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Best Buffalo County Grants for Nonprofits in South Dakota

Looking for grants for 501(c)(3) nonprofit organizations working in Buffalo County, South Dakota? Find the perfect grant for your nonprofit on Instrumentl.

9,000+

Available grants

$3.82B

Total funding

$5K

Median grant

9,000+ grants
$3.82B total
$5K median

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9,007 Results based on applied filters

Scleroderma-Related Lung Disease— The Debra Lurvey Memorial Research Grant

National Scleroderma Foundation
Private
United States
US $200,000
The Scleroderma-Related Lung Disease— The Debra Lurvey Memorial Research Grant, provided by the National Scleroderma Foundation, aims to support research in scleroderma-related lung disease. With a funding amount of $200,000, the grant encourages established investigators to explore innovative solutions and enhance understanding of this condition, ultimately working towards improving the quality of life for affected individuals and advancing medical knowledge in the field.
Rare Diseases Immune System Diseases Interstitial Lung Disease

Prader-Willi Syndrome Mini-Fellowship Grant ( up to $25,000)

Prader Willi Syndrome Association (Usa)
Private
United States
Up to US $25,000
The Prader-Willi Syndrome Mini-Fellowship Grant aims to enhance understanding of Prader-Willi Syndrome (PWS) through clinical proctorships. Offering up to $25,000 USD, this grant supports providers in shadowing experts in PWS while engaging in an academic project. PWSA | USA, dedicated to advancing research since 1983, focuses on high-impact projects that translate biomedical knowledge into effective treatments, ultimately improving the lives of those affected by PWS.
Endocrine & Metabolic Diseases Neurological Diseases & Disorders

NMDP Amy Strelzer Manasevit Research Program Grant

National Marrow Donor Program
Private
United States
Up to US $400,000
The NMDP Amy Strelzer Manasevit Research Program Grant supports early-career researchers in hematopoietic cell transplantation and cellular therapy. With a maximum funding of $400,000 over five years, it aims to address complications post-transplant, such as infection and relapse. This prestigious grant encourages innovative research proposals, particularly those targeting HLA-mismatched donor outcomes. By fostering new talent in the field, the program is essential for advancing our understanding of critical post-transplant challenges.
Cell Biology Hematological Systems

NMDP Barbara Buchbinder Nurse Research Program Grant

National Marrow Donor Program
Private
United States
US $25,000
The NMDP Barbara Buchbinder Nurse Research Program Grant supports pediatric BMT nurses conducting research to enhance transplant experiences and outcomes for children. With only 4% of federal funding allocated to childhood cancer, this program, honoring a dedicated nurse, aims to attract new talent to the field. Each selected Buchbinder Scholar receives a $25,000 award to pursue relevant investigations, emphasizing the importance of supportive care in pediatric allogeneic hematopoietic cell transplants.
Children’s Health & Pediatrics Hematological Systems Cell Biology +1 more

HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed) (356460)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,050,000
The HEAL Initiative aims to develop safe and effective non-addictive pain therapeutics. This funding opportunity encourages translational research to support drug discovery, focusing on assays, screening for hits, and initial characterization of potential therapeutic agents, including small molecules and biologics. Applications are due by 5 PM local time, with optional Letters of Intent recommended 30 days prior to the proposal deadline.
Anesthesia and Pain Medicine

Doyle Undergraduate Fellowship

New Hampshire Sea Grant
Association/Society
United States
Up to US $5,000
The Doyle Undergraduate Fellowship, offered by New Hampshire Sea Grant, provides a unique opportunity for undergraduates to engage in marine resource projects while receiving mentorship and training. This paid fellowship supports students interested in marine-related research and education, with potential earnings of up to $5,000 over a 10-week summer period. By participating, fellows gain valuable insights into coastal and marine management, enhancing their skills and expanding their professional networks.
Oceanography Marine / Ocean Conservation Freshwater Conservation +5 more

FNBO: Capital or Major Donations

First National Bank of Omaha
Corporate
Colorado, Illinois +6 more
Unspecified amount
FNBO: Capital or Major Donations aims to support nonprofit organizations through significant financial contributions for capital projects. This initiative focuses on enhancing community well-being by addressing key areas such as affordable housing, environmental stability, and education. FNBO prioritizes partnerships with nonprofits dedicated to long-term impacts, especially for historically underrepresented populations. By fostering community engagement and providing essential resources, FNBO strives to create a positive influence in the regions it serves.
Sustainability Art & Culture Humanities & Social Science +20 more

Biophilia Foundation Grants

Biophilia Foundation Inc
Private
United States
US $5,000 - US $25,000
The Biophilia Foundation Grants support biodiversity conservation on private lands, focusing on systemic change through community engagement. The foundation encourages organizations to submit letters of inquiry detailing their mission, tax status, funding requests, and intended outcomes. They prioritize private land conservation, ecosystem restoration, and innovative policy initiatives, especially in the arid Southwest and Chesapeake Bay regions. Grants typically range from $5,000 to $25,000, with larger amounts available for established partnerships.
Environmental Conservation Land / Habitat Conservation Green Economy & Jobs +7 more

Food Access and Retail Expansion (FARE) Fund Grant

The Reinvestment Fund Inc
Private
United States
US $20,000 - US $250,000
The Food Access and Retail Expansion (FARE) Fund Grant, part of America’s Healthy Food Financing Initiative, aims to enhance access to nutritious food in underserved regions. With a budget of $60 million over five years, the initiative supports innovative fresh food retail projects, offering grants and loans to address barriers in food access. This funding is crucial for catalyzing sustainable food enterprises and improving local food systems, ultimately fostering healthier communities.
Food Delivery & Distribution Services Food Access & Hunger

National Pride Grant for LGBTQIA+ Small Businesses

Founders First Community Development Corporation Inc
Private
United States
US $1,000
The National Pride Grant for LGBTQIA+ Small Businesses, opening for applications on April 22, 2025, offers $25,000 in funding distributed as $1,000 micro grants to 25 eligible LGBTQIA+ business owners. Designed to support diverse founder-led enterprises, this initiative encourages professional development and aids in achieving over $1 million in revenue. Eligible participants must have a U.S.-based business and meet specific criteria regarding ownership, revenue, and employee count.
LGBTQIA+ Services Business Development

C Spire Wireless Foundation Grant

C Spire Wireless Foundation
Private
United States
Unspecified amount
The C Spire Wireless Foundation Grant supports STEM education initiatives in Mississippi, Tennessee, and Alabama. Aimed at 501(c)(3) organizations, it focuses on projects that enhance digital literacy, technology skills, and workforce development. With a commitment to community transformation, the foundation prioritizes local projects that improve tech education and broadband access, creating a stronger future for the region. Applications must be submitted 150 days before the event, with a review period of up to four weeks.
STEM / STEAM Education Workforce Preparation & Job Readiness Technology Access & Digital Literacy

C Spire Wireless Foundation Sponsorship

C Spire Wireless Foundation
Private
United States
Unspecified amount
The C Spire Wireless Foundation provides sponsorships primarily focused on STEM education, aiming to enhance digital literacy and workforce development in underserved communities. Organizations eligible for support must be 501(c)(3) tax-exempt entities dedicated to these educational initiatives. Preference is given to projects based in the foundation's service region. Proposals should be submitted at least 90 days prior to events for consideration, with a review process taking two to three weeks.
STEM / STEAM Education Workforce Preparation & Job Readiness Technology Access & Digital Literacy

Ernest F. Hollings Undergraduate Scholarship

National Oceanic and Atmospheric Administration (NOAA)
Federal Government
American Samoa, Guam +4 more
Up to US $40,000
The Ernest F. Hollings Undergraduate Scholarship offers up to $9,500 annually for two years, alongside a paid summer internship at NOAA. This program enhances students' training in oceanic and atmospheric sciences, aiming to increase public understanding and support for environmental stewardship. Eligible students must be U.S. citizens, enrolled full-time in relevant disciplines, and maintain a minimum GPA of 3.0. The experience fosters valuable skills and networks, with 100% of alumni recommending the scholarship.
Humanities & Social Science STEM / STEAM Education Engineering +12 more

NICHD Resource Program Grants in Bioinformatics (P41 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $8,750,000
The NICHD Resource Program Grants in Bioinformatics aim to support the operation and enhancement of vital bioinformatics databases for research on animal models of embryonic development. These grants promote user training, data curation, and interoperability with NIH resources, ensuring wide dissemination of critical tools and resources to the research community. Applications are due by 5:00 PM local time, with optional Letters of Intent encouraged 30 days prior to the proposal deadline.
Biomedical informatics Developmental Biology / Embryology

BRAIN Initiative: Reagent Resources for Brain Cell Type-Specific Access to Broaden Distribution of Enabling Technologies for Neuroscience (U24 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The BRAIN Initiative's funding opportunity aims to support the establishment of facilities at minority-serving and IDeA-eligible institutions for the production and distribution of brain cell type-specific reagents. These reagents will enhance neuroscience research by enabling precise manipulation and access to brain cell types, facilitating advancements in understanding circuit functions in various species. The initiative encourages collaboration among awardees to optimize the use of these essential resources across the neuroscience community.
Neuroscience

Wallerstein Foundation Grant

Wallerstein Foundation for Geriatric Life Improvement Inc.
Private
United States
Unspecified amount
The Wallerstein Foundation for Geriatric Life Improvement is dedicated to enhancing the lives of elderly individuals through targeted support for non-profit organizations. Grants focus on critical areas such as dementia care, wellness programs, and community engagement initiatives. The foundation prioritizes projects that meet the unique needs of seniors, promoting health and active lifestyles. By funding specific projects rather than general support, the foundation aims to make a meaningful impact on the quality of life for senior citizens.
Senior Services Aging / Gerontology Dementia & Alzheimer’s Disease +3 more

Ruby Bridges Walk to School Day Mini-Grant

Safe Routes to School National Parternship
Private
United States
US $500 - US $1,000
The Ruby Bridges Walk to School Day Mini-Grant supports events that honor civil rights activist Ruby Bridges by encouraging students to walk to school and engage in discussions about activism, anti-racism, and anti-bullying. Grants of $500 or $1000 are available based on the number of students reached. This initiative aims to inspire positive changes within communities and promote meaningful dialogue among young people about social justice issues.
Youth Services Civic Engagement & Education Racial / Ethnic Justice & Rights +2 more

Gilead Medical Education Grants - Independent Medical Education Funding

Gilead Sciences Foundation
Private
American Samoa, Guam +4 more
Unspecified amount
Gilead Medical Education Grants fund innovative, data-driven programs that enhance healthcare infrastructure and support vulnerable communities globally. Focused on core therapeutic areas like HIV, liver diseases, and oncology, these grants aim to deliver impactful continuing medical education for healthcare providers. Eligible applicants include for-profit medical education companies and nonprofit organizations. Gilead prioritizes programs that demonstrate a strong capacity to achieve specific educational outcomes, ensuring that support reaches those who need it most.
Medical Education & Professional Training

American College of Bankruptcy Foundation - Pro Bono Grant

American College Of Bankruptcy Foundation
Private
United States
Up to US $20,000
The American College of Bankruptcy Foundation offers a Pro Bono Grant aimed at supporting legal services organizations that align with its mission. Grants typically do not exceed $15,000, with some exceptions for innovative projects up to $20,000. Eligible initiatives focus on bankruptcy law and pro bono assistance, while ineligible projects include lobbying, fundraising, and those not directly related to debtor-creditor education. The Foundation encourages efforts that promote legal aid for disadvantaged communities.
Law Legal Services

Single Ventricle Research Fund (SVRF) - Independent Investigator Track

Additional Ventures Foundation
Private
Countries
Up to US $600,000
The Single Ventricle Research Fund (SVRF) offers annual grants aimed at enhancing research and care for individuals with single ventricle heart defects. With awards of up to $600,000, the SVRF encourages innovative projects that align with the Additional Ventures Research Roadmap. This initiative not only supports novel treatments but also fosters collaboration across disciplines to address critical challenges in single ventricle heart disease management.
Cardiovascular Diseases & Systems Heart Disease Preventative Healthcare

The Applied Materials Momentum Fund - Emergency Financial Assistance

Applied Materials Foundation
Corporate
United States
Up to US $595
The Applied Materials Momentum Fund offers emergency financial assistance to students facing unexpected financial obstacles while pursuing degrees in engineering. This initiative supports basic needs such as food, housing, and transportation, ensuring that students can continue their education without interruption. It aims to empower women engineers and underrepresented groups in the semiconductor industry, fostering a diverse and resilient workforce for the future.
Aerospace Engineering Chemical Engineering Computer Science & Engineering +10 more

The Applied Materials Momentum Fund - Bridge Grants

Applied Materials Foundation
Corporate
United States
Approximately US $1,100
The Applied Materials Momentum Fund - Bridge Grants aim to support students facing financial obstacles in completing their computing degrees. This initiative fosters diversity in the semiconductor industry by encouraging women engineers and providing them with career-building opportunities. Eligible candidates include U.S. citizens, DACA recipients, and F1 visa holders pursuing engineering majors. The fund not only alleviates financial stress but also opens doors to internships and full-time positions at Applied Materials, thus enhancing educational progress and career advancement.
Science Communications Physics Bioengineering +10 more

The Applied Materials Momentum Fund - Last Mile Grants

Applied Materials Foundation
Corporate
United States
Up to US $10,000
The Applied Materials Momentum Fund is dedicated to enhancing educational opportunities for students in the semiconductor industry, particularly supporting women engineers. This initiative provides essential financial assistance through various grant types, including emergency mini-grants and larger Last Mile grants, aimed at helping students overcome financial barriers in their pursuit of degrees. By fostering diverse and resilient teams, the fund contributes to innovation and growth in technology and engineering fields.
Science Communications Physics Bioengineering +10 more

Boustany Foundation: Sport 4 Children Award

Boustany Foundation
Private
Austria, Belarus +29 more
Up to €50,000
The Boustany Foundation's Sport 4 Children Award aims to enhance children's lives through sports, fostering happiness, health, and social skills. Open to organizations globally, the award supports projects that utilize sports for children's well-being. With a funding of 50,000 Euros, it encourages innovative and inclusive initiatives that promote participation in sports, aiming to create positive behavioral changes and community engagement. The foundation believes in the transformative power of sports to build responsible and healthy adults.
Youth Services Sports & Athletics

The Amy Heryford Ousley and James Heryford Ousley Educational Fund

Amy Heryford Ousley And James Heryford Ousley
Private
United States
Unspecified amount
The Amy Heryford Ousley and James Heryford Ousley Educational Fund, established in 2005, provides scholarships to Klamath and Lake County students attending nonprofit colleges in the U.S. The fund, initially valued at $6.5 million, has awarded over $2.5 million in scholarships. Eligible students must have attended a Klamath County high school for four years, maintain a minimum GPA, and enroll as full-time students. Scholarships can reach up to $3,000 annually for up to five years.
Academic Scholarship Programs

Covista Foundation Grant

Adtalem Global Education Foundation
Private
United States
Unspecified amount
The Adtalem Global Education Foundation, established in 2010, is dedicated to enhancing education and community development. Based in Chicago, it focuses on expanding educational access, particularly for underrepresented minorities in the healthcare sector. The foundation prioritizes initiatives that promote economic growth through skills-based workforce development, address healthcare disparities, and increase access to quality education for underserved populations. Its commitment to civic engagement and equality reflects its mission to empower communities.
Health & Medicine Economic Services & Development Workforce Preparation & Job Readiness +3 more

Professional Pipeline Grant - American College of Bankruptcy (formerly Diversity, Equity and Inclusion Grant)

American College Of Bankruptcy Foundation
Private
United States
Up to US $15,000
The Professional Pipeline Grant from the American College of Bankruptcy Foundation aims to foster diversity in the insolvency industry. This grant supports legal services organizations working to create an inclusive pipeline for students and professionals facing barriers to success. With grants typically capped at $10,000, the Foundation may offer higher amounts for innovative new programs. Applicants are encouraged to utilize available resources to enhance their proposals and maximize funding opportunities.
Diversity, Equity & Inclusion Law Financial Literacy +1 more

Buffalo County Grants for Nonprofits Highlights

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Read more about each grant below or start your 14-day free trial to see all Buffalo County grants recommended for your specific programs in South Dakota.

Last updated: November 2, 2026. Next update: December 6, 2026.

Grant Insights : Grant Funding Trends in South Dakota

Average Grant Size

What's the typical amount funded for South Dakota?

Grants are most commonly $110,621.

$110,621

Total Number of Grants

What's the total number of grants in Buffalo County Grants for Nonprofits year over year?

In 2024, funders in South Dakota awarded a total of 6,460 grants.

2022 6,268

2023 6,140

2024 6,460

Top Grant Focus Areas

Among all the Buffalo County Grants for Nonprofits given out in South Dakota, the most popular focus areas that receive funding are Education, Human Services, and Philanthropy, Voluntarism & Grantmaking Foundations.

1. Education

2. Human Services

3. Philanthropy, Voluntarism & Grantmaking Foundations

Funding Over Time

How is funding for Buffalo County Grants for Nonprofits changing over time?

Funding has increased by 17.48%.

2022 $638,830,994

2023 $606,495,212
-5.06%

2024 $712,509,384
17.48%

South Dakota Counties That Receive the Most Funding

How does grant funding vary by county?

Minnehaha County, Lake County, and Pennington County receive the most funding.

County Total Grant Funding in 2024
Minnehaha County $176,653,145
Lake County $117,647,066
Pennington County $90,630,616
Brookings County $75,457,854
Todd County $56,559,538