Best Dukes County Grants for Nonprofits in Massachusetts

The National Institute of Allergy and Infectious Diseases (NIAID) is funding research to enhance drug susceptibility testing (DST) for mycobacteria. This initiative aims to improve testing for tuberculosis (TB) and non-tuberculous mycobacterial (NTM) infections, which are on the rise. Current methods are slow and ineffective against drug-resistant strains, making rapid DSTs essential for effective treatment and reducing transmission rates. Innovative approaches, including rapid genotypic and phenotypic methods, will be supported to address these challenges.

The Childhood Asthma in Urban Settings Clinical Research Network (CAUSE) aims to enhance asthma prevention and treatment in economically disadvantaged pediatric populations. Funded by the NIH, CAUSE supports multi-site clinical studies to identify innovative strategies and treatment targets for asthma. Utilizing systems biology, the network seeks to discover specific disease endotypes suitable for new therapeutic approaches, addressing the high burden of asthma in urban settings.

The BRAIN Initiative seeks to develop innovative tools and approaches for neuroscience research, focusing on cell-specific and circuit-specific processes within the central nervous system. This initiative encourages projects that enhance our understanding of brain architecture and function through novel technologies for characterizing neural components and advancing methods for recording and modulating neural activity. Applications are invited to address significant challenges and promote transformative breakthroughs in neuroscience.

The National Institute of Mental Health is inviting research applications for the AIDS Research Center program, which includes Developmental Centers and full Research Centers. This initiative aims to enhance interdisciplinary HIV/AIDS research through collaboration and innovative approaches across various scientific domains. The program emphasizes alignment with national strategies and encourages applications from teams skilled in fostering partnerships with diverse stakeholders. Although applications are currently not being solicited, this notice allows potential applicants time to prepare strong proposals.

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing research on immune tolerance through its Collaborative Network. This program aims to clarify the mechanisms of immune tolerance and develop interventions for related diseases, including transplant rejection and autoimmune disorders. Key objectives include conducting clinical trials on tolerogenic strategies and refining immune assays. This initiative is supported by regulations under the Public Health Service Act, ensuring a structured approach to improving patient outcomes.

The Clinical Data, Safety and Statistical Centers (CDSSC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance clinical research through comprehensive support. This includes statistical analysis, protocol development, and oversight of safety monitoring in studies related to asthma, autoimmune diseases, and transplantation. By coordinating these efforts, the program seeks to facilitate impactful research outcomes and improve public health outcomes through informed data-driven decisions.

The Translational Transplantation Tolerance Cooperative Study Group, supported by the National Institute of Allergy and Infectious Diseases, aims to advance transplant tolerance strategies that promote long-term graft survival without lifelong immunosuppression. This initiative focuses on developing, optimizing, and evaluating methods to induce immune tolerance in allogeneic transplants through collaborative efforts across multiple centers, utilizing translationally relevant models to ensure effective outcomes.

The NIAID aims to enhance our understanding of the interplay between chronic and infectious diseases through innovative precision systems biology research. By utilizing advanced technologies such as multi-omics and artificial intelligence, the initiative focuses on uncovering critical pathways that connect infections to chronic health issues. This multidisciplinary approach leverages longitudinal patient data to inform and improve prevention and treatment strategies, ultimately seeking to provide insights into disease progression and host-pathogen interactions.

The Asthma and Allergic Diseases Cooperative Research Centers (AADCRC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance research on asthma and related allergic diseases. This initiative fosters multi-center, multidisciplinary research to explore disease mechanisms and treatment responses. By promoting clinical trials and observational studies, the AADCRC seeks to advance understanding and improve interventions for conditions such as asthma and food allergies, ultimately benefiting public health.

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing organ transplantation outcomes through the Clinical Trials in Organ Transplantation in Children and Adults (CTOT-CA) program. This initiative supports multicenter clinical trials and mechanistic studies related to heart, lung, kidney, liver, and intestinal transplants, as well as non-hematopoietic cellular transplantation. By exploring immune mechanisms and innovative therapies, the program aims to enhance the success and efficacy of organ transplantation.

The NIAID aims to enhance infectious disease research by supporting human microphysiologic systems (MPS) development. These in vitro platforms mimic human tissue functions, promoting drug and biological product development while reducing animal use. This initiative aligns with NIH’s commitment to innovative research practices and regulatory acceptance. By focusing on MPS in infectious disease contexts, NIAID seeks to streamline therapeutic advancements and establish robust human tissue models, addressing critical challenges in understanding and treating infections.

About 

The National Sea Grant College Program was established by the U.S. Congress in 1966 and works to create and maintain a healthy coastal environment and economy. The Sea Grant network consists of a federal/university partnership between the National Oceanic and Atmospheric Administration (NOAA) and 34 programs in every coastal and Great Lakes state, Puerto Rico, and Guam.

The Northeast Sea Grant Consortium is a regional collaboration that includes 8 Sea Grant programs in 7 Northeast states: Connecticut, Maine, Massachusetts, New Hampshire, New York, Rhode Island, and Vermont.

The Northeast Sea Grant Consortium collaborates on regional initiatives in research, education, extension, and communications—leveraging local expertise to create regional benefits and accomplishments.

American Lobster Initiative (ALI) Collaborative Research

The Sea Grant American Lobster Initiative is pleased to announce funding to support new collaborative research projects that closely align with emerging lobster industry and management needs. This request for proposals (RFP) adds to the substantial breadth of previous ALI-funded research by prioritizing projects that create “actionable science” (outputs and findings of the scientific process are useful to and usable by end-user communities) through the co-creation of information and/or products. 

To reach this goal, the ALI seeks to support collaborative research practices, the sharing of knowledge, expertise, and resources/capacities amongst the many people who comprise the American lobster industry. Projects must be developed and led by collaborative research teams that include at least one fishing industry representative, such as a commercial fisherman or a representative from a commercial fishing business, including cooperatives, dealers and processors. This call emphasizes research conducted with and for the industry, offering an exciting opportunity to support and elevate industry-research-management partnerships to address current ecological, regulatory, and socio-economic challenges faced by the American lobster fishery.

The Sea Grant American Lobster Initiative invites proposals for collaborative research projects to be funded from December 1, 2026 to December 31, 2028. Projects can be up to two years in duration, with a recommended duration of no less than 18 months. 

This opportunity is designed to support collaborative research conducted by those affiliated with the American lobster industry (including shoreside supply chain businesses), and any public or private higher education institution, municipal, state, federal, or tribal entity, research laboratory, or other community or non-profit institution. This opportunity is not open to single investigator proposals.

A total of $400,000 is available to support up to 8 two-year project awards. Project budgets cannot exceed $100,000 (including all direct and indirect costs), and must include non-federal cost share is required for this competition. See full RFP for guidance.

ASPCA Reimagining Racers: Grants for Adopting Out Retired Racehorses Grant

ASPCA Right Horse Adoption Partners, ASPCA Right Horse Industry Partners, and organizations actively participating in the warm-up ring (defined as groups that are actively working to achieve the 13 criteria for Partnership and are participating on myrighthorse.org) are invited to apply for a grant to support an increase in capacity and/or efficiency of programs aimed at adopting out retired Thoroughbred racehorses. 

Funding requests for this grant initiative should focus on:

Activities that increase capacity, decrease length of stay, reduce cost of care or increase efficiencies, and/or improve humane outcomes in other ways. Examples:

• Training programs
• Programs that engage new adopters and grow the market share for adoption
• Medical make-ready or rehabilitation with a focus on innovation and/or sustainability
• Collaborations with other equine industry organizations to increase support for retired racehorses

Proposals will be evaluated on their potential (within the 12-month grant term) to: 

• Increase capacity (the number of horses that can be rehabilitated, trained, and placed)
• Decrease length of stay
• Decrease cost of care
• Reduce risk, harm or suffering for retired racehorses

Requests may be for the creation of new programs or the expansion of existing programs. Programs that test innovative ideas are welcome.

Grant Amounts

Grants will generally range from $10,000-$40,000, with a maximum individual grant amount of $60,000. The total funding amount available for this grant opportunity is $200,000. 

Eligibility

ASPCA Right Horse Adoption Partners, ASPCA Right Horse Industry Partners, and active Warm-Up Ring participants (defined as groups that are actively working to achieve the 13 criteria for Partnership and are participating on myrighthorse.org) whose mission or operations focus significantly on serving retired Thoroughbred racehorses are eligible to apply for this grant opportunity. Adoption organizations must be up to date on reporting data biannually to the Equine Welfare Data Collective (EWDC). If you’re unsure about your eligibility, you may contact therighthorse@aspca.org to confirm before applying.   

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) was founded on the belief that animals are entitled to kind and respectful treatment by humans. We invite all voices to join us in working together to improve the lives of animals in need.

The ASPCA Right Horse Grants aim to enhance equine adoptions and support community equines by funding programs that boost shelter capacity or assist in keeping owned equines in their homes. Grants between $5,000 and $50,000 are available, with a total funding pool of up to $750,000. Eligible applicants include ASPCA Right Horse Adoption Partners and organizations committed to the welfare of retired Thoroughbred racehorses. Proposals should clearly outline the objectives and expected impacts.

Small Business Technical Assistance Grant Program

The Small Business Technical Assistance (SBTA) Grant Program supports Massachusetts-based nonprofit organizations that provide technical assistance and business support services to small and microbusinesses. Eligible applicants include certified Community Development Corporations (CDCs), certified Community Development Financial Institutions (CDFIs), and other nonprofit organizations with established community-focused small business assistance programs.

The program is designed to help nonprofits deliver services that strengthen businesses with:

• Fewer than 20 employees, and
• Annual revenues of no more than $2.5 million.

For FY27, grants of up to $150,000 are available to support programming that promotes business growth, stability, job creation, and local economic development. Program goals include:

• Expand the availability and quality of technical assistance for small and microbusinesses.
• Build organizational capacity among nonprofit providers serving small businesses.
• Increase equitable access to capital, guidance, and business resources.
• Strengthen local and regional small business ecosystems across Massachusetts.

Driving University Impact: Expanding the Public Exchange Network Grant

How the Public Exchange Network Works

No single university – even a large R1 – has enough faculty expertise available to meet the needs of every partner. The Public Exchange Network was designed to help universities work together seamlessly to build robust partnerships and generate more collective impact. Universities joining the network are independent but affiliated members, with full control over their own program and project portfolios. As a national network with local, on-the-ground capacity, Public Exchange Network members can also share approaches that work, scale solutions to common problems, and build cross-regional partnerships together. 

As an institutional partner in the Public Exchange Network, universities will build capacity to develop, test and implement solutions to the most urgent problems in their regions and beyond. Universities joining the Public Exchange Network get:

• The tools, templates and training they need to start right away;
• A shared brand they can plug into on day one;
• A network of faculty, past and potential partners and philanthropic relationships, benefitting everyone in the network. 

Public Exchange Network Expansion grants will cover 75-80% of the minimum estimated annual costs for two years to launch a new Public Exchange. To launch a Public Exchange, universities must have the following in place: (1) a staff executive director with experience launching and leading social impact partnerships, (2) a project seed fund, and (3) a modest operations budget. We also recommend some in-kind project management support from an existing university staff member. The grant includes a two-year Public Exchange Executive Director (ED) compensation subsidy of $300,000 to launch the Public Exchange on campus, and a 2-year license to use the Public Exchange brand. New Public Exchange Network members will also receive ongoing support and guidance from current Public Exchange leadership and staff at USC and WashU, including recruitment support and intensive training for hiring and onboarding an executive director, a sub-site on the Public Exchange website, incubation and project management support from current Public Exchange staff, and a suite of tools for developing and implementing Public Exchange projects.

The NIH Research Evaluation and Commercialization Hubs (REACH) program aims to facilitate the translation of biomedical discoveries into marketable products to enhance patient care. By funding five new academic entrepreneurship hubs, NIH will provide essential resources such as funding, mentorship, and expertise in product development. These hubs will address high-priority technologies and foster public-private partnerships, ultimately supporting the goals of federal research initiatives and addressing local health needs in underserved areas.

About Henry L. Hillman Foundation

Henry L. Hillman Foundation inspires, invests in, and leverages great ideas to improve the quality of life in Pittsburgh and southwestern Pennsylvania.

Backup Power When Your Community Needs It

The Powered & Prepared Initiative seeks proposals from nonprofit and municipal organizations in southwestern Pennsylvania for backup power solutions that allow those organizations to offer essential services during emergencies without disruption.

Southwestern Pennsylvania is increasingly impacted by severe weather events that cause widespread power outages and disruptions. The Powered & Prepared Initiative, supported by Henry L. Hillman Foundation, seeks proposals from nonprofit and municipal organizations for backup power solutions that allow those organizations to offer essential services during emergencies without disruption.

The Massachusetts Preservation Projects Fund (MPPF) is a state-funded 50% reimbursable matching grant program established in 1984 to support the preservation of properties, landscapes, and sites (cultural resources) listed in the State Register of Historic Places. By providing assistance to historic cultural resources owned by nonprofit or municipal entities, the Massachusetts Historical Commission hopes to ensure their continued use and integrity. 

An award from the George and Viola Hoffman Fund may be made annually for student research toward a master’s thesis or doctoral dissertation on a geographical subject in Eastern Europe. Eastern Europe includes the countries of East Central and Southeast Europe from Poland south to Romania, Bulgaria, and the successor states of the former Yugoslavia. Topics may be historical or contemporary, systematic or regional, limited to a small area or comparative.

The F26AS00104 State ANS Management Plan 2026 aims to combat aquatic nuisance species through pre-proposals followed by full applications. Managed by the US Department of the Interior's Fish and Wildlife Service, this initiative requires a 25% cost-share and limits administrative costs to 5%. Applications are due by October 14, 2026, though the funding opportunity closes on December 16, 2026. The plan is crucial for maintaining biodiversity and supporting a coordinated national approach to invasive species management.

Through the Water Quality Monitoring Grant (“WQMG”) program, MassDEP seeks to support both new and ongoing water quality monitoring initiatives conducted by federally recognized tribal nations located in the Commonwealth, community water quality monitoring groups, and other non-profit organizations. Such initiatives, include: (1) direct monitoring of rivers, streams, lakes, ponds, and estuaries through field and laboratory work; (2) associated capacity-building actions (including, but not limited to training and outreach) that improve the organization’s ability to monitor surface waters through field and laboratory work; and (3) developing regional and long-term monitoring programs and networks. 

The purpose of Community Workforce Partnerships Grant is to support community-led workforce development initiatives that support economic mobility within a single Massachusetts municipality. Projects must respond to a community-defined economic need or opportunity and demonstrate a clear link to stable employment and/or wage growth within one year.

Department of Fish and Game (DFG)

The Department of Fish and Game’s mission is to conserve the Commonwealth’s abundant marine and freshwater fisheries, wildlife, plants, and natural communities, as well as the habitats that support them, for the benefit and enjoyment of all people.

Massachusetts Community Biodiversity Grants

About the Opportunity

The Community Biodiversity Grants program supports local efforts to protect and restore biodiversity everywhere.

The Massachusetts Biodiversity Goals establish an ambitious, whole-of-government approach to rebuild biodiversity and invest in nature to sustain our health and well-being, food security, economy, and way of life. The plan sets four key goals—Protect, Restore, Sustain, and Connect—each with specific strategies for action for 2030, 2040, and 2050. 

The Community Biodiversity Grants program seeks proposals for projects that drive on-the-ground progress towards the Biodiversity Goals. The program will award grants between $20,000 and $150,000 to support biodiversity conservation and bring nature to every neighborhood.

Massachusetts Department of Elementary and Secondary Education 

The Massachusetts Department of Elementary and Secondary Education oversees public education for pre-K through grade 12 across the Commonwealth of Massachusetts with a mission to strengthen the public education system so that all students are prepared for postsecondary success, meaningful employment, and responsible citizenship, while working to close proficiency gaps statewide. Its vision centers on equitable, high-quality, student-centered learning that supports academic achievement, culturally responsive practice, and inclusive opportunity for every learner. The Department’s funding priorities and programs emphasize equitable student access and outcomes, diversity and culturally responsive teaching, strong teacher effectiveness and professional development, family and community engagement, and strategic support—such as quality improvement grants, safe and supportive school initiatives, and data-driven accountability tools—that advance excellence and equity in Massachusetts public education.

FY2027: Title II, Part A: Supporting Effective Instruction

Purpose

Title II, Part A of the federal Elementary and Secondary Education Act (ESEA) provides supplemental resources to school districts to improve high quality systems of support for excellent teaching and leading.

Title II, Part A is one of four principal programs that are available to districts through formula grants under the Every Student Succeeds Act (ESSA), the current reauthorization of ESEA. The other programs are Title I, Part A; Title III, Part A; and Title IV, Part A.

The Massachusetts Department of Elementary and Secondary Education is guided by its Educational Vision where:

• All students in Massachusetts, particularly students from historically underserved groups and communities, will have equitable opportunities to excel in all content areas across all grades.
• Culturally and linguistically sustaining classroom and school practices will support students to thrive by creating affirming environments where students have a sense of belonging, engage in deeper learning, and are held to high expectations with targeted support.

DESE partners with districts, schools, and programs to:

• Cultivate systems to support the whole student and foster joyful, healthy, and supportive learning environments so that all students feel valued, connected, nourished, and ready to learn. Strategic Objective 1 — "Whole Student"
• Promote deeper learning so that all students engage in grade-level work that is real-world, relevant, and interactive. Strategic Objective 2 — "Deeper Learning"
• Develop and sustain a workforce that is diverse, culturally responsive, well-prepared, and committed to continuous improvement, so that all students have equitable access to effective educators. Strategic Objective 3 — "Diverse and Effective Workforce"

Priorities

The priorities of Title II, Part A are to:

• increase student achievement consistent with challenging State academic standards;
• improve the quality and effectiveness of teachers, principals, and other school leaders;
• increase the number of teachers, principals, and other school leaders who are effective in improving student academic achievement in schools; and
• provide low-income and minority students equitable access to effective teachers, principals, and other school leaders.

The One Stop is a single application portal and collaborative review process that allows applicants to access a series of grant programs that support community economic development. The Executive Office of Economic Development (EOED) partners with the Executive Office of Housing and Livable Communities (EOHLC) and Massachusetts Development Finance Agency (MassDevelopment), to make targeted grant investments based on a Development Continuum. 

The Massachusetts Vacant Storefront Program was created through Section 5 of chapter 288 of the Acts of 2018 to aid municipalities of the Commonwealth of Massachusetts in their efforts to revitalize their downtown and commercial areas by encouraging new occupancy of long-term vacant storefronts. An award from the Massachusetts Vacant Storefront Program in the FY27 Round of the Community One Stop for Growth allows a municipality to request tax credits for Vacant Storefronts to be assigned to an eligible business within the community by the Economic Assistance Coordinating Council (EACC).