Best Grants for International Development in Africa

The Big G Charitable Foundation, founded in 2009 by Mike Galesi, is dedicated to supporting environmental conservation and emergency relief efforts. Inspired by his father, John (Big G), Mike's commitment to helping others drives the foundation's mission to protect the defenseless and promote sustainability. Through grants, the foundation aids qualified non-profit organizations focused on these critical areas, ensuring that both our planet and those in crisis receive the support they need.

The DanPaul Foundation aims to enhance early childhood development by training teachers and parents, protecting children from abuse, and promoting social responsibility. They provide grants to non-profits for programs that focus on education, health, and welfare of youth. Key initiatives include scholarships, environmental education, and support for underprivileged children. Grant amounts range from a few hundred dollars to $15,000 annually, with a focus on impactful, community-driven projects.

The Draper Richards Kaplan Foundation provides grants to early-stage social entrepreneurs working on scalable solutions to pressing social and environmental issues. By supporting organizations with innovative approaches and proven impact, they aim to uplift underserved communities globally. The foundation offers operational support, funding of up to $300,000 over three years, and fosters a collaborative community among its portfolio organizations. They focus on candidates demonstrating measurable impact and sustainable growth potential.

The MacFarlane Foundation, established in 2009, is dedicated to enhancing the quality of life for individuals and communities through strategic grantmaking. It supports U.S. public charities focused on education, economic empowerment, climate change, health, and women's well-being. Grants range from $10,000 to $250,000, with a commitment to fostering growth in organizations. The foundation invites proposals annually, ensuring impactful contributions to various causes both domestically and internationally.

The Michael & Susan Dell Foundation provides grants to organizations focused on improving the lives of children in urban poverty in the U.S., India, and South Africa. They prioritize projects in education, health, and family economic stability. Grants typically do not exceed 25% of a project's budget or 10% of an organization's annual expenses. The foundation seeks to partner with organizations already making an impact, ensuring funding supports impactful social enterprises.

Roche Corporate Donations and Philanthropy (CDP) focuses on impactful projects that foster sustainable development, engage employees, and leverage Roche's expertise. Their philanthropic efforts prioritize humanitarian, educational, environmental, and cultural initiatives, aiming to build stronger communities and support innovative projects. Eligibility is limited to local organizations, while ineligible projects include those with political or religious ties. The foundation strives to create a positive societal impact through collaboration and strategic partnerships.

Save the Rhino International (SRI) Grant aims to protect critically endangered rhinos through strategic funding and collaboration. With a focus on key populations like black, Sumatran, and Javan rhinos, SRI emphasizes law enforcement, biological management, and stopping illegal markets. They support field programs that meet specific eligibility criteria and prioritize sustainable financing mechanisms. SRI's efforts aim for the long-term recovery of these species, ensuring their survival and promoting international awareness and support for rhino conservation.

The Skees Family Foundation offers mission-aligned Seed Grants to nonprofits focused on job creation and readiness, primarily outside the U.S. These grants, beginning at $2,500 and increasing over three years, aim to support organizations with annual budgets of $250,000 or less. By prioritizing international efforts, the foundation seeks to maximize the impact of its limited resources, fostering growth in community-based organizations dedicated to alleviating poverty and promoting economic development globally.

 

Skees Family Foundation

The Skees Family Foundation, a 501(c)3 private charitable foundation (EIN#83-0411607), works with nonprofits (NPOs) and nongovernmental organizations (NGOs) serving families in need around the world.

The Skees Family Foundation — family helping families — extends self-help to youth and families to end poverty worldwide. We support organizations in the U.S., Africa, Asia, Central and South America, India, and the Pacific to promote job creation and economic development. We value love in action to create equal opportunity for all. And as a diverse multigenerational group with limited time and funds, we believe that we — and you — can change the world for good.

Mission: Skees Family Foundation works to end global poverty by partnering with community-based organizations to create fulfilling jobs and build job readiness through vocational or entrepreneurial training.

How We’re Different

We approach grantmaking in ways that differ from many funders, in ways intended to minimize the power imbalance between nonprofits and funders:

• No Restrictions: Unrestricted funding shows trust and respect for our partners. They know where the money is most needed, and we don’t have the burden of keeping track of specific projects.
• No Applications: All the information we need is found through our own research. This helps us keep our workload lighter by not having to go through hundreds of applications, and it provides our new partners a welcome surprise, with infinite return on investment. 
• Limited Reporting: We have calls once a year with our partners to discuss how they’re doing and their plans for the future. We don’t ask for written reports – we talk to our partners and create enduring relationships. 
• Multi-Year Grants: Two to six-year grants give us the opportunity to build relationships with our partners and for them to have the security of longer-term funding.
• Storytelling Assistance: Through our Seeds of Hope blog and the My Job social mission project, we tell the stories of our partners. We get to shine a light on their work, and they get a bit of free promotion!
• Funding Channels: Our partners are often challenged in finding their next level of funding. In response, we are creating a network of funders to help guide our partners toward their next grant. We can pass on our knowledge about individual organizations, as well as receive recommendations from other funders, saving everyone a lot of time.
• Direct Impact Investments: For many of our partners, the ability to scale rests on access to capital, and we often maintain relationships through direct impact investments. This allows us to stay in touch with our partners and invest in someone we trust, while giving them access to affordable debt and a reasonable return to the Skees corpus.
• 100% ESG Market Investments: Beyond impact investments, the remaining majority of the corpus is invested with an Environmental Social Governance screen, ensuring our corpus is working for good. This helps us increase our impact substantially while avoiding investments that are working in contradiction with our mission, all while maintaining strong returns to support our grantmaking.

Mission-Aligned Grantmaking

Our mission-aligned grants are focused on organizations whose primary work is outside of the United States. We do this for two reasons:

• Given our relatively small grantmaking budget, funding international programs allows each dollar to go further than it would in the U.S, enabling our foundation to have greater impact with our limited resources.
• We support organizations without geographic limitations through our discretionary board and family grants, both in the U.S. and abroad, that our family members are connected to and passionate about.

These grants are typically distributed every three years, and go out at the start of the new year.

Catalyst Grants

Catalyst Grants are three-year grants, distributing $25,000 in year one, $15,000 in year two and $10,000 in year three. These grants are for organizations that have demonstrated some success with their models and are ready to work at a broader level by scaling or deepening their programs. Catalyst Grants are focused on organizations with an annual budget of less than $500,000, but groups with budgets of up to $1 million are eligible.

It is our hope that Catalyst Grants truly serve as a catalyst for organizations ready to scale, which our foundation views as critical to long-term change. Although the funds are for general operating expenses, we encourage these organizations to invest in expanding and deepening their programs in a self-sustaining way.

By allocating a large proportion of our annual grantmaking budget to a few nonprofits through our Catalyst Grants, we aim to have a more meaningful impact on our Catalyst partner organizations and the issue areas in which they work. 

The Tingari-Silverton Foundation Grant supports transformational initiatives that align with the United Nations Sustainable Development Goals. Targeted towards Australia-based NGOs and select international organizations, the foundation seeks projects that yield significant social impact. Organizations must demonstrate innovative approaches and measurable outcomes. Notably, grants are not available for individuals or for-profit entities. This opportunity is ideal for those ready to revolutionize their communities through impactful solutions.

The World Land Trust Grant focuses on supporting projects that protect biodiversity and ecosystems, primarily in the Global South. The grant prioritizes sustainable conservation activities such as land acquisition and habitat restoration. While aimed at NGOs, it may also support other organizations that can effectively contribute to conservation. Current priorities include projects in Asia, West Africa, and North Africa, with an emphasis on exceptional conservation value.

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

Catalyzing Innovation through Partnerships

At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.

About this Challenge

This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).

Award Structure and Funding Level

To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:

For technically ambitious or higher-risk, earlier-stage concepts focused on feasibility testing, assay or workflow prototyping, and initial cost-reduction validation. Intended approaches that require focused development to demonstrate viability.

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

Catalyzing Innovation through Partnerships

At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.

About this Challenge

This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).

Award Structure and Funding Level

To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:

For concepts with preliminary feasibility evidence that are ready to advance from prototype toward an integrated workflow—optimizing performance, broadening assay or pathogen coverage, and generating more robust cost-reduction and performance data.

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

Catalyzing Innovation through Partnerships

At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.

About this Challenge

This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).

Award Structure and Funding Level

To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:

For more mature concepts aimed at workflow refinement, performance optimization, and generation of proof-of-concept and validation data in relevant public-health use cases in LMICs.

The Wikimedia Foundation General Support Fund empowers organizations and volunteers to enhance free knowledge globally. It supports diverse projects that align with Wikimedia's mission, focusing on knowledge equity and regional engagement. Eligible applicants include Wikimedia Movement organizations that dedicate their efforts exclusively to Wikimedia projects. Funding can cover various expenses, including operational and programmatic costs, ensuring sustainable development in underrepresented communities.

Pure Ocean invites innovative projects focused on marine conservation through its 2025 Call for Projects. This initiative emphasizes sustainable practices, engaging local communities, and exploring nature-based solutions. It seeks to address critical themes such as marine pollution, biodiversity protection, and ecosystem resilience amid climate change. By supporting scientific research and public awareness efforts, Pure Ocean aims to safeguard fragile marine ecosystems and inspire collaborative action for a healthier ocean.

The Cowles Charitable Trust Grant supports initiatives aligned with the philanthropic legacy of Gardner Cowles, Jr. Focused on education, social justice, health, and the arts, it favors organizations recognized as 501(c)(3) by the IRS. The Trust encourages applications for general operating support and seeks partnerships rather than being the sole funder. Notably, it considers applications from established partners and supports efforts in Downstate New York and South Florida, with a preference for diverse funding sources.

The Tomberg Family Philanthropies supports impactful programs in education, health, environment, and poverty alleviation, focusing on projects that empower communities for sustainable change. They exclusively fund 501(c)(3) nonprofit organizations in the U.S. and seek innovative initiatives that maximize limited resources. Note that grants typically do not cover ongoing operational costs or projects run by religious organizations. Applications for the current funding cycle are open until September 8, 2025.

The Conservation, Food & Health Foundation Grant Program aims to enhance public health, food security, and environmental conservation in underfunded regions across Africa, Asia, the Caribbean, Latin America, and the Middle East. It supports innovative projects and applied research that promote local solutions, leadership development, and community capacity building. With grants typically ranging from $25,000 to $50,000, the program prioritizes initiatives that foster sustainability, replication, and systemic change beyond immediate project goals.

The CPPS Heritage Mission Fund Grant supports initiatives aligned with Precious Blood Spirituality, focusing on dignity, healing, and community solidarity. Starting in 2026, applications will be accepted once a year, with a two-hour window for Letters of Inquiry. Grants range from $5,000 to $100,000, addressing unmet needs through various project types, including startup support and capital projects. This fund emphasizes the interconnectedness of all life and the importance of serving the common good.

The FAWCO Foundation Development Grant funds impactful projects that promote sustainability and immediate assistance to communities. With over 50 years of support, FAWCO clubs nominate grassroots organizations lacking sponsorship. Key focus areas include education, human rights, and global issues, aiming to empower disadvantaged women and children through initiatives like literacy programs, vocational training, and cultural understanding. This grant fosters collaboration and ensures that local charities receive much-needed recognition and support on a global scale.

The Hansen Family Foundation Grant seeks to empower organizations that uphold the American values of life, liberty, and the pursuit of happiness. Focused on diverse causes like children, education, animals, environmental conservation, humanitarian efforts, and arts, the foundation is committed to supporting initiatives that create positive change. Eligible applicants must be 501(c)(3) nonprofits, while political campaigns and organizations with high budgets or overheads are ineligible. This grant fosters impactful contributions to society.

The International Foundation Grant is aimed at U.S.-based non-profit organizations working in developing countries to enhance health, education, and income levels for impoverished communities. While currently not accepting new applications, the foundation reviews proposals from previously invited organizations. The focus lies on holistic, community-driven projects in sectors such as agriculture, education, environment, and health. Partnerships with local entities are encouraged to ensure sustainable and impactful outcomes.

The F5 STEM Education and AI Grants for Women and Girls of Color aim to support nonprofit organizations that enhance access to STEM education and career opportunities for underrepresented groups. With a focus on women and girls of color, the grants provide $50,000 in unrestricted funding to organizations with a commitment to increasing representation in the tech sector. Applications from around the world are welcomed, with priority given to those emphasizing AI literacy and tool usage.

The KFAS: Al-Sumait Prize for Health recognizes groundbreaking contributions to food security, health, and education in Africa. This prestigious award, established in honor of Dr. Abdulrahman Al-Sumait, seeks nominations for individuals or institutions that have made significant advancements in various fields, including sustainable agriculture and innovative health solutions. The prize aims to celebrate impactful research and initiatives that contribute to the continent's socio-economic development, with nominations open for the 2025 cycle.

The Gupta Family Foundation Grant aims to empower disadvantaged individuals by providing financial support to organizations that foster self-reliance. Headquartered in Herndon, Virginia, the foundation offers grants ranging from $5,000 to over $250,000, prioritizing smaller organizations with a strong commitment to their missions. Eligibility typically includes US-based IRS 501(c)(3) entities, with operations extending to countries like India and Kenya. The foundation emphasizes mission alignment and effective resource allocation to ensure maximum impact.

The John and Maria Laffin Trust provides funding for education, animal welfare, medical research, and human services to 501(c)(3) organizations. It allocates 20% for education, 30% for animal welfare, 25% for medical research, and 25% for humanitarian efforts. There are no geographic restrictions for medical research and human services grants, and organizations must meet IRS requirements for tax-exempt status. This trust honors the legacy of Valentina Laffin, who was dedicated to community service.