Best Operating Grants for Nonprofits in Kentucky

The Opioid Crisis Response Program Fellowship, offered by Equal Justice Works, addresses the opioid epidemic by mobilizing public interest lawyers to provide vital civil legal aid to underserved communities affected by Opioid Use Disorder. This two-year fellowship enables attorney fellows to advocate for clients' rights, reduce barriers to treatment, and enhance community education about legal impacts. Through collaboration with various stakeholders, the program aims to improve health outcomes and foster systemic change in the fight against this public health crisis.

The AAAP Foundation: Poultry Scholarship supports students pursuing careers in poultry health and food safety in North America. Offered by the American Association of Avian Pathologists, the scholarship aims to enhance scientific knowledge and promote the well-being of poultry. Eligible candidates must be enrolled in accredited veterinary colleges or universities with relevant programs. Scholarships may reach up to $1,500, with undergraduate awards capped at $500, fostering the next generation of poultry medicine professionals.

Hungry for Music

The Hungry for Music story began in 1992, when Founder and Director Jeff Campbell (in photo) organized a street musician concert to benefit the homeless. Within three years, he formed a 501(c)(3) nonprofit organization, dedicated to expanding opportunities in music for children.

Since then, Hungry for Music has placed more than 27,000 instruments into the hands of aspiring musicians. Children whose trajectory has been altered by the uplifting and life-changing gift of music.

We've delivered everything from guitars and trombones to violins and xylophones to kids in 50 states and 35 countries.

We collect and redistribute more than 2,000 instruments annually and, in our 31-year journey, we've become a full-time force for good in the musical community.

Request an Instrument

Hungry for Music collects and distributes instruments including brass, woodwinds, strings, electric keyboards, drums and other percussion, as well as amps and accessories.

Who Hungry for Music Helps

• Music teachers at Title One schools who identify children who cannot participate because of lack of funding.
• Music directors at innovative after-school music programs.
• Social workers who have young clients who would benefit from music therapy.

We only accept requests from public school music teachers, administrators, after-school/summer music program directors, and social workers. 

In our history, we have supported music programs in 40 different countries through stateside sponsors (i.e. business, school, church). We do not accept requests directly from international programs.

After-School & Summer Programs

Hungry for Music supports more than three dozen after-school/summer music programs annually across the United States. To be added to our distribution, a site visit is required.

The 2026 National Urban and Community Forestry Challenge Cost Share Grant Program aims to tackle economic, health, and environmental issues in communities through innovative tree resource utilization. By transforming wood from various sources into valuable products like lumber and biochar, this initiative promotes local economies and enhances community resilience. Projects should align with community forestry plans, adhere to safety standards, and provide job creation opportunities, ultimately fostering sustainable urban forest management and utilization.

The RMEF Grant Program lies at the core of advancing our mission.

RMEF established the program in 1986 to provide financial and logistical support to projects that align with our priorities and goals. Grant funds raised by RMEF members, volunteers and generous donors from across the country translate into significantly more conservation accomplishment when matched with partner funds. The RMEF Grant Program also aims to build recognition for RMEF’s work, grow engagement, and boost local fundraising efforts.

Governed by clear guidelines and criteria, the RMEF Grant Program seeks to foster meaningful collaborations and long-term impacts in the conservation of natural resources and outdoor traditions. Grant project partners include federal, state, local, and tribal wildlife and land management agencies, private landowners and local stakeholders, sportsmen and women, and conservation organizations, universities, foundations and the outdoor industry. Eligible projects primarily focus on habitat stewardship, land conservation and access, wildlife management, and hunting heritage.

We support organizations recognized by the Internal Revenue Service (IRS) as a 501(c)3 entity, federal, state, local, or tribal government entities, sportsmen’s organizations, or educational institutions. All applicants must have a Federal Employer Identification Number (EIN) issued by the IRS. RMEF does not offer grants to individuals.

Hunting Heritage

Ensuring our hunting heritage is central to RMEF’s mission. Hunters—America’s first conservationists—remain the driving force behind wildlife conservation. RMEF funds hunting heritage and conservation education to help more people experience the outdoors, learn the skills of hunting, and carry forward the traditions that define big game country, including outdoor skills programs/events, hunter or conservation outreach, mentored hunts, and other similar activities.

The Philadelphia Chromosome Negative Myeloproliferative Neoplasms (MPN) Grant, offered by the Patient Advocate Foundation, provides crucial financial assistance to patients facing this cancer type. It covers out-of-pocket healthcare costs, including medication copays and insurance premiums, ensuring those affected can access necessary treatments. With a focus on personalized case management, the foundation has supported millions in navigating their healthcare needs, emphasizing the importance of timely and affordable care for patients diagnosed with MPN.

The Spaulding Foundation

The Spaulding Foundation was established in 1998 by Ruth E. Spaulding, who was born in Northside and remained a lifelong resident of Greater Cincinnati. During her life, many people were touched by her benevolent and charitable giving. This private foundation is funded by her estate.

The Spaulding Foundation focuses its grant-making in the areas of mental health, physical and mental disabilities, substance abuse/chemical addiction, and domestic violence, rape and abuse. In addition, The Foundation has continued Mrs. Spaulding’s close relationship with The Cincinnati Zoo & Botanical Garden.

The Foundation welcomes opportunities to partner with organizations sharing our common goals. 

The Carl & Marilynn Thoma Foundation offers Collections-Related Grants for Nonprofits, aimed at enhancing public interest in art through innovative projects. Grants support exhibitions, academic convenings, research, and catalog publication, focusing on art from the Spanish Americas, digital media, and more. The foundation prioritizes proposals from 501(c)(3) organizations in the U.S., particularly from New Mexico, Oklahoma, and Texas, fostering partnerships that advance art scholarship and cultural engagement.

Harry C. Anthony, Jr. Scholarship

Essay:

• Describe yourself and explain why you are interested in a career in medicine.

Awards:

• One-time award of $2,500

The Mosaic Company Foundation Community Investment Grant aims to create a lasting impact in communities by supporting initiatives in three key areas: Food, Water, and Local Community. With an annual investment of approximately $12 million, the foundation addresses food security, promotes water conservation, and enhances community sustainability. Eligible applicants must be recognized charitable organizations, primarily in North America, committed to improving quality of life through innovative solutions and partnerships.

The Ethel Strickarz Memorial Scholarship aims to address community needs through educational support in special education and related fields. Funded by the Community Foundation of Elmira-Corning and the Finger Lakes, it encourages students pursuing careers in human services, nursing, psychology, speech pathology, or therapy. This scholarship reflects a commitment to holistic community development by fostering future professionals dedicated to improving lives and addressing urgent societal challenges.

Funding Innovative Research

Cannonball Kids’ cancer Foundation (CKc) prioritizes funding clinical trials, research that is nearing translation to a clinical trial, and young investigator grants.

Grants funded by CKc must be innovative and provide better quality of life or symptom relief than current treatments. 

When possible, CKc will prioritize funding research:

• with a focus on cancers that are under-funded or under-researched,
• with a focus on patient populations who are traditionally underserved.

When possible, CKc will prioritize funding researchers of diverse backgrounds.

For CKc, “innovation” means the invention or application of novel methods or treatments, specifically treatments that have fewer side-effects than standard care, increase a child’s quality of life, and/or create an option for care where there otherwise were few or none (either on primary diagnosis, relapse, or for recalcitrant cancers).

Research Grants

Grant Program: Clinical Trial

$200,000 over 3 years

• PI must hold an academic appointment at the Assistant Professor level or higher
• Preclinical studies must be complete
• If an FDA Investigational New Drug (IND) application is necessary for the proposed clinical study, the IND application should already have passed FDA initial review and be active
• If the PI has recruited additional patient enrollment sites, local IRB approval must be obtained for each site.

• How many treatment options would this study provide for children?
• How accessible is this study for children and families to access?

The Smart Growth America Community Connectors Grant Program supports small and mid-sized cities in addressing divisive infrastructure caused by dangerous roads. With funding from the Robert Wood Johnson Foundation, this program aims to reconnect communities through temporary street safety projects while fostering skills and partnerships. Eligible teams must represent populations of 50,000 to 500,000 and include both government and community-based organizations. Priority will be given to projects benefiting low-income communities historically affected by disinvestment.

The David Moses Bridges Scholarship honors the legacy of a renowned Passamaquoddy artist and activist, providing essential support for individuals dedicated to the preservation of Wabanaki culture, traditional arts, and environmental stewardship. This scholarship aims to foster connections between master artists and apprentices, promote research on David's impactful life and work, and protect culturally significant natural spaces. It empowers artists and scholars to continue the vital work of preserving indigenous knowledge and practices for future generations.

The Rare Impact Fund, founded by Selena Gomez, is dedicated to transforming mental health support for young people. With a commitment to mobilizing $100 million, the fund aims to enhance access to mental health services and promote a stigma-free community. Through public Requests for Proposals, the initiative seeks to strengthen the nonclinical youth mental health workforce, ensuring effective support systems that reflect the diverse backgrounds of youth. This innovative approach fosters lasting change in mental health care.

The Core State Injury Prevention Program (Core SIPP) aims to enhance public health infrastructure and partnerships to prevent unintentional injuries through data-driven strategies. Focusing on key areas such as traumatic brain injury, falls among older adults, and drowning, it seeks to improve community safety by strengthening data use and fostering collaborations. This initiative supports states in identifying local injury concerns, thus promoting evidence-based prevention approaches and increasing the capacity for sustained public health actions.

Disabled Veterans National Foundation

The Disabled Veterans National Foundation (DVNF) was established in 2007 to support veterans facing challenges that traditional systems could not fully address. From its earliest days, DVNF has been focused on closing critical gaps in care and providing resources that help veterans rebuild their lives with dignity and stability.

Guided by this commitment, DVNF developed its Health & Comfort programs, offering emergency financial assistance, housing transition support, food assistance, comfort kits, and wellness initiatives. These programs are designed to meet veterans where they are and to provide practical solutions that restore hope and stability. Today, DVNF continues to grow as a trusted national nonprofit. Every day, our team works with a clear purpose: to change lives for the men and women who have served our country.

Homeless To Housing Program - Household Comfort Support

DVNF is dedicated to assisting disabled and at-risk veterans in their transition from homelessness to permanent housing. Recognizing that securing a home is a significant milestone, DVNF understands that true stability is achieved when a house becomes a home, furnished with essential items that provide comfort and functionality. We help cover essential costs related to securing and creating comfortable housing for at-risk veterans.

The H2H Program offers comprehensive support to veterans by providing: Household Comfort Support of up to $2,000 worth of essential household items to ensure veterans have a stable, safe, and comfortable living environment.

For Financial Assistance: Payments are processed through two payment cycles each month, around the 15th and 30th. For Furniture Assistance: Once the List of Items form is completed, DVNF staff will purchase the requested items, which should arrive within 7-10 business days.

The National Girls and Women in Sports (NAGWS) Legacy Award, established by SHAPE America, honors exemplary contributions to increasing opportunities for women in sports. This annual award recognizes current SHAPE America members who submit impactful proposals related to women's sports, with a monetary prize of $1000. The award will be presented at the National Convention & Exposition, with a special deadline of November 1st. Nominations can include various initiatives aimed at empowering women in sports.

This funding opportunity invites Small Business Technology Transfer (STTR) grant applications aimed at developing FDA-regulated medical products for patients with opioid and stimulant use disorders. Projects may focus on pharmacotherapeutics or diagnostic devices, including software. The initiative seeks to address the ongoing opioid crisis by supporting innovations that enhance treatment options for individuals and communities affected by these disorders.

AARP Foundation

AARP Foundation strengthens financial resilience for and with older adults by empowering individuals and improving systems.

AARP empowers people to choose how they live as they age. There are 125 million Americans who are 50 or older, and people want their money, health and happiness to last as long as they do. We are a wise friend and fierce defender, focusing on the priorities of older Americans.

Purpose Prize® from AARP

Honoring extraordinary people 50-plus who put their purpose into action.

Purpose is a powerful force for good. The Purpose Prize from AARP honors extraordinary older Americans who put their purpose into action to support AARP’s mission of empowering people to choose how they live as they age. Winners receive $75,000 and a year of organizational support from AARP to grow the impact of their nonprofits. Examples of organizational support include data and evaluation, governance and succession planning, fundraising strategy, and prospectus development.

The Quadratec Cares 'Energize The Environment' Grant Program is dedicated to supporting individuals and organizations in the U.S. focused on environmental improvement. With two grants of $3,500 awarded annually, the program encourages initiatives like trail restoration and community educational projects. This grant aims to empower passionate individuals to enhance environmental awareness and stewardship, ensuring a healthier planet for future generations.

Department for Local Government

​​​​​​​​​​​​​​​​​​​The Department for Local Government (DLG), under the Office of the Governor, provides financial help in the way of grant and loan assistance, as well as advising local governments in matters of budget, personnel and other issues relevant to those entities.​

Community Development Block Grant (CDBG) Program

The Department for Local Government (DLG) administers approximately $26 million annually from the U.S. Housing and Urban Development’s (HUD) Community Development Block Grant (CDBG) program.

The CDBG program provides assistance to communities for use in revitalizing neighborhoods, expanding affordable housing and economic opportunities, providing infrastructure and/or improving community facilities and services. With the participation of their citizens, communities can devote these funds to a wide range of activities that best serve their own particular development priorities.

All project activities must meet at least one of three national objectives:

• Benefit to low and moderate income persons
• Prevention or elimination of slums or blight
• Meeting particularly urgent community development needs​

Funds are designated for various program areas including Community Projects, Community Emergency Relief Fund, Economic Development, Housing, Public Facilities, and Public Services (Recovery Kentucky).​

Public Services (Recovery Kentucky)

​​​​​CDBG Public Services funds, in the form of operational costs to support the Recovery Kentucky Program, will be made available in 2026 to existing Recovery Kentucky Substance Abuse Centers. These centers serve individuals who have a history of substance abuse, with an emphasis on the homeless, those at risk of becoming homeless and those referred by the judicial system.

The Harris and Frances Block Foundation, established in 2001, supports small grassroots organizations focused on social and environmental justice. They prioritize equitable solutions and sustainable community development, funding initiatives related to environmental education, justice, and food security. Grants are available to non-profit, tax-exempt organizations in specific geographical areas including Vermont, North Carolina, Virginia, and New York City, excluding funding for lobbying, land acquisition, and scholarships.

The Broadcasters Foundation of America Monthly Grant provides essential financial assistance to broadcasters facing acute hardships due to serious illnesses or accidents. This initiative aims to support those who have dedicated significant years to the broadcasting profession, ensuring they receive medical aid and relief from financial burdens. Eligible applicants can apply for monthly grants if they meet specific employment and hardship criteria, helping them navigate difficult times with dignity and support.

The Tribal Colleges Extension Program Special Emphasis (TCEP-SE) aims to enhance community engagement through pilot projects at 1994 Institutions, targeting issues like agricultural productivity, food systems, and public health. This program is open to a wide range of Tribal colleges and universities, promoting workforce development and youth involvement in agriculture. By addressing local needs, TCEP-SE fosters community vitality and prepares the next generation of Tribal agriculture leaders.

The Social Impact Fund - Nationwide Grant supports innovative solutions addressing health care access, food security, and economic empowerment. Funded by the American Heart Association, this grant prioritizes community-led projects from organizations with under $10M in revenue. Eligible entities include both for-profit and nonprofit organizations based in the U.S. and Puerto Rico. Grants can provide up to $250,000 to initiatives that demonstrate measurable impact, fostering sustainable change in health and wellness.

The Legacy Foundation of Kentuckiana Grant supports 501c3 nonprofit organizations in specific counties of Kentucky and Indiana, with a focus on improving health and advancing social justice for vulnerable populations. They offer funding ranging from $25,000 to $500,000, encouraging impactful proposals while engaging in relational philanthropy. Interested organizations must submit a Letter of Interest, with cycles in May and December, to explore potential alignment and funding opportunities.