Best Large Grants for Nonprofit Organizations in Indiana

The MPPEP Phase 3 program aims to enhance processing capabilities for invasive, wild-caught catfish, benefiting both processors and fishers. By increasing processing capacity and volume, the initiative seeks to create fair wages and stable job opportunities, fostering economic growth in rural areas. This grant will support innovative strategies that ensure sustainable practices and elevate incomes within the community, thus contributing to the overall development of the meat and poultry sector.

The Alpha Gamma Delta Foundation provides grants aimed at combating hunger in the U.S. and Canada, focusing on direct food assistance, food rescue, and nutrition education. Eligible organizations can receive up to $10,000 in funding, with an average grant size of $5,000. Since its inception, the Foundation has awarded over $2 million to support local food programs, ensuring communities have access to essential resources and assistance for those in need.

The Therapeutic Giving program by Johnson & Johnson Innovative Medicine focuses on supporting nonprofit organizations that enhance patient access to treatment in cardiovascular and metabolic health. Applications are encouraged for initiatives that promote education, empower patients, and address healthcare disparities. Eligible organizations must be IRS 501(c)(3) certified, with a preference for programs demonstrating measurable outcomes. The funding period for local organizations extends from January to October 15th, while national organizations can apply in September.

The Therapeutic Giving program by Johnson & Johnson Innovative Medicine focuses on enhancing patient access to treatment in cardiovascular and metabolism areas. Nonprofit organizations classified as 501(c)(3) are eligible to apply for funding. The program emphasizes innovative initiatives that address healthcare disparities and improve patient outcomes through education, advocacy, and support services. Applications are evaluated based on design, capacity, and potential impact, with a preference for programs over event-based funding.

The H. Hovnanian Family Foundation Grant supports the Armenian community in Armenia and the U.S., focusing on Monmouth and Ocean Counties, New Jersey. The Foundation prioritizes education, healthcare, arts, and youth development through grants to registered non-profits. Proposals should demonstrate sustainability and community impact, with favorable consideration given to projects that engage local stakeholders and foster collaboration. Applications are accepted year-round, with a maximum funding limit of $10,000 for operational expenses.

The Garden Club of America Board of Associates Centennial Pollinator Fellowship offers funding for research on pollinator decline, specifically targeting bees, bats, butterflies, and moths. This fellowship, established in 2013, supports graduate students in U.S. institutions with annual funding typically around $4,000. It aims to enhance knowledge in pollinator science while fostering a new generation of scientists dedicated to conservation. Recipients may reapply for additional funding in subsequent years.

The DARRP Restoration Implementation Grants aim to enhance marine and coastal habitat restoration through collaboration between NOAA and non-federal partners. These grants address oil spills and hazardous substance releases by supporting restoration activities authorized under various environmental laws. Eligible applicants will implement projects that promote sustainable fisheries, recover endangered species, and boost local economies. Through careful planning and evaluation, recipients will contribute to effective restoration strategies that align with NOAA's mission and the needs of coastal communities.

The St. Mary's Bank Charitable Foundation 1908 Funds Grants provide financial support to nonprofit organizations in New Hampshire, focusing on community development and services. Established to uphold St. Mary’s Bank's commitment to social responsibility, these grants, ranging from $500 to $5,000, aim to foster financial independence and address issues like homelessness, youth support, and civic engagement. The Foundation prioritizes projects that benefit local communities and promote long-term sustainability.

The J.R. Simplot Company Foundation Grant supports U.S. non-profit organizations focused on art, education, youth, community, and global food and agriculture. Established in 1929, the foundation is committed to enhancing community welfare through creative cultural endeavors, educational initiatives, health services, and youth programs. Applications are reviewed quarterly, ensuring a timely response to organizations dedicated to making a positive impact in their communities.

About the Emporia Community Foundation

Our Mission

To connect caring people with causes that build stronger communities within the Emporia area which includes Chase, Coffey, Greenwood, Lyon, Morris, Osage and Wabaunsee counties.

Sadie Jones Fund

The original focus of the Sadie Jones Fund was to provide for vision and hearing needs for individual children in Lyon and Chase counties. While the purpose has expanded, individual children are still eligible to receive assistance.

The GLS Campus Suicide Prevention program aims to enhance behavioral health services for college students, addressing critical issues such as suicide, depression, and substance use disorders. By fostering a culture of help-seeking and reducing stigma, this initiative ensures that at-risk students receive timely intervention and support. The program represents a vital investment in the mental well-being of students, promoting a healthier campus environment through evidence-based strategies and comprehensive public health approaches.

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

Breast Cancer Screening & Prevention Initiative

The Breast Cancer Screening & Prevention Initiative, supported by the McKesson Foundation and administered by the NAFC, aims to expand access to lifesaving breast cancer screening and prevention services for uninsured and medically underserved. Through this initiative, the NAFC will provide $30,000 grants to members to establish or strengthen breast cancer screening programs in alignment with evidence-based guidelines from the U.S. Preventive Services Task Force and the American Cancer Society. Funding will support activities such as improving patient identification and referral systems, increasing access to mammography services through partnerships or mobile units, strengthening staffing and technology capacity, and providing patient education and case management to ensure follow-through with recommended screenings. By enhancing early detection and preventive care, the initiative seeks to reduce barriers to care and improve health outcomes for women who might otherwise go without critical cancer screening services.

The W. Wesley Eckenfelder Graduate Research Award, administered by the AEESP Foundation, recognizes outstanding graduate students in environmental engineering and science whose research enhances wastewater management knowledge. This prestigious annual award offers a $1,500 honorarium and a plaque for winners, along with a $500 travel stipend for attending the AAEES awards ceremony. Eligible candidates include both Master’s and Ph.D. students who demonstrate exemplary academic performance and innovative research contributions.

The Robert Silman Award, presented biennially by the James Marston Fitch Charitable Foundation, recognizes innovative proposals in the preservation, restoration, or adaptive reuse of the built environment. Open to professionals in various design fields, the award encourages originality and practical applications that advance preservation in the U.S. With a funding limit of $15,000, it seeks projects that demonstrate a clear plan for dissemination and positive community impact, especially for underrepresented groups.

The FY26 Tick-Borne Disease Research Program (TBDRP) Idea Development Award aims to fund innovative research that enhances understanding and treatment of Lyme disease and other tick-borne diseases. The program encourages creative approaches that challenge existing paradigms and fosters impactful discoveries. A special career development option is available for early-career investigators, offering mentorship and a tailored review process to support significant research advancements.

The Easement Restoration and Stewardship program, funded by the USDA NRCS, focuses on restoring and managing Wetland and Floodplain Easements. It includes developing restoration plans, conducting assessments, and implementing stewardship activities to enhance ecological health. Awardees will collaborate with NRCS personnel to ensure effective restoration design and maintenance strategies, fostering sustainable landscapes. This initiative addresses critical habitat conditions and promotes long-term environmental benefits for protected lands.

The LAST MILE program, initiated by the NIAID, aims to enhance the implementation and effectiveness of HIV prevention and treatment strategies through real-world effectiveness trials. By fostering collaborations and focusing on diverse populations, this initiative seeks to translate clinical findings into practical applications. The program supports research across various disciplines, aligning with the NIH's mission to improve HIV/AIDS outcomes and address associated comorbidities. This multifaceted approach promises to bridge the gap between clinical trials and community-based interventions.

The National Oceanic and Atmospheric Administration (NOAA) is inviting proposals for projects that enhance coastal flood protection through public-private partnerships, innovative insurance products, and improved sediment management. This initiative aims to utilize natural infrastructure to bolster flood preparedness and resilience. Funding of up to $2,000,000 is available for selected projects, supporting research teams that collaborate with regional stakeholders. Proposals must be submitted via Grants.gov, ensuring accessibility to critical resources and information.

The Alzheimer's Disease Programs Initiative (ADPI) aims to foster the development of dementia-capable community health worker programs within the National Aging Network. This initiative, supported by the US HHS: Administration for Community Living (ACL), seeks to enhance dementia screening, reduce barriers to care, and improve access to essential services for individuals with dementia and their caregivers. By integrating community health workers into aging services, the program aspires to elevate the quality of life for those affected.

The Paul L. Busch Award, provided by the Water Research Foundation, honors individuals for innovative research in water quality. This prestigious award supports promising researchers with a $100,000 grant to advance their work. The selection process is inclusive, with no restrictions based on race, gender, or nationality, and encourages applications from diverse candidates. Recipients are expected to collaborate with U.S.-based organizations, fostering practical applications of their research in the water environment.

The Zero Suicide Initiative aims to enhance suicide prevention within Indian health systems by implementing the Zero Suicide framework. This program focuses on culturally informed strategies to empower Tribal health systems, fostering leadership, workforce development, and effective suicide risk identification. It emphasizes timely engagement and evidence-based treatment, ensuring continuity of care and quality improvement, ultimately enhancing outcomes for American Indian and Alaska Native individuals at risk for suicide.

McCullough-Hyde Memorial Hospital

Community Grants

The McCullough-Hyde Foundation is excited to announce the launch of the Community Granting Program, as part of the expanded philanthropic mission of the Foundation. It is anticipated that more than $200,000 in funding will be available annually through this grant-making program.

The Community Granting Program is a philanthropic program that makes investments that address significant health needs of local communities. The Foundation will partner with and provide funding to local organizations that are leading the way to build healthier communities.

The McCullough-Hyde Foundation invites proposals from organizations for programs and projects that focus on education, prevention programs, awareness efforts, wellness opportunities and direct care in the following areas:

Programs and projects that prevent, manage, and reduce the burden of chronic conditions including, but not limited to, heart disease, hypertension, stroke, and diabetes. Eligible initiatives may focus on education, early detection, care coordination, wellness promotion, and access to treatment and support services.

Programs and projects that promote and sustain healthy lifestyle choices, including, but not limited to, physical activity, nutrition, tobacco cessation, and preventive care. Eligible initiatives should be community-centered and designed to empower individuals and families to take control of their health through activities, education, engagement, and improved access to wellness opportunities that support active living, particularly among youth and families.

Programs and projects that improve access to and quality of mental health and substance use services, reduce stigma, and promote emotional well-being across all age groups. Eligible initiatives may include, but are not limited to, prevention, early intervention, treatment, recovery support, education, and outreach related to conditions including, but not limited to, anxiety, depression, and addiction.

Programs and projects that address the underlying social and economic conditions influencing health outcomes, including, but not limited to, access to healthcare, food, housing, transportation, education and employment. Eligible initiatives should aim to reduce barriers to health and wellness by improving the environments where people live, work, and play.

The FY26 Tick-Borne Disease Research Program (TBDRP) Therapeutic/Diagnostic Research Award aims to foster innovative therapeutic and diagnostic research for Lyme disease and other tick-borne conditions. This award supports early-stage drug discovery and evaluation studies, as well as novel diagnostic methods that can be seamlessly implemented in clinical environments, ultimately enhancing patient care and quality of life.

The Ella B. Cleveland Trust Grant supports charitable medical research organizations focusing on leukemia, muscular dystrophy, and cerebral palsy. Established in memory of Ella B. Cleveland, the trust prioritizes 501(c)(3) entities and has no geographic limitations, though it often funds organizations in Georgia. Applications are accepted year-round, with an average grant size of $5,000, and total annual giving ranging from $10,000 to $15,000.

The Zero Hunger | Zero Waste Foundation Grant supports nonprofit organizations focused on ending hunger and reducing food waste. Since its inception, the foundation has allocated over $59 million to enhance food security through innovative programs and community engagement. Eligible applicants include 501(c)(3) nonprofits addressing critical needs such as food access, nutrition education, and support for vulnerable populations. This initiative aims to create equitable food systems and ensure that no one goes hungry.

The Pierce's Disease and Glassy-winged Sharpshooter Board offers grants to support research and outreach aimed at safeguarding California vineyards from serious pests and diseases. Prior funding has varied from $4,300 to $383,000, with projects typically lasting one to three years. Emphasis is placed on solutions that effectively address pest issues, encouraging multi-disciplinary teams to enhance the impact of their work on winegrape health.

The Arthur N. Rupe Foundation Grant focuses on promoting positive social change through scholarly studies, education, and public debate. It supports projects related to caregiving, civil debate, and public policy, aiming to enhance the quality of life in America. The foundation prioritizes specific project funding over general operations and does not support individuals or capital campaigns. Grant inquiries are invited through a letter of inquiry process, ensuring alignment with its mission.