Best Large Grants for Nonprofit Organizations in Arkansas

The Community Practice Innovation Award by the Rheumatology Research Foundation aims to foster innovative ideas from the rheumatology community that enhance practice implementation and sustainability. Grants, up to $80,000 for one year, support projects in quality improvement, implementation, and pilot studies. Recipients are expected to share findings with the broader community through presentations and disseminate tools developed with the funding. This initiative emphasizes improving patient care through effective collaboration and innovative practices.

The George C. Cotzias, MD, Memorial Fellowship, established by the American Parkinson Disease Association, supports young neurologists in their research and treatment of Parkinson's disease and related disorders. Funded at $125,000 annually for three years, this fellowship encourages recent graduates to develop their careers in neurology, ensuring they have the mentorship and resources necessary for success. The fellowship aims to honor Dr. Cotzias' legacy and inspire the next generation of leaders in neurology.

This program aims to enhance education for healthcare professionals regarding new therapies and patient management in ulcerative colitis (UC). It focuses on multi-channel educational strategies to address the evolving landscape of UC treatment. Key areas include educating on new oral therapies, transitioning to advanced therapies, and managing isolated proctitis. Organizations such as healthcare institutions and medical education companies are eligible to apply, ensuring a comprehensive approach to improving UC care.

The Hearst Foundation: Education Grant aims to support outstanding nonprofits that promote education across various levels, focusing primarily on higher education. With a minimum grant size of $100,000, the foundation prioritizes organizations demonstrating significant impact and sustainability. They support innovative educational models, professional development, and scholarships, specifically targeting underserved populations. Since the 1940s, the foundation has evolved while maintaining its commitment to fostering healthy and productive lives for all individuals in the United States.

The OREF/ASES Rockwood Clinical Shoulder Research Grant aims to foster innovative clinical research in shoulder care. By offering seed funding to new investigators, this grant supports promising projects that demonstrate clinical relevance and practical application. Successful completion will position principal investigators to pursue larger NIH or DOD funding opportunities, further advancing shoulder research. This initiative underscores the commitment to nurturing talent and excellence within the field.

The NIDCD Early Career Research (ECR) Award (R21) provides support for emerging researchers focused on hearing, balance, smell, taste, voice, speech, or language. This award is designed to help scientists establish their independent research careers and is not intended for thesis or dissertation work. The funding can be utilized for various projects, including secondary data analysis and the development of new research methodologies, facilitating the transition to larger R01 applications.

The Catalyst Award, offered by the American Lung Association, supports innovative research on lung disease and biology. This mentored grant provides $50,000 annually for up to two years, prioritizing novel projects with collaborative training plans. The American Lung Association aims to improve lung health and prevent diseases through research, education, and advocacy, focusing on defeating lung cancer and fostering a tobacco-free future.

The Innovation Award by the American Lung Association offers $75,000 annually for up to two years, aimed at supporting promising investigators in lung disease research. With a legacy of over 120 years, the Association seeks to fund innovative projects that can significantly impact lung health. Eligible candidates must demonstrate prior excellence in their careers and have held a K or R type award within the last three to five years. This initiative fosters groundbreaking advancements in lung disease science.

The Patient-Centered Outcomes Research Institute (PCORI) will announce funding for patient-centered comparative clinical effectiveness research (CER) studies focusing on rare diseases. This initiative encourages collaboration and aims to fill critical research gaps affecting approximately 30 million Americans with rare diseases. Applications can request up to $12 million over five years, including coverage for patient care costs. This funding opportunity is set to open on August 12, 2025, with a focus on addressing pressing patient-centered CER questions.

The Birth Center Membership Support Grants, offered by the American Association of Birth Centers Foundation, aim to assist birth centers facing financial hardships in paying membership fees. Eligible centers can receive support covering up to 50% of the fees, whether they are applying for membership for the first time or renewing their membership. This initiative emphasizes the importance of maintaining high standards in maternity care and supports centers committed to serving low-income women.

Rails-to-Trails Conservancy (RTC) Trail Grants

RTC’s Trail Grants are building strong foundations in communities for equitable trail network development and activation—investing in transformative projects and programs that create more access to trails for more people across the country.  

Our grants support organizations at all levels—from local and national nonprofits to public agencies—with a focus on community-based leadership, engagement and long-term impact.  

Since 2008, RTC has provided over $3.7 million in grant funding to more than 280 organizations seeking to create, connect and maintain the nation’s trails, building vibrant trail networks that connect neighborhoods and regions, and make it possible for America to walk, bike and be active outside.

Conserving Black Modernism Grant Program

The African American Cultural Heritage Action Fund (AACHAF), a program of the National Trust for Historic Preservation, has launched the Conserving Black Modernism grant program through funding from and a partnership with the Getty Foundation’s Keeping it Modern initiative. The Conserving Black Modernism grant program is designed to empower and equip preservationists and stewards with funding and technical support to preserve the material heritage, innovation, and legacy of modern architectural sites designed by Black architects.

Integrated into the Action Fund’s existing National Grant Program, the Conserving Black Modernism grant program will support non-profits and municipalities to steward 16 historic assets of modern architecture through funding, technical assistance, public awareness, and education. The program will support eligible project planning activities and seeks to develop future-looking plans that model and strengthen stewardship, interpretation, and asset management. This program aims to increase recognition of Black architects and their artistic expressions as well as diversify the meaning of American modern architecture and design. The Action Fund invites proposals from a broad pool of applicants who steward these places for public benefit and access.

Grants made from Conserving Black Modernism will total $150,000 each. Funding will be flexible and can support planning activities, limited capital improvements, and indirect costs. Funding ratios will be balanced to support and prioritize comprehensive project planning needs. For example, a $150,000 project planning grant with 10% indirect can be allocated to advance a full-scale building evaluation and preservation plan. The grant period for this type of project will be 12 months.

Conserving Black Modernism grants can also support projects consisting of a mix of project planning and limited capital improvements. Funding ratios will be balanced to prioritize project planning. For example, an applicant may propose a project which allocates $90,000 for planning activities, $45,000 for capital expenses, and $15,000 for indirect expenses. The grant period for this type of project will be 18 months.

Grantees can address the building’s priority needs and experience the full cycle of planning, design, and construction. Additional grantee support will include technical assistance, promotion, and conservation management training.

Historic Asset Example Archetypes

While this is not an exhaustive list, we are particularly interested in the following 20th-century property archetypes:

• Buildings Located on HBCU Campuses
• Community and Cultural Centers
• Schools
• Libraries
• Houses and Residences
• Spaces Associated with Sports & Recreation
• Green Book Sites
• Sites associated with Women’s History
• Sites associated with LGBTQ+ History

The Aim High Grant Program, funded by the New York Life Foundation, offers 15 two-year grants of $100,000 each to support out-of-school time programs that assist middle school students in their transition to high school. This initiative addresses chronic absenteeism and promotes educational attainment in low-income communities, enhancing the cognitive, social, and emotional development of youth. By fostering skills necessary for academic success, the program aims to create brighter futures for participants.

The Howard D. Colman Scholarship supports high school seniors from Boone and Winnebago Counties pursuing degrees in engineering or technology fields. Established in memory of entrepreneur Howard D. Colman, the scholarship offers $2,500 in the first year, with potential renewal up to $10,000 for three additional years, contingent on meeting criteria. Recipients gain hands-on experience through internships with local firms, fostering connections to the Rockford area.

The Stout Foundation Grant supports organizations aligned with the values of its founder, Mr. Stout. Grants are awarded exclusively to entities with 501(c)(3) tax-exempt status and focus on charitable, educational, and scientific purposes. Preference is given to organizations with low overhead costs and those located in areas frequented by Foundation members. The Foundation aims to promote effective use of funds while remaining flexible in its grant-making approach.

Howard Hughes Medical Institute

More than 70 years ago, the Howard Hughes Medical Institute (HHMI) was founded with a mission to advance basic biomedical research and science education. Today, we invest in exceptional scientists at all career stages, catalyzing breakthroughs, new technologies, and the next generation of transformative clinical therapies. Our pathbreaking science takes place at more than 60 host institutions across the US, and at our Janelia Research Campus.

Cech Fellows Program

The Cech Fellows Program is a paid, nine-week summer research experience for rising college juniors and seniors designed to empower the next generation of scientific leaders through mentorship, hands-on research, and community. 

The Cech Fellows Program gives undergraduate students in the life sciences the opportunity to conduct hands-on research with leading scientists at HHMI laboratories across the US, from universities and research institutions to HHMI’s Janelia Research Campus outside of Washington, DC. Students are matched with HHMI scientists conducting fundamental research that advances our understanding of biology and health. 

This immersive program gives students the chance to contribute to real scientific discovery, receive professional mentorship, explore potential careers in biological and biomedical research, and connect with a community of like-minded peers.  

Gain Hands-On Experience in Research & Lab Work

The HHMI Cech Fellows Program is a 9-week, full-time, immersive research experience running from June 14, 2027 to August 12, 2027. Fellows: 

• conduct cutting-edge basic research in an HHMI lab for their own educational benefit  
• participate in professional development workshops   
• engage with a vibrant scientific community  
• build essential skills for future success in a scientific career   

Funding & Logistics 

As a Cech Fellow, students:  

• receive a $15,000 stipend if placed in an HHMI lab at a host institution, intended to cover travel, housing, meals, and incidentals. (Students are responsible for arranging their own housing.) 
• receive a $12,000 stipend if placed at HHMI’s Janelia Research Campus. (Students placed at Janelia have access to free, on-campus housing.)
• participate in an end-of-summer symposium at the Janelia Research Campus in Ashburn, VA, from August 10–12, 2027, at which they present their research and meet other Cech Fellows from across the country. Food, lodging, and travel to and from the symposium are provided by HHMI. 
• are matched with a local contact from their host lab who will provide suggestions for local housing options. Students are expected to travel to arrive at their host institutions by June 14, 2027.  

The NNLM Region 5 Professional Development Award offers funding for individuals at member institutions to enhance their knowledge and skills in health-related areas. This initiative aims to support meetings, workshops, and training that focus on health literacy, public health, and evidence-based practices. By fostering professional development, the NNLM seeks to improve healthcare services and access to health information across various communities, ultimately contributing to better public health outcomes.

Foundation of the Federal Bar Association

The Foundation of the Federal Bar Association provides the best way for practitioners to give back to the Federal legal community. Chartered by Congress in 1954, the Foundation serves people in communities across the United States through its generous grants, scholarships, and programming.

Our Mission: The Foundation’s mission is to:

• Promote and support legal research and education;
• Advance the science of jurisprudence;
• Facilitate the administration of justice;
• Foster improvements in the practice of Federal law

Foundation Grants

Foundation grants support community service projects and civics programs which comply with the Foundation’s mission to promote and support legal research and education; advance the science of jurisprudence; facilitate the administration of justice; and foster improvements in the practice of Federal law.

Civics Education Grant

The Civics Grant Program is designed to support projects and initiatives that promote a wider public understanding of democratic principles, the judicial system and the rule of law. Through targeted funding, the program empowers FBA chapters, sections, divisions, national standing committees (FBA entity), and other organizations to develop and support projects in their communities that foster public understanding of the rights and responsibilities of American citizenship, particularly among younger Americans.

Applicants may only receive one (1) Foundation grant per year.

The Eppley Foundation for Research, established in 1947, supports advanced scientific research in chemistry, physics, and biology. It prioritizes innovative studies, particularly in medical investigations and climate change. The foundation does not fund social sciences or projects with ample existing financial support. Applicants must hold a PhD or MD and be associated with a nonprofit in the US. The foundation aims to foster groundbreaking research that is unlikely to be replicated elsewhere.

Cherokee Nation Foundation

The Cherokee Nation Foundation is a nonprofit organization serving the Cherokee Nation, a federally recognized tribe of more than 470,000 citizens. Its mission is to provide educational opportunities to Cherokee students so they can reach their full potential. The Cherokee Nation Foundation is a tax-exempt charitable organization under Section 501(c)(3) of the Internal Revenue Code.

Scholarships

Cherokee Nation Foundation offers a diverse range of scholarships to help reverse the trend of rising student debt. Students may receive up to two CNF scholarships per academic year. All opportunities are reserved for Cherokee Nation citizens, unless otherwise noted in the description.

Senior Master Sergeant Texie C. Taylor, USAF Memorial Scholarship

Applicant must be a junior or senior undergraduate or graduate student majoring in physics, chemistry, biology, medicine, nursing (RN), engineering (aerospace, civil, chemical, electrical, mechanical) or mathematics with a minimum 3.0 GPA. This is a one-year scholarship reserved for Cherokee Nation citizens residing within the Cherokee Nation jurisdictional area.

The Inspire Grants for Small Museums (2027) initiative, funded by the Institute of Museum and Library Services, aims to empower small museums across various disciplines. This program focuses on project-based funding to enhance public service through educational programs, exhibits, and community partnerships. By supporting small, often underfunded institutions, Inspire seeks to strengthen their capacity to engage communities and improve collections management, fostering experiential learning and discovery.

The Guido's Fresh Marketplace Scholarship Fund, established by the Berkshire Taconic Community Foundation, honors the legacy of Guido Masiero, a dedicated educator and entrepreneur. This scholarship aims to support graduating high school students from public schools in Pittsfield, Lenox, or Great Barrington, Massachusetts, who are pursuing higher education in physical education, health, wellness, or business studies. The fund reflects the foundation's mission to enhance community opportunities and economic mobility.

The Community Development Block Grant Program for Indian Tribes and Alaska Native Villages aims to foster viable communities by providing funding for decent housing, suitable living environments, and economic opportunities for low- and moderate-income individuals. Notably, the program also includes Imminent Threat Grants to address urgent public health or safety issues. These competitive grants are essential for enhancing community welfare and addressing immediate challenges faced by tribal residents.

The A.J. Muste Memorial Institute's Social Justice Fund Grant supports grassroots activist projects in the U.S. and abroad, focusing on those with limited funding access. Prioritizing efforts to dismantle systemic injustices, the grant seeks proposals from organizations lacking mainstream support, especially those addressing issues like immigration violence, racial inequalities, and economic exploitation. The fund emphasizes direct activism and diverse leadership, making it a vital resource for community-driven initiatives in the pursuit of social justice.

The Andrea Wagner Women in Science Scholarship Fund, established by the Berkshire Taconic Community Foundation, offers financial support to female students in the region pursuing degrees in math, chemistry, physics, engineering, or biology. To qualify, applicants must be residents of the Berkshire Taconic region, enrolled as freshmen, sophomores, or juniors at a four-year college, and maintain a minimum GPA of 3.3. This initiative aims to empower women in science and foster educational advancement.

Alliance for Social Trust: Trust in Practice Awards

Trust is the foundation of vibrant, resilient communities and healthy civic life. Across the country, local and national organizations are demonstrating the profound ways trust shapes our collective well-being—strengthening relationships between neighbors, cultivating confidence in institutions, and enabling people to work together to solve shared challenges. These efforts are often rooted in the knowledge and leadership of those closest to the work. 

The Trust in Practice Awards support non-profit organizations that are collaborating on new initiatives to build trust across local or virtual communities. Grantees will be part of a national network dedicated to fostering trust through the Alliance for Social Trust’s programs and storytelling platforms. Award recipients will also participate in the annual Trust in Practice Summit to celebrate the work of trust builders.

The Garden Club of America and the Royal Horticultural Society offer prestigious Interchange Fellowships aimed at fostering British-American collaboration in horticulture and landscape architecture. These fellowships provide American and British scholars with transformative experiences in the UK and US, respectively, focusing on hands-on horticultural work and education. The program includes financial support for travel and living expenses, ensuring fellows gain significant exposure to diverse horticultural practices and build valuable professional connections.