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Best Large Grants for Nonprofit Organizations in Indiana

Find the perfect Large Grants for Nonprofit Organizations in Indiana on Instrumentl. 10,000+ Large Grants for Nonprofit Organizations in Indiana in the United States.

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$2.62B

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$5K

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10,000+ grants
$2.62B total
$5K median

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US Dept. of Transportation Grant - Safe Streets and Roads for All (SS4A) Grant Program: Planning and Demonstration

Oregon Department of Forestry (ODF)
State/Local Government
Oregon, United States
US $100,000 - US $5,000,000

Oregon Department of Forestry

Vision: Complex and resilient forest ecosystems that endure and adapt.

Mission: To protect and promote resilient forests that benefit all Oregonians.

US Dept. of Transportation Grant - Safe Streets and Roads for All (SS4A) Grant Program

The purpose of this Notice of Funding Opportunity is to solicit applications for Safe Streets and Roads for All (SS4A) grants.

Funds for the fiscal year (FY) 2026 SS4A grant program are to be awarded on a competitive basis to support planning, infrastructural, behavioral, and operational initiatives to prevent death and serious injury on roads and streets involving all roadway users, including pedestrians; bicyclists; public transportation, personal conveyance, and micromobility users; motorists; and commercial vehicle operators.

The SS4A Grant Program includes: 1) Planning and Demonstration Grants; and 2) Implementation Grants.

Planning and Demonstration Grants

Planning and Demonstration Grant Eligibility Requirements

Eligible activities for a Planning and Demonstration Grant include: develop a new Action Plan, conduct supplemental safety planning to update an existing Action Plan, or carry out safety demonstration activities to inform the development of or update to an Action Plan.

These activities may be bundled in any combination, provided that the requirements in this Notice are met. DOT encourages complementary but distinct activities, including but not limited to safety demonstration activities that will help inform the development of an Action Plan. Any applicant that meets the eligibility requirements may apply for a Planning and Demonstration Grant to develop an Action Plan. 

  • Expected number of awards: 400 to 700

Public Transportation & Mass Transit Systems Automotive Safety Pedestrian & Bike-Friendly Infrastructure

Dementia CAReS Grants for American Indian and Alaska Native Communities

US Dept. of Health & Human Services: Indian Health Service
Federal Government
United States
US $750,000
The Dementia CAReS Grants aim to enhance the lives of American Indian and Alaska Native communities affected by dementia. By providing funding, training, and support, this initiative focuses on developing actionable strategies within Tribal and Urban Indian settings. Key activities include establishing a network of dementia champions and promoting local best practices. The goal is to empower communities to improve dementia care and outcomes through collaborative efforts and innovative approaches.
Indigenous Health Systems Native American Services Indigenous Services +1 more

AWWA Scholarship Program - Veolia Water Technologies & Solutions Vernon D. Lucy III Scholarship

American Water Works Association (AWWA)
Association/Society
North America
US $5,000
The AWWA Scholarship Program, specifically the Veolia Water Technologies & Solutions Vernon D. Lucy III Scholarship, offers a $5000 award to undergraduate students pursuing careers in the water sector. Established by the American Water Works Association, this scholarship honors the mentorship of Vernon D. Lucy III and aims to support the next generation of water industry professionals. Eligible candidates must demonstrate interest in water-related fields, underscoring AWWA's commitment to fostering future leaders.
Water Resource Management Academic Scholarship Programs

AWWA Scholarships Program - Mueller Water Products Continuing Education Scholarship

American Water Works Association (AWWA)
Association/Society
North America
US $5,000
The AWWA Scholarships Program, led by the American Water Works Association, aims to support the future of the water industry by investing in students. The Mueller Water Products Continuing Education Scholarship awards $5,000 to an undergraduate student employed by a water utility, emphasizing the importance of practical experience in education. This scholarship not only aids financial needs but also encourages students to pursue careers in water supply, fostering growth in this vital sector.
Water Resource Management Academic Scholarship Programs

Susie Kubié Symphonic Music Scholarship

Albuquerque Community Foundation
Private
United States
Up to US $4,000
The Susie Kubié Symphonic Music Scholarship, established in 2017, provides financial support to talented young musicians from the Albuquerque Youth Symphony Program (AYSP). Each year, up to $4,000 is awarded to new or renewing scholars pursuing a music degree. Applicants are required to submit a personal essay, letters of reference, and a video performance. This scholarship not only aids students in their educational pursuits but also honors Susie Kubié's legacy of dedication to music education.
Education - Higher Education Vocational & Trade Education Career / College Preparation +3 more

AHRQ Understanding and Improving Diagnostic Safety in Ambulatory Care: Incidence and Contributing Factors (R01) (349962)

US Department of Health and Human Services: Agency for Healthcare Research and Quality (AHRQ)
Federal Government
American Samoa, Guam +4 more
Up to US $2,000,000
The AHRQ is inviting proposals for research focused on improving diagnostic safety in ambulatory care settings. This funding opportunity aims to understand the incidence and contributing factors of diagnostic errors that occur across various ambulatory care services. Proposals should address the complexities of diagnostic safety to enhance patient care and outcomes.
Patient Care & Services Home Health Care Health Care Access & Delivery +1 more

See, Test & Treat Grant - Multiyear Funding

College Of American Pathologists Foundation
Private
United States
Up to US $50,000
The See, Test & Treat Grant offers vital funding for cancer screening and health education programs targeting medically underserved communities. This pathologist-led initiative aims to reduce healthcare barriers, empower preventive care, and connect patients with local resources. Eligible organizations can apply for up to $50,000 over three years, fostering sustainable health improvements. The program emphasizes same-day results for screenings and culturally appropriate education, ensuring equitable access to essential healthcare services.
Reproductive Health Breast Cancer Reproductive Education +1 more

Cohort Studies of HIV/AIDS and Substance Use (U01 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute on Drug Abuse (NIDA) invites applications for longitudinal cohort studies focusing on HIV and substance use. This initiative aims to foster multidisciplinary research addressing HIV-associated co-morbidities and substance use disorders. The program encourages collaboration with a NIDA-funded Coordinating Center to enhance research agendas that align with NIH-HIV priorities, ensuring impactful policy and practice outcomes in the field of HIV/AIDS and substance use.
HIV / AIDS Addiction & Substance Use Disorders

Walking Classroom Grant Program

Alliance For A Healthier Generation
Private
United States
Unspecified amount in in-kind support
The Walking Classroom Grant Program, offered by the Alliance for a Healthier Generation, enables classroom teachers in public schools to receive donated materials for their students. This innovative program promotes physical activity while maintaining instructional time through engaging podcasts. Ideal for grades 3-8, it enhances cognitive function and retention. Schools with the greatest need, both socioeconomically and academically, are prioritized, ensuring that all students can benefit from this unique educational approach.
Academic Success & Enrichment Education - Middle School Education - Elementary School +2 more

COPIC Medical Foundation Grants

Copic Medical Foundation
Private
United States
Unspecified amount
The COPIC Medical Foundation Grants aim to improve healthcare outcomes by funding programs that enhance patient safety and reduce medical errors. With over $10 million awarded since its inception in 1991, the foundation focuses on scalable solutions to address healthcare fragmentation. This final grant cycle emphasizes innovative approaches that can be replicated across the healthcare community. Organizations must be 501(c)(3) certified or have a fiduciary partner to qualify for funding.
Medical Education & Professional Training Health Information Technology Patient Safety +1 more

Indigo Oak Fund: Grant for Women & Children's Issues

Vance R and Colleen H Andrus Family Foundation
Private
United States
Unspecified amount
The Indigo Oak Fund, a Colorado-based private foundation, focuses on empowering women and children through various initiatives. By funding organizations that address issues such as domestic abuse, food insecurity, and gender equity, the Fund aims to improve lives and foster lifelong learning. Their mission emphasizes recognizing individual potential and ensuring equal opportunity for all, making a significant impact in communities across Colorado and the Bay Area.
Women & Girl Services Women's Rights & Equality Women's Health +4 more

Mobilize Power Fund Grant

Third Wave Fund
Private
American Samoa, Guam +4 more
Up to US $20,000
The Mobilize Power Fund Grant, offered by the Third Wave Fund, supports youth-led gender justice activism. This rapid response fund targets organizations led by young women of color and LGBTQ+ youth, providing up to $10,000 for urgent needs. It prioritizes groups addressing recent incidents that threaten their work, fostering community power and leadership. Organizations with budgets under $500,000 can apply, aiming for impactful, time-sensitive initiatives that promote social change.
Sexuality & LGBTQIA+ Rights Women's Rights & Equality Reproductive Rights +1 more

Farmer First Regenerative Pilot Program

USDA: Natural Resources Conservation Service of Tennessee
State/Local Government
United States
Unspecified amount

Farmer First Regenerative Pilot Program

Regenerative Agriculture is a conservation management approach that emphasizes natural resources through improved soil health, water management, and natural vitality for the productivity and prosperity of American agriculture and communities.

In December 2025, NRCS launched the NRCS Regenerative Pilot Program, a farmer first, outcomes-based approach to conservation designed to return the agency to its core mission – helping people help the land. NRCS is investing $700 million to specifically support regenerative agriculture, including:

  • $400 million through the Environmental Quality Incentives Program (EQIP); and
  • $300 million through the Conservation Stewardship Program (CSP)

This pilot program addresses whole-farm resource concerns through support for voluntary regenerative agriculture conservation plans. It also puts American farmers first as a part of the solution to Make American Healthy Again (MAHA) by supporting access to American-grown whole foods, critical to addressing the chronic disease crisis nationwide.

For too long, divided and highly specific funding pools have unintentionally encouraged isolated, practice-by-practice conservation, rather than holistic management. By integrating bundled regenerative practices into single applications, closing program loopholes, and recognizing outcomes, NRCS will deliver lasting benefits for farmers, natural resources, and the American consumer.

Emphasizing regenerative agriculture builds upon NRCS’s 90 years of existing conservation work by restoring land health, improving long-term productivity, and ensuring American grown production for the future. 

The contract length will be a minimum of 5 years.

Agriculture Farmland Preservation Agricultural Crops +1 more

Agriculture and Food Research Initiative Competitive Grants Program Education and Workforce Development (361169)

USDA: National Institute of Food and Agriculture (NIFA)
Federal Government
United States
US $10,000 - US $650,000
The Agriculture and Food Research Initiative (AFRI) focuses on enhancing education and workforce development in food and agricultural sciences. It invites applications for various grants aimed at professional development, non-formal education for youth, community college training, and fellowships for both predoctoral and postdoctoral candidates. The program, managed by the USDA's National Institute of Food and Agriculture, emphasizes the cultivation of skills necessary for the future workforce in agriculture, with multiple deadlines for submissions.
Agriculture Workforce Preparation & Job Readiness Food Safety +1 more

Indigenous Scholarships: Arts Fund (AUS to USA and USA to AUS)

American Australian Association
Private
Australia, United States
US $10,000
The Indigenous Scholarships: Arts Fund facilitates artistic development for Aboriginal Australian, Torres Strait Islander, Native American, Alaskan Native, and Native Hawaiian artists. Offering up to $5,000, it supports projects in each other's countries, with applications due in March and September. Since 2002, over $1 million has been awarded to more than 500 artists, fostering cultural exchange and growth in the arts between Australia and the USA.
Writing & Literature Performing Arts Media Arts +5 more

WFA’s Wild Felid Legacy Scholarship

Wild Felid Research & Management Association
Association/Society
Algeria, American Samoa +43 more
US $1,000 - US $2,000
The Wild Felid Legacy Scholarship, established by the Wild Felid Research and Management Association in 2009, supports graduate students researching wild felids in the Western Hemisphere. It awards one to three scholarships ranging from $1200 to $1500, based on financial need and research impact. To date, 38 scholarships totaling over $44,000 have been awarded in memory of dedicated biologists who contributed to wildlife conservation. Recipients are recognized in the WFA's newsletter, the Wild Felid Monitor.
Wildlife Management Wildlife Rehabilitation & Sanctuaries Wildlife Health

Morgan Stanley Alliance for Children’s Mental Health Innovation Awards

Morgan Stanley Foundation Inc.
Corporate
United States
US $100,000
Morgan Stanley Alliance for Children’s Mental Health Innovation Awards aim to fund innovative mental healthcare solutions for children in the U.S. This initiative invites U.S.-based 501(c)(3) charities with revenues under $5 million to submit projects. With up to $550,000 in grants, the program focuses on addressing critical mental health issues among youth, fostering equity in access to care, and supporting nonprofits led by young leaders. Awards include up to $100,000 for general and $50,000 for Next Gen projects.
Depression / Anxiety Children’s Mental Health Social / Emotional Learning & Development

Lynne Goldsborough Yowell Scholarship

Northern Piedmont Community Foundation
Private
United States
Unspecified amount
The Lynne Goldsborough Yowell Scholarship, managed by the Northern Piedmont Community Foundation, supports students from Madison and Culpeper County public high schools. It is awarded to high school graduates or current college students pursuing an Arts Major, defined as visual arts, music, theater, or culinary arts. Emphasizing academic merit and financial need, this scholarship honors the legacy of Lynne Goldsborough Yowell, a dedicated community advocate.
Education - Higher Education Educational Access & Equity Art Education +4 more

Bernice Ash Memorial Award

Namm Foundation
Private
United States
US $5,000
The Bernice Ash Memorial Award honors the legacy of a retail music visionary by providing a $5,000 grant to mid-career professionals employed by NAMM member companies. This award aims to support emerging leaders in the music industry through professional development opportunities and a one-year mentorship with NAMM Young Professionals. Eligible applicants must have at least five years of experience and agree to use the funds for professional training, enhancing their leadership skills and career growth.
Music Music Education Workforce Preparation & Job Readiness +1 more

Bioavailability and Transformation of Dissolved Organic Nitrogen and Phosphorus Across WRRFs RFP

Water Research Foundation
Private
North America
Up to US $275,000

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5429 - Bioavailability and Transformation of Dissolved Organic Nitrogen and Phosphorus Across WRRFs

Project Objectives

  • Survey and characterize dissolved organic nitrogen and phosphorus (DON/DOP) concentrations and speciation across North American wastewater facilities, including but not limited to influent, secondary effluent, tertiary effluent, digester supernatant, thermal hydrolysis process (THP) centrate, autothermal thermophilic digestion (ATAD) sidestreams, and dewatering recycle streams.
  • Understand the dynamics of DON/DOP in effluent, including quantifying the bioavailable fraction of DON/DOP in different relevant process streams, evaluating their transformation into nitrogenous disinfection by-product (N-DBP) precursors, determining bio-uptake rates representative of receiving water conditions, and measuring the timescale for biodegradation in receiving waters.
Water Resource Management Hydrology

Measurement and Evaluation Graduate Student Award

Society Of Health And Physical Educators
Private
United States
Unspecified amount
The Measurement and Evaluation Graduate Student Award, offered by SHAPE America, aims to support graduate students specializing in psychomotor measurement and evaluation. This scholarship assists with professional expenses, ensuring candidates can focus on their studies. Eligible applicants must be current SHAPE America members and pursuing relevant master's or doctoral degrees. The award prioritizes those who have completed their first year of study, promoting excellence in health and physical education across the U.S.
Kinesiology & Sports Medicine Education - K through 12 Dance +3 more

Building Bright Futures: Education

Greater Cincinnati Foundation
Private
Boone County, Kentucky, Butler County, Ohio +6 more
Up to US $50,000
The Greater Cincinnati Foundation's Building Bright Futures: Education initiative aims to empower children and young adults by funding innovative programs that foster academic success. This inaugural grant cycle focuses on evidence-based solutions that enhance mentoring, tutoring, and socio-emotional development. Eligible organizations must demonstrate a commitment to high-quality education in the Greater Cincinnati region. Funding can support new initiatives, program expansions, or operational support, ensuring every child has the opportunity to thrive.
Academic Success & Enrichment After School / Summer Educational Programs Tutoring & Mentoring +2 more

NRF Foundation: Bright Futures Scholarship

NRF Foundation
Private
United States
Up to US $1,200
The NRF Foundation Bright Futures Scholarship provides a unique opportunity for undergraduate students to attend the 2026 NRF Foundation Student Program in New York City at no cost. This need-based scholarship allows students to explore career paths in the retail industry, meet leading recruiters, and gain insights from industry executives. Eligible students can receive free travel and accommodation for this enriching experience, which takes place from January 8-11, 2026.
Education - Higher Education Workforce Preparation & Job Readiness Academic Scholarship Programs +2 more

Veterans & Nature Grant

National Environmental Education Foundation
Private
United States
Up to US $10,000

2026 Veterans and Nature Grant

Supporting the health, well-being, and community connection of America's veterans

The National Environmental Education Foundation (NEEF) is pleased to announce grant funding supported by the American Medical Association (AMA) to expand access to nature-based experiences that support the health, well-being, and community connection of America's veterans. AMA has partnered with NEEF to bring an evidence-based health perspective to this effort, underscoring the growing body of research linking time in nature to improved physical and mental health outcomes.

Background

A Pew Research Center survey found that roughly one in four veterans say the transition back to civilian life was at least somewhat difficult. This is especially true for those who return home with stress or trauma. The National Alliance on Mental Illness estimates 11-20% of veterans are believed to experience post-traumatic stress disorder (PTSD) each year.

Nature offers profound restorative benefits for veterans navigating the challenges of post-service life. Time spent outdoors — whether hiking, fishing, camping, or simply sitting among trees — has been shown by numerous studies to reduce symptoms of PTSD, anxiety, and depression, conditions that affect veterans at disproportionately high rates.

Quieting hypervigilance, allowing space for reflection, fostering camaraderie, and reducing isolation are all mental and physical benefits that be found through outdoor recreation. Using America’s public lands to do so provides a powerful and accessible path forward.

Overview

Through the 2026 Veterans and Nature grant, NEEF aims to expand access to nature-based experiences that support veteran health, well-being, and community connection by

  • Providing opportunities for outdoor activities on public land that improve the physical and mental health of veterans
  • Increasing veterans’ understanding of the physical and mental health benefits of time in nature

The grant will provide up to $10,000 per grantee for projects on federal, state, local, or nonprofit public lands that address physical and mental health in veteran communities.

Examples of project types include outdoor activities, such as hiking, biking, climbing, or fishing; wellness activities, such as forest bathing or meditation; environmental education, such as community science; adaptive programming; and conservation volunteering. Projects are not limited to those listed here.

Mental Health & Psychiatric Diseases Environmental Education Military & Veterans Services +5 more

NASPGHAN Foundation Abbott Advanced Fellowship Training in Pediatric Nutrition

North American Society For Pediatric Gastroenterology, Hepatology & Nutrition
Association/Society
United States
US $70,000
The NASPGHAN Foundation Abbott Advanced Fellowship in Pediatric Nutrition offers up to $75,000 for one year of advanced training in pediatric nutrition for members of NASPGHAN. This fellowship aims to enhance pediatric nutrition expertise by supporting a well-defined clinical experience and focused research project. Eligible applicants must be MDs or DOs and members in good standing, with a preference for those seeking training at different institutions. This initiative addresses the increasing importance of pediatric nutrition in child health.
Eating Disorders Digestive System Health & Diseases Nutrition & Healthy Eating +1 more

Dr. Carol J. Chrisman Nursing Scholarship

Ashland County Community Foundation
Private
United States
Unspecified amount
The Dr. Carol J. Chrisman Nursing Scholarship, offered by the Ashland County Community Foundation, supports registered nurses and nursing students from Ashland County pursuing advanced degrees at Ashland University. This scholarship honors Dr. Chrisman's legacy in nursing and community health, encouraging local nurses to further their education. Eligible applicants include full-time nursing students and those employed in public health within the area, with prior recipients allowed to reapply once.
Education - Higher Education Career / College Preparation Education - High School +3 more

Chronic Lymphocytic Leukemia Fund

Healthwell Foundation
Private
United States
Up to US $8,000
The Chronic Lymphocytic Leukemia Fund, managed by the HealthWell Foundation, aims to alleviate financial burdens for underinsured patients battling chronic lymphocytic leukemia (CLL). This fund provides essential support for prescription copays and premiums, ensuring that patients can access necessary treatments without the stress of financial constraints. Since its inception, the foundation has awarded over $1.2 billion in grants, helping more than 1.1 million patients. The initiative emphasizes the importance of accessible healthcare and aims to improve the quality of life for those affected by this condition.
Cancer / Oncology Leukemia Health Care Access & Delivery +1 more

Large Grants for Nonprofit Organizations in Indiana Highlights

Looking for large grants for nonprofit organizations in Indiana?


Read more about each grant below or start your 14-day free trial to see all large grants for nonprofit organizations in Indiana recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in Indiana

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Large Grants for Nonprofit Organizations in Indiana grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

49 Large Grants for Nonprofit Organizations in Indiana over $25K in average grant size

37 Large Grants for Nonprofit Organizations in Indiana over $50K in average grant size

33 Large Grants for Nonprofit Organizations in Indiana supporting general operating expenses

200+ Large Grants for Nonprofit Organizations in Indiana supporting programs / projects

600+ Grants on Instrumentl focused on Food Access & Hunger

400+ Grants on Instrumentl focused on Disaster Relief / Humanitarian Aid

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in Indiana?

Most grants are due in the second quarter.

Q1
24.6%
Q2
28.1%
Q3
23.6%
Q4
23.7%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in Indiana?

Grants are most commonly $14,375.

$375 $375 Min.
$14,375 $14.4 K Median
$429,344 $429.3 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for Indiana?

Grants are most commonly $158,271.

$158,271

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in Indiana year over year?

In 2024, funders in Indiana awarded a total of 42,920 grants.

2022 40,294

2023 39,261

2024 42,920

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in Indiana given out in Indiana, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in Indiana changing over time?

Funding has increased by 35.58%.

2022 $4,633,293,808

2023 $4,997,384,462
7.86%

2024 $6,775,520,204
35.58%

Indiana Counties That Receive the Most Funding

How does grant funding vary by county?

Marion County, Monroe County, and Tippecanoe County receive the most funding.

County Total Grant Funding in 2024
Marion County $5,951,081,269
Monroe County $587,464,361
Tippecanoe County $370,158,455
St Joseph County $332,109,828
Allen County $235,684,076