Best Buffalo County Grants for Nonprofits in South Dakota

The Ruth Mitchell Hanson Scholarship is designed to support talented students from Saginaw County pursuing a career in music. Established in memory of Ruth Mitchell Hanson, a passionate composer and music instructor, this scholarship aims to honor her legacy and encourage future musicians. Eligible applicants must have a minimum GPA of 3.25, be high school seniors, and be enrolled full-time in a music program at an accredited college or university. Awards typically range from $500 to $4,000.

The Alma Gilmore Doud Memorial Scholarship honors a dedicated community servant from Saginaw. Established by the Saginaw Community Foundation, this scholarship supports students pursuing Career and Technical Education (CTE) programs or undergraduate degrees. Applicants must have a minimum GPA of 3.0 and reside in the Great Lakes Bay Region. Priority is given to members of the First Congregational Church. Awards typically range from $500 to $4,000, addressing the growing demand for skilled trades in today's workforce.

The Balcueva Family Memorial Scholarship, established in 1998, honors the memory of four sons lost to congenital heart defects. This scholarship supports students pursuing environmental sciences, reflecting the family's commitment to environmental stewardship. With awards ranging from $500 to $4,000, it aims to inspire future generations to protect our natural resources. Applicants must be Saginaw County residents with a minimum 3.0 GPA, enrolled full-time in undergraduate studies. This initiative reflects the community's values and dedication to environmental preservation.

The Bernice Barlow NAACP Scholarship, awarded by the Saginaw Community Foundation, supports high school seniors pursuing higher education or vocational training. Applicants must have a minimum GPA of 2.0 and be current members or children of members of the Saginaw NAACP Branch. This scholarship honors Bernice Barlow, a dedicated educator and NAACP leader, providing financial assistance to foster educational opportunities in the community. Awards typically range from $500 to $4,000, helping students achieve their career goals.

Career and Technical Education

The goal of the South Dakota Department of Education is for all students to graduate college, career, and life ready. The Division of College, Career and Student Success provides support for students' preparations for postsecondary education and the workforce. Services are connected to approved Career & Technical Education (CTE) programs, work-based learning, student organizations and more. In-line with the department's aspiration, DCCSS works to ensure students not only graduate from high school, but that they are prepared to navigate the transitions and life events that come after high school.

Workforce Education Grants

In 2013, the South Dakota Legislature established the Workforce Education Fund through SB 235. Part of that fund was designated to provide grants for Career & Technical Education (CTE) programs in secondary schools.

The Workforce Education Grants provide school districts and private, nonprofit entities who provide specialized training in South Dakota the opportunity to make transformative change in career and technical education programs. High quality CTE programs give students the knowledge, skills and experiences to be well prepared for postsecondary education and the workforce. Partnerships among secondary education, postsecondary education, and business & industry lay the foundation for modern CTE programs.

Grant Purpose & Eligibility

The Workforce Education Grants are designed to support and align secondary school CTE systems with South Dakota's postsecondary education programs and workforce needs, developing the state's talent pipeline for workforce development and economic growth. Projects are meant to serve middle and high school students.

Eligible applicants are Local Education Agencies (LEAs) with projects designed to serve middle and high school students. The LEAs who are awarded grants will serve as fiscal agents through the completion of their projects. All applications must demonstrate commitment by all grant partners to the grant project and its sustainability following the conclusion of the grant.

The Tobacco Prevention & Cessation RFA aims to support community-driven initiatives that promote tobacco-free lifestyles in South Dakota. With a focus on collaboration among local organizations, this funding opportunity seeks to implement strategies outlined in the SD-TCP State Plan, which emphasizes long-term changes to reduce tobacco-related health issues. By fostering partnerships and investing in impactful projects, the RFA is dedicated to decreasing the prevalence of tobacco use and its associated harms in the state.

The DOW Combat Readiness – Medical Research Program's FY26 Translational Research Award supports innovative research aimed at improving trauma care outcomes. This program emphasizes hypothesis-driven studies that can transition promising technologies into practical solutions for enhancing casualty survivability. Applicants must provide preliminary data and utilize validated animal models, with a focus on projects that meet a minimum technology readiness level of 4, ensuring a mature translational research effort.

The National Institute of Allergy and Infectious Diseases (NIAID) is funding research to enhance drug susceptibility testing (DST) for mycobacteria. This initiative aims to improve testing for tuberculosis (TB) and non-tuberculous mycobacterial (NTM) infections, which are on the rise. Current methods are slow and ineffective against drug-resistant strains, making rapid DSTs essential for effective treatment and reducing transmission rates. Innovative approaches, including rapid genotypic and phenotypic methods, will be supported to address these challenges.

The Childhood Asthma in Urban Settings Clinical Research Network (CAUSE) aims to enhance asthma prevention and treatment in economically disadvantaged pediatric populations. Funded by the NIH, CAUSE supports multi-site clinical studies to identify innovative strategies and treatment targets for asthma. Utilizing systems biology, the network seeks to discover specific disease endotypes suitable for new therapeutic approaches, addressing the high burden of asthma in urban settings.

The BRAIN Initiative seeks to develop innovative tools and approaches for neuroscience research, focusing on cell-specific and circuit-specific processes within the central nervous system. This initiative encourages projects that enhance our understanding of brain architecture and function through novel technologies for characterizing neural components and advancing methods for recording and modulating neural activity. Applications are invited to address significant challenges and promote transformative breakthroughs in neuroscience.

The National Institute of Mental Health is inviting research applications for the AIDS Research Center program, which includes Developmental Centers and full Research Centers. This initiative aims to enhance interdisciplinary HIV/AIDS research through collaboration and innovative approaches across various scientific domains. The program emphasizes alignment with national strategies and encourages applications from teams skilled in fostering partnerships with diverse stakeholders. Although applications are currently not being solicited, this notice allows potential applicants time to prepare strong proposals.

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing research on immune tolerance through its Collaborative Network. This program aims to clarify the mechanisms of immune tolerance and develop interventions for related diseases, including transplant rejection and autoimmune disorders. Key objectives include conducting clinical trials on tolerogenic strategies and refining immune assays. This initiative is supported by regulations under the Public Health Service Act, ensuring a structured approach to improving patient outcomes.

The Clinical Data, Safety and Statistical Centers (CDSSC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance clinical research through comprehensive support. This includes statistical analysis, protocol development, and oversight of safety monitoring in studies related to asthma, autoimmune diseases, and transplantation. By coordinating these efforts, the program seeks to facilitate impactful research outcomes and improve public health outcomes through informed data-driven decisions.

The Translational Transplantation Tolerance Cooperative Study Group, supported by the National Institute of Allergy and Infectious Diseases, aims to advance transplant tolerance strategies that promote long-term graft survival without lifelong immunosuppression. This initiative focuses on developing, optimizing, and evaluating methods to induce immune tolerance in allogeneic transplants through collaborative efforts across multiple centers, utilizing translationally relevant models to ensure effective outcomes.

The NIAID aims to enhance our understanding of the interplay between chronic and infectious diseases through innovative precision systems biology research. By utilizing advanced technologies such as multi-omics and artificial intelligence, the initiative focuses on uncovering critical pathways that connect infections to chronic health issues. This multidisciplinary approach leverages longitudinal patient data to inform and improve prevention and treatment strategies, ultimately seeking to provide insights into disease progression and host-pathogen interactions.

The Asthma and Allergic Diseases Cooperative Research Centers (AADCRC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance research on asthma and related allergic diseases. This initiative fosters multi-center, multidisciplinary research to explore disease mechanisms and treatment responses. By promoting clinical trials and observational studies, the AADCRC seeks to advance understanding and improve interventions for conditions such as asthma and food allergies, ultimately benefiting public health.

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing organ transplantation outcomes through the Clinical Trials in Organ Transplantation in Children and Adults (CTOT-CA) program. This initiative supports multicenter clinical trials and mechanistic studies related to heart, lung, kidney, liver, and intestinal transplants, as well as non-hematopoietic cellular transplantation. By exploring immune mechanisms and innovative therapies, the program aims to enhance the success and efficacy of organ transplantation.

The NIAID aims to enhance infectious disease research by supporting human microphysiologic systems (MPS) development. These in vitro platforms mimic human tissue functions, promoting drug and biological product development while reducing animal use. This initiative aligns with NIH’s commitment to innovative research practices and regulatory acceptance. By focusing on MPS in infectious disease contexts, NIAID seeks to streamline therapeutic advancements and establish robust human tissue models, addressing critical challenges in understanding and treating infections.

The Domestic and Sexual Abuse Program (DASA)

Funds are appropriated through the State of South Dakota general funds annually. Funds are awarded to provide domestic violence and sexual assault prevention and education programs, to provide training programs for the staff and volunteers of the shelter service programs and to provide assistance to shelter programs that serve victims of domestic violence and sexual assault.

South Dakota Department of Public Safety

The South Dakota Department of Public Safety includes 14 agencies with the mission to keep South Dakota a safe place in which to live, work, visit and raise a family.

Victims' Assistance Program Grants

The Victims' Assistance Program provides grant funding for agencies that provide services to victims of domestic violence, sexual assault, stalking and other violent crimes. The Victims' Assistance Program funding includes: VOCA, FVPSA, STOP, SASP and DASA Grants.

Victims of Crime Act (VOCA) Grant

Funds are awarded by the US Department of Justice, Office for Victims of Crime. The funds come entirely from fines and penalties assessed against convicted federal criminals. Funds are awarded to provide direct assistance to innocent victims of violent crime.

Agencies who are currently not funded with Victims’ Assistance grants, but who are considering applying for a grant(s) are strongly encouraged to contact the Victims’ Services Program director prior to grant announcements being released for the upcoming funding cycle.

Accelerating the Development of Combined CGM–Pump Devices

A combined continuous glucose monitor (CGM) and insulin pump device represents an innovative approach to simplifying diabetes management by integrating two essential technologies into a single device. This approach has the potential to improve quality of life for people with type 1 diabetes (T1D) by reducing the burden associated with wearing and managing multiple devices.

Despite this promise, the development of combined CGM–pump devices presents technical and commercialization challenges. These include the need for further advances in device compatibility and lifespan, system reliability, and scalable manufacturing, while maintaining affordability and broadaccessibility. In addition, a potential insulin dilution effect may require adjustment of the CGM algorithm.

Breakthrough T1D invites applications for research and development projects that address key technical, clinical, and translational challenges related to combined CGM–pump devices, with the goal of accelerating their development and improving outcomes for people living with T1D.

In response to this announcement, applications may request up to a total of $900,000 USD for up to three years. 

The Paul Lawson Memorial Aviation Scholarship is dedicated to supporting deserving students aged 15-25 from Maryland and West Virginia who are pursuing aviation lessons. Established in memory of Paul Lawson, this scholarship aims to empower young individuals to achieve their dreams in aviation. Offered by the Community Foundation of Washington County MD, it reflects the commitment of local families and organizations to enhance educational opportunities in the community.

The DoW Bone Marrow Failure Idea Development Award supports innovative, high-impact research aimed at understanding and curing bone marrow failure diseases. This grant is available to both Established Investigators and Early-Career Investigators, with no preliminary data required for applications. Reviewers assess proposals based on specific criteria tailored to the investigator's career stage. The focus is on achieving interpretable results that contribute significantly to the field.

The DoW Bone Marrow Failure Investigator-Initiated Research Award supports innovative research aimed at advancing the understanding and treatment of bone marrow failure. This funding opportunity encourages applications for translational and clinical studies, requiring preliminary data to strengthen proposals. Unique features include the ability for a partnering Principal Investigator to contribute to the research, thereby fostering collaboration while maintaining a focus on significant advancements in patient care.

The DoW Rare Cancers Idea Development Award promotes innovative research ideas for rare cancers, encouraging applicants to provide preliminary data and exploratory aims. This funding opportunity, offered by the US DOD: U.S. Army Medical Command, seeks projects with the potential for high-impact findings that can significantly benefit the patient community. It aims to foster new avenues of investigation and support discovery-driven research in the field of rare cancers.

The 2026 Rare Cancers Research Program Resource and Community Development Award aims to enhance rare cancer research through improved resources and datasets. It addresses critical gaps in research resources, communication strategies, and data sharing infrastructures. Key features include engaging patient advocates throughout the research process and ensuring sustainability of community platforms. This funding opportunity emphasizes community building and the dissemination of findings to benefit scientific and patient communities alike.

The FY26 Joint Warfighter Medical Research Program's Military Medical Research and Development Award aims to fund the continuation of previous Department of War-funded research addressing high-priority medical needs for Service Members and Military Health System beneficiaries. It supports various projects, including late-stage preclinical studies and clinical research. Eligibility requires prior DOD funding, and a Clinical Research Option is available for studies involving human subjects or biological samples.