Best Large Grants for Nonprofit Organizations in Kentucky

The COPIC Medical Foundation Grants aim to improve healthcare outcomes by funding programs that enhance patient safety and reduce medical errors. With over $10 million awarded since its inception in 1991, the foundation focuses on scalable solutions to address healthcare fragmentation. This final grant cycle emphasizes innovative approaches that can be replicated across the healthcare community. Organizations must be 501(c)(3) certified or have a fiduciary partner to qualify for funding.

The Dr. Carol J. Chrisman Nursing Scholarship, offered by the Ashland County Community Foundation, supports registered nurses and nursing students from Ashland County pursuing advanced degrees at Ashland University. This scholarship honors Dr. Chrisman's legacy in nursing and community health, encouraging local nurses to further their education. Eligible applicants include full-time nursing students and those employed in public health within the area, with prior recipients allowed to reapply once.

Cumberland Community Foundation ("CCF") manages more than 60 scholarship endowment funds created by local individuals, families, civic organizations, and corporations who want to provide a path to higher education for future generations. 

Each year, Cumberland Community Foundation announces more than $1,000,000 in college scholarships to students from southeastern North Carolina.

Brian Edkins Memorial Scholarship

Graduating senior from Cape Fear High School; South View High School (Cumberland County) or Scotland High School (Scotland County, NC).

The Bernice Ash Memorial Award honors the legacy of a retail music visionary by providing a $5,000 grant to mid-career professionals employed by NAMM member companies. This award aims to support emerging leaders in the music industry through professional development opportunities and a one-year mentorship with NAMM Young Professionals. Eligible applicants must have at least five years of experience and agree to use the funds for professional training, enhancing their leadership skills and career growth.

The TURTLE Program aims to empower Tribal Entities by fostering a skilled workforce in biomedical research. It supports undergraduate and graduate students in health research, ensuring they complete their degrees and transition into impactful careers. With phased awards, the program emphasizes effective training and mentoring, inviting eligible organizations to apply. Applications will undergo NIH's peer-review process, ensuring only the most meritorious proposals are funded, ultimately enhancing Tribal health research capabilities.

Samardzija-Gutesha Family Fund

The Field of Interest Fund reflects the Samardzija-Gutesha family’s values and commitment to giving back. It supports education and hands-on learning in farming, soil health, and water conservation, with a focus on FFA members and associate-level college students.

Scholarships benefit graduating seniors and second-year post-high school students who are originally from DeKalb County high schools with FFA programs.

The Samardzija-Gutesha Family Fund provides scholarships for post-high school students pursuing education in agriculture or conservation, as well as paid internships with local farmers, and conservation professionals. It also supports educational seminars on topics such as sustainable farming and agricultural business, and provides grants to local organizations that align with the donor’s values.

In its first year, the Fund awarded $65,000 in scholarships to eight graduating seniors from DeKalb, Genoa-Kingston, Indian Creek, Somonauk, and Sycamore high schools (pictured above). Each student attending a two-year college received a $5,000 scholarship, while students planning to attend a four-year university received $10,000.

The Southern NM Down Syndrome Families Scholarship Fund Endowment aims to provide financial support for individuals with Down syndrome pursuing post-secondary education or life skills training at accredited institutions. Managed by the Community Foundation of Southern New Mexico, this scholarship embodies the mission of improving quality of life and fostering educational opportunities for diverse communities. It encourages applicants from various backgrounds, including those with disabilities, to achieve their academic and personal goals.

The Pediatric Scientist Development Program (PSDP) supports early-career pediatricians committed to research. It emphasizes flexible research proposals, fostering scientific inquiry in pediatrics, particularly in areas like prematurity and health equity. Funded by March of Dimes and other organizations, the program aids scholars in gaining vital training and mentorship while contributing to advancing pediatric health outcomes. Applicants must have completed pediatric residency in the USA or Canada and demonstrate a strong commitment to medical research.

The Reproductive Scientist Development Program (RSDP) aims to enhance maternal and infant health by supporting early-career researchers in obstetrics and gynecology. This program encourages applicants committed to advancing their careers in academic research. With a focus on health equity and the training of scholars, RSDP seeks to foster impactful research proposals that address critical issues such as prematurity and maternal morbidity. Funded by the March of Dimes and other organizations, it empowers diverse talent in the field.

Hungry for Music

The Hungry for Music story began in 1992, when Founder and Director Jeff Campbell (in photo) organized a street musician concert to benefit the homeless. Within three years, he formed a 501(c)(3) nonprofit organization, dedicated to expanding opportunities in music for children.

Since then, Hungry for Music has placed more than 27,000 instruments into the hands of aspiring musicians. Children whose trajectory has been altered by the uplifting and life-changing gift of music.

We've delivered everything from guitars and trombones to violins and xylophones to kids in 50 states and 35 countries.

We collect and redistribute more than 2,000 instruments annually and, in our 31-year journey, we've become a full-time force for good in the musical community.

Request an Instrument

Hungry for Music collects and distributes instruments including brass, woodwinds, strings, electric keyboards, drums and other percussion, as well as amps and accessories.

Who Hungry for Music Helps

• Music teachers at Title One schools who identify children who cannot participate because of lack of funding.
• Music directors at innovative after-school music programs.
• Social workers who have young clients who would benefit from music therapy.

We only accept requests from public school music teachers, administrators, after-school/summer music program directors, and social workers. 

In our history, we have supported music programs in 40 different countries through stateside sponsors (i.e. business, school, church). We do not accept requests directly from international programs.

Title One School Music Teachers

Our music instrument donation program for Title One public schools is designed to support teachers who have a few students who cannot participate in class because of financial need. We do not outfit entire music programs. 

Hungry for Music

The Hungry for Music story began in 1992, when Founder and Director Jeff Campbell (in photo) organized a street musician concert to benefit the homeless. Within three years, he formed a 501(c)(3) nonprofit organization, dedicated to expanding opportunities in music for children.

Since then, Hungry for Music has placed more than 27,000 instruments into the hands of aspiring musicians. Children whose trajectory has been altered by the uplifting and life-changing gift of music.

We've delivered everything from guitars and trombones to violins and xylophones to kids in 50 states and 35 countries.

We collect and redistribute more than 2,000 instruments annually and, in our 31-year journey, we've become a full-time force for good in the musical community.

Request an Instrument

Hungry for Music collects and distributes instruments including brass, woodwinds, strings, electric keyboards, drums and other percussion, as well as amps and accessories.

Who Hungry for Music Helps

• Music teachers at Title One schools who identify children who cannot participate because of lack of funding.
• Music directors at innovative after-school music programs.
• Social workers who have young clients who would benefit from music therapy.

We only accept requests from public school music teachers, administrators, after-school/summer music program directors, and social workers. 

In our history, we have supported music programs in 40 different countries through stateside sponsors (i.e. business, school, church). We do not accept requests directly from international programs.

Social Workers & School Counselors

Social workers and school counselors can submit a request application for a student if they have access to instruction through a music program. 

Mr. Holland’s Opus Foundation

Who knew that a movie made 30 years ago would become the catalyst for the creation of a namesake non-profit, changing the lives of hundreds of thousands of kids by giving them access to learn and play music in school – keeping music education alive and strong across the country?

Mr. Holland’s Opus Foundation was inspired by the acclaimed motion picture Mr. Holland’s Opus, the story of the profound effect a dedicated music teacher had on generations of students. Michael Kamen, who wrote the score for the film, started the foundation in 1996 as his commitment to the future of music education.

The Foundation donates high-quality musical instruments to deserving, under-funded music programs, and provides an array of support services to school districts. By increasing the school’s inventory of quality, playable instruments, music teachers are given the tools they need to deliver a quality music education to students who want to learn. In collaboration with committed school districts, the Foundation’s investments are strategically placed as part of a K–12 district-wide plan to achieve positive and lasting results. Generations of students will benefit.

Instrument Grants

Mr. Holland’s Opus Foundation donates musical instruments to schools nationwide with a focus on increasing student access to music education programs in low-income communities.

Mr. Holland’s Opus Foundation grants consist of musical instruments and equipment only; no cash grants are provided. Our team handles sourcing, ordering, and delivering the instruments. As part of the application process, we work with the teacher to assess the program’s needs to determine the appropriate instruments and equipment. Note that only student model instruments are provided, and the brand is at the Foundation’s discretion.

The Michigan Professional Insurance Agents Scholarship (MIPIA) is offered by the Four County Community Foundation to seniors and recent graduates in Michigan planning to major in Insurance/Risk Management. This scholarship provides up to four awards and aims to foster education in the insurance field. Award recipients will be honored at the Foundation Scholarship Celebration in May, ensuring recognition of their achievements and contributions to the community.

Oregon Department of Forestry

Vision: Complex and resilient forest ecosystems that endure and adapt.

Mission: To protect and promote resilient forests that benefit all Oregonians.

US Dept. of Transportation Grant - Safe Streets and Roads for All (SS4A) Grant Program

The purpose of this Notice of Funding Opportunity is to solicit applications for Safe Streets and Roads for All (SS4A) grants.

Funds for the fiscal year (FY) 2026 SS4A grant program are to be awarded on a competitive basis to support planning, infrastructural, behavioral, and operational initiatives to prevent death and serious injury on roads and streets involving all roadway users, including pedestrians; bicyclists; public transportation, personal conveyance, and micromobility users; motorists; and commercial vehicle operators.

The SS4A Grant Program includes: 1) Planning and Demonstration Grants; and 2) Implementation Grants.

Implementation Grants

Implementation Grants fund projects and strategies identified in an Action Plan that address roadway safety problems. Implementation Grants may also fund supplemental planning and demonstration activities, as well as project-level planning, design, and development activities for projects and strategies identified in an Action Plan (e.g., project-level 21 National Environmental Policy Act (NEPA) compliance, associated environmental review activities, permits and approvals, construction design, etc.). 

• Expected number of awards: 40 to 70

The Sidney R. Baer, Jr. Foundation offers Social Support Grants aimed at improving the lives of individuals living with schizophrenia and bipolar disorder. These grants focus on reducing stigma through education and advocacy, fostering a compassionate environment. The foundation prioritizes organizations that provide tangible support and resources, ensuring a meaningful impact on mental health. By addressing the challenges faced by those with mental illness, the foundation strives to create a more inclusive society that recognizes and supports their needs.

Oregon Department of Forestry

Vision: Complex and resilient forest ecosystems that endure and adapt.

Mission: To protect and promote resilient forests that benefit all Oregonians.

US Dept. of Transportation Grant - Safe Streets and Roads for All (SS4A) Grant Program

The purpose of this Notice of Funding Opportunity is to solicit applications for Safe Streets and Roads for All (SS4A) grants.

Funds for the fiscal year (FY) 2026 SS4A grant program are to be awarded on a competitive basis to support planning, infrastructural, behavioral, and operational initiatives to prevent death and serious injury on roads and streets involving all roadway users, including pedestrians; bicyclists; public transportation, personal conveyance, and micromobility users; motorists; and commercial vehicle operators.

The SS4A Grant Program includes: 1) Planning and Demonstration Grants; and 2) Implementation Grants.

Planning and Demonstration Grants

Planning and Demonstration Grant Eligibility Requirements

Eligible activities for a Planning and Demonstration Grant include: develop a new Action Plan, conduct supplemental safety planning to update an existing Action Plan, or carry out safety demonstration activities to inform the development of or update to an Action Plan.

These activities may be bundled in any combination, provided that the requirements in this Notice are met. DOT encourages complementary but distinct activities, including but not limited to safety demonstration activities that will help inform the development of an Action Plan. Any applicant that meets the eligibility requirements may apply for a Planning and Demonstration Grant to develop an Action Plan. 

• Expected number of awards: 400 to 700

The CDC is offering funding to enhance collaboration among tuberculosis control programs and various partners in the U.S. This initiative aims to strengthen relationships with national TB control entities, federal agencies, academia, and community organizations. The goal is to promote health and quality of life by preventing, controlling, and eventually eliminating tuberculosis in the United States, building on previous funding opportunities.

The Greater Cincinnati Foundation's Building Bright Futures: Education initiative aims to empower children and young adults by funding innovative programs that foster academic success. This inaugural grant cycle focuses on evidence-based solutions that enhance mentoring, tutoring, and socio-emotional development. Eligible organizations must demonstrate a commitment to high-quality education in the Greater Cincinnati region. Funding can support new initiatives, program expansions, or operational support, ensuring every child has the opportunity to thrive.

The Susie Kubié Symphonic Music Scholarship, established in 2017, provides financial support to talented young musicians from the Albuquerque Youth Symphony Program (AYSP). Each year, up to $4,000 is awarded to new or renewing scholars pursuing a music degree. Applicants are required to submit a personal essay, letters of reference, and a video performance. This scholarship not only aids students in their educational pursuits but also honors Susie Kubié's legacy of dedication to music education.

The NRF Foundation Bright Futures Scholarship provides a unique opportunity for undergraduate students to attend the 2026 NRF Foundation Student Program in New York City at no cost. This need-based scholarship allows students to explore career paths in the retail industry, meet leading recruiters, and gain insights from industry executives. Eligible students can receive free travel and accommodation for this enriching experience, which takes place from January 8-11, 2026.

Farmer First Regenerative Pilot Program

Regenerative Agriculture is a conservation management approach that emphasizes natural resources through improved soil health, water management, and natural vitality for the productivity and prosperity of American agriculture and communities.

In December 2025, NRCS launched the NRCS Regenerative Pilot Program, a farmer first, outcomes-based approach to conservation designed to return the agency to its core mission – helping people help the land. NRCS is investing $700 million to specifically support regenerative agriculture, including:

• $400 million through the Environmental Quality Incentives Program (EQIP); and
• $300 million through the Conservation Stewardship Program (CSP)

This pilot program addresses whole-farm resource concerns through support for voluntary regenerative agriculture conservation plans. It also puts American farmers first as a part of the solution to Make American Healthy Again (MAHA) by supporting access to American-grown whole foods, critical to addressing the chronic disease crisis nationwide.

For too long, divided and highly specific funding pools have unintentionally encouraged isolated, practice-by-practice conservation, rather than holistic management. By integrating bundled regenerative practices into single applications, closing program loopholes, and recognizing outcomes, NRCS will deliver lasting benefits for farmers, natural resources, and the American consumer.

Emphasizing regenerative agriculture builds upon NRCS’s 90 years of existing conservation work by restoring land health, improving long-term productivity, and ensuring American grown production for the future. 

The contract length will be a minimum of 5 years.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5429 - Bioavailability and Transformation of Dissolved Organic Nitrogen and Phosphorus Across WRRFs

Project Objectives

• Survey and characterize dissolved organic nitrogen and phosphorus (DON/DOP) concentrations and speciation across North American wastewater facilities, including but not limited to influent, secondary effluent, tertiary effluent, digester supernatant, thermal hydrolysis process (THP) centrate, autothermal thermophilic digestion (ATAD) sidestreams, and dewatering recycle streams.
• Understand the dynamics of DON/DOP in effluent, including quantifying the bioavailable fraction of DON/DOP in different relevant process streams, evaluating their transformation into nitrogenous disinfection by-product (N-DBP) precursors, determining bio-uptake rates representative of receiving water conditions, and measuring the timescale for biodegradation in receiving waters.

The PERF: Career Development Grants - CNS Elterman Research Grant, established by the Pediatric Epilepsy Research Foundation in partnership with the Child Neurology Society, supports early-stage investigators in pediatric neurology. Eligible candidates can receive $150,000 over two years to conduct clinical or basic science research. This initiative aims to foster the development of researchers focused on pediatric epilepsy and related conditions, enhancing the field through innovative studies and collaboration.

The PERF: Career Development Grants - CNS Shields Research Grant supports early-stage investigators in pediatric neurology research. Offered by the Pediatric Epilepsy Research Foundation and the Child Neurology Society, this grant provides $150,000 over two years. Eligible applicants must be within 10 years of completing their terminal degree and have not received independent funding. The grant emphasizes clinical research, fostering advancements in the treatment of pediatric neurological conditions.

The Wild Felid Legacy Scholarship, established by the Wild Felid Research and Management Association in 2009, supports graduate students researching wild felids in the Western Hemisphere. It awards one to three scholarships ranging from $1200 to $1500, based on financial need and research impact. To date, 38 scholarships totaling over $44,000 have been awarded in memory of dedicated biologists who contributed to wildlife conservation. Recipients are recognized in the WFA's newsletter, the Wild Felid Monitor.

The Laura Turner Dugas Fund for Allen County aims to enhance the community's quality of life by funding programs that address crucial needs such as education, health services, the arts, public recreation, and beautification. This private fund supports 501(c)(3) organizations based in Allen County, prioritizing projects that demonstrate sustainability and measurable outcomes. The fund seeks to build a legacy for future generations, promoting philanthropic giving and community engagement.

The Community Foundation of South Central Kentucky supports philanthropic initiatives aiming to enhance community welfare through grants. Focused on lasting impact, the foundation funds projects in five key areas: education, health and human services, the arts, public recreation, and beautification. Eligible applicants include 501(c)(3) organizations within the BRADD area of Kentucky. The foundation prioritizes projects that address community needs while excluding funding for individuals, capital campaigns, endowments, and general operating expenses.