Best Indianapolis Grants for Nonprofits in Indiana

The National Science Foundation's Engineering Directorate (NSF ENG) promotes groundbreaking research in chemical, bioengineering, energy, and transport systems. Key programs include Chemical Process Systems, Engineering Biological and Biomedical Systems, Energy, Water, and Resource Engineering, and Transport Phenomena. NSF ENG seeks innovative, transformative proposals that push the boundaries of foundational research, regardless of immediate commercial applications, and emphasizes diverse funding opportunities based on availability.

The MPS Materials Research Programs, funded by the National Science Foundation, aim to enhance the understanding of materials and their diverse applications. These programs cover areas such as biomaterials, ceramics, condensed matter physics, and electronic materials. With an emphasis on transformative research, NSF MPS encourages proposals that are innovative and foundational, without the necessity for immediate commercial outcomes, fostering long-term advancements in materials science.

The BJA FY 2026 Kevin and Avonte Program aims to reduce the injuries and fatalities of individuals with dementia and developmental disabilities who wander from safe environments. This funding opportunity supports law enforcement and public safety agencies in implementing locative technologies to track missing individuals and develop programs that enhance safety and facilitate rescues, ultimately ensuring the well-being of vulnerable populations.

The ADCMS Competitive Grant Program, administered by the DOT Federal Highway Administration, aims to incentivize eligible State Departments of Transportation and partners to implement innovative technology in construction projects. This initiative promotes collaboration among various entities, including local governments and private industries, with a required cost share of 20% to enhance project viability and effectiveness. The program encourages joint applications to maximize the impact of technological advancements in the construction sector.

The Cold Chain Grants for Emergency Food Assistance, funded by the Agricultural Marketing Service, aim to support eligible organizations in enhancing cold storage capabilities within the food supply chain. This initiative focuses on providing essential nutrition assistance to low-income individuals through subawards to food banks and nonprofit organizations. By investing in cold storage equipment, the program seeks to improve the management and distribution of food resources, ensuring that vulnerable populations receive adequate support.

The BJA FY 2026 Second Chance Act aims to enhance education and employment opportunities for adults and youth transitioning from incarceration. By funding state, local, and tribal governments, as well as community organizations, this initiative seeks to improve academic and vocational training in prisons. The program focuses on developing marketable skills, leveraging technology, and aligning with local job markets to foster job readiness, improve employment outcomes, and reduce recidivism.

The BJA FY 2026 Comprehensive Opioid, Stimulant, and Substance Use Site-Based Program aims to combat the rising crisis of substance use and overdose deaths. This funding opportunity supports state, local, territorial, and tribal governments in implementing comprehensive responses, including law enforcement initiatives, prevention programs, and recovery services. Applications are due by October 1, 2026, providing a crucial chance to enhance community safety and health through targeted interventions.

The BJA FY 2026 Second Chance Act Family-Based Substance Use Disorder Treatment Program aims to provide essential treatment and recovery support services for parents with substance use disorders (SUD) who have minor children or are pregnant. Eligible applicants include state, local, tribal governments, and nonprofit organizations, which can apply for funding to implement family-based programs in various settings. This initiative seeks to reduce recidivism and enhance reentry outcomes for both parents and their children.

The ONR FY27 Young Investigator Program invites cutting-edge research proposals in priority areas that align with the interests of ONR Program Officers. This federal funding opportunity aims to support innovative projects led by early-career researchers, fostering advancements in science and technology relevant to the Navy. Interested applicants can find detailed eligibility criteria and contact information on the ONR website, encouraging collaboration and engagement in impactful research.

The BJA FY 2026 Local Law Enforcement Crime Gun Intelligence Center Integration Initiative aims to support law enforcement agencies in establishing and expanding Crime Gun Intelligence Centers (CGICs). This initiative encourages interagency collaboration for the effective management and analysis of crime gun evidence, enhancing the ability to swiftly identify crime guns and their sources. In partnership with the ATF, this program seeks to reduce firearm-related crime and improve prosecution outcomes.

The Surveillance and Case Control Study of Stillbirth and Birth Defects (SUCCSSBD) aims to enhance the quality of birth defects and stillbirth surveillance in the U.S. By modernizing data collection through electronic case reporting, the initiative seeks to improve data quality and timeliness. The study will focus on identifying risk factors for birth defects and stillbirths, addressing a significant public health issue that affects thousands of pregnancies annually. CDC funding will support three key components in this effort.

The Preventing Violence Affecting Young Lives (PREVAYL 2.0) initiative aims to provide multiyear funding for state and local health departments to implement violence prevention strategies for adolescents and young adults. Key focuses include enhancing data-driven decision-making, building capacity for evidence-based strategies, integrating youth mental health support, fostering multisector collaborations, and prioritizing the prevention of various forms of violence, ensuring comprehensive support for youth development.

PetSmart Charities

We’re proud to celebrate over 30 years of being the leading funder of animal welfare in communities across North America. Since 1994, we’ve granted over $600 million to change-making organizations that help transform the lives of pets and those who love them.

Our Mission: We make the world a better place for pets by investing in community partners that advocate and care for the well-being of pets and all who love them.

Adoption Growth Grants 

Purpose

Adoption Growth grants drive lifesaving outcomes by supporting successful, sustainable in-store adoption programs, events, and results in partnership with PetSmart stores.

Funding Support

Funding may be used for costs associated with building or enhancing your organization’s adoption program in partnership with PetSmart stores, including:

• Staff positions supporting in-store adoption programs and events.
• Marketing and advertising for in-store adoption programs.
• Volunteer or foster support, incentives, and recruitment related to in-store adoption events.
• Event supplies, including containment and enrichment materials.
• Shelter software and technology needs.
• Vehicle repairs or transportation to adoption events.
• Innovative in-store adoption ideas and pilot programs.
• Other costs directly associated with facilitating PetSmart adoptions and in-store events.

There are two Cohorts under this funding: Cohort 1-  Accelerating in-store adoptions; and Cohort 2: Capacity Building.

Cohort 1- Accelerating in-store Adoptions

Applicants must have completed 500 or more adoptions in a PetSmart store in the U.S. within the last 12 months.

Preference will be given to organizations that demonstrate a clear plan to expand an existing in-store adoption program or introduce new in-store adoption models that will increase adoptions.

Four Required Steps

Applicants must complete all four required steps below before submitting a grant application:

• Step 1 - Watch the kick-off video and complete the Adoption Accessibility Questionnaire
• Step 2 - Confirm eligibility and connect with your Adoptions Grant Manager: After completing the questionnaire, you will receive an email confirming your eligibility. Eligible partners will be invited to a call with their Adoptions Grant Manager to discuss the grant opportunity, expectations, and potential fit.
• Step 3 - Engage your PetSmart store partners: Discuss your intent to apply, align on goals, and gain their commitment to support the success of your in-store adoption program.
• Step 4-  Submit your application.

T7 Social Impact GrantsThe T.D. Jakes Foundation (TDJF), in partnership with Wells Fargo, is proud to launch the Social Impact Grant Challenge, a transformative funding opportunity designed to identify, support, and amplify nonprofit organizations creating meaningful change in communities across the United States.

Designed around the T.D. Jakes Foundation's pillars of service (Educational Access & Workforce Readiness, financial inclusion, and community transformation and well-being), the Challenge seeks innovative nonprofit organizations that are addressing critical social issues through impactful, scalable, and sustainable solutions.

Finalists selected through this process will have the opportunity to showcase their organization through a live presentation at the inaugural Thriving Seven (T7) Summit, taking place November 12 –14 in Atlanta, Georgia. In addition to competing for grant funding, finalists will gain national visibility for their work and connect with nonprofit leaders, funders, and changemakers from across the country.Grant Funding: A total of $1,500,000 in grant funding is anticipated to be awarded: 

• One (1) - $500,000 grant
• One (1) - $250,000 grant
• Two (2) - $100,000 grant
• Eleven (11) - $50,000 grant

The OVC FY 2026 Services for Victims of Human Trafficking aims to enhance victim service programs across the United States. This initiative supports victims by providing critical services to address their diverse needs, including mental health support and assistance with legal challenges. By funding comprehensive programs, the Office for Victims of Crime seeks to combat human trafficking effectively and promote recovery for affected individuals, ensuring their rights and well-being are prioritized.

The OVC FY 2026 Preventing Trafficking of Girls program aims to provide crucial prevention and early intervention services for girls at risk of human trafficking. This initiative, backed by the US DOJ's Office of Justice Programs, supports efforts to protect vulnerable populations, including young women up to age 25, from both sex and labor trafficking. Applicants are encouraged to outline their strategies to effectively serve survivors and address diverse needs in their proposals.

The OVC FY 2026 grant aims to improve outcomes for child and youth victims of human trafficking by integrating policies at state and Tribal levels. This funding opportunity focuses on developing strategic plans to address the challenges faced by minor victims, enhance coordination among systems like child welfare and juvenile justice, and ensure effective identification and prosecution of traffickers. By fostering multidisciplinary approaches, the program seeks to provide comprehensive support and services to these vulnerable populations.

The Agriculture Risk Management Education Partnerships Competitive Grants Program (ARME) aims to educate agricultural producers on various risk management activities, including crop insurance, debt reduction, and market assessment. Emphasizing farm viability, the program seeks to provide technical assistance and outreach to farmers and ranchers to improve their risk management strategies, as outlined in the Agriculture Risk Protection Act of 2000. This initiative is funded by the USDA's National Institute of Food and Agriculture (NIFA).

The FY26 Breast Cancer Research Program's Clinical Research Extension Award aims to enhance breast cancer clinical studies by extending data collection and follow-up. This funding mechanism emphasizes the importance of patient participation and addresses challenges from early trial terminations. Notably, applications must include two breast cancer consumer advocates and can feature either a single Principal Investigator or a duo. This initiative seeks to improve outcomes through comprehensive data analysis and patient engagement.

The FY26 Breast Cancer Research Program's Breakthrough Award supports transformative research aimed at significant advancements in breast cancer treatment. This award offers various funding levels, including Population Science Studies, allowing for innovative approaches that can lead to clinical applications. Each application must align with overarching BCRP challenges, ensuring a focus on impactful research. The program acknowledges both individual and collaborative Principal Investigators, emphasizing the importance of timely submissions to avoid administrative issues.

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) is set to renew a Notice of Funding Opportunity (NOFO) focused on advancing translational research in maternal and pediatric pharmacology. This initiative aims to enhance precision medicine by developing innovative tools and therapeutics for pregnant and lactating women, infants, and children. The goal is to improve the safety and efficacy of medications while ensuring effective patient-provider communications. Applications are not currently being solicited.

The Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Centers (MDSRC) program is designed to enhance research on muscular dystrophy through a collaborative, center-based approach. By fostering interdisciplinary projects and providing essential training for emerging scientists, the MDSRCs aim to drive innovation in both basic and clinical research. Engaging patient and advocacy communities is a key component, ensuring research is patient-centered and informed by real-world needs. This initiative is supported by various legislative authorities.

The National Institutes of Health is funding a groundbreaking project to enhance our understanding of Type 1 diabetes (T1D) through multimodal AI. This initiative aims to integrate diverse datasets to explore the interactions of biological processes in T1D development. By leveraging advanced AI models, the research will uncover critical insights, identify biomarkers, and pave the way for personalized medicine approaches, ultimately improving prevention and treatment strategies for this complex disease.

The SCORCH Program: Phase 2 aims to enhance the understanding of single cell biology in the context of HIV and Substance Use Disorder (SUD). Building on previous research, this initiative will explore new single cell approaches to investigate the interactions between SUD and HIV progression at various biological levels. By leveraging advanced techniques, the program seeks to identify candidate mechanisms and potential therapeutic targets, ultimately contributing to innovative solutions for SUDs and HIV-related challenges.

The National Violent Death Reporting System (NVDRS) is a crucial surveillance initiative by the CDC aimed at understanding violent deaths and suicides. This funding opportunity supports state and local entities in modernizing NVDRS, enhancing data collection and reporting processes. Key activities include timely data updates, modernization assessments, and pilot projects for improved data systems. The goal is to create a sustainable national surveillance system that provides reliable data to inform public health actions and enhance violence and suicide prevention efforts.

About USA Track & Field Foundation Inc

The USA Track & Field Foundation was established in 2002. Our Foundation provides a means to attract and guide funds to new and innovative track & field programs, with an emphasis on providing opportunities for youth and elite athletes.

Mission: 

To support the development of emerging elite athletes, while fostering integration within the broader track & field community. To facilitate the physical, educational, social and character development of youth track & field athletes and to help prepare them to mature and succeed in adult life.Team and Club SupportThe USA Track & Field Foundation may be able to provide support to certain Elite Track & Field / Running clubs in the US.

About She+ Foundation The SHE+ Foundation, formerly known as The Patty Brisben Foundation for Women’s Sexual Health, was founded by Patty Brisben in 2005 after she recognized the profound need for a movement to address the too often ignored aspects of women’s sexual health. The SHE+ Foundation is committed to changing the narrative. We are here to advocate, educate, and fund research that advances the understanding and treatment for women’s sexual health, and improves quality of life for all women.Mission: Our mission is to advance women's sexual health and well-being through groundbreaking research, comprehensive education, and unwavering support. We strive to eradicate stigma, empower women with knowledge, and ensure equitable access to quality healthcare for all, regardless of socioeconomic status, race, or geography.About She+ Foundation GrantWe fund a wide range of projects that align with our mission to advance women's sexual health. This includes:

• Research Studies: Clinical and academic research aimed at understanding and improving women's sexual health.
• Educational Programs: Initiatives that provide education and awareness on topics related to women's sexual health.
• Community Outreach: Programs that engage and support local communities, offering resources and support for women's sexual health.
• Innovative Treatments: Development and implementation of new treatments and therapies for women's sexual health issues.