Best Grants for 501(c)(3) in Iowa

The Therapeutic Giving initiative by Johnson & Johnson focuses on funding programs in neuroscience aimed at enhancing patient access to treatments and promoting health equity. Nonprofit organizations classified as 501(c)(3) can apply for support from March 1 to May 31. The initiative emphasizes innovative, measurable programs in areas like Alzheimer’s disease and mental health, prioritizing those that address healthcare disparities and improve quality of life for affected individuals.

The Mosaic Company Foundation Community Investment Grant aims to create a lasting impact in communities by supporting initiatives in three key areas: Food, Water, and Local Community. With an annual investment of approximately $12 million, the foundation addresses food security, promotes water conservation, and enhances community sustainability. Eligible applicants must be recognized charitable organizations, primarily in North America, committed to improving quality of life through innovative solutions and partnerships.

The Therapeutic Giving program from Johnson & Johnson Innovative Medicine aims to support local and regional organizations focused on improving patient access to treatment and advancing health equity. Eligible applicants include 501(c)(3) nonprofit organizations, with funding preferences for programs that address significant healthcare disparities, mental health initiatives, and innovative solutions with measurable outcomes. The application period for local organizations runs from March 1 to May 31, while national organizations can apply in September.

The U.S. Healthcare Donations program by Amgen aims to support not-for-profit organizations in the healthcare sector. As a leading biotechnology company, Amgen provides funding for initiatives that improve science, technology, education, and public awareness on medical conditions. Organizations eligible for funding must be tax-exempt entities, focusing on genuine philanthropic efforts that align with Amgen's mission to enhance health outcomes and reduce the burden of diseases.

The Entergy Charitable Foundation Grant focuses on supporting initiatives that foster thriving communities through education, poverty solutions, and environmental programs. The foundation prioritizes funding for 501(c)(3) organizations and similar entities. Key areas include education development, innovative poverty solutions, and environmental restoration efforts, such as coastal wetland preservation. Organizations are encouraged to apply at least three months before funding is needed, ensuring timely support for impactful community projects.

The CCCF Impact Grant provides funding between $10,001 and $25,000 for projects that enhance quality of life in Clay County, Iowa. The grant prioritizes economic development, cultural activities, parks, and health services. Eligible applicants include 501(c)(3) non-profits and local government units. This initiative aims to support impactful community projects, fostering collaboration and growth within the county. For more details, contact the Clay County Community Foundation.

The CCCF Simple Grant supports innovative projects under $3,000 that enhance the quality of life in Clay County, Iowa. The Clay County Community Foundation seeks to connect donors with impactful causes, focusing on economic development, health services, and community activities. Eligible applicants include 501(c)(3) non-profits and local government units. Grants prioritize projects that foster community engagement and address local needs, ensuring sustainable benefits for the county's residents.

The Clay County Community Foundation (CCCF) offers Standard Grants ranging from $3,001 to $10,000 for non-profit organizations and local governments in Clay County, Iowa. These grants aim to enhance the quality of life through projects in areas such as economic development, cultural activities, and health services. The foundation prioritizes initiatives that connect donors with impactful causes, ensuring that funds are used effectively to address community needs and support innovative programs.

The Maine Cancer Foundation is seeking proposals for cancer screening initiatives aimed at early detection and prevention. This RFP focuses on screenings for breast, cervical, colorectal, lung, prostate, and skin cancers. Proposals should align with evidence-based practices endorsed by the CDC and U.S. Preventive Services Task Force. Interested applicants are encouraged to consult with MCF prior to submission to discuss project concepts and receive feedback on draft applications.

Iowa Department of Health and Human Services

Iowa HHS provides high quality programs and services that protect and improve the health and resiliency of individuals, families, and communities.

Maternal Health Hub and Spoke

The Iowa Department of Health and Human Services (the Agency) is providing this notice of intent to release a request for proposal (RFP) on or around July 2026, for Maternal Health Hub and Spoke networks. This procurement is for establishing the framework for hub and spoke networks of care for the delivery of maternal health care in Iowa. The Agency anticipates successful applicants will be required to complete some activities related to behavioral health care for the maternal health population.

The Agency anticipates that this work may include forming rural provider strategic partnerships, advancing telehealth, establishing referral networks and agreements (particularly among non-affiliated provider organizations), provider recruitment, equipment purchases and associated minor renovations, and other funds needed to establish or advance the provision of maternal health care at hub and spoke sites. Please see the Agency’s Rural Health Transformation Grant website (Rural Health Transformation (RHT) | Health & Human Services) for additional information about the Healthy Hometowns initiative.

Iowa Department of Natural Resources

The Iowa Department of Natural Resources (DNR) manages fish and wildlife programs, ensures the health of Iowa’s forests and prairies, and provides recreational opportunities in Iowa’s state parks.

Just as importantly, the DNR carries out state and federal laws that protect air, land and water through technical assistance, permitting and compliance programs. The DNR also encourages the enjoyment and stewardship of natural resources among Iowans through outreach and education. Our mission is to conserve and enhance our natural resources in cooperation with individuals and organizations to improve the quality of life in Iowa and ensure a legacy for future generations.

Urban Forestry Development Grant

Through the USDA Forest Service Inflation Reduction Act, the Iowa Department of Natural Resources (DNR) is a pass-through partner for the Urban Forestry Development grants for communities.

The Urban Forestry Development Grant provides reimbursable grants to complete projects such as creating community forestry plans, building urban food forests, hosting educational programming, and workforce development through forestry internships. The grant is a two-year program.

The Urban Forestry Development grants are available to community governmental entities, volunteer organizations, and service organizations involved with local urban and community forest services, to improve management, care, and public engagement with trees growing in parks, natural areas, and along public rights-of-way. Grants will also support projects in Iowa communities through investments in community-identified urban forestry needs, advancing environmental or health benefits.

Iowa Department of Health and Human Services

Iowa HHS provides high quality programs and services that protect and improve the health and resiliency of individuals, families, and communities.

Iowa Fatherhood Initiative

The purpose of this Request for Proposal is to solicit applications that will enable the Iowa Department of Health and Human Services (referred to as Agency) to select the most qualified applicant to provide comprehensive fatherhood services, including family economic advancement, parenting education, access and visitation supports, financial literacy, and employment readiness programming to strengthen families and promote self-sufficiency. 

TC Energy’s Build Strong program supports vital organizations in communities near its operations. By providing grants, scholarships, and in-kind support, the program aims to enhance safety, education, environmental protection, and community well-being. Eligible applicants include non-profits and community groups addressing local needs. Ineligible activities include operational expenses and for-profit endeavors. The program prioritizes projects demonstrating measurable community impact, fostering a collaborative relationship between TC Energy and local stakeholders.

The Thornton S. Glide, Jr. and Katrina D. Glide Foundation provides grants to qualified 501(c)(3) organizations in California that focus on animal protection, land conservancy, agriculture, and civic endeavors. Established in 1995, the foundation prioritizes grants for specific capital acquisitions and does not support operational costs or direct aid to individuals. Emphasizing local impact, California-based organizations are favored over out-of-state counterparts.

The WNAN Natural History Research Grant supports research in biological natural history within western North America. Grants of up to $2,500 are available for five authors to assist with travel, supplies, and other research-related expenses. This initiative particularly encourages applicants from institutions where research is not the primary focus, aiming to foster diverse contributions to natural history.

Iowa Department of Health and Human Services

Iowa HHS provides high quality programs and services that protect and improve the health and resiliency of individuals, families, and communities.

Temporary Assistance for Needy Families (TANF)

Purpose

The purpose of this Request for Proposal (RFP) is to solicit applications that will enable the Iowa Department of Health and Human Services (referred to as Agency) to select the most qualified applicants to provide state-wide and local programming that supports economic mobility for Iowa families. Funds are made available through the Temporary Assistance for Needy Families (TANF) program and must achieve one of the four purposes of TANF:

• Provide assistance to needy families
• End dependence on benefits
• Prevent and reduce out-of-wedlock pregnancies
• Encourage two-parent families

Priority Projects will demonstrate that they can make measurable progress in the following areas:

• Reducing barriers to consistent and stable employment for the TANF-eligible (≤ 200% FPL) population
• Enhancing opportunities for TANF-eligible Iowans who are employed to increase their income
• Reducing dependence on government-provided benefits or assistance
• Improving overall education and work-readiness gains for the TANF-eligible population
• Enhancing community-based and local programming focused on economic mobility for the TANF-eligible population

Iowa Department of Health and Human Services

Iowa HHS provides high quality programs and services that protect and improve the health and resiliency of individuals, families, and communities.

Refugee Youth Mentoring Program

Purpose

The purpose of this RFP  is to select qualified applicants to provide Youth Mentoring (YM) services to Office of Refugee Resettlement (ORR) eligible youth ages 15–24 in Iowa, consistent with ORR guidance. Program goals are to promote positive civic/social engagement and support educational/vocational advancement. Services include matching youth with mentors (one-on-one or group) and providing case management to support educational and career development, within five years of the youth’s date of eligibility.  The Agency anticipates awarding multiple contracts from this procurement. 

The AdvoCare Foundation, established in 1993, aims to promote health and wellness for children through its grant program. Focused on year-round initiatives, the foundation supports local communities where AdvoCare distributors operate. Grants typically last one year with an average funding of $25,000, although multi-year support may be available. The foundation prioritizes programs that foster positive health changes and encourages collaborative efforts with previous grantees.

The Strengthening Families and Communities Grant by Telligen Community Initiative focuses on enhancing the resilience of youth and families through community-based funding. This initiative is transitioning to two-year funding periods, with applications due in March and October for different states. The grant aims to address social determinants of health, providing targeted support based on extensive applicant feedback. The program emphasizes a narrowed applicant pool to ensure more consistent funding for impactful projects.

The Destination Iowa Fund Grant Program, funded with $6.5 million, aims to enhance tourism in Iowa by supporting cities, counties, and non-profits in developing vertical infrastructure for Primary Destinations. Eligible projects can receive grants covering up to 25% of costs, with minimum project thresholds of $5 million for urban and $1.5 million for rural areas. This initiative seeks to boost community quality of life and drive economic development, particularly in rural regions.

The Thriving Community Impact Fund offers grants ranging from $2,500 to $49,999 to support community health initiatives. Gundersen Health emphasizes collaboration and addressing social needs to foster well-being. Eligible organizations include non-profits, schools, and government agencies. The fund prioritizes projects that align with the Community Health Improvement Plan, focusing on health equity, civic engagement, and neighborhood enhancement. This initiative aims to empower communities and improve health outcomes while fostering corporate social responsibility.

The WKKF Grant, offered by the W.K. Kellogg Foundation, is dedicated to fostering a future where every child and family thrives. With a focus on nurturing early education, accessible healthcare, and equitable food systems, this grant supports initiatives that empower communities across the U.S. and parts of Mexico and Haiti. Organizations meeting IRS regulations and being legal entities, particularly 501(c)(3) nonprofits, are encouraged to apply for funding to create lasting impacts in their communities.

The Iowa's Living Roadways Community Visioning Grant Program aims to enhance transportation in small Iowa communities by fostering strategic planning and community engagement. Participants develop conceptual plans to address local transportation needs, focusing on pedestrian and bicycle facilities, safety education, and beautification efforts. With a commitment of $2,000, eligible communities under 10,000 residents can seek funding sources and technical assistance for project implementation, ensuring that their transportation vision aligns with federal guidelines.

The NACD Technical Assistance Grants program, in partnership with NRCS, has been enhancing conservation district support since 2018. By funding staff hires, it aims to improve service for agricultural producers and address conservation workload challenges. The initiative focuses on outreach, education, and civic engagement to empower local communities, promote sustainability, and support historically underserved producers in implementing conservation practices, thereby fostering both individual and community resilience.

The Kosciuszko Foundation offers Tuition Scholarships for American students of Polish descent pursuing graduate studies in the U.S. Scholarships can provide up to $12,000 for full-time studies, including master's and Ph.D. programs. Eligible applicants must be U.S. citizens or legal residents with Polish heritage and maintain a minimum GPA of 3.0. This program aims to foster educational exchanges and cultural understanding between the U.S. and Poland, supporting various fields of study.

The Levin Family Foundation Grant supports nonprofits focused on critical issues in Montgomery County, Ohio, such as the opiate epidemic, human trafficking, anti-bullying, and suicide prevention. Established in 1996, the foundation has invested over $12 million globally, emphasizing projects that align with its mission. Eligible organizations must be IRS 501(c)(3) tax-exempt. Priority is given to initiatives in the Greater Dayton Area, fostering positive community impact.

The Old National Bank Foundation offers grants to nonprofit organizations for community impact initiatives across Indiana, Illinois, Kentucky, Tennessee, Michigan, Minnesota, Iowa, and Wisconsin. Focused on four key areas—Affordable Housing, Workforce Development, Economic Development, and Financial Empowerment—the foundation prioritizes programs that support underrepresented communities. Organizations must have 501(c)(3) status and align with the foundation’s funding priorities to qualify for grants, which can be applied for every two years.