Best Indianapolis Grants for Nonprofits in Indiana

Syndax Pharmaceuticals, Inc.

At Syndax, we are determined to realize a future in which people with cancer live longer and better than ever before. We believe that it takes a community to build a great medicine, and that is why we are working to set the new standard for developing medicines in the field of oncology – one that revolves around collaboration, shared learning, and excellence.

Syndax’s mission is to obtain regulatory approval and commercialize drugs that extend and improve the lives of cancer patients by drawing on the newest scientific research and advances, collaborating with determined problem solvers, and identifying value in overlooked aspects of science.

Educational Funding

At Syndax, we are committed to the goal of supporting objective, balanced and scientifically rigorous education that furthers improvements in science, medicine, and patient care. We accomplish this goal, in part, by providing grants for independent medical education (IME) programs. These can include live, online, and/or enduring programs that educate healthcare providers (HCPs), patients, or caregivers. Programs that are funded via Syndax medical education grants must be primarily dedicated, in both effort and time, to medical, health or scientific topics that are objective, balanced, unbiased, and scientifically rigorous. Medical education grants must never be made with the intent to directly or indirectly reward, influence or encourage the recipient to prescribe, purchase, sell or arrange for any Syndax product.

The Institute of Education Sciences (IES) offers training programs through the National Center for Special Education Research (NCSER) to enhance special education research. For FY 2027, the focus is on Methods Training, particularly on analyzing large datasets related to learners with disabilities. This initiative supports early career researchers and current education researchers in developing rigorous methodologies to address significant educational challenges, aiming to inform policy and practice in special education.

The Institute of Education Sciences (IES) offers research training programs aimed at advancing education research through two key initiatives: the Early Career Development and Mentoring Program and the Methods Training Program. These programs support emerging researchers in developing their skills and enhancing their research capabilities to address vital education issues. The funding is designed for early career investigators and current education researchers, fostering rigorous and relevant research that informs education policy and practice.

The NSF State and Regional AI Infrastructure Hubs program seeks to enhance access to computational resources essential for AI-driven scientific exploration. By forming flexible consortia among government, academia, and industry, these hubs aim to foster innovation and workforce development in AI. The initiative aligns with national R&D priorities, emphasizing the critical role of AI in advancing scientific discovery and expanding infrastructure to support this mission across various disciplines.

The Development of Fiscal Year 2027 Commercial Vehicle Safety Plans aims to enhance national safety goals by reducing incidents involving commercial motor vehicles. This initiative, funded by the US Department of Transportation's FMCSA, provides crucial financial support to states and territories. Through the Motor Carrier Safety Assistance Program, the focus is on minimizing crashes, injuries, and fatalities associated with commercial vehicle operations, ensuring safer roads for all.

The DARPA PINPOINT program seeks innovative proposals focused on the physics and nonlinear control of inertial measurement units (IMUs) for tactical and unmanned missions. The initiative aims to break the performance plateau of MEMS IMUs by exploring novel sensor architectures like electromagnetically levitated proof masses and non-linear resonators. This program emphasizes co-designing sensor packages with advanced adaptive control systems to manage complex dynamics, encouraging revolutionary advances in science and technology.

The National Foundation for the Centers for Disease Control and Prevention offers funding to support administrative expenses that bolster CDC's mission. This initiative enhances partnerships to address health threats both domestically and globally. Projects funded through this grant align with CDC's strategic goals, focusing on measurable outcomes such as program support and participation from various CDC Centers and Offices. Importantly, this grant only supports non-research activities.

The Domestic Violence Prevention grant aims to enhance access to forensic healthcare services for American Indian and Alaska Native victims of domestic violence and related issues. By fostering multidisciplinary partnerships, this initiative promotes trauma-informed care and improves victim support across IHS Areas. The focus is on developing comprehensive, culturally sensitive services that ensure timely interventions and coordinated responses to vulnerable populations, thereby enhancing overall victim well-being and safety.

The Tribal Epidemiology Centers initiative aims to support currently unserved areas through a new cohort of TEC sites. Funded by the US Dept. of Health & Human Services: Indian Health Service, this program seeks to enhance public health capacity within tribal communities, ensuring access to essential health services and resources. The initiative underscores a commitment to addressing health disparities and promoting wellness among Native populations.

The Public Health Nursing initiative aims to enhance the health and wellness of American Indian and Alaska Native men by implementing a culturally sensitive case management model. Through this program, Public Health Nurses will provide preventive health services, facilitate access to care, and encourage healthy lifestyle choices. By promoting early identification and management of health issues, the initiative strives to improve overall community health outcomes through targeted, collaborative interventions.

The National Urban Indian Health Program aims to enhance behavioral health services for Urban Indian communities by fostering awareness, advocacy, and collaboration across the nation. By providing technical assistance and training to Urban Indian Organizations, the program seeks to improve access to culturally relevant behavioral health care for American Indian and Alaska Native populations residing in urban areas, ultimately leading to better health outcomes and community support.

The NIH Common Fund Data Ecosystem aims to enhance the reusability of biomedical data through collaboration between Common Fund programs and external data resources. This funding opportunity encourages projects that connect various biomedical data ecosystems, including the HEAL Data Ecosystem and the BRAIN Initiative. By fostering partnerships, the initiative seeks to improve the accessibility and interoperability of valuable datasets, ultimately advancing research efforts. Note that clinical trials are excluded from this funding opportunity.

The Domestic Violence Prevention (DVP) grant from the IHS aims to enhance the capacity of Tribes and Urban Indian Organizations to combat domestic and sexual violence. This initiative promotes culturally appropriate, trauma-informed services, focusing on victim advocacy and collaboration across sectors. It addresses critical issues like human trafficking and child maltreatment, ensuring long-term sustainability through evidence-based practices and data sharing, ultimately improving community health and safety for AI/AN populations.

The Urban Indian Health 4-in-1 Program is designed to enhance the health and well-being of urban Native Americans through targeted initiatives in immunization, health promotion, disease prevention, mental health support, and addressing alcohol and substance abuse issues. Funded by the US Dept. of Health & Human Services, this program aims to improve access to essential health services and foster healthier communities among urban Indian populations.

The Youth Regional Treatment Center Aftercare Program aims to support American Indian and Alaska Native youth in maintaining safety, sobriety, and success post-discharge from Youth Regional Treatment Centers. This initiative enhances culturally relevant, community-based aftercare by fostering care coordination, building partnerships, and addressing barriers to improve youth outcomes.

The Urban Indian Health Program - Education & Research collaborates with the US Dept. of Health & Human Services to enhance educational and research opportunities for urban Indian populations. This initiative aims to address health disparities and ensure that urban Indians have access to quality health services and information. By partnering with various urban Indian organizations, the program fosters community engagement and empowers individuals through education and research, ultimately improving health outcomes.

The Suicide Prevention, Intervention, and Postvention program aims to reduce suicide rates among American Indian and Alaska Native populations. By enhancing care coordination and culturally relevant behavioral health services, it targets at-risk youth with early intervention strategies. This initiative emphasizes community engagement and collaboration among families, youth, and partners, fostering a comprehensive approach to prevention and support for those affected by suicide.

The Tribal Self-Governance Planning and Negotiation Cooperative Agreements are designed to assist tribes in planning and preparing to manage healthcare services for their members through the Tribal Self Governance Program. The Indian Health Service will provide three awards under this initiative, aiming to empower tribal organizations in their efforts to enhance healthcare delivery and self-determination.

The Law School Admission Council, Inc. (“LSAC”) is committed to promoting access in legal education and the legal profession. The LSAC Pathway Grant (the “Grant”) program makes awards to nonprofit institutions for programming focused on one or more of the following strategic goals:

• Goal 1: Early Access/Outreach - Introducing the law and careers in law to students, particularly students facing access and opportunity barriers to information and education, before high school graduation
• Goal 2: Supporting Admissions - Ensuring all applicants, including applicants facing access and opportunity barriers to information, education, and other supports/resources, have access, opportunity, and support in the law school admission process
• Goal 3: 1L Retention - Reducing attrition rates and increasing persistence for law students after the first year of law school, particularly students facing access and opportunity barriers to information, education, and other supports/resources

The Lawson Charitable Foundation offers Amplify Grants to support nonprofits in New England and beyond, focusing on large-scale initiatives and fundraising efforts. With grants ranging from $1,000 to $2,000, these funds are intended to inspire additional donations and enhance organizational capacity. Eligible applicants must be registered 501(c)(3) nonprofits, aligning with the foundation's mission and demonstrating sustainability beyond the grant period. Priority is given to projects serving New England.

The CAFE Group 

We resource leaders, invest in their genius, and bring people together to reimagine what philanthropy can do.

Founded by Liz and Don Thompson, The CAFE Group is a national nonprofit transforming how change is resourced. 

With a focus on education equity, social capital, and philanthropic transformation, we pair catalytic funding, community-rooted leadership development, and cross-sector collaboration to strengthen the people and institutions shaping a more just future. Everything we do is grounded in relationship, because we believe the way resources move matters just as much as where they land.

The 1954 Project Luminary Award

The 1954 Project Luminary Award celebrates transformational education nonprofit leaders dedicated to serving Black students and communities through powerful investments in their organizations' ability to create lasting change.

The Luminary Experience

Each Luminary organization gets more than funding. Through The 1954 Project, leaders gain a community, a platform, and space to grow with tailored support over the course of the three year journey.​

• $1 Million, Unrestricted: Catalytic funding to expand what’s working.
• Leadership Coaching + Capacity Support: Guidance from peers and experts who are committed to helping you build a lasting, impactful organization.
• National Network: Luminaries join a powerful community of innovators, change-makers, and visionaries driving systemic progress to support students and communities across the U.S.

The 1954 Project’s Impact Areas

We focus on three interconnected areas critical to advancing equity:

• Innovation in Teaching and Learning: Create education models that center Black students through culturally affirming approaches that challenge traditional structures and transform how learning happens, ultimately serving all students. 
• Diversity in Education: Build pathways that increase and sustain Black educators and education leaders who transform where and how students learn.
• Pathways to Economic Mobility: Build pathways to wealth, ownership, and economic power for Black students, families, and communities through innovative educational programming.

Our Selection Criteria

We seek out extraordinary applicants who embody our values and vision across three categories:

Leader: We look for leaders whose influence and vision contribute to the collective well-being and advancement of the Black community. These leaders:

• Are Visionary: They demonstrate a strategic and pragmatic mindset, articulating a transformative vision for significant, positive change.
• Show Demonstrated Commitment: They embody steadfast dedication to your cause, inspiring and influencing others, and galvanizing community involvement.
• Are Adaptive: They assertively tackle challenges, turning setbacks into opportunities for innovation, while maintaining humility and thoughtfulness in problem-solving.

Organization: We look for organizations that drive significant change, anchored by a deep love for people and driven by the genius within communities of color. These organizations: 

• Have a Defined Problem: They clearly identify the issue they are addressing and explain in detail how your organization tackles root causes. 
• Take a Strategic Approach: They have clear, measurable, and achievable organizational goals with a well-defined strategy informed by thorough analysis. 
• Show Demonstrated Impact: They have a tested model that has produced positive results, incorporating continuous learning and iteration. 
• Have a Transformation Plan: They present a clear plan for using the $1M award to advance your organization's mission, vision, and long-term goals. 
• Embrace Collaboration: They use collaborate to build partnerships based on trust, love, and common goals. 

Radical Imagination: We seek leaders who challenge and redesign societal norms to build a just and equitable future. They demonstrate:

• Community-Rooted Leadership: They maintain and cultivate genuine community ties, integrating professional expertise and personal commitment to drive visionary, impactful strategies. 
• Long-Term Commitment: They are in it for the long haul, committing to sustained impact across generations and prioritizing long-lasting solutions over short-term gains. 
• Collectivism: They embody the philosophy of "I am because we are," actively engaging in collaborative networks and fostering community-reflective solutions. 

The 2026 National Urban and Community Forestry Challenge Cost Share Grant Program aims to tackle economic, health, and environmental issues in communities through innovative tree resource utilization. By transforming wood from various sources into valuable products like lumber and biochar, this initiative promotes local economies and enhances community resilience. Projects should align with community forestry plans, adhere to safety standards, and provide job creation opportunities, ultimately fostering sustainable urban forest management and utilization.

The Healthy Tomorrows Partnership for Children Program (HTPCP) aims to enhance access to essential preventive clinical and public health services for children through community-driven initiatives. Funded by the US HHS: Health Resources & Services Administration (HRSA), this program focuses on empowering local communities to implement effective strategies that improve children's health outcomes and promote overall well-being. Projects funded under this initiative will play a vital role in ensuring healthier futures for children.

The Alliance for Innovation on Maternal Health (AIM) program aims to enhance maternal health outcomes by providing technical assistance across all U.S. states and territories. This initiative focuses on implementing best practices to improve safety during childbirth, ultimately saving lives. By supporting jurisdictions and birthing facilities involved in AIM, the program seeks to promote quality improvements in maternal health care, ensuring safer births and better health for mothers and infants.