Best Addiction and Substance Abuse Grants in North Carolina

North Carolina nonprofits planning innovative arts or human services projects can apply for the Joy W. Pope Memorial Grant Funds, with awards from US $20,000 - US $100,000 for project-specific work. With a mission to foster innovation, John William Pope Foundation supports capital improvements, program development, equipment, and technology, including initiatives addressing addiction and substance use disorders.

Nonprofit 501(c)(3) organizations in North Carolina working on addiction and substance use disorders can seek project or capital support to improve prevention, treatment, and recovery services. Focused on education, healthcare/rehabilitation, and human and community services, the Philip L Van Every Foundation offers US $10,000 - US $50,000 for established programs with strong leadership and results.

About QuikTripQuikTrip believes in investing in the communities in which our employees live and work. Every year, QuikTrip donates 5% of our annual net profit to qualified 501c3 non-profit agencies, which includes our United Way campaign match, support for National Safe Place agencies, Folds of Honor scholarships and many other agencies that support at-risk youth and early childhood education.Mission: To wisely invest dollars in community efforts that will help impact (in measurable terms) individuals in our society who are dependent on the charitable support of others. We believe the most effective way to do that is to invest our contribution dollars and volunteers in strategic efforts that help those at risk reach their functional capacity as successful, independent citizens.About QuikTrip Charitable GrantsQuikTrip funds 501c3 agencies located in the cities in which we have stores and our employees live and work. Funding can include: “in-kind” products (coupons, gift cards or product donation), formal grants, fundraiser/event sponsorships and employee volunteer time.Focus Areas:

• Creating Safe Communities
  • First Responders: QuikTrip is proud to partner with law enforcement and first responders in every market we serve, making sure that they have the tools, training and support they need to keep our communities safe and to return home safely to their families after each shift.
  • Homeless Outreach & Alternatives to Police Response: To significantly reduce non-emergency calls and help people in crisis get back on their feet, QuikTrip funds dedicated homeless outreach teams across our communities. These teams engage individuals experiencing homelessness and living in encampments – connecting people to services, shelter, detox and long-term care.

• Creating Strong Communities
  • Ending Homelessness: We support emergency, transitional and permanent supportive housing, diversion and prevention programs, and more.
  • Mental Health & Substance Abuse : We know that healthy communities are safe communities, which is why we invest in detox and substance abuse treatment centers, and behavioral health centers and services to end the perpetuation of cycles of trauma and addiction.
  • At-Risk Youth: We especially prioritize services for at-risk youth – those aging out of foster care, justice-involved or without stable support systems.
• Additional Community Commitments
  • United Way: Employee donation matching in all markets.
  • Folds of Honor: Scholarships for families of fallen or wounded service members and first responders.
  • National Safe Place: QT stores serve as Safe Place locations for youth in crisis, with trained staff ready to assist.

Nonprofit and community organizations expanding substance use disorder prevention, treatment, services, or supports in North Carolina can apply for up to US $500,000 annually to address access gaps. North Carolina Department of Health and Human Services supports addiction and substance use disorders programs statewide through at least 12 contracts aimed at building an equitable system of care.

Nonprofit and local government organizations working on addiction and substance use disorders, alcoholism, or drug use disorder can apply for funding, including those in North Carolina if they are Native American organizations. Focused on education, health, public safety, treatment, housing, and related services, the Confederated Tribes of Siletz Indians supports charitable programs across the U.S.

Addiction and substance use researchers working with adult populations that experience health disparities can apply for National Institutes of Health funding to test SBIRT/P approaches. Grants from NIH help North Carolina and other U.S. teams evaluate screening, brief intervention, and referral to treatment or prevention in collaboration with healthcare and community partners.

Grants from Amerihealth Caritas Foundation help North Carolina 501(c)(3) nonprofits run project-specific programs addressing addiction and substance use disorders, children’s mental health, and related trauma. Organizations with $300,000–$10 million in revenue that serve Medicaid-enrolled communities can apply for US $100,000 - US $150,000 to improve healing behaviors, health care access, and family empowerment.

CAREs Flexible Funding

Healthcare Foundation of Wilson (HFW) CAREs about our nonprofit partners that provide CARE (Compassion, Assistance, Responsiveness, and Engagement) for our community. As a response to support the work done by these organizations, the HFW seeks proposals from nonprofit organizations located in Wilson, NC, for an unrestricted funds grant. Funds may be used for general operating support.

Request Range:

• Up to $15,000

As a partner organization, it is essential to note that maintaining compliance with the public support test is the nonprofit’s own responsibility. Please review the information provided on the IRS website. If you are unsure of your public support status, please contact an accounting professional. 

Purpose:

Nonprofits can utilize these funds to support any operating needs within the organization. These funds are not intended for past, present, or future programming needs.

Award Distribution:

Awards will be issued quarterly through a competitive grant process. Up to $50,000 will be issued each quarter.

The nonprofit’s mission and/or vision must align with at least one of our four focus areas.

• Access to Healthcare
• Active Living / Healthy Eating
• Alcohol / Substance Misuse
• Behavioral / Mental Health

The NCDDG program supports innovative research aiming to discover and develop new treatments for mental disorders, including substance use and alcohol use disorders. This initiative encourages collaborations between academic and industry partners to advance neurostimulation techniques and drug/device development. Applicants are invited to submit proposals that focus on specific projects utilizing the U01 mechanism, with a clear emphasis on rationally designed candidate agents and cutting-edge technologies. Letters of Intent are encouraged 30 days prior to the submission deadline.

The Strengthening Services to Prevent the Infectious Disease Consequences of Drug Use initiative aims to enhance prevention services for infectious diseases among people who use drugs (PWUD). It encompasses two components: a biennial survey to assess service gaps and capacity, and increased support for testing and treatment services. The initiative seeks to improve data utilization in service provision, ultimately increasing testing for HBV, HCV, and HIV, and ensuring more PWUD engage in treatment and care.

The Chemical Countermeasures Research Program (CCRP) Initiative aims to support vital research on the harmful effects of acute exposure to Ultra-Potent Synthetic (UPS) opioids, including fentanyl and its combinations. This funding opportunity encourages studies that enhance understanding and mitigation strategies for these substances, focusing on both immediate and long-term health impacts. Applications are due by 5:00 PM local time, with optional Letters of Intent accepted 30 days prior to the proposal deadline.

The Residential Treatment for Pregnant and Postpartum Women program aims to deliver essential services to women facing substance use disorders. By offering comprehensive residential treatment options, the program supports both recovery and the well-being of mothers and their children. Funded by the Substance Abuse and Mental Health Services Administration, this initiative addresses the unique challenges of pregnant and postpartum women, ensuring they receive the care necessary for a successful recovery journey.

The Rural Communities Opioid Response Program focuses on enhancing behavioral health care services for children and adolescents in rural areas. By providing essential funding, this initiative aims to tackle mental health and substance use disorders, ensuring that young individuals receive the support they need. The program, administered by the Health Resources and Services Administration, is crucial in addressing the unique challenges faced by rural communities, promoting healthier outcomes for future generations.

The Rural Communities Opioid Response Program - Overdose Response aims to enhance healthcare access in rural areas by addressing urgent needs related to substance use disorder services. This initiative focuses on reducing overdose risks through targeted interventions and support, ensuring that rural communities receive necessary assistance. Funded by the Health Resources and Services Administration, this program is crucial for mitigating the opioid crisis in underserved regions, improving health outcomes, and promoting overall community well-being.

The Drug-Free Communities (DFC) Support Program, initiated by the Drug-Free Communities Act of 1997, aims to bolster community coalitions dedicated to preventing youth substance use. Funded by the US HHS's Substance Abuse and Mental Health Services Administration (SAMHSA), this program focuses on collaboration among various stakeholders, including government and non-profit entities, to effectively reduce substance abuse among youth and promote protective factors within communities.

Clinician-scientist training programs in addiction and substance use disorders in North Carolina can apply for institutional career development support, with awards up to US $750,000. Grants from the National Institutes of Health help eligible institutions provide intensive, supervised research training that advances substance use and substance use disorder research toward independent clinical research careers.

Research institutions and teams conducting HIV and substance use studies, including addiction and drug use disorders, can apply for up to US $1,500,000 in funding, including projects based in North Carolina. Focused on high-priority HIV research, the National Institutes of Health invites detailed proposals from basic, clinical, and implementation scientists working with people who use drugs.

The Drug-Free Communities (DFC) Support Program aims to foster collaboration among community coalitions to combat youth substance use. Established by the Drug-Free Communities Act of 1997, it encourages partnerships among various stakeholders, including governmental and non-profit agencies. The program focuses on reducing substance use among youth and promoting protective factors within communities. This funding opportunity is available for those who have completed the initial funding cycle or experienced funding interruptions, supporting their ongoing efforts to create a healthier environment for youth.

North Carolina research institutions and clinical trial teams focused on addiction and substance use disorders can access funding through the Food and Drug Administration to study analgesics, anesthetics, and addiction. Awards of US $2,000,000 support clinical trials, outcome measures, neurodevelopmental assessments, and evidence-based plans to improve prescribing for pain, anesthesia, and substance use disorders.

About Samba RecoverySamba Recovery is dedicated to empowering individuals recovering from alcoholism and drug addiction by restoring confidence and fostering resilience. Through a foundation of compassion, support, and holistic care, we guide individuals toward renewed health and wellness, meaningful relationships, and the discovery of their inner strengths—assisting them to achieve their fullest potential.Hope for Addiction ScholarshipSamba Recovery’s Hope for Addiction Scholarship is an annual $1,000 award dedicated to encouraging more young people to join the fight against addiction by pursuing degrees that directly support individuals and families affected by substance use disorders.

We welcome applications from all eligible students, with special encouragement for those who are in recovery themselves or who have been impacted by addiction within their families.Application requirements:

• Proof of college enrollment or acceptance
• Pursuing a degree with the goal of working with individuals and/or families impacted by addiction
• Completed application form
• An original 500 to 1000 word essay on how you are planning to use your degree to help individuals and families struggling with addiction, and why helping those affected by substance use disorder is important to you

Healthcare organizations, 501(c)(3) nonprofits, government agencies, and schools in Wilson County can receive funding to improve healthcare access, behavioral and mental health, and address alcohol and substance misuse among youth. Healthcare Foundation of Wilson prioritizes innovative, evidence-based programs serving residents through age 29 in the greater Wilson, North Carolina community.

The Evergreen Foundation Grant supports not-for-profit organizations in Western North Carolina that provide essential services for individuals with behavioral health, intellectual, and developmental disabilities. Established in 1977, the Foundation allocates funding through a competitive grant process, typically issuing 25 to 30 grants annually. Eligible applicants include agencies serving these populations and those with 501(c)(3) status. Priorities include infrastructure support, education, and advocacy, ensuring vital services reach the communities in need.

The GSK IMPACT Awards in North Carolina honor outstanding nonprofit organizations making a significant impact on community health. This annual program, in partnership with the Triangle Community Foundation, recognizes up to ten organizations for their exemplary contributions to health and wellness. Applicants must demonstrate a commitment to improving community health through innovative and effective programs. Eligible organizations must operate in the Triangle area and meet specific criteria regarding revenue and community impact.

The NIH is offering access to biospecimens from the ABCD, HBCD, and PATH studies to promote research on health and disease across a lifetime. This initiative encourages projects that utilize these samples to deepen understanding of genetic and environmental influences, particularly substance exposure. Researchers can submit proposals to maximize the scientific utility of these resources, in alignment with the goals outlined under federal health regulations.

The Healthcare Foundation of Wilson (HFW) offers responsive grants aimed at improving health and wellness in the Wilson, NC community. Established in 2014, HFW prioritizes tax-exempt organizations that address healthcare access, active living, and mental health. Funding is directed towards innovative programs, especially those targeting youth, while ensuring eligibility criteria, including three years of operational history, are met. This initiative reflects HFW's commitment to reinvesting resources back into the community.

The HEAL Initiative aims to combat the opioid crisis through action-oriented research that enhances the translation of addiction epidemiology, prevention, treatment, and recovery services into practice. It prioritizes scalable, evidence-based approaches targeting various levels, including individual and community. The initiative supports a range of methods for research deployment, emphasizing collaboration between researchers and decision-makers to improve outcomes for those affected by addiction and related chronic pain.

This NOFO invites applications for innovative research aimed at developing and implementing interventions to prevent and treat substance use disorders (SUDs) and overdose. It encourages studies that can rapidly advance candidate solutions towards regulatory approval or clinical use, while also addressing co-morbid SUDs. The initiative supports a wide range of research including basic, clinical, translational, and implementation strategies to tackle drug misuse and related health issues, such as HIV/AIDS.