Best Large Grants for Nonprofit Organizations in Massachusetts

The Leukemia Exploration and Prevention Grant Program (LEAP) aims to advance cancer interception and prevention strategies for patients with RUNX1 familial platelet disorder. This initiative, supported by the American Cancer Society, focuses on understanding the mechanisms behind leukemia development and fostering innovative research leading to effective treatment options. Grants of up to $215,000 per year for four years are available, emphasizing the urgent need for targeted therapies in high-risk populations.

The Leukemia Exploration and Prevention Grant Program (LEAP) aims to advance cancer interception and prevention for patients with RUNX1 familial platelet disorder (RUNX1-FPD). This program supports interdisciplinary research teams investigating the mechanisms of leukemogenesis and innovative treatment strategies. With funding of up to $430,000 per year, LEAP encourages projects focused on both understanding clonal evolution and developing novel therapeutic approaches. The initiative seeks to bridge critical knowledge gaps and provide urgent interventions for high-risk populations.

The Diane and Peter Christodoulou Memorial Scholarship, administered by the Community Foundation of the Ozarks, aims to support students with learning disabilities. Offering two scholarships of $1,250 each, eligibility requires a GPA of 2.5 or higher and proof of disability. High school seniors must submit their IEP, while undergraduates need a verification letter from their Disability Service Coordinator. This initiative promotes academic achievement and community engagement among students facing learning challenges.

The NASPGHAN Foundation/APGNN Susan Moyer Research Grant supports impactful research and quality improvement initiatives aimed at enhancing nursing care for children with gastrointestinal and nutritional disorders. Grants ranging from $500 to $5000 are available for eligible Registered Nurses who are APGNN members. Awardees must present their findings at the NASPGHAN Annual Meeting and adhere to specific funding guidelines, including IRB approval and acknowledgment of support in publications.

The Henry Luce Foundation's Asia: Responsive Grants program supports initiatives that enhance understanding of East and Southeast Asia. With a focus on academic research, cultural exchange, and public education, the program seeks to promote collaboration between American and Asian institutions. Grants are awarded primarily to U.S.-based non-profits, fostering innovative teaching, resource development, and policy engagement, while prioritizing projects that bridge diverse disciplines and geographic divides.

The NIH is seeking innovative computational approaches to enhance the curation of biomedical research assets at scale. This initiative aims to accelerate access to secure datasets and computational models, facilitating transformative discoveries in biomedical science. Key deadlines for applications range from January 2025 to January 2027, covering standard, renewal, and AIDS-related grants. Applicants are encouraged to submit Letters of Intent 30 days prior to application deadlines to ensure a streamlined review process.

The NINDS Faculty Development Award aims to enhance diversity in neuroscience research by supporting junior faculty from underrepresented backgrounds. This award provides essential research cost support, protected research time, and mentorship for individuals holding doctoral degrees within their first three years on a faculty tenure track. It specifically encourages research proposals that do not involve independent clinical trials, while allowing participation in trials led by mentors. Key application deadlines span from October 2024 to June 2027.

Our Opportunities

Thank you for inquiring about scholarship opportunities offered through the Greater Kansas City Community Foundation and Greater Horizons

Please begin by completing your General Application. This is your profile. You will then be prompted to complete a second set of questions that will help to match you to different scholarship opportunities. Please be sure to read through each question and answer to the best of your ability. Upon completion, you will be given a list of applications that you qualify for, but may require additional information. You can apply to as many scholarships as you wish.

You are not considered for a scholarship until you select and apply to each specific opportunity.

Virginia Hannah Brown Scholarship

The purpose of the Fund shall be to provide scholarships to graduating seniors from Tazewell High School located in Tazewell, Virginia, or from Richlands High School in Richlands, Virginia, who are furthering their education at any accredited two or four year college, university and/or technical school. The scholarship is primarily intended to provide financial assistance to students who have potential, but who may not otherwise qualify for other academic or athletic scholarships because of GPA or lack of involvement in extracurricular activities.

Scholarships will be sent directly to the school and will be made co-payable to the school and the student.

Scholarship amount is $3,000 per year, paid as $1,500 each semester upon meeting renewal criteria.

Each scholarship is renewable for up to four (4) years if the student remains enrolled in an accredited college, university or technical school; completes fifteen (15) credit hours each semester; and maintains a 3.0 GPA.

This grant aims to enhance applied regulatory science research for the evaluation and treatment of cardiotoxicity associated with oncology therapeutics. The initiative will facilitate collaboration with the FDA to develop effective methodologies and solutions, ensuring that research outcomes are directly relevant to regulatory decision-making. Key activities include regular communication with funded investigators and a focus on improving detection and management of cardiotoxicity, ultimately leading to impactful publications and presentations.

GWCF: Esler Family Foundation Inspiring Generosity Match Fund

The Esler family, founders of the Esler Family Foundation, have committed $1 million over two years to the Inspiring Generosity Match Fund, which will be hosted at the community foundation as a donor advised fund. 

The Inspiring Generosity Match Fund was developed to provide general operating, program, project, or capital project support to nonprofits doing critical work in Worcester County while also providing an incentive to organizations and donors to double their impact with a dollar-for-dollar match. The Esler family believes that matching grants help organizations reach their goals faster, create opportunities to build new relationships, and create a broader and more sustainable community of support. 

Areas of Support

Mental Health

We support organizations working to increase access to support and reduce stigma, prioritizing organizations that:

Reduce barriers to mental health care

Provide programs and services to improve mental health for underserved communities

Evaluate the effectiveness of program models in reducing depression and anxiety, and driving broader well-being outcomes

Youth Opportunity

We invest in organizations working to build equitable and dynamic futures for young people (up to 24 years old), prioritizing organizations that:

• Support students' academic and personal growth
• Deliver job readiness and life skills programming to prepare and empower young people (up to 24 years old)
• Provide post-secondary opportunities

Economic Mobility

We support organizations focused on helping individuals and families to build livelihoods, improve their quality of life, and contribute to a vibrant economy, prioritizing organizations that:

• Deliver job readiness skills programming including ESOL and career training
• Foster and empower entrepreneurship
• Provide support and resources around financial literacy

Scope & Selection Criteria

• The grant size for this program is $10,000 - $25,000.
• Requests can be for general operating, program, project, or capital project support.
• Grantees will be assessed in the following areas:
  • Alignment with at least one of the above areas of support
  • Organizations with roots in Worcester County and proven impact for residents
  • Plan for leveraging matching requirement to meet new donors and deepen engagement with existing donors

Match Requirement

Grantees will receive 50% of the grant up front. The remaining portion of funds raised will be disbursed at the end of the grant period.

Grantees will have until 12/31/2026 to raise their match. Funds raised in the 2026 calendar year can count towards the match requirement.

The NIH StrokeNet initiative invites applications for clinical trials and biomarker studies aimed at stroke treatment, recovery, and prevention. This funding opportunity encourages collaborative projects that validate promising interventions and scientific aims within the NIH StrokeNet framework. Key deadlines for submissions span from February 2025 to November 2026, with support provided by the National Coordinating Center and Regional Coordinating Centers to ensure efficient study implementation and participant recruitment.

Enterprise Community Partners

Enterprise Community Partners is a national nonprofit that exists to make a good home possible for the millions of families without one. Home is where life happens, where plans are made, and futures begin. It is the foundation for dignity, health, education, wealth, and community. Yet rents keep going up, paychecks don’t keep pace, and good homes in strong neighborhoods are increasingly out of reach.

The system doesn’t work. It must be changed, and it must be changed by us.

Enterprise has the breadth, scale, and expertise to do it. We support community development organizations on the ground. We aggregate and invest billions to improve housing and strengthen communities across the U.S. We advance housing policy at every level of government. We build and manage communities ourselves. Everything we do is informed by the residents we serve.

Together with our partners, we focus on the greatest need — the massive shortage of affordable rental homes — to achieve three goals:

• Increase the supply of affordable homes
• Advance racial equity after decades of systematic racism in housing
• Support residents and strengthen communities to be resilient to the unpredictable, and make upward mobility possible

Since 1982, we have invested $92.0 billion and created 1.1 million homes across all 50 states, the District of Columbia, Puerto Rico, and the U.S. Virgin Islands. We do all this to make home and community places of pride, power, and belonging.

National Housing Innovation Grant Competition

Home is foundational. It’s where we plant roots, raise and care for our families, and build community bonds. Yet in every corner of the country, millions of people of all ages and backgrounds need a home they can afford.

Wells Fargo is meeting this moment with a powerful grant opportunity. Together with Enterprise, Wells Fargo has launched the third iteration of the Housing Affordability Breakthrough Challenge. The 2026 cycle of the housing innovation competition will identify and propel proven, ready-to-scale solutions that transform current practices and increase housing choice and access.

Eligible applicants will compete for five individual grants of $2 million to advance their innovation and drive meaningful, systems-level change in the housing and adjacent industries. Winners will gain access to mentorship and coaching from industry leaders and experts and join a powerful network of Breakthrough Challenge innovators.

Focus Areas

This third cycle of the Housing Affordability Breakthrough Challenge aims to meet the nation’s affordable housing challenges across all types of communities: Native, rural, suburban, tribal, and urban.

Proposals must encompass one or more of three focus areas:

• Design and Construction
• Finance
• Service Delivery and Programs

Applicants will be asked to show how their proof of concept or pilot program has achieved clear outcomes and success, and provide a clear pathway to expanding the innovation’s reach and impact

Round 1: Criteria and Scoring

Your innovation must meet the criteria below to advance to the official scoring stage.

Type of Community

Innovations can serve all types of communities:

• Rural
• Urban
• Suburban
• Tribal

Location

Priority scoring will be given to applications from entities that are based in – or whose innovations are designed for – one or more of these 28 states, plus D.C.:

• Alaska, Arizona, Arkansas, California, Colorado, Florida, Georgia, Idaho, Illinois, Iowa, Maryland, Massachusetts, Minnesota, Montana, Nevada, New Jersey, New Mexico, New York, North Carolina, North Dakota, Pennsylvania, South Carolina, South Dakota, Tennessee, Texas, Utah, Virginia, Washington, Washington D.C.

Affordability

Innovations must serve residents at these income levels:

• Rental: 80% AMI or below
• Homeownership: 120% AMI or below
• Workforce housing: 120% AMI or below

The FY26 Breast Cancer Research Program's Clinical Research Extension Award aims to enhance breast cancer clinical studies by extending data collection and follow-up. This funding mechanism emphasizes the importance of patient participation and addresses challenges from early trial terminations. Notably, applications must include two breast cancer consumer advocates and can feature either a single Principal Investigator or a duo. This initiative seeks to improve outcomes through comprehensive data analysis and patient engagement.

About Us

The Community Foundation of NCW is a tax-exempt philanthropic organization that helps individuals, families, businesses, and agencies support charitable causes throughout Chelan, Douglas, and Okanogan counties.

Don and Ellen Garrison Service to Community and School Scholarship

The Don and Ellen Garrison Scholarship celebrates a family history rooted in the Okanogan Valley, beginning when Don's family homesteaded south of Malott in 1917. Don and Ellen built a life of community leadership and dedication, operating their orchard and serving on various local boards. Their commitment to the region remains strong, as both of their sons became educators in Washington, with one son teaching in Okanogan where his father, Don, graduated in 1933.

This award supports graduating seniors of Okanogan High School planning to attend a trade school or college in the U.S. The scholarship seeks applicants who reflect the family's commitment to activity and service. Required criteria include lettering in athletics, participating in a school club or activity, and having a consistent record of community service.

The Andee Jorgensen Scholarship, managed by the Renton Regional Community Foundation, supports students from King County demonstrating financial need and resilience against personal hardships. With an award of $1,000, this scholarship honors civic leader Andee Jorgensen and is available for high school, undergraduate, and graduate students. Preference is given to those engaged in community service. The foundation aims to foster education and empower local youth to pursue their academic ambitions while overcoming challenges.

The American Heart Association (AHA) is launching the RFP for a Strategically Focused Research Network (SFRN) aimed at enhancing the early detection and delaying the progression of valvular heart disease. This initiative seeks collaborative proposals from researchers to address critical questions and advance understanding in this field. With a maximum budget of $4.4 million and a duration of four years, the AHA plans to award at least three grants based on scientific merit and alignment with its mission.

The St. Baldrick's Foundation offers Infrastructure Awards to support institutions in enhancing their capacity for childhood cancer clinical trials. These grants are aimed at smaller entities lacking necessary resources, enabling them to hire personnel and acquire vital tools to increase participation. Since 2005, the Foundation has invested over $356 million in childhood cancer research, focusing on collaboration and innovation to find cures. Institutions in the U.S. are eligible, promoting broader access to crucial clinical trials.

The Beattie Family Foundation offers educational scholarships aimed primarily at medical and nursing students facing financial challenges. These scholarships, ranging from $2,000 to $5,000, support individuals currently enrolled in accredited institutions who demonstrate strong academic capabilities. Additionally, limited funds are available for vocational or trade school tuition for those aspiring to enter skilled labor professions. The foundation prioritizes applicants based on financial need and academic performance.

The DOW Combat Readiness – Medical Research Program's FY26 Translational Research Award supports innovative research aimed at improving trauma care outcomes. This program emphasizes hypothesis-driven studies that can transition promising technologies into practical solutions for enhancing casualty survivability. Applicants must provide preliminary data and utilize validated animal models, with a focus on projects that meet a minimum technology readiness level of 4, ensuring a mature translational research effort.

The Larry A. Weaver, Jr. Memorial Scholarship, offered by the Community Foundation of the Ozarks, awards $4,000 to a graduating high school senior or HiSet diploma holder who is a member of the Buffalo Baptist Church in Buffalo, MO. Applicants must demonstrate financial need via FAFSA-SAI, submit a transcript, and provide an essay detailing community service and school activities, along with a recommendation letter from a church staff member.

The Climate Smart Communities Initiative (CSCI) Grant supports US-based projects aimed at enhancing community resilience against climate change. With a budget of $1.5-2 million, grants typically range from $75,000 to $115,000. CSCI prioritizes projects that focus on historically disinvested populations facing climate vulnerabilities, emphasizing equity, nature-based solutions, and community capacity building. The initiative encourages collaboration between climate adaptation practitioners and local government entities to address climate impacts effectively.

The SOT Undergraduate Research Award supports outstanding undergraduate students presenting original toxicology research at the SOT Annual Meeting. Awardees receive recognition, complimentary registration, lodging, and travel funding up to $800. This award encourages students to pursue graduate studies in toxicology or related fields and includes mentorship opportunities during the meeting, fostering their academic and professional growth.

Rapid Cancer Grants

Fast Funding for Home Cancer Care Research

We fund healthcare researchers to rapidly explore the feasibility of home infusion as a solution to the ongoing challenges of capacity shortage, site of care management, and financial toxicity in cancer care.

Traditional funding pathways for new care models are too slow to impact patients, so we’ve streamlined the process. By providing funding approvals within 14 days, we enable healthcare teams to quickly launch and evaluate home-based cancer care programs that improve access and affordability.  

What can a Rapid Cancer Grant be used for?

Projects must comprise of research investigating the feasibility, safety, or economic benefit of cancer care at home and must include delivering care to patients via an IRB approved study. IRB approval may be obtained after grant approval. Projects may include assessing suitability of home infusion, enabling access to lab draws at home, or remote care co-ordination to reduce time toxicity for patients.

If you’re a healthcare worker at an oncology practice, hospital or academic institution in the United States and are interested in continuing or launching a new home cancer care initiative, we invite you to apply for a Rapid Cancer Grant.

The TTP Bridge Program aims to enhance the safety and accessibility of bridges in Tribal communities, addressing the urgent need for infrastructure improvements. With aging bridges affecting economic development and children's transportation, this program allows federally recognized Indian Tribes to apply for funding for planning, construction, and rehabilitation of bridges. By focusing on TTP bridges in poor condition, the initiative seeks to strengthen economic foundations and ensure better connectivity with markets, benefiting both families and communities.

The Graduate Professional Advancement Grant at Montana State University provides funding for graduate students in their 3rd semester or higher to present at professional conferences. This grant encourages scholarly research and supports students by covering travel costs, up to $750. Applications are reviewed monthly on a first-come, first-serve basis, and funding is limited based on availability. Students must be in good standing and have their committee on file to be eligible.

The Classics for Kids Matching Grant Program, established by the Classics for Kids Foundation, aims to enhance music education for at-risk and rural youth by providing matching grants for fine stringed instruments. Since 1998, over $2 million has been allocated to support more than 300 programs across all 50 states. Schools and non-profits demonstrating need and commitment are encouraged to apply, fostering lifelong benefits of music participation and education.