Best Large Grants for Nonprofit Organizations in Indiana

The NCDDG program supports innovative research aiming to discover and develop new treatments for mental disorders, including substance use and alcohol use disorders. This initiative encourages collaborations between academic and industry partners to advance neurostimulation techniques and drug/device development. Applicants are invited to submit proposals that focus on specific projects utilizing the U01 mechanism, with a clear emphasis on rationally designed candidate agents and cutting-edge technologies. Letters of Intent are encouraged 30 days prior to the submission deadline.

The National Cooperative Drug/Device Discovery/Development Groups (NCDDG) program invites applications to foster innovative research in treating mental disorders and substance use issues. This initiative promotes collaboration between academia and industry, supporting diverse, multidisciplinary projects aimed at developing rational therapies and neurostimulation techniques. Applicants are encouraged to submit Letters of Intent 30 days before the proposal deadline to enhance project alignment with funding goals.

The IAC Arts Project Support Grant offers funding for Indiana 501(c)3 nonprofits and public entities to carry out specific arts projects or activities. Applicants can propose diverse projects like art events, performances, exhibitions, or workshops that foster public engagement, especially in underserved communities. This initiative, supported by the Indiana Arts Commission, aims to enhance access to quality arts experiences and support local artists, enriching Indiana's cultural landscape without a match requirement.

Indiana Office of Community and Rural Affairs

The Indiana Office of Community and Rural Affairs works with Indiana communities to build relevant and economically thriving places where people want to live, work and grow.

Mission: The Indiana Office of Community and Rural Affairs works with local, state and national partners to provide resources and technical assistance to aid communities in shaping and achieving their vision for community and economic development.

CDBG Planning Grant - Economic Recovery Plan

The Planning Grant Program leverages Community Development Block Grant (CDBG) funding from the U.S. Department of Housing and Urban Development to encourage communities to plan for long-term, holistic improvement. The Office of Community and Rural Affairs (OCRA) seeks applications from local units of government for programs funded through the State CDBG program. Eligible local units of government are counties, cities, or incorporated towns not located within an entitlement community. Unincorporated areas must apply through the county in which they are located. Eligible planning activities consist of all costs associated with data gathering, study, analysis, and preparation of plans and the identification of actions to implement such plans.

Economic Recovery Plan identifies strategies to recover and bolster the local economy in the aftermath of the COVID-19 pandemic. 

The Dr. Ralph and Marian Falk Medical Research Trust – Falk Catalyst Awards support high-risk, high-reward biomedical research with up to $350,000 in funding over one to two years. These awards aim to address critical scientific challenges and enable the translation of innovative research into clinical practices. Projects focus on identifying biological markers, therapeutic targets, and developing interventions to disrupt disease processes, ultimately improving treatment outcomes for patients.

Industrial Grant Development Fund (IGDF)

The Industrial Grant Fund (IDGF) provides assistance to municipalities and other eligible entities as defined under I.C. 5-28-25 with off-site infrastructure improvements needed to serve the proposed project site. Upon review and approval of the Local Recipient’s application, project specific Milestones are established for completing the improvements. IDGF will reimburse a portion of the actual total cost of the infrastructure improvements. The assistance will be paid as each Milestone is achieved, with final payment upon completion of the last Milestone of the infrastructure project. 

The Norfolk Southern Corporate Giving: Safety First Grant Program aims to enhance community safety across its 22-state network. With grants ranging from $1,000 to $15,000, it supports organizations that provide safety services or promote safe behavior. This program reflects Norfolk Southern's commitment to diversity, equity, and inclusion, empowering employees to engage locally. By investing in safety and workforce development, Norfolk Southern fosters thriving communities, demonstrating its dedication to social responsibility and community well-being.

The Pipeline Grants Competition by the Russell Sage Foundation aims to bolster early-career scholars and enhance diversity in the social sciences. It supports innovative research focusing on economic mobility and systemic inequalities in the U.S. Eligible applicants can receive up to $35,000 individually or $50,000 in teams. The foundation emphasizes methodological diversity and interdisciplinary collaboration, encouraging novel data usage. Projects should align with RSF's mission to improve social conditions, prioritizing underrepresented scholars from under-resourced institutions.

The PreservINg Main Street Grant, initiated by the Indiana Office of Community and Rural Affairs, aims to enhance local economies through the preservation of historic properties in Indiana. This program supports eligible communities with funding up to $2 million for downtown revitalization projects, alongside opportunities for capacity building in partnership with Indiana Humanities and Indiana Landmarks. It offers a sustainable approach to historic preservation while fostering community engagement and economic development.

The Will Rogers Motion Picture Pioneers Assistance Fund offers crucial financial support and counseling for individuals in the theatrical exhibition and distribution sectors facing health-related challenges. This fund assists with medical expenses, housing emergencies, and essential services like vocational rehabilitation and equipment aid. Eligible applicants must have a minimum of three years in exhibition or five years in distribution. The fund aims to provide a safety net for those impacted by illness, injury, or significant life changes.

Clinical & Translational Science (CTS) Pilot Grant Program

The objective of the new Indiana CTSI Clinical & Translational Science (CTS) pilot grant mechanism is to initiate or continue translational science projects that help identify translational methods and processes relevant across a range of diseases, treatments, and interventions. The key objective of the projects should be to develop methodological innovations and/or produce crosscutting solutions for common and persistent challenges to reduce, remove, or bypass significant bottlenecks across the continuum of translation.

Applications to this program are limited to a total of $40,000 and are 12 months (1 year) in duration. There will be no ability to apply for a no cost extension with this new grant.

The HDR Foundation Grant Cycle supports community organizations aligned with HDR's values, focusing on education, healthy communities, and environmental stewardship. This employee-funded initiative emphasizes the importance of employee engagement in grant proposals, requiring a clear scope of work and completion within a year. Eligible applicants include U.S.-based nonprofits, educational institutions, and tribal governments, while grants are not provided for faith-based organizations or individual support.

Community Foundation of Randolph County

Our mission is to bring people and resources together to strengthen the quality of life, both now and in the future, for the residents of Randolph County.

The Community Foundation’s work falls into three major categories: grant-making, donor service, and community convening. Our most visible activities are the grants and scholarships we award each year. Most of these awards come from income earned from permanently endowed funds. Scholarships and other grants come from funds that donors have established for specific purposes.

Diana Fahl Sciences Scholarship

In the early 1990’s Diana Fahl began working at Indiana University East, she saw there was a financial need for single mothers. Diana came up with the idea to create a fundraiser cookbook, with faculty, staff and students submitting recipes. Diana served as the editor, and it was a hit; they reached the level for two endowed scholarships. Ten years later Diana saw that the student body had changed to a more traditional student body with a large percentage of freshman students not advancing to sophomore level. Diana proposed a new scholarship as a two-fold scholarship, the high school graduate would receive the first component of the scholarship their freshman year of college, then, as the student proceeds to their sophomore year they would get an increased additional payment from the scholarship. Diana served as editor of this cookbook and two more endowed scholarships were created.

After decades of working with the community and creating needed scholarships, Diana is overwhelmed with pride to have a science scholarship in her name.

This scholarship may be awarded to students who are a Randolph County resident, graduate from a Randolph County school, and plans to pursue a degree in the Sciences (not including nursing) at Indiana University East.

Community Foundation of Randolph County

Our mission is to bring people and resources together to strengthen the quality of life, both now and in the future, for the residents of Randolph County.

The Community Foundation’s work falls into three major categories: grant-making, donor service, and community convening. Our most visible activities are the grants and scholarships we award each year. Most of these awards come from income earned from permanently endowed funds. Scholarships and other grants come from funds that donors have established for specific purposes.

David E. Hyre Memorial Scholarship Fund

The David E. Hyre Memorial Scholarship was created by Mr. Hyre’s daughters in his memory. David Hyre, born in 1943, graduated Winchester High School in 1961. He also attended Purdue University (Mechanical Engineering Bachelors), University of Michigan (Mechanical Engineering Masters), and Michigan State University (M.B.A.). He was a part of the Chrysler Institute of Engineering (CIE Program). He worked as an engineer and a manager during his 35 years at Chrysler until he retired in 2001. David was very active with Habitat for Humanity and ushered at the Maddie Kelly Center for the Arts in Niceville, FL. He was also an election poll volunteer and Special Deputy for Okaloosa County, FL. His favorite hobby was collecting watches; he was a member of the National Association of Watch and Clock Collectors and participated in shows across the country.

This is a four-year scholarship for a student graduating from a Randolph County high school attending Purdue University studying engineering.

The PLTW Engineering Program Expansion in Indiana aims to enhance educational opportunities through the Step Up Indiana STEM Grant. Schools can utilize a total award of $15,000 to implement new PLTW programs or expand existing ones for the 2026-2027 academic year. Eligible uses include additional courses, class periods, and teacher training, while ensuring that funds are allocated effectively to support STEM education initiatives.

The David M. Dolan Scholarship, offered by the International Association for Great Lakes Research, supports master's and Ph.D. students engaged in applied environmental statistics and modeling related to the Great Lakes. The scholarship provides a $3,000 award, complimentary conference registration, and IAGLR membership. Recipients must present their research at the annual IAGLR conference. Eligibility is limited to those whose research aligns with Dr. Dolan's work, and previous awardees are not eligible.

The Preschool Development Grant Birth Through Five (PDG B-5) SMART Grant aims to enhance early care and education systems in the U.S. by supporting targeted investments in technology and data analytics. This initiative, led by the Administration for Children and Families, encourages states to improve program quality, family choice, and data-driven decision-making for children from birth to five years old. The funding is designed to create measurable outcomes and strengthen coordination within the mixed-delivery system.

Ripley County Community Foundation

The Ripley County Community Foundation was established in 1997 with $19,000 by a group of local citizens who had the vision to leave a lasting legacy for future generations. 

Mission: We serve Ripley County by growing and sustaining a culture of giving and investing resources to meet community needs.

Lilly Endowment Community Scholarship

The Lilly Endowment Community Scholarship Program will provide one scholarship for otherwise reimbursed full tuition, required fees, and a special allocation of up to $900.00 per year for required books and equipment for four years of undergraduate study on a full-time basis. The undergraduate study will lead to a baccalaureate degree at any Indiana public or private nonprofit college or university accredited by the Higher Learning Commission of the North Central Association of Colleges and Schools.

Phase II: Timed Essay

Phase II of the selection process consists of a timed essay portion, which will be administered directly at your high school.

The DGLF Youth Literacy Grants, established by the Dollar General Literacy Foundation, aim to enhance literacy among underperforming students in K-12. Organizations such as schools and libraries can apply for funding to implement or expand literacy programs, purchase necessary materials, and acquire technology. With over $159 million awarded to date, the foundation supports efforts that provide equitable education opportunities, ensuring every child has the chance to learn and succeed, regardless of their background.

About the Foundation

The Putnam County Community Foundation (PCCF) partners with those who give to enrich life and strengthen community for this and future generations. We envision a Putnam County that thrives on generosity, connection, and quality of life. Guided by our core values of integrity, leadership, community, and stewardship, we connect generous hearts with local needs to create lasting, meaningful change.

Scholarships

The Putnam County Community Foundation (PCCF) administers more than 40 scholarship funds, each established by a generous donor with a unique purpose. Many of these scholarships are named in honor or in memory of a loved one.

Alpha Gamma Delta Eta Alumnae Scholarship

To be eligible for the Alpha Gamma Delta Eta Alumnae Scholarship award a candidate must be a sophomore or junior who will be enrolled as a junior or senior for the upcoming academic year at an accredited Indiana college or university.

Criteria

The following four criteria are used to evaluate candidates for the Alpha Gamma Delta Eta Alumnae Scholarship:

• Intellectual and social commitment
• Scholastic ability
• Extracurricular achievements;
• Ability to articulate a career plan that shows motivation, initiative and commitment.

What Is Kiwanis?

Kiwanis is a global service organization of volunteers committed to improving the lives of children—one community at a time. Our members take action every day by:

• Sheltering the homeless and supporting families in crisis
• Feeding the hungry and organizing food drives
• Mentoring at-risk youth and empowering young leaders
• Raising funds for pediatric medical research and care
• And much more—all focused on helping children in our communities thrive

All Indiana Kiwanians make up the membership of the Kiwanis Indiana Foundation, Inc. (aka the Indiana District Foundation) The Foundation has 501(c)(3) status.

J.L. McCulloch Award

A personal gift of $1,000 to the Kiwanis Indiana Foundation, Inc., by an individual entitles him or her to the J.L. McCulloch Award. The recipient of this award is recognized with a framed medallion, a ribboned medallion, and either a lapel pin or a pendant.

This is the Indiana District’s most prestigious award and is named for our first Kiwanis Indiana District Governor. The receiving of this award by its honored recipients has left a legacy to the service. This continues the good works begun by the man for whom it is named.

About the Indiana Department of Veterans Affairs

The Indiana Department of Veterans Affairs (IDVA) is a state agency dedicated to serving. Its mission is to Support, Serve, and Advocate for the Indiana Veterans Community. IDVA aims to make Indiana the choice for veterans to Live, Work, and Thrive. 

Community Challenge Strategic Plan Affiliated Grants

The Indiana Department of Veterans Affairs is seeking applications for the Grants for Veterans’ Services – Community Challenge Strategic Plan Affiliated Grants program. This solicitation is open to non-profit organizations registered with the Indiana Secretary of State. Eligible organizations will apply for grant funds that directly support an Indiana Community Challenge (ICC) coalition partner who has completed the ICC Community Planning Grant Program.

The grant amounts will be between $1,000 and $15,000, depending on each applicant’s need for funds, the availability of funding, and the volume of eligible applicants. 

All applications, procedures, and documentation should follow the Indiana Code, Indiana Administrative Code, and Indiana Department of Veterans Affairs’ policies.

The Dunkin' Joyful Spaces Grant supports children's hospitals and community health centers in creating joyful environments for pediatric patients. Launched in 2022, this initiative helps fund play areas, healing gardens, and other kid-friendly spaces, enhancing the hospital experience. Grants typically range from $25,000 to $65,000 annually, with a maximum of $150,000 over three years. This opportunity encourages creativity in designing spaces that provide comfort and joy to children and their families during hospital stays.

The Doctoral Fellowship Program, initiated by NASA's National Space Grant College and Fellowship Program, aims to enhance STEM education and research opportunities across the U.S. The Indiana Space Grant Consortium (INSGC) offers fellowships ranging from $6,000 to $20,000 for eligible doctoral students engaged in STEM projects. This initiative supports the INSGC's mission to inspire and educate the next generation of scientists and engineers, ensuring a bright future for technological innovation and workforce development.

About the Indiana Department of Veterans Affairs

The Indiana Department of Veterans Affairs (IDVA) is a state agency dedicated to serving. Its mission is to Support, Serve, and Advocate for the Indiana Veterans Community. IDVA aims to make Indiana the choice for veterans to Live, Work, and Thrive. 

Veteran Service Organizations Grant

The Indiana Department of Veterans Affairs (IDVA) is seeking applications from eligible Veteran Service Organizations (VSO).

The grant amounts will vary depending on each applicant’s need for funds, past performance assisting veterans in securing available benefits, and the volume of eligible VSO applicants.

All applications, procedures, and documentation should follow Indiana Code, Indiana Administrative Code, and Indiana Department of Veterans Affairs’ policies.

The Masters’ Fellowship Program, offered by the Indiana Space Grant Consortium, provides financial support ranging from $6,000 to $8,000 for graduate students engaged in STEM research or education. This initiative aims to enhance opportunities for students at INSGC affiliate institutions, fostering diversity and inclusion within STEM fields. Eligible applicants must be U.S. citizens enrolled full-time and in good academic standing. The program encourages reapplication for continued support in subsequent years.

About MCCF

Mission & Priorities

Our goal at Madison County Community Foundation is to invest in lasting positive change to elevate and strengthen Madison County. We envision Madison County as a community where every person has the opportunity to thrive. 

Lilly Endowment Community Scholarship Program

The Lilly Endowment Community Scholarship for Madison County is administered by the Madison County Community Foundation.

Madison County's Lilly Endowment Community Scholarship is awarded to two students, who will be provided eight semesters of full tuition, required fees, and a special allocation of $900 per year for required books and required equipment for four years of undergraduate study on a full time basis, leading to a baccalaureate degree at any Indiana public or private college or university accredited by the Higher Learning Commission of the North Central Association of Colleges and Schools.

In our selection process, applications will be reviewed by a committee of community members. Reviews are completed anonymously without disclosure of student or parent identity. Each Lilly finalist who is not selected as a recipient will be awarded a $1,000 scholarship from the Madison County Community Foundation.

The primary purposes of the Lilly Endowment Community Scholarship Program are:

to help raise the level of educational attainment in Indiana;

to increase awareness of the beneficial roles Indiana community foundations can play in their communities; and

to encourage and support the efforts of current and past Lilly Endowment Community Scholars to engage with each other and with Indiana business, governmental, educational, nonprofit and civic leaders to improve the quality of life in Indiana generally and in local communities throughout the state.