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Multiplex Platforms to Assess Indicators of Micronutrient Status, Inflammation and Infectious Disease
The Challenge
Although combined immunological measurement of several micronutrient biomarkers has been demonstrated, current methods still have important limitations. These include heterogeneity in the composition of standards and controls; inconsistent batch-to-batch performance of analyte-binding molecules; variable reactivity for some analytes, especially soluble transferrin receptor (sTfR); and a functional analytical range that is too narrow to cover the physiological values of some analytes, such as CRP. It would also be valuable to add bioindicators for vitamins B1, B2, B9 and B12, which may require binding molecules that recognize metabolites or proteins associated with deficiency, a specific vitamer (plasma methyl-tetrahydrofolate without reacting with folic acid), comparable reactivity across vitamers (several folate forms in red blood cells), or a specific carrier-protein form (holo-transcobalamin rather than apo-transcobalamin or haptocorrin for vitamin B12).
The improved assays must combine high analytical specificity, sensitivity and robustness with a functional analytical range matched to the physiological values expected in the target populations (women of reproductive age, including during pregnancy and lactation, preschool-age children and older adults). Assays must remain low-cost (no more than US$20 for all analytes measured in duplicate) and require very small sample volumes, preferably less than 10 µL of plasma or serum). The tests are intended for population surveillance rather than local clinical (point-of-care) use. They should be designed to run many samples in a single batch in a small number of national or regional reference laboratories. The goal is to reduce dependence on expensive, infrequent population surveys and on export of samples to specialized laboratories in high-income settings.
This challenge is structured around two alternatives, a minimum-scope approach and an optimistic-scope approach. Targets are aligned with the candidate Target Product Profile for this platform, and applicants will be held to the relevant performance, cost and instrument targets.
Multiplex Platforms to Assess Indicators of Micronutrient Status, Inflammation and Infectious Disease
The Challenge
Although combined immunological measurement of several micronutrient biomarkers has been demonstrated, current methods still have important limitations. These include heterogeneity in the composition of standards and controls; inconsistent batch-to-batch performance of analyte-binding molecules; variable reactivity for some analytes, especially soluble transferrin receptor (sTfR); and a functional analytical range that is too narrow to cover the physiological values of some analytes, such as CRP. It would also be valuable to add bioindicators for vitamins B1, B2, B9 and B12, which may require binding molecules that recognize metabolites or proteins associated with deficiency, a specific vitamer (plasma methyl-tetrahydrofolate without reacting with folic acid), comparable reactivity across vitamers (several folate forms in red blood cells), or a specific carrier-protein form (holo-transcobalamin rather than apo-transcobalamin or haptocorrin for vitamin B12).
The improved assays must combine high analytical specificity, sensitivity and robustness with a functional analytical range matched to the physiological values expected in the target populations (women of reproductive age, including during pregnancy and lactation, preschool-age children and older adults). Assays must remain low-cost (no more than US$20 for all analytes measured in duplicate) and require very small sample volumes, preferably less than 10 µL of plasma or serum). The tests are intended for population surveillance rather than local clinical (point-of-care) use. They should be designed to run many samples in a single batch in a small number of national or regional reference laboratories. The goal is to reduce dependence on expensive, infrequent population surveys and on export of samples to specialized laboratories in high-income settings.
This challenge is structured around two alternatives, a minimum-scope approach and an optimistic-scope approach. Targets are aligned with the candidate Target Product Profile for this platform, and applicants will be held to the relevant performance, cost and instrument targets.
The Oliver Foundation
The Oliver Foundation was founded by Mrs. William B. Oliver (Cluthe) in 1995 and official programs for the Prevention of Childhood Obesity began in 2004. The foundation is dedicated to the prevention of childhood obesity.
The Oliver Foundation is a Houston-based 501(c) (3) non-profit operating foundation dedicated to the prevention of childhood obesity. We provide funding of various levels and time frames to qualified grant recipients. The grants, by application, are based on the Oliver Foundation’s Seven Healthy Messages to promote a healthy lifestyle to kids and teens, referred to as “The Seven Healthy Choices!”
Healthy Choices Grant Level 2
The goal of the Oliver Foundation is to encourage children, families and communities in Texas to improve the eating and physical activity patterns of Pre-school, Elementary, Middle School and High School students.
Level 2 grants are awarded for a two-year (4 semesters) or longer program that includes a minimum of 5 of the 7 Healthy Messages. A physical activity and nutrition educational component are required as two of the 5 or more Healthy Messages.
Level 2 grants are intended to create a long-term sustainable program at the campus level. All programs must have a sustainability plan. Grants that are purchasing equipment or supplies that are on an annual renewal basis, the grant must include a plan to renew said equipment/supplies for subsequent years.
Yawkey Foundation
The story of Tom and Jean Yawkey and their impact on the lives of children and families goes back over eight decades to the commitments they made to the people of Massachusetts, New England, and Georgetown County, South Carolina. The Yawkeys’ love for these communities, and their quiet sense of responsibility for those in need, is captured in the careful steps they took to ensure that their legacy would live on through the work of the Yawkey Foundation. The Yawkeys were perhaps best known for their longtime ownership of the Boston Red Sox. More quietly, but with just as much passion and commitment, Tom and Jean Yawkey were also engaged in an unwavering dedication to those most in need.
Today, the Yawkey Foundation remains as committed as ever to continuing to honor Tom and Jean Yawkey and their commitment to those in need. Having awarded more than $620 million to-date in charitable grants to organizations focused on Health Care, Education, Human Services, Youth and Amateur Athletics, Arts and Culture, and Conservation and Wildlife, the Yawkey Foundation is committed to preserving and sustaining the charitable values of the Yawkeys by investing in impactful nonprofits providing resources, opportunity, and dignity to the vulnerable and underserved. The Yawkey Foundation is committed to providing support for program and small capital needs connected to a nonprofit’s established mission and proven program/service delivery connected to the mission.
Program and Small Capital Grants
Program and Small Capital Grants support high-impact, strategic, and responsive nonprofit organizations in delivering their core missions through discrete and timebound projects. Program & Small Capital Grants help address an immediate need that is critical to the organization’s work.
Program and Small Capital Grants may fund a discrete timebound program need, one small project, or a piece of equipment aligned with a nonprofit’s purpose. These grants are extremely competitive, and the Yawkey Foundation will receive many more compelling Initial Proposals than it will be able to fund. Initial Proposals should demonstrate an awareness of and alignment with the Yawkey Foundation’s mission and Areas of Giving. Additionally, the most competitive Initial Proposals will reflect a nonprofit’s strong leadership and proven impact in providing direct services and programs for unmet needs in underserved regions aligned with the Yawkey Foundation’s geographic priority areas, including Gateway Cities in Eastern Massachusetts.
Nonprofits may submit only one Initial Proposal to the Yawkey Foundation during a calendar year, irrespective of the Type of Grant. Organizations that have not been previously funded by the Foundation in recent years are encouraged to submit Initial Proposals for Program & Small Capital Grants to familiarize the Foundation with its work before submitting an Initial Proposal for Strategic Investment or Transformational Capital.
Areas of Giving: Human Services; Youth & Amateur Athletics; Education; Conservation & Wildlife; Arts & Culture; and Health Care.
Health Care Support
Access to high quality health care, particularly for those disadvantaged members of the community, was an issue of great importance to Tom and Jean Yawkey. Tom Yawkey was instrumental in the founding of Georgetown Memorial Hospital, which brought much-needed health care to the rural area of Georgetown, South Carolina. In addition, the Yawkeys first lent their extraordinary support to Dr. Sidney Farber by initiating the Red Sox relationship with Dr. Farber, and laid the groundwork for establishment of The Jimmy Fund in 1953. That relationship lasted throughout both of their lifetimes and continues to this day.
The Yawkey Foundation continues to support medical institutions, including transformational construction and renovation projects to help leading medical institutions expand their footprints and ability to provide expert medical care. Understanding the real link between medical needs and behavioral health needs, particularly in children, the Foundation has also played a leading role in supporting organizations providing access to behavioral and mental health treatment programs.
NAFC Open Grant/Product Donation Applications
The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.
NAFC Patient Care Fund
The NAFC Patient Care Fund supports direct patient services that expand immediate access to care. This funding is designed to help NAFC members meet urgent patient needs by supporting clinical supplies, expanded services, contracted providers, transportation assistance, medication access, and other direct care resources.
Gropper Clement Legacy Scholarship
To provide financial support to graduates of Huron, James Valley Christian, Kadoka and Miller High Schools.
Grants for BIPOC organizations fund programs aimed at advancing equity, inclusion, and opportunities for Black, Indigenous, and People of Color. The following grants support initiatives in education, healthcare, business development, and social justice, driving systemic change and community empowerment.
Find 8,000+ grant opportunities dedicated to BIPOC-led initiatives, with $3.34B in funding available. Instrumentl’s database provides tailored searches, deadline tracking, and insights into funders that prioritize diversity and equity. Join 4,000+ nonprofits leveraging Instrumentl to achieve meaningful impact.
How common are grants in this category?
Quite common — grants in this category are more prevalent than in others.
Over the past year, when are grant deadlines typically due for grants for BIPOC?
Most grants are due in the first quarter.
What's the typical grant amount funded for Grants for BIPOC?
Grants are most commonly $32,500.
These grants are usually funded by private foundations and philanthropic organizations, such as the Ford Foundation and the Kellogg Foundation. Government agencies at all levels often provide funding, especially for diversity and inclusion initiatives. Companies with social responsibility programs and community development groups are key funders.
Organizations that qualify for Black, Indigenous, and people of color (BIPOC) grants support ethnic and Indigenous minorities, LGBTQ+ members, refugees, and people who are or were incarcerated. They also assist unhoused individuals, veterans or their families, and people with disabilities. These organizations focus on racial equity, economic justice, and health disparities.
Applicants for BIPOC grants are typically US 501(c)(3) nonprofits, similar international organizations, advocacy groups, or community groups. These organizations are led by and serve BIPOC.
Based on Instrumentl’s live grant database for grants for bipoc grants, deadlines are most common in Q1, accounting for 29.7% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.
Funding for BIPOC grants aims to empower nonprofits that are led by and serve BIPOC communities. These grants support programmes that address systemic inequalities, promote social justice, enhance economic opportunities, and support community development within BIPOC communities. The grants are often directed towards initiatives in education, entrepreneurship, social justice, and healthcare access.
On average, grants in grants for bipoc provide funding between $0 and $188,250,000, with typical awards falling around $32,500 (median) and $633,837 (average). These insights can help nonprofits align their funding requests with what grantmakers typically offer in this space.
To improve success for BIPOC grants, organizations should:
For additional guidance, explore our step-by-step guide to crafting compelling grant proposals.
Instrumentl simplifies the grant application process for BIPOC organizations by matching them with the most relevant funders, saving time and ensuring no opportunity is overlooked. The platform also tracks applications, allowing organizations to stay on top of deadlines without stress. See how Lutheran Braille Workers increased their grant submissions by 150%.