Best Large Grants for Nonprofit Organizations in Indiana

The Utility Arborist Research Fund Grant Program, managed by the TREE Fund and UAA, offers $50,000 in funding for 2024 to support vital research in utility tree care. The program prioritizes proposals focusing on employee safety, service reliability, and regulatory compliance. Grants range from $10,000 to $50,000, with the aim of addressing pressing issues in vegetation management. Applications are welcomed from those aligned with these priorities, promoting safety and efficiency in the utility industry.

The Mobilize Power Fund Grant, offered by the Third Wave Fund, supports youth-led gender justice activism. This rapid response fund targets organizations led by young women of color and LGBTQ+ youth, providing up to $10,000 for urgent needs. It prioritizes groups addressing recent incidents that threaten their work, fostering community power and leadership. Organizations with budgets under $500,000 can apply, aiming for impactful, time-sensitive initiatives that promote social change.

The Carl Marshall and Mildred Almen Reeves Foundation, established in 1997, supports local organized charities in Columbus, Indiana. Grants are aimed at nonprofit organizations focused on education, history, and the arts. Eligible applicants must be 501(c)(3) organizations, with an emphasis on projects rather than operational costs. The foundation seeks to enhance community engagement by requiring matching funds from other sources. This commitment honors the philanthropic legacy of Mrs. Mildred Reeves, who deeply valued local community support.

The Steven Scott Quinn Scholarship Fund, established by the Stark Community Foundation, aims to support Stark County, Ohio residents pursuing higher education in fields such as culinary arts, hospitality, nursing, nutrition, physical therapy, and occupational therapy. This initiative reflects the Foundation's long-standing commitment to enhancing the community through philanthropy and addressing diverse educational needs since its inception in 1963.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Eosinophilic esophagitis

Help with healthcare costs for eosinophilic esophagitis

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Eosinophilic Esophagitis (EoE) is a disorder of the esophagus and is increasingly recognized as a major cause of swallowing difficulties in children and adults. It is a chronic disease of the immune system and can be triggered by a food allergy, acid reflux, or an airborne allergy. An allergic trigger causes the immune system to overact which causes many white blood cells, or eosinophils, to collect in the esophagus. This causes the esophagus to become inflamed and not contract properly. The esophagus can also narrow and develop rings or abscesses. This condition can become worse over time.

The COPIC Medical Foundation Grants aim to improve healthcare outcomes by funding programs that enhance patient safety and reduce medical errors. With over $10 million awarded since its inception in 1991, the foundation focuses on scalable solutions to address healthcare fragmentation. This final grant cycle emphasizes innovative approaches that can be replicated across the healthcare community. Organizations must be 501(c)(3) certified or have a fiduciary partner to qualify for funding.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Multiple sclerosis (MS)

Help with healthcare costs for Multiple sclerosis (MS)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Multiple sclerosis (MS) is a potentially disabling disease of the central nervous system in which the insulating covers of the nerve cells in the brain and spinal cord are damaged. MS is a chronic disease that affects the nervous system.

The Diversity Mentorship Grant Program aims to enhance ethnic diversity in dermatology by providing mentorship to underrepresented medical students. Participants receive 160 hours of hands-on experience with a dermatologist, fostering a deeper understanding of the field. A stipend of $1,500 is available for travel and living expenses. Applications are open until November 1 for the upcoming year, encouraging students from diverse backgrounds, including Black, Hispanic, and Native American groups, to apply.

The Donald C. and Laura M. Harrison Family Foundation, established in 2006, aims to enhance educational opportunities for underprivileged students in the Greater Cincinnati area. With a focus on innovative programs and scholarships, the foundation supports initiatives in primary, secondary, and adult education. Grants range from $5,000 to $15,000 annually, promoting sustainability and collaboration with other donors. Eligible applicants must be IRS-designated 501(c)(3) organizations, prioritizing local community impact.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Multiple sclerosis (MS) health equity

Help with healthcare costs for multiple sclerosis (health equity)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

Health Equity Funds offer help to eligible patients living in areas identified as having increased social and financial needs, as well as higher rates of chronic conditions. Eligibility is determined in part by home address zip code. 

About the disease

Multiple sclerosis (MS) is a potentially disabling disease of the central nervous system in which the insulating covers of the nerve cells in the brain and spinal cord are damaged. MS is a chronic disease that affects the nervous system.

The Women’s Fund Grants Program, conducted by the Community Foundation Alliance, Inc., supports nonprofit organizations serving Vanderburgh County. This year's cycle includes two Impact Grants of $50,000 each for programs and projects, alongside four additional grants of $20,000 for finalists. Eligible organizations must demonstrate long-term planning, financial sustainability, and a commitment to gender equity. Applications will be accepted from 501(c)(3) tax-exempt entities and governmental agencies.

The BRCFSC Community Grants, offered by the Blue River Community Foundation, support projects in Art & Culture, Health, Education, and Social Services for Shelby County residents. These grants are funded through various unrestricted family and interest funds, promoting initiatives that address beautification, youth support, and disability services. Eligible organizations must demonstrate sound accounting practices, while projects already in progress or focused on travel or political campaigns are ineligible. This competitive grant cycle encourages community-driven development.

About Samba RecoverySamba Recovery is dedicated to empowering individuals recovering from alcoholism and drug addiction by restoring confidence and fostering resilience. Through a foundation of compassion, support, and holistic care, we guide individuals toward renewed health and wellness, meaningful relationships, and the discovery of their inner strengths—assisting them to achieve their fullest potential.Hope for Addiction ScholarshipSamba Recovery’s Hope for Addiction Scholarship is an annual $1,000 award dedicated to encouraging more young people to join the fight against addiction by pursuing degrees that directly support individuals and families affected by substance use disorders.

We welcome applications from all eligible students, with special encouragement for those who are in recovery themselves or who have been impacted by addiction within their families.Application requirements:

• Proof of college enrollment or acceptance
• Pursuing a degree with the goal of working with individuals and/or families impacted by addiction
• Completed application form
• An original 500 to 1000 word essay on how you are planning to use your degree to help individuals and families struggling with addiction, and why helping those affected by substance use disorder is important to you

The Rural Maternity and Obstetrics Management Strategies Program (Rural MOMS) aims to enhance access to maternity and obstetrics care in rural areas through collaborative networks. Funded by the US HHS: Health Resources & Services Administration (HRSA), this initiative focuses on innovative strategies to improve healthcare delivery for mothers and infants in underserved regions, ensuring that quality care is accessible where it is needed most.

The Wild Felid Legacy Scholarship, established by the Wild Felid Research and Management Association in 2009, supports graduate students researching wild felids in the Western Hemisphere. It awards one to three scholarships ranging from $1200 to $1500, based on financial need and research impact. To date, 38 scholarships totaling over $44,000 have been awarded in memory of dedicated biologists who contributed to wildlife conservation. Recipients are recognized in the WFA's newsletter, the Wild Felid Monitor.

The DOE Computational Science Graduate Fellowship (CSGF) supports U.S. citizens and permanent residents pursuing Ph.D. degrees in computational sciences. Established in 1991, it provides a $45,000 annual stipend, full tuition, and a $1,000 professional development allowance over a maximum of four years. The program encourages interdisciplinary research, offering fellows practical experience in DOE laboratories, enhancing their careers in high-performance computing and scientific research across various fields.

About

What is the Community Foundation of Orange, Sullivan and Rockland?

The Community Foundation of Orange, Sullivan and Rockland is a tax exempt, non-profit, publicly supported, philanthropic institution with the long-term goal of building permanent, named funds for the broad based charitable benefit of the individuals and families in the region. Funds are established through contributions from individuals, families, businesses or 501(c)3 organizations, each one with its own specific purpose. The Foundation’s Board of Directors oversees these funds in perpetuity, to ensure that donor’s intentions are honored, now and forever.

The Community Foundation of Orange and Sullivan received accreditation with the nation’s highest standard for philanthropic excellence in 2014. National Standards for U.S. Community Foundations™ establish legal, ethical, effective practices for community foundations. The rigorous accreditation process provides quality assurance to donors and to their legal and financial advisors.

Boss Women UNITED Grant Program

Boss Women UNITED’s mission is to foster the success and advancement of women in the financial services industry by supporting continuing education and professional development opportunities.

Through this program, grants of up to $500 are available to help offset costs associated with certifications, licensing, trainings, and career development opportunities for women working within the financial services industry, including across all broker-dealers (BDs).

Michael Dean Guilliams Memorial Scholarship Fund

Fund provides scholarship assistance to deserving students who are pursuing further educational studies in a career and technical field.

Amount

$1,500+

The NCMA Education and Research Foundation Grant aims to support the concrete masonry and hardscape industry through research and educational initiatives. With over $2 million invested, the Foundation invites proposals from qualified professionals, emphasizing national and regional benefits. Eligible projects should focus on workforce development, educational opportunities for students, and collaborative efforts with other organizations. Notably, certain entities, such as those involved in political campaigns or proprietary projects, are ineligible for funding.

The Mentored Quantitative Research Development Award (K25) aims to attract researchers in quantitative science and engineering to focus on NIH-relevant health research. This award provides protected time for supervised study and research, allowing professionals from fields like mathematics, statistics, and engineering to integrate their expertise into health-related studies. The K25 is specifically for lead investigators of independent clinical trials or related studies, fostering innovation in clinical research and career development.

The Koerner Family Foundation Scholarship, offered by the Four County Community Foundation, supports high school seniors and recent graduates from Almont, Dryden, and Romeo High Schools. Eligible students must plan to major in business, engineering, IT, medical health fields, natural sciences, or vocational training, with a minimum GPA of 2.50. Award recipients will be honored at a Scholarship Celebration in May and at their respective high school awards events.

The Zendesk Tech for Good Impact Awards support nonprofits by providing them with essential software, grants, and pro bono assistance to enhance their impact on vulnerable populations. The program aims to foster community connections, promote resilience during crises, and create career pathways in technology. Eligible organizations must demonstrate a commitment to utilizing technology in their services, enhancing their ability to support beneficiaries effectively. This initiative empowers nonprofits to leverage technology for greater social good.

The AAO-HNSF Bobby R. Alford Endowed Research Grant offers $30,000 for one year to support innovative research in otolaryngology. This grant aims to facilitate the career development of young investigators and promote research that may lead to significant advancements in understanding diseases of the head and neck. Eligible projects should have direct clinical significance for patients and can include basic, translational, and clinical research.

The Change Ripley County Grant, initiated by the Ripley County Community Foundation, empowers local youth aged 13-23 to engage with their communities. By partnering with local nonprofits, these young leaders can secure grants of up to $10,000 to implement projects that foster positive change. This biannual grant focuses on initiatives that address community needs while promoting leadership and collaboration among youth and organizations in Ripley County.

This funding opportunity invites applications for a Research Coordinating Center (RCC) to lead a consortium aimed at optimizing anti-obesity medication (AOM) strategies for children and adolescents. The RCC will manage collaborative trials, focusing on developmental stages for AOM use, treatment effectiveness, and lifestyle interventions. By harmonizing data collection and analysis, the RCC aims to enhance research efforts and outcomes in combating youth obesity while ensuring safe AOM usage.

The RCCF Women’s Giving Circle Grants support nonprofit organizations serving women and children in Ripley County. Established by the Linda S. Phaneuf Women & Children Fund, these grants aim to address community needs through innovative projects. Grants of up to $2,000 will be available in April 2024, with potential for a second cycle during the Day of Giving. The initiative encourages collaboration and aims for significant community impact.

The Safe Arborist Techniques Fund Grant Program, established by the Tree Research and Education Endowment Fund and the International Society of Arboriculture, aims to enhance worker safety in arboriculture through research and development. Grants focus on biomechanics and tree failure mechanisms, supporting innovative practices that protect both workers and the community. Proposals are evaluated on their potential impact, scientific rigor, and the experience of the investigative team, ensuring they align with the mission of the TREE Fund.