focused on making grants to support environmental, human services and other causes.

The Lawrence Foundation was established in mid-2000. We make both program and operating grants and do not have any geographical restrictions on our grants. Nonprofit organizations that qualify for public charity status under section 501(c)(3) of the Internal Revenue Code or other similar organizations are eligible for grants from The Lawrence Foundation.  

Grant Amount and Types

Grants typically range between $5,000 - $10,000. In some limited cases we may make larger grants, but that is typically after we have gotten to know your organization over a period of time. We also generally don’t make multi-year grants, although we may fund the same organization on a year by year basis over a period of years.

General operating or program/project grant requests within our areas of interests are accepted. In general, regardless of whether a grant request is for general operating or program/project expenses, all of our grants will be issued as unrestricted grants.

The Foundation is dedicated to providing financial assistance to organizations committed to improving our world. Solutions to the problems of today's world still lie in the values of innovation, practicality, hard work, and compassion.

The Foundation considers applications for grants in the following areas:

• Education
• Social Service
• Health care
• Civic and cultural
• Environmental

The categories above are not intended to limit the interest of the Foundation from considering other worthwhile projects. In general, the Foundation guidelines are broad to give us flexibility in providing grants.

The majority of our grants are made in the U.S. However, like Dr. Scholl, we recognize the need for a global outlook. Non-U.S. grants are given to organizations where directors have knowledge of the grantee.

Mission

The mission of the Hearst Foundations is to identify and fund outstanding nonprofits to ensure that people of all backgrounds in the United States can build healthy, productive and satisfying lives. Through its grantmaking, the Hearst Foundations support well-established nonprofit organizations that address significant issues within their major areas of focus—culture, education, health and social service—and that primarily serve large demographic and/or geographic constituencies. In each area of funding, the Foundations seek to identify those organizations achieving truly differentiated results relative to other organizations making similar efforts for similar populations. The Foundations also look for evidence of sustainability beyond their support.

Whether providing a scholarship to a deserving student, supporting a rural health clinic or bringing artists into schools so children can see firsthand the beauty of the arts, the Foundations’ focus is consistent: to help those in need, those underserved and those underrepresented in society. Since the Foundations were formed in the 1940s, the scale and capabilities of the grant making have changed, but the mission has not.

Culture Grant

The Hearst Foundations fund cultural institutions that offer meaningful programs in the arts and sciences, prioritizing those that enable engagement by young people and create a lasting and measurable impact. The Foundations also fund select programs nurturing and developing artistic talent. Supported organizations include arts schools, ballets, museums, operas, performing arts centers, symphonies and theaters.

Funding Priorities in Culture

In the recent past, 25% of total funding has been allocated to Culture. Organizations with budgets over $10 million have received 60% of the funding in Culture.

The Hearst Foundations are only able to fund approximately 25% of all grant requests, of which about 80% is directed to prior grantees and about 20% is targeted toward new grantees.

Types of Support

Program, capital and, on a limited basis, general and endowment support

Helping Build Better Futures

Our mission is to deliver great value to our customers every day. For over four decades, our deep commitment to the principles of providing value and caring for others has helped define our culture. It extends beyond the walls of our stores, distribution centers, and offices, and into our local communities around the world. The intersection of these principles defines our global community mission:

Deliver great value to our communities by helping vulnerable families and children access the resources and opportunities they need to build a better future.

Our Social Impact Areas

We bring our community relations mission to life around the world by focusing our giving on four social impact areas where we believe we can have the most impact and are critical to helping families and children succeed and thrive.

Basic Needs

We are passionate about supporting nonprofit organizations that help fill critical basic needs such as a warm meal, clean clothing, and a safe place to sleep for vulnerable families.

Education & Training

Our efforts have focused on quality enrichment and extracurricular programs that provide skills, resources, and opportunities to support school and career success for children, teens, and young adults.

Patient Care & Research

We support organizations that deliver services to families and children facing health challenges and life-threatening illnesses.

Empowering Women

We support programs that provide services ranging from help for those fleeing domestic violence, to others that offer education, training, and job placement resources.

Helping the Disadvantaged Become Self-Reliant

Gupta Family Foundation is a private, nonprofit foundation headquartered in Herndon, Virginia, USA. Our mission is to support organizations that provide focused intervention in the lives of people who have been disadvantaged in some way to help them become self-reliant. We take a very broad view of “disadvantage” to include anything that holds a person back from realizing their potential, such as poverty, physical or mental disability, social alienation, etc. The foundation also supports relief agencies that serve people affected by emergencies such as natural disasters.

The foundation evaluates and awards annual and multi-year grants ranging from $5,000 to over $250,000 (USD). Our focus is on funding smaller organizations all around the world that are led by individuals with a deep personal commitment to their missions. 

Our selection criteria include:

• Mission alignment
• The organization is run by the founder or, if not, by a successor who embodies the original inspiration, passion and commitment of the founder.
• At least 90% of grant monies reaches the intended beneficiaries.
• The organization is non-sectarian, i.e.,
  • It does not, directly or indirectly, support or condone the proselytization of any religion,
  • It is not supported by or affiliated to a religious organization.

Global Impact Cash Grants

Cisco welcomes applications for Global Impact Cash Grants from community partners around the world who share our vision and offer an innovative approach to a critical social challenge.

We identify, incubate, and develop innovative solutions with the most impact. Global Impact Cash Grants go to nonprofits and non-governmental organizations (NGOs) that address a significant social problem. We’re looking for programs that fit within our investment areas, serve the underserved, and leverage technology to improve the reach and efficiency of services. We accept applications year-round from eligible organizations. An initial information form is used to determine whether your organization will be invited to complete a full application.

Social Investment Areas

At Cisco, we make social investments in three areas where we believe our technology and our people can make the biggest impact—education, economic empowerment, and crisis response, the last of which incorporates shelter, water, food, and disaster relief. Together, these investment areas help people overcome barriers of poverty and inequality, and make a lasting difference by fostering strong global communities.

Education Investments

Our strategy is to inclusively invest in technology-based solutions that increase equitable access to education while improving student performance, engagement, and career exploration. We support K-12 solutions that emphasize science, technology, engineering, and math (STEM) as well as literacy. We also consider programs that teach environmental sustainability, eliminate barriers to accessing climate change education, and invite student engagement globally to positively affect the environment.

What we look for:

• Innovative early grade solutions using the internet and technology to bridge the barriers preventing access to education for underserved students globally.
• Solutions that positively affect student attendance, attitudes, and behavior while inspiring action by students to improve learning outcomes, whether they participate in person, online, or in blended learning environments. 
• Solutions with high potential to replicate and scale globally, thereby increasing the availability of evidence-based solutions that support student-centricity, teacher capacity in the classroom, and increased parental participation to help students learn and develop.

Economic Empowerment

Our strategy is to invest in early stage, tech-enabled solutions that provide equitable access to the knowledge, skills, and resources that people need to support themselves and their families toward resilience, independence, and economic security.

Our goal is to support solutions that benefit individuals and families, and that contribute to local community growth and economic development in a sustainable economy.

We target our support in three interconnected areas:

• Skills development to help job seekers secure dignified employment and long-term career pathways in technology or other sectors, including environmental sustainability/green jobs.
• Inclusive entrepreneurship with small businesses as engines of local growth as well as high growth potential start-ups as large-scale job creators nationally and internationally, in technology or other sectors, including environment sustainability/green businesses.
• Banking the unbanked through relevant and affordable financial products and capacity building services.

Cisco Crisis Response

We seek to help overcome the cycle of poverty and dependence and achieve a more sustainable future through strategic investments. We back organizations that successfully address critical needs of underserved communities, because those who have their basic needs met are better equipped to learn and thrive.

What we look for:

• Innovative solutions that increase the capacity of grantees to deliver their products and services more effectively and efficiently
• Design and implementation of web-based tools that increase the availability of, or improve access to, products and services that are necessary for people to survive and thrive
• Programs that increase access to clean water, food, shelter, or disaster relief and promote a more sustainable future for all
  • By policy, relief campaigns respond to significant natural disaster and humanitarian crises as opposed to those caused by human conflict. Also by policy, our investments in this area do not include healthcare solutions.

Climate Impact

Our strategy is to invest US$100 million in Cisco Foundation funds over the next decade to help reverse the impact of climate change, working toward a sustainable and regenerative future for all.

The commitment includes both grant and impact investment funding for early-stage climate innovation. Both categories of support will be focused on bold climate solutions, and the grants side will also concentrate on community education and activation. Grants will go to exceptionally aligned nonprofit organizations, while impact investments will go to highly promising for-profit solutions through the private sector and climate impact funds.

Funding comes from the Cisco Foundation and will focus on:

• Identifying bold and innovative solutions that:
  • Draw down the carbon already in the atmosphere
  • Regenerate depleted ecosystems and broadly support the transition to a regenerative future
• Developing curricular initiatives to spur community engagement that can lead to measurable behavioral change and collective action

We will prioritize organizations that can achieve, measure, and report outcomes such as:

• Reduction, capture, and/or sequestering of greenhouse gas and carbon emissions
• Increased energy efficiency and improved mapping and management of natural resources, such as ecosystem restoration, forest treatments, reforestation, and afforestation that also will help repair our water cycles
• Transition to inclusive, just, coliberatory, and regenerative operating models, ways of being, and ways of organizing economies
• Creation of, and increase in, access to green jobs and job training
• Changes in community and individual behavior that lead to carbon footprint reduction, community climate resilience, and localized roadmaps to a sustainable shared climate future for all

Charitable Contributions

Costco Wholesale’s primary charitable efforts specifically focus on programs supporting children, education, and health and human services in the communities where we do business. Throughout the year we receive a large number of requests from nonprofit organizations striving to make a positive impact, and we are thankful to be able to provide support to a variety of organizations and causes. While we would like to respond favorably to all requests, understandably, the needs are far greater than our allocated resources and we are unable to accommodate them all.

Warehouse Donations:

Warehouse donations are handled at the warehouse level - please consult your local warehouse for up-to-date information regarding their donations contacts and review process.

Grant Applications

If the request is under consideration, you may be contacted by staff for any additional information needed. Applications are reviewed within 4-6 weeks, and decisions are made based on several factors, including: type of program; identified community need not otherwise available; indication that evidenced based data will establish measurable results of intended outcomes; community collaboration; broad base of financial support; project budget and operating expenses.

The Sidney Stern Memorial Trust is devoted solely to the funding of charitable, scientific, medical and educational organizations.

The Board endeavors to support soundly-managed charitable organizations that give service with a broad scope, have a substantial effect on their target populations, and contribute materially to the general welfare. The Board does not discriminate on the basis of ethnicity, race, gender, sexual orientation or religion.

Mission

To provide financial and other resources to improve the lives of individuals with intellectual and developmental disabilities.

Vision

Our vision is one of lasting progress and sustainable solutions to address the range of needs among the intellectual and developmental disabilities population. We envision a world where these individuals are celebrated for their unique gifts. We want families to have open access to resources and information they need to make decisions about best-in-class care for their loved ones. We imagine a world where local communities are actively engaged in learning from and receiving the meaningful contributions of individuals with intellectual and developmental disabilities by including them in the fabric of the community.

Funding Priorities

The Enterline Foundation’s overarching funding priority is to increase access to services for adults with intellectual and developmental disabilities. Believing that an adequate direct support professional (DSP) workforce is essential to ensuring the provision of services, The Foundation will focus its giving in 2025 on initiatives that support the recruitment and retention of DSPs. Although not limited to these examples, initiatives could include:

• Internship programs
• New hire welcoming, orientation and coaching 
• Training and professional development including certification programs
• Establishment of career ladders
• Connection to community resources for nonwork related needs of DSPs
• Improvements to organizational culture
• Communication and feedback soliciting initiatives
• Recognition and appreciation activities
• Front line supervisor coaching and development
• Technology needed to support data collection and employee experience

Funding Amount

Not to exceed $25,000. One year in duration.

Max and Victoria Dreyfus Foundation Grant

The Foundation will consider requests to support museums, cultural and performing arts programs; schools and hospitals; educational, skills-training and other programs for youth, seniors, and persons with disabilities; environmental and wildlife protection activities; and other community-based organizations and programs.

Who We Are

The Creag Foundation is a private grant making foundation established in 2009 in Woodinville, Washington.

The founders of the Creag Foundation believe that meaningful change can only be achieved through hard work, creativity and passion. They also understand the practical mechanisms that allow charitable organizations to succeed and grow. As a group, Creag Foundation principals are dedicated to helping today’s most innovative programs improve the human condition in a wide variety of ways.

Our Focus

The broad purpose of the Foundation is to support the efforts of nonprofit organizations who are innovators in the field of human services. Our particular focus is on smaller organizations that are starting out or established organizations that are looking for funding to take their organization in a new direction.

What We Fund

/ What We Fund

The Creag Foundation is focused on innovation in the industry. We will consider proposals from 501(c)(3) organizations that are finding new ways to address societal issues facing the nonprofit community. Applicants must have held 501(c)(3) status for one year before submitting. If your organization has held 501(c)(3) status for over a year, and your believe that your organization has a new approach to an existing social problem or is addressing a previously unaddressed social issue, you are welcome to contact us and request that we consider your organization for a funding opportunity.

Mission

Driven by a philanthropic calling to support marginalized communities throughout the world, the Semnani Family Foundation partners with on-the-ground organizations and leverages its resources in a cost-effective and efficient manner that delivers the maximum benefit.

History

Guided by his grandmother Maliheh’s example and teachings, Khosrow Semnani and his wife Ghazaleh established the Semnani Family Foundation in 1993. The foundation’s first grant was issued through CARE International to an orphanage in Romania that cared for newborns affected by HIV. Over the last few decades, the foundation has continued to build upon its mission to empower the disaffected, partnering with a variety of organizations in different countries who can make the greatest impact.

In addition to its global influence, the Semnani Family Foundation established roots within the state of Utah with the founding of Maliheh Free Clinic in 2005 to provide free healthcare to thousands of uninsured people in the Salt Lake City area.

Where We Work

The Semnani Family Foundation focuses primarily on promoting health, education, and disaster relief for marginalized communities all around the world. Driven by a clear mission to adapt and serve at the global level, we have leveraged our resources to make a meaningful impact in the following countries so far:

• Afghanistan
• Bosnia
• Colombia
• England
• Ethiopia
• Ghana
• Guatemala
• India
• Iran
• Kenya
• Madagascar
• Mali
• Mexico
• Pakistan
• Philippines
• Romania
• Somalia
• South Africa
• Tanzania
• Tonga
• Uganda
• United States
• Yemen

At the heart of the Foundation lies a fervent commitment to human welfare, always prioritizing health and the needs of society’s most vulnerable.

Background

Governmental public health (GPH) is a fundamental system for protecting and improving population health in all communities. This system works toward preventing and eliminating health inequities while responding and meeting emergency and emergent needs. Transforming governmental health to address structural barriers to health and advancing an equitable system where governmental public health and communities work in collaboration and share power fosters health equity and helps communities thrive. Non-governmental organizations, power-building organizations, and public health professionals are crucial components to this transformation by supporting the priorities, meeting the needs, and holding public health accountable to communities they serve while protecting the integrity and historic health justice orientation of the governmental public health system. The connected systems of both public health and healthcare systems have often failed to provide adequate consideration for the needs of adults with developmental disabilities, resulting in many experiencing these systems as a source of harm and mistrust. These systems can have a disparate impact on populations that have experienced systems of oppression, including ableism1. Society has traditionally looked at disability through a medical model of inability and dependence. These structural barriers are further intensified for individuals experiencing multiple systems of oppression, as racism and ableism1 mutually reinforce each other. There are medical professionals and disability advocates who are actively involved in and leading change toward more equitable public health and healthcare systems. WITH Foundation (WITH) promotes comprehensive healthcare for adults with developmental disabilities in the United States that is designed to address their unique and fundamental needs. WITH embraces an intersectional approach, centers the expertise and leadership of those most impacted by this injustice, is committed to cultural humility5 and addressing power imbalances, and values innovation. In alignment, the Robert Wood Johnson Foundation (RWJF) is a leading national philanthropy dedicated to taking bold leaps to transform health in our lifetime. To get there, we must work to dismantle structural racism and other barriers to health. Through funding, convening, advocacy, and evidence-building, RWJF works side-by-side with communities, practitioners, and institutions to achieve health equity faster and pave the way, together, to a future where health is no longer a privilege, but a right.

RFP Advancing Disability Justice in Public Health—New Funding Opportunity

This is an invitation for collaborative proposals that advance disability justice6 in public health and center the goals, perspectives, and needs of adults with intellectual and developmental disabilities (I/DD) in Communities of Color. The efforts supported through this RFP will contribute to a public health system that is fair and just, treats all people with dignity and respect, and rectifies past harms and prevents future ones. Proposals should prioritize one of the following approaches:

Implementation: Support implementation of models, i.e., testing and advancing solutions to enhance governmental public health in being trustworthy, accountable, truly collaborative, and anti-racist. Models should support the leadership of and power sharing with adults with intellectual and Developmental Disabilities in Communities of Color, or those with a demonstrated track record of working with Adults with I/DD in Communities of Color;

Educational resources: Developing public health curriculum and/or training resources with Adults with Intellectual and Developmental Disabilities in Communities of Color, and/or creating/leveraging networks supporting resource dissemination and utilization within public health and disability justice6 ecosystems, helping public health systems become more accountable to Adults with Intellectual and Developmental Disabilities in Communities of Color – communities that have been historically marginalized.

Advocacy, Power and Bridging: Support regional or national advocacy, community power building to build and shift power, and bridging between governmental public health with entities such as grassroots organizing groups, social movement groups, movement-building organizations, community-based organizations, community organizing groups, and base-building groups related to the care that Adults with Intellectual and Developmental Disabilities in Communities of Color receive within public health; and

Research: Identify and close gaps in knowledge and inform efforts to improve health related to the care Adults with Intellectual and Developmental Disabilities in Communities of Color receive, i.e., community-based or community-led research that assists disability-led organizations in illuminating and addressing structural barriers within the governmental health system that are experienced by Adults with Intellectual and Developmental Disabilities in Communities of Color.

Community Partnership Award

The Mutual of America Foundation Community Partnership Award recognizes outstanding nonprofit organizations in the United States that have shown exemplary leadership by facilitating partnerships with public, private or social sector leaders who are working together as equal partners, not as donors and recipients, to build a cohesive community that serves as a model for collaborating with others for the greater good.

Each year, the Mutual of America Foundation sponsors a national competition in which hundreds of organizations demonstrate the value of their partnership to the communities they serve, their ability to be replicated by others and their capacity to stimulate new approaches to addressing significant social issues.

Six organizations are selected by an independent committee to receive the Community Partnership Award.

• The Thomas J. Moran Award is given to the national award-winning program and includes $100,000 and a documentary video about the program.
• The Frances R. Hesselbein Award is given to a partnership that is addressing social challenges in more than one community, or which demonstrates the potential to be replicated in other communities. This recipient receives $75,000.
• Four other organizations are named Honorable Mention recipients for their programs, and each receives $50,000.

Since its inception in 1996, the Community Partnership Award has recognized 262 partnerships from cities and towns across America. Like so many of our clients working in the nonprofit community, Mutual of America is dedicated to having a direct, positive impact on society.

About the Foundation

Jesse W. Couch lived a life of zeal, honor, and dedication to the betterment of his community. The Couch family now humbly stewards the foundation he created to carry on his legacy of service for future generations. We believe that impact is best accomplished through partnerships with local organizations that know the people and communities they serve. We invest in and support efforts to protect the environment, further conservation and preservation initiatives, and save historical architecture that preserves community heritage. We also support initiatives that promote wellness and mental health and organizations seeking to provide and further education for all communities.

Annual Grant Focus

Each year, we seek to partner with and support non-profit organizations making an impact in the focus areas listed here. 

The focus area for this year is Wildlife Conservation. We believe it's our duty to conserve the lands and waters on which all life depends. We envision a world where everyone works in harmony to protect what is important so that all life on this planet can thrive.

About Us

The Patient-Centered Outcomes Research Institute (PCORI) is an independent, nonprofit research organization that seeks to empower patients and others with actionable information about their health and healthcare choices. We fund comparative clinical effectiveness research (CER), which compares two or more medical treatments, services, or health practices to help patients and other stakeholders make better informed decisions.

Since its authorization by Congress in 2010, PCORI has awarded more than $3 billion to fund nearly 2,000 research and related projects (explore our research portfolio). PCORI-funded research studies produce important results that are published in leading medical journals and presented at major scientific meetings. Results from studies we have funded are also taken up in a variety of clinical guidelines. We post results from every study we fund, with versions for both patients and clinicians. 

In 2019, PCORI’s funding was reauthorized, with additional research priorities—intellectual and developmental disabilities and maternal morbidity and mortality—and a mandate to consider, as appropriate, the full range of outcomes data, including the potential burdens and economic impacts of the use of medical treatments, items, and services for different stakeholders in the research we fund.

PCORI is committed to transparency and a rigorous stakeholder-driven process that emphasizes patient engagement. PCORI uses a variety of forums and public comment periods to obtain public input to enhance its work. PCORI helps people make informed healthcare decisions and improves healthcare delivery and outcomes by producing and promoting high-integrity, evidence-based information that comes from research guided by patients and other stakeholders.

The Jordan Spieth Family Foundation focuses on impactful and direct lines of support through our four mission pillars: Individuals with Special Needs, Junior Golf, Military Families and Veterans and Pediatric Cancer. All grant applicants' primary work must fall very specifically within one or more of these areas. For each initiative we support, JSFF seeks to fund achievable ideas that aim to help remove barriers and/or provide opportunities that directly impact individuals and families within our mission focus. Ideally the primary work of each grant should take place within the 2025 calendar year. 

Individuals with Special Needs

The Foundation seeks to partner with programs that close the gap for those with cognitive or neurological special needs, ensuring these children and young adults have access to developmental programming and vocational opportunities to expand their communication, self-help, and social skills. We focus on pursuing partners that create developmental opportunities and promote inclusion for the intellectually disabled.

Junior Golf

We believe the game of golf can be a conduit for many life skills and an on-ramp for expanding youth horizons. The Foundation will focus on junior golf programs that are diverse, emphasize outreach and remove potential socio-economic barriers to the game. We also pursue partnerships with groups that utilize golf as an avenue to furthering education and/or mentorship opportunities.

Military Families and Veterans

In an effort to honor those military members who have served our country, the Foundation pursues established grant partners who directly impact service members and/or their families through financial aid opportunities, familial respite support, mental and physical therapies and avenues that look to provide long-term support mechanisms.

Pediatric Cancer

Our goal is to fund programs that offer direct care for children fighting cancer and their families. This includes supporting child life services, emotional and social therapies, familial respite, and avenues to overcome financial burdens on families when facing a diagnosis. Additionally, the ultimate goal of the JSFF and our partners would be to eradicate pediatric cancers, and we welcome grant applications for research and clinical trials.

Please see FAQs for additional guidelines.

The Foundation was established in December 2013 by Kathryn B. McQuade, after retiring from 33 years of working in the business community. I was blessed to have been born into a loving middle class family. My father worked very hard to insure that all of his children were given an opportunity for a good education and my mother, “a stay at home Mom’ was always there for us. My world was safe and comfortable. My life is in stark contrast to how much of the rest of the world lives. I continue to read of the terrible injustices waged against women and children globally and hope that this foundation can provide them the opportunity and resources to succeed. We will support organizations that help us achieve our goal of Striving to make sustainable improvements in women and children’s rights education and welfare.

Kathryn McQuade Foundation Grant

The Foundation will make timely decisions on your grant request and provide clear communications on our expectations of reporting progress.

Women

The Foundation’s goal is to provide women assistance and provide them an opportunity to succeed. Assistance can take many forms, however our goal is to help them become self sufficient and enable them to lift themselves out of poverty and provide for their children. Access to education, job training and professional skills, even access to capital in order to build a business are possible ways we will consider helping women to succeed. Grant requests should focus on enabling the women to sustain financial independence.

We look forward to hearing of the many creative ways organizations are working on helping women succeed through out the world. To help women is to help their children and the communities they live in.

Children

Too many children in the US and across the world live in poverty and lack the access to education. Education and/or appropriate skills training are necessary to break the cycle of poverty and crime. While the assistance to women may take many forms, the foundation’s focus for children will target education and/ or skills training. The Foundation is open to many ideas on how to accomplish this goal and look forward to receiving proposals to help all children achieve their potential.

The Labcorp Charitable Foundation

We believe every person deserves equitable care and education.

In 2020 Labcorp established a private charitable 501(c)(3) foundation to advance our desire to bring quality healthcare access to all by supporting education and our local communities. 

Common grant opportunities include:

• Supporting food pantries and meal programs
• Providing healthcare and patient services for underserved populations
• Encouraging STEM programming
• Advocating for healthy lifestyles through ongoing medical research and screening

Project CASK Grant Program

Project CASK, in collaboration with the Orphan Disease Center, is seeking proposals to advance research that supports therapeutic development for CASK gene disorders.

Background

The X-linked CASK gene provides instructions for making a protein called calcium/calmodulin-dependent serine protein kinase (CASK), which is primarily found in neurons and helps control the expression of other genes involved in brain development. Mutations on the CASK gene are currently associated with two disorders, microcephaly with pontine and cerebellar hypoplasia (MICPCH) and XL-ID with or without nystagmus. The spectrum of neurological phenotypes associated with CASK variants is broad and includes global developmental delays, intellectual disability, epilepsy, or other seizure disorders, hypotonia, swallowing or feeding challenges, hearing and vision issues, and other neurological symptoms. 

Funding

Proposed funding period is one or two years, beginning about one month after full applications are received.  

The Engagement Award Program is now accepting Letters of Intent (LOIs) for the Engagement Award: Capacity Building funding opportunity. This opportunity aims to build the capacity and skills of patients and stakeholders to engage in all phases of patient-centered comparative clinical effectiveness research (CER).

Award

You may propose projects that will last up to two years and cost up to $300,000.

People With Disabilities Foundation Grants

In February 2017, PWDF announced a pilot grant program to help other nonprofit agencies in their work to integrate people with psychiatric, intellectual, and/or developmental disabilities (P/IDD) into the whole of society. Grants may be used for a specific program, project, or general operating expenses if related to a specific project or program in furtherance of providing advocacy, education, vocational, or other services to people with psychiatric and/or developmental disabilities.

PWDF’s Grant Program is accepting LOIs for new grant awards. LOIs must be submitted on PWDF’s LOI form and received by November 6, 2024, to be considered for the next grant cycle. The date of approval will depend on the date of the next Board meeting at which grants are reviewed. 

Rapid advances in genotyping and next generation sequencing technologies have led to the identification of genetic variants that are associated with a wide variety of congenital defects including human congenital anomalies (HCAs), intellectual developmental disabilities (IDDs) and inborn errors of metabolism (IEMs). Large quantities of genomic data collected from pediatric congenital anomalies cohorts are available to the research community through several databases such as the Database of Genotypes and Phenotypes (dbGaP), the Gabriella Miller Kids First Data Resource Portal, the European Genome-Phenome Archive and Clinical Genome Resource (ClinGen). The purpose of this initiative is to promote the screening, functional validation and characterization of congenital anomaly-associated genetic variants identified through public facing databases and individual efforts using in-silico tools, appropriate animal models, in vitro systems or multi-pronged approaches. This initiative addresses a challenging gap between identifying sequence variations of potential interest and recognizing which of those variations have functional effects on the phenotype of interest.