Best Addiction and Substance Abuse Grants in North Carolina

Grants from Amerihealth Caritas Foundation help North Carolina 501(c)(3) nonprofits run project-specific programs addressing addiction and substance use disorders, children’s mental health, and related trauma. Organizations with $300,000–$10 million in revenue that serve Medicaid-enrolled communities can apply for US $100,000 - US $150,000 to improve healing behaviors, health care access, and family empowerment.

North Carolina nonprofits planning innovative arts or human services projects can apply for the Joy W. Pope Memorial Grant Funds, with awards from US $20,000 - US $100,000 for project-specific work. With a mission to foster innovation, John William Pope Foundation supports capital improvements, program development, equipment, and technology, including initiatives addressing addiction and substance use disorders.

Nonprofit 501(c)(3) organizations in North Carolina working on addiction and substance use disorders can seek project or capital support to improve prevention, treatment, and recovery services. Focused on education, healthcare/rehabilitation, and human and community services, the Philip L Van Every Foundation offers US $10,000 - US $50,000 for established programs with strong leadership and results.

Nonprofit and community organizations expanding substance use disorder prevention, treatment, services, or supports in North Carolina can apply for up to US $500,000 annually to address access gaps. North Carolina Department of Health and Human Services supports addiction and substance use disorders programs statewide through at least 12 contracts aimed at building an equitable system of care.

North Carolina research institutions and healthcare or community partners working on addiction and substance use disorders can access funding through the National Institutes of Health to test SBIRT/P approaches for adults facing health disparities. Projects must prospectively evaluate screening, brief intervention, and referral to treatment or prevention for alcohol, tobacco, and other drug use.

Addiction and substance use researchers working with adult populations that experience health disparities can apply for National Institutes of Health funding to test SBIRT/P approaches. Grants from NIH help North Carolina and other U.S. teams evaluate screening, brief intervention, and referral to treatment or prevention in collaboration with healthcare and community partners.

Nonprofit and local government organizations working on addiction and substance use disorders, alcoholism, or drug use disorder can apply for funding, including those in North Carolina if they are Native American organizations. Focused on education, health, public safety, treatment, housing, and related services, the Confederated Tribes of Siletz Indians supports charitable programs across the U.S.

This NOFO invites applications for innovative research aimed at developing and implementing interventions to prevent and treat substance use disorders (SUDs) and overdose. It encourages studies that can rapidly advance candidate solutions towards regulatory approval or clinical use, while also addressing co-morbid SUDs. The initiative supports a wide range of research including basic, clinical, translational, and implementation strategies to tackle drug misuse and related health issues, such as HIV/AIDS.

Just One More Grant aims to transform lives by providing financial support to individuals and nonprofit organizations in the U.S. who are overcoming challenges like mental health issues, drug misuse, and educational barriers. The foundation encourages applications from those committed to personal growth and community support. Though current grants are paused for nonprofits, interested individuals with actionable plans are invited to apply. More information and past winners can be found on their website.

The HEAL initiative aims to translate addiction research into practice to combat the opioid crisis and overdose events. It focuses on identifying barriers to reducing substance use and developing scalable, evidence-based interventions. Emphasizing recovery, prevention, and the integration of mental health, the initiative encourages collaboration among experts in various fields. Although applications are not currently solicited, potential applicants are urged to prepare for future opportunities to apply innovative solutions to enhance addiction treatment and prevention efforts.

The Opioid Crisis Response Program Fellowship, offered by Equal Justice Works, addresses the opioid epidemic by mobilizing public interest lawyers to provide vital civil legal aid to underserved communities affected by Opioid Use Disorder. This two-year fellowship enables attorney fellows to advocate for clients' rights, reduce barriers to treatment, and enhance community education about legal impacts. Through collaboration with various stakeholders, the program aims to improve health outcomes and foster systemic change in the fight against this public health crisis.

The National Cooperative Drug/Device Discovery/Development Groups (NCDDG) program invites applications to foster innovative research in treating mental disorders and substance use issues. This initiative promotes collaboration between academia and industry, supporting diverse, multidisciplinary projects aimed at developing rational therapies and neurostimulation techniques. Applicants are encouraged to submit Letters of Intent 30 days before the proposal deadline to enhance project alignment with funding goals.

The NCDDG program supports innovative research aiming to discover and develop new treatments for mental disorders, including substance use and alcohol use disorders. This initiative encourages collaborations between academic and industry partners to advance neurostimulation techniques and drug/device development. Applicants are invited to submit proposals that focus on specific projects utilizing the U01 mechanism, with a clear emphasis on rationally designed candidate agents and cutting-edge technologies. Letters of Intent are encouraged 30 days prior to the submission deadline.

The Substance Use/Substance Use Disorder Dissertation Research Award supports doctoral candidates in completing their dissertation research on substance use disorders. This initiative encourages diverse applicants and aligns with NIDA funding priorities. Key deadlines include February 16 and June 16 of 2025 and 2026 for standard applications, with specific dates for renewal and AIDS-related projects. This funding aims to enhance the research workforce in the field.

The Chemical Countermeasures Research Program (CCRP) Initiative aims to support vital research on the harmful effects of acute exposure to Ultra-Potent Synthetic (UPS) opioids, including fentanyl and its combinations. This funding opportunity encourages studies that enhance understanding and mitigation strategies for these substances, focusing on both immediate and long-term health impacts. Applications are due by 5:00 PM local time, with optional Letters of Intent accepted 30 days prior to the proposal deadline.

The NIDA Research Education Program (R25) aims to enhance the training of a workforce skilled in biomedical, behavioral, and clinical research, particularly regarding substance use disorders. This program supports educational activities that prepare clinicians and clinical researchers. Applications are due by 5:00 PM local time, with optional Letters of Intent encouraged 30 days prior to the full proposal deadline. This initiative does not fund non-research-related clinical training.

The Tobacco, Alcohol, and Cannabis Policy Research for Health Equity grant aims to support research on policies affecting tobacco, alcohol, and cannabis use in the U.S. This initiative focuses on how these policies impact populations facing health disparities. Key components include engaging community organizations to advance equity in cancer prevention. Important deadlines for applications range from February 2025 to October 2027, providing opportunities for both standard and renewal submissions.

Research institutions studying addiction and substance use policy can apply for NIH R21 funding of up to US $275,000 in the U.S., including North Carolina. Grants from the National Institutes of Health help organizations examine how tobacco, alcohol, and cannabis policies affect use, exposure, and health disparities to advance cancer prevention and health equity.

Research institutions studying addiction and substance use disorders in the U.S. and territories, including work relevant to North Carolina, can seek pilot or exploratory funding for time-sensitive substance use epidemiology and health services research. US Dept. of Health & Human Services: National Institutes of Health supports projects responding to sudden drug issues, policy shifts, and emerging clinical or justice system opportunities, awarding up to US $275,000.

North Carolina research institutions and clinical trial teams focused on addiction and substance use disorders can access funding through the Food and Drug Administration to study analgesics, anesthetics, and addiction. Awards of US $2,000,000 support clinical trials, outcome measures, neurodevelopmental assessments, and evidence-based plans to improve prescribing for pain, anesthesia, and substance use disorders.

Research institutions and teams conducting HIV and substance use studies, including addiction and drug use disorders, can apply for up to US $1,500,000 in funding, including projects based in North Carolina. Focused on high-priority HIV research, the National Institutes of Health invites detailed proposals from basic, clinical, and implementation scientists working with people who use drugs.

The Rural Communities Opioid Response Program focuses on enhancing behavioral health care services for children and adolescents in rural areas. By providing essential funding, this initiative aims to tackle mental health and substance use disorders, ensuring that young individuals receive the support they need. The program, administered by the Health Resources and Services Administration, is crucial in addressing the unique challenges faced by rural communities, promoting healthier outcomes for future generations.

The Rural Communities Opioid Response Program - Overdose Response aims to enhance healthcare access in rural areas by addressing urgent needs related to substance use disorder services. This initiative focuses on reducing overdose risks through targeted interventions and support, ensuring that rural communities receive necessary assistance. Funded by the Health Resources and Services Administration, this program is crucial for mitigating the opioid crisis in underserved regions, improving health outcomes, and promoting overall community well-being.

The BJA FY 2026 Second Chance Act Family-Based Substance Use Disorder Treatment Program aims to provide essential treatment and recovery support services for parents with substance use disorders (SUD) who have minor children or are pregnant. Eligible applicants include state, local, tribal governments, and nonprofit organizations, which can apply for funding to implement family-based programs in various settings. This initiative seeks to reduce recidivism and enhance reentry outcomes for both parents and their children.

The BJA FY 2026 Comprehensive Opioid, Stimulant, and Substance Use Site-Based Program aims to combat the rising crisis of substance use and overdose deaths. This funding opportunity supports state, local, territorial, and tribal governments in implementing comprehensive responses, including law enforcement initiatives, prevention programs, and recovery services. Applications are due by October 1, 2026, providing a crucial chance to enhance community safety and health through targeted interventions.

The BJA FY 2026 Public Safety and Mental Health Initiative aims to enhance public safety by addressing untreated mental illness and substance use. This program supports coordinated intervention efforts across various agencies, improving access to treatment and reducing recidivism. By fostering comprehensive service networks, it seeks to restore order in communities affected by homelessness and mental health challenges, ultimately enhancing community well-being and trust in public spaces.

The Applied Drug Policy Research Experiences project aims to provide graduate students and recent post-graduates with hands-on research opportunities to support the National Drug Control Strategy. Through rigorous studies and data analyses, this initiative will explore the evolving dynamics of illicit drug supply and usage, assisting public health and safety officials in anticipating drug-related issues and crafting effective responses to safeguard the American public.