Best Addiction and Substance Abuse Grants in North Carolina

Grants from Amerihealth Caritas Foundation help North Carolina 501(c)(3) nonprofits run project-specific programs addressing addiction and substance use disorders, children’s mental health, and related trauma. Organizations with $300,000–$10 million in revenue that serve Medicaid-enrolled communities can apply for US $100,000 - US $150,000 to improve healing behaviors, health care access, and family empowerment.

North Carolina nonprofits planning innovative arts or human services projects can apply for the Joy W. Pope Memorial Grant Funds, with awards from US $20,000 - US $100,000 for project-specific work. With a mission to foster innovation, John William Pope Foundation supports capital improvements, program development, equipment, and technology, including initiatives addressing addiction and substance use disorders.

Nonprofit 501(c)(3) organizations in North Carolina working on addiction and substance use disorders can seek project or capital support to improve prevention, treatment, and recovery services. Focused on education, healthcare/rehabilitation, and human and community services, the Philip L Van Every Foundation offers US $10,000 - US $50,000 for established programs with strong leadership and results.

Nonprofit and community organizations expanding substance use disorder prevention, treatment, services, or supports in North Carolina can apply for up to US $500,000 annually to address access gaps. North Carolina Department of Health and Human Services supports addiction and substance use disorders programs statewide through at least 12 contracts aimed at building an equitable system of care.

Nonprofit and local government organizations working on addiction and substance use disorders, alcoholism, or drug use disorder can apply for funding, including those in North Carolina if they are Native American organizations. Focused on education, health, public safety, treatment, housing, and related services, the Confederated Tribes of Siletz Indians supports charitable programs across the U.S.

North Carolina research institutions and healthcare or community partners working on addiction and substance use disorders can access funding through the National Institutes of Health to test SBIRT/P approaches for adults facing health disparities. Projects must prospectively evaluate screening, brief intervention, and referral to treatment or prevention for alcohol, tobacco, and other drug use.

Addiction and substance use researchers working with adult populations that experience health disparities can apply for National Institutes of Health funding to test SBIRT/P approaches. Grants from NIH help North Carolina and other U.S. teams evaluate screening, brief intervention, and referral to treatment or prevention in collaboration with healthcare and community partners.

The NCDDG program supports innovative research aiming to discover and develop new treatments for mental disorders, including substance use and alcohol use disorders. This initiative encourages collaborations between academic and industry partners to advance neurostimulation techniques and drug/device development. Applicants are invited to submit proposals that focus on specific projects utilizing the U01 mechanism, with a clear emphasis on rationally designed candidate agents and cutting-edge technologies. Letters of Intent are encouraged 30 days prior to the submission deadline.

The National Cooperative Drug/Device Discovery/Development Groups (NCDDG) program invites applications to foster innovative research in treating mental disorders and substance use issues. This initiative promotes collaboration between academia and industry, supporting diverse, multidisciplinary projects aimed at developing rational therapies and neurostimulation techniques. Applicants are encouraged to submit Letters of Intent 30 days before the proposal deadline to enhance project alignment with funding goals.

Universities, research institutions, and similar organizations focused on substance use and addiction can seek funding to provide skills-development courses and hands-on research experiences, including for North Carolina participants. Focused on building a diverse biomedical and behavioral science workforce, the National Institutes of Health offers up to US $1,250,000 for structured research education programs.

This funding opportunity invites Small Business Technology Transfer (STTR) grant applications aimed at developing FDA-regulated medical products for patients with opioid and stimulant use disorders. Projects may focus on pharmacotherapeutics or diagnostic devices, including software. The initiative seeks to address the ongoing opioid crisis by supporting innovations that enhance treatment options for individuals and communities affected by these disorders.

The Substance Use/Substance Use Disorder Dissertation Research Award supports doctoral candidates in completing their dissertation research on substance use disorders. This initiative encourages diverse applicants and aligns with NIDA funding priorities. Key deadlines include February 16 and June 16 of 2025 and 2026 for standard applications, with specific dates for renewal and AIDS-related projects. This funding aims to enhance the research workforce in the field.

The HEAL Initiative's Career Development Awards aim to empower early career researchers and clinicians in implementation science. By providing training and funding, this initiative seeks to address substance use prevention and treatment through research projects that align with the HHS Overdose Prevention Strategy. Focused on vital areas such as opioid prescribing, OUD treatment, and recovery support, the program aspires to cultivate a new generation of experts who will significantly impact addiction clinical practices and mentorship.

The Opioid Crisis Response Program Fellowship, offered by Equal Justice Works, addresses the opioid epidemic by mobilizing public interest lawyers to provide vital civil legal aid to underserved communities affected by Opioid Use Disorder. This two-year fellowship enables attorney fellows to advocate for clients' rights, reduce barriers to treatment, and enhance community education about legal impacts. Through collaboration with various stakeholders, the program aims to improve health outcomes and foster systemic change in the fight against this public health crisis.

The Chemical Countermeasures Research Program (CCRP) Initiative aims to support vital research on the harmful effects of acute exposure to Ultra-Potent Synthetic (UPS) opioids, including fentanyl and its combinations. This funding opportunity encourages studies that enhance understanding and mitigation strategies for these substances, focusing on both immediate and long-term health impacts. Applications are due by 5:00 PM local time, with optional Letters of Intent accepted 30 days prior to the proposal deadline.

The HEAL initiative aims to translate addiction research into practice to combat the opioid crisis and overdose events. It focuses on identifying barriers to reducing substance use and developing scalable, evidence-based interventions. Emphasizing recovery, prevention, and the integration of mental health, the initiative encourages collaboration among experts in various fields. Although applications are not currently solicited, potential applicants are urged to prepare for future opportunities to apply innovative solutions to enhance addiction treatment and prevention efforts.

The NIDA Research Education Program (R25) aims to enhance the training of a workforce skilled in biomedical, behavioral, and clinical research, particularly regarding substance use disorders. This program supports educational activities that prepare clinicians and clinical researchers. Applications are due by 5:00 PM local time, with optional Letters of Intent encouraged 30 days prior to the full proposal deadline. This initiative does not fund non-research-related clinical training.

Clinician-scientist training programs in addiction and substance use disorders in North Carolina can apply for institutional career development support, with awards up to US $750,000. Grants from the National Institutes of Health help eligible institutions provide intensive, supervised research training that advances substance use and substance use disorder research toward independent clinical research careers.

Just One More Grant aims to transform lives by providing financial support to individuals and nonprofit organizations in the U.S. who are overcoming challenges like mental health issues, drug misuse, and educational barriers. The foundation encourages applications from those committed to personal growth and community support. Though current grants are paused for nonprofits, interested individuals with actionable plans are invited to apply. More information and past winners can be found on their website.

Research institutions and teams conducting HIV and substance use studies, including addiction and drug use disorders, can apply for up to US $1,500,000 in funding, including projects based in North Carolina. Focused on high-priority HIV research, the National Institutes of Health invites detailed proposals from basic, clinical, and implementation scientists working with people who use drugs.

North Carolina research institutions and clinical trial teams focused on addiction and substance use disorders can access funding through the Food and Drug Administration to study analgesics, anesthetics, and addiction. Awards of US $2,000,000 support clinical trials, outcome measures, neurodevelopmental assessments, and evidence-based plans to improve prescribing for pain, anesthesia, and substance use disorders.

This NOFO invites applications for innovative research aimed at developing and implementing interventions to prevent and treat substance use disorders (SUDs) and overdose. It encourages studies that can rapidly advance candidate solutions towards regulatory approval or clinical use, while also addressing co-morbid SUDs. The initiative supports a wide range of research including basic, clinical, translational, and implementation strategies to tackle drug misuse and related health issues, such as HIV/AIDS.

The Applied Drug Policy Research Experiences project aims to provide graduate students and recent post-graduates with hands-on research opportunities to support the National Drug Control Strategy. Through rigorous studies and data analyses, this initiative will explore the evolving dynamics of illicit drug supply and usage, assisting public health and safety officials in anticipating drug-related issues and crafting effective responses to safeguard the American public.

The Evergreen Foundation Grant supports not-for-profit organizations in Western North Carolina that provide essential services for individuals with behavioral health, intellectual, and developmental disabilities. Established in 1977, the Foundation allocates funding through a competitive grant process, typically issuing 25 to 30 grants annually. Eligible applicants include agencies serving these populations and those with 501(c)(3) status. Priorities include infrastructure support, education, and advocacy, ensuring vital services reach the communities in need.

About Samba RecoverySamba Recovery is dedicated to empowering individuals recovering from alcoholism and drug addiction by restoring confidence and fostering resilience. Through a foundation of compassion, support, and holistic care, we guide individuals toward renewed health and wellness, meaningful relationships, and the discovery of their inner strengths—assisting them to achieve their fullest potential.Hope for Addiction ScholarshipSamba Recovery’s Hope for Addiction Scholarship is an annual $1,000 award dedicated to encouraging more young people to join the fight against addiction by pursuing degrees that directly support individuals and families affected by substance use disorders.

We welcome applications from all eligible students, with special encouragement for those who are in recovery themselves or who have been impacted by addiction within their families.Application requirements:

• Proof of college enrollment or acceptance
• Pursuing a degree with the goal of working with individuals and/or families impacted by addiction
• Completed application form
• An original 500 to 1000 word essay on how you are planning to use your degree to help individuals and families struggling with addiction, and why helping those affected by substance use disorder is important to you

The Drug-Free Communities (DFC) Support Program aims to foster collaboration among community coalitions to combat youth substance use. Established by the Drug-Free Communities Act of 1997, it encourages partnerships among various stakeholders, including governmental and non-profit agencies. The program focuses on reducing substance use among youth and promoting protective factors within communities. This funding opportunity is available for those who have completed the initial funding cycle or experienced funding interruptions, supporting their ongoing efforts to create a healthier environment for youth.

The GSK IMPACT Awards in North Carolina honor outstanding nonprofit organizations making a significant impact on community health. This annual program, in partnership with the Triangle Community Foundation, recognizes up to ten organizations for their exemplary contributions to health and wellness. Applicants must demonstrate a commitment to improving community health through innovative and effective programs. Eligible organizations must operate in the Triangle area and meet specific criteria regarding revenue and community impact.