Best Mellette County Grants for Nonprofits in South Dakota

Greenawalt Foundation

Building Stronger Communities

At The Greenawalt Foundation, we believe that opportunity is the foundation of prosperity. By supporting organizations that educate, train, and empower people in the trades, we’re helping to build a stronger, more sustainable future for all.

Skilled Trades Grant Opportunities

The Greenawalt Foundation advances opportunities in the skilled trades through funding for accredited pre-apprenticeship and apprenticeship programs, workforce training initiatives, and youth career exploration experiences. These programs promote technical readiness and connect STEM education to modern trades careers, building a stronger, more sustainable workforce. Foundation support focuses on expanding access and creating equitable pathways to prosperity for individuals pursuing skilled trades careers. Through these efforts, the Foundation helps develop the next generation of skilled professionals who will shape the future of our communities.

Eligible Grant Categories

• Skilled Trades Training Support
• Pre-Apprenticeship or Apprenticeship Programs
• Youth Career Exploration Camps

Seeding Research, Networking, and Capacity Building at Minority-Serving Institutions

Introduction & Purpose

RWJF is committed to ensuring everyone has a fair and just opportunity to be as healthy as possible. To achieve this goal, we support research that examines the historical and systemic factors that cause health inequities. Some of those determinants are poverty, discrimination, and limited access to quality education, housing, safe environments, and healthcare. As attacks on data and academic freedom and ongoing funding cuts to federal health equity research and programs continue, philanthropy’s work to achieve fair and equitable health, including a more equitable research funding ecosystem, is more important than ever. While philanthropic support for Minority-Serving Institutions (MSIs) has increased in recent years, there is more to be done to rectify historical disparities in funding. 

This call for proposals (CFP) provides support to health equity research centers at MSIs to strengthen research infrastructure and capacity-building. Capacity-building will help develop staff, skills, culture, resources, and systems that enable research to happen effectively. Specific work that RWJF may fund under this CFP includes specific skill or methodology training; faculty release time; support for research assistants, advisors, and project staffing; mentoring, professional development and collaboration, and more.

Through this CFP, RWJF will expand its efforts to transform deeply rooted beliefs about which data and research methods are valued, whose perspectives are prioritized, and which populations deserve resources. By supporting the infrastructure and capacity-building needs of MSIs, this opportunity strengthens their ability to generate critical evidence and to cultivate transformative, actionable solutions toward health equity. 

RWJF believes in health equity research that is grounded in systems thinking; supports and disseminates evidence identifying and implementing structural solutions to racial and health inequities. This CFP seeks mission-aligned institutions to participate in cohort-style peer learning to advance their ability to engage in health equity research and apply for competitive funding opportunities in the future.

Although no single philanthropy can fill the gap left by federal funding cuts, this CFP demonstrates strong support for research, historically underrepresented researchers, and research centers that are positioned to pave the way toward a future where health is not a privilege, but a right.

The Cooperative Endangered Species Conservation Fund: Recovery Land Acquisition Grant Program, initiated in FY 2001, aims to foster collaboration between State and Federal entities in conserving listed species. This program provides funding for acquiring critical land parcels to support U.S. Fish and Wildlife Service-approved recovery plans. By securing habitats at risk from development, the initiative directly addresses the primary threat to endangered species, ensuring effective and immediate conservation actions.

The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to enhance our understanding of biological processes driven by somatic mutations in human tissues through innovative technology development. Since its inception in 2023, the program has produced multi-omic datasets from human tissues representing all germ layers. The NIH is now advancing to Stage 2, focusing on collaborative efforts to refine and implement validated technologies for somatic mutation detection and functional interpretation, promoting rigorous and cost-effective methodologies.

The Cancer Prevention and Control Programs aim to eliminate cancer through collaborative efforts among state, territorial, and tribal organizations. Funded by the CDC, this program supports initiatives such as breast and cervical cancer screening, cancer control planning, and cancer surveillance. By fostering partnerships and community involvement, the program seeks to improve health outcomes and achieve the mission of 'All People Free of Cancer.' This comprehensive approach ensures that resources are effectively coordinated to address the cancer burden in communities.

This funding opportunity from the US Dept. of Health & Human Services: National Institutes of Health (NIH) aims to advance mechanistic research on metal exposure and its effects on human health. Studies should focus on biological processes altered by metals, including their absorption, transport, and immune interactions. Innovative methodologies and human biospecimens are encouraged to explore how metals might impact immune homeostasis and cross biological barriers, providing insights into health risks associated with metal exposure.

The TURTLE Program aims to empower Tribal Entities by fostering a skilled workforce in biomedical research. It supports undergraduate and graduate students in health research, ensuring they complete their degrees and transition into impactful careers. With phased awards, the program emphasizes effective training and mentoring, inviting eligible organizations to apply. Applications will undergo NIH's peer-review process, ensuring only the most meritorious proposals are funded, ultimately enhancing Tribal health research capabilities.

The TIRBEE funding opportunity supports federally-recognized Tribes and Tribal Entities in establishing or enhancing Institutional Review Boards. This initiative aims to strengthen the capacity for biomedical research involving human participants within these communities by improving review and oversight capabilities. Eligible organizations are invited to apply, with applications subject to NIH's standard peer-review process to ensure only the most meritorious proposals are considered.

The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to enhance our understanding of somatic mutations and their impact on human biology and disease. This initiative will establish a Tissue Procurement Center (TPC) to collect and provide clinically relevant tissue samples from a diverse set of healthy donors. The TPC will support ongoing research by ensuring high-quality, well-characterized specimens are available for functional analyses, advancing the field of somatic mosaicism.

The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to enhance understanding of biological processes and disease mechanisms due to somatic mutations in human tissues. Since 2023, it has produced multi-omic datasets from various human tissues. The NIH plans to advance this initiative by establishing the National Somatic Mosaicism Commons Data Analysis & Organizational Center, which will oversee data management, develop analytical tools, and provide training to facilitate research and clinical applications.

The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to uncover biological processes and disease mechanisms influenced by somatic mutations. Since its inception in 2023, it has produced valuable multi-omic datasets from diverse human tissues. The upcoming Stage 2 Genome Characterization Centers will focus on understanding the impact of these mutations in both healthy and clinically significant samples, enhancing our knowledge of somatic mosaicism's role in human health and disease.

In collaboration with Cummins Inc., the American Library Association (ALA) invites applications from U.S. public libraries to participate in A Year of STEM, 12 months of curated STEM programming to foster curiosity and STEM-mindedness in early childhood learners across the country. 

Twenty-five libraries will be chosen to participate in A Year of STEM, receiving professional development to prepare them for the project, copies of a newly created A Year of STEM programming guide developed by librarian advisors, a $5,000 programming stipend, four STEM kits (to be delivered quarterly), and support from ALA’s Public Programs Office staff throughout the project implementation period.

LRPenn.com is home to the novels, plays, and screenplays of LR Penn. His books specializes in Thrillers, Dramatic Comedies, and Film Noir. Thanks to the generous support of our sponsors, grants may be available to nonprofit theater companies in the United States with 501(c)(3) status that are staging productions of plays written by LR Penn.  

The Technology Development Program by the US Department of Health & Human Services focuses on advancing technology research from proof-of-concept to prototype development. This initiative prioritizes innovation to enhance biomedical research, emphasizing technological improvements without the inclusion of biological hypothesis testing. Eligible projects should aim at significant technological advancements to maximize impact in the field.

The R21 Clinical Trial Not Allowed funding opportunity invites innovative research to develop and enhance research models and biological materials vital for studying human health and diseases. It emphasizes the need for new approach methodologies (NAMs) to improve the identification of confounding factors in biomedical research. Projects should have broad applicability across multiple NIH Institutes, focusing on various body systems and disease categories, ensuring relevance to a wide range of health issues.

The FY2026/2027 Community Compass Technical Assistance and Capacity Building Program provides competitive grants to organizations capable of delivering technical assistance (TA) to communities served by HUD. With up to $86 million available, recipients are expected to develop educational tools, collaborate with HUD, and show a strong record of performance. This initiative aims to enhance community systems, support high-priority projects, and ensure effective training delivery, fostering impactful outcomes across the nation.

The National Institute of Mental Health (NIMH) is launching a funding opportunity to establish a research network focused on rapid-acting psychotropic interventional drugs (RAPIDs), including ketamine and psilocybin. This initiative seeks to generate real-world evidence on the effectiveness and safety of these treatments for serious mental illnesses. By addressing critical questions around their implementation in clinical practice, the NIMH aims to facilitate the safe integration of RAPIDs into healthcare, ultimately improving mental health outcomes.

The National Endowment for the Humanities invites K-12 teachers and higher education faculty to apply for the Landmarks of American History and Culture and Summer Institutes program. This initiative aims to enhance humanities education through professional development opportunities, fostering a deeper understanding of historical and cultural landmarks. Participants will engage in enriching experiences designed to improve teaching practices and student learning outcomes in the humanities.

The USEA Foundation has established the TEAPRO Grant (Training and Education in the Art of Pace and Riding in the Open), which is available to organizers, trainers, education groups and others to support opportunities for riders and horses to practice galloping, trot sets, and other forms of riding in the open as well as learn about fitness and conditioning for both horse and rider. The aim is to further education in these skills and to support many of the sport's stakeholders in doing so— riders, horses, trainers, organizers, coaches, clinicians, etc. Examples include funding for: a clinician to conduct a session on how to gallop horses in the open; a clinic where riders work to develop a feel for pace at walk, trot and canter over terrain; a seminar to educate riders on how to safely and effectively build the fitness level of their horse and themselves; portable steeplechase jumps that will be used to create a steeplechase course at one or more facilities; offsetting costs for the equipment required to accurately measure and set up a galloping or trot set track.Grant Funding: Grant funds will be awarded to address specific funding needs up to a maximum of $3,000 per applicant. Total awards per year shall not exceed $8,000.

The Bee Foundation For Brain Aneurysm Prevention (TBF) invites proposals that further the mission of reducing the number of deaths caused by brain aneurysms. Proposals directed at understanding the early detection, pathophysiology, genetic predisposition, or treatment will take priority. Proposals from a variety of disciplines (including but not limited to translational Neurosciences, Neurosurgery, Neurology, Radiology, Genetics) are encouraged and multidisciplinary proposals that illustrate a multi-faceted approach will be weighted highly.The purpose of this program is to promote novel approaches to the early detection and prevention of ruptured cerebral aneurysms, or early emergency and critical care treatment (excluding device therapies). We invite proposals that test an innovative hypothesis or develop new outcomes via interdisciplinary or translational research. Applications with more than one investigator must indicate how the different expertise of the co-investigators will contribute to the overall goals of the project.  Grant Funding:

• $20-25,000 total amount to be distributed, but not limited to only 1 awarded applicant
• Applicants may request up to $25,000

The Elizabeth M. Keithley, Ph.D. Early Stage Investigator Awards (EMKESIA) offers funding of up to $50,000 per year for early-stage researchers focused on hearing and balance research. Managed by the Hearing Health Foundation, the program encourages innovative projects and supports the next generation of scientists. Eligible applicants must hold relevant degrees and demonstrate a pathway to independence in their research careers, contributing to advancements in hearing health solutions.

Elizabeth Ratta, a brain aneurysm survivor and a Bee Foundation ‘share your story’ contributor is passionate about spreading brain aneurysm awareness and particularly in the populations they disproportionately affect- those who are Black, Hispanic and women. This research grant is named for Elizabeth’s grandma, Rita who had an unruptured brain aneurysm, but at a time when there was limited treatment and support.About Rita Skertich GrantThe Rita Skertich Grant is specifically intended to fund research topics that focus on prevention and treatment of brain aneurysms in the Black and Hispanic population and women; the populations most affected by brain aneurysms. African Americans and Hispanics are twice as likely to have a rupture compared to white Americans. Women are more likely than men (3:2 ratio) to have a brain aneurysm and 1.5 times more at risk of rupture than men. The research funded by this grant will support efforts to improve outcomes, accessibility and a greater understanding of discrepancies in the statistics for these populations with a focus on prevention. The preference is that this grant will be given to a Black, Hispanic and/or female researcher with other underrepresented research groups also considered.Grant Funding: 

• $15,000 total amount to be distributed, but not limited to only 1 awarded applicant
• Applicants may request up to $15,000

The Focused Discovery Awards (HHF-FDA) by the Hearing Health Foundation provide up to $50,000 annually for innovative research in hearing and balance. Targeted at early career investigators, these grants aim to foster groundbreaking projects that enhance understanding and treatment of hearing loss, benefiting millions. Applicants must demonstrate a strong research background and institutional support, ensuring that funds are directed towards high-impact projects that can lead to future funding from major research institutions.

The Focused Discovery Awards - Type 2 (HHF-FDA-2) provide funding of up to $50,000 for innovative research addressing hearing and balance issues. Open to investigators at any career stage, these grants aim to support new lines of inquiry in underfunded areas of otology. The Hearing Health Foundation encourages applications that demonstrate strong research training and institutional support, fostering advancements in hearing health for millions affected by related conditions.

The Expanded Discovery Awards (HHF-EDA) by the Hearing Health Foundation provide crucial funding up to $100,000 per year for innovative research in hearing and balance. These awards support both emerging and established investigators addressing specific topics in the field. With a focus on early career researchers, HHF-EDA aims to foster groundbreaking work that can lead to significant advancements in treatment and understanding of hearing loss, benefiting millions affected by these conditions.

Governor’s Office of Economic Development

Our Mission: The Governor’s Office of Economic Development drives the economic development environment that ensures the next generation can succeed in South Dakota.

No matter what your economic development needs are in South Dakota, the Governor’s Office of Economic Development can help. We have an array of resources at our disposal – from financing to research, from networking to cutting red tape – that you can use to help your new or existing business flourish.

Workforce Development Program

The South Dakota Workforce Development Program is a commitment by the State of South Dakota to extend education and training resources so that South Dakota employers will be provided with a well-trained and skilled workforce. Through matching grants, the Workforce Development Program funds industry-education partnerships through which customized training programs and short-term, job-specific training is delivered. The Workforce Development Program supports up to one-half the total cost of training. 

How it Works

When the applicant is approved, the award is made on a reimbursement basis upon completion of the training. Awards will be paid on a per-person basis with 85% of the grant paid upon receipt of the initial report and 15% paid upon receipt of the follow-up report.

Governor’s Office of Economic Development

Our Mission: The Governor’s Office of Economic Development drives the economic development environment that ensures the next generation can succeed in South Dakota.

No matter what your economic development needs are in South Dakota, the Governor’s Office of Economic Development can help. We have an array of resources at our disposal – from financing to research, from networking to cutting red tape – that you can use to help your new or existing business flourish.

Local Infrastructure Improvement Program

Purpose

The Board of Economic Development may provide grants to assist in funding the construction or reconstruction of infrastructure for the purpose of serving economic development projects.

Helping Infrastructure Support Investment

The Local Infrastructure Improvement Program provides grants to local development corporations, tribal governments, municipalities, counties, or other political subdivisions to construct or reconstruct public infrastructure associated with an economic development project.

How it Works

Applicants must identify an economic development project and then work with their area planning district to submit a completed application before funding is considered.

If the board approves the application, the applicant must comply with the conditions of approval to remain eligible for the grant. GOED will issue payment within 30 days of receiving the required compliance documentation.