Best Large Grants for Nonprofit Organizations in Minnesota

The Minnesota Pollution Control Agency (MPCA) is offering $1.6 million in planning grants for climate resilience projects across Minnesota. These funds aim to help communities assess vulnerabilities related to stormwater management, wastewater systems, and public services in the face of climate change. This initiative supports local efforts to enhance resilience, reduce flood risks, and adapt to changing environmental conditions, ensuring healthier communities and sustainable natural resources.

The Minnesota Pollution Control Agency is offering $1.1 million in Small Communities Planning Grants to support climate planning projects in communities with populations under 10,000. This initiative aims to enhance resilience against stormwater issues, improve wastewater systems, and adapt community services to changing climate conditions. By partnering with local governments, the MPCA is addressing the urgent impacts of climate change through innovative, community-centered approaches.

The Sustaining Environmental Systems Grant aims to ensure equitable access to healthy land and water for all Minnesotans. The Mortenson Family Foundation supports community-led environmental solutions and multi-year grants to partner organizations. It prioritizes partnerships that focus on sustainability, racial justice, and community engagement, fostering innovative approaches to restore relationships with nature and address climate change impacts. The foundation seeks organizations that can deliver tangible environmental outcomes while empowering historically marginalized communities.

The IMPLICIT Grant, funded by the Minnesota Department of Health, aims to enhance maternal and perinatal care by implementing the IMPLICIT model in at least five clinics over three years. This initiative addresses critical factors such as smoking and maternal depression to reduce birth defects. A total funding of $130,000 is available, providing annual stipends of $18,000 to participating clinics, which will also receive essential training and support to ensure sustainable healthcare improvements.

The Medica Foundation Grant for MN Early Childhood Health supports early intervention programs aimed at the growth and development of children from birth to age 12. With a focus on health equity, the grant prioritizes proposals that serve marginalized communities, including BIPOC, immigrants, and individuals experiencing homelessness. Grants can be up to $100,000 and are awarded to eligible 501(c)(3) organizations in Minnesota. This initiative aims to improve healthcare access and quality through measurable outcomes.

The Environmental Justice Thriving Communities Grantmaking Program, led by The Minneapolis Foundation, supports community-based nonprofits in the Great Lakes region. With a focus on underserved communities, grants will total $40 million over three years, aiming to enhance environmental health, education, and resilience. The program prioritizes applications from federally recognized tribes and organizations with limited budgets, fostering inclusive community engagement and sustainable development. Eligible projects include environmental assessments, public health initiatives, and job training.

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

NAFC Healthcare Services Expansion Fund

The NAFC Healthcare Services Expansion Fund supports the launch or expansion of clinical programs and new service areas that increase access to care for underserved patients. This funding is designed to help NAFC members introduce new services or grow existing programs that address unmet community health needs and improve access to comprehensive, patient-centered care.

The FY 2027 Clean Water Fund (CWF) Projects and Practices Grants Request For Proposals (RFP) is now open, and includes two programs:

Projects and Practices, and

Projects and Practices Drinking Water. 

Grants Program

The Board of Water and Soil Resources (BWSR) Clean Water Fund Competitive Grants Program supports activities that restore, protect, and enhance water quality.

This RFP includes:

• Projects and Practices
  • This grant makes an investment in on-the-ground projects and practices that will protect or restore water quality in lakes, rivers or streams, or will protect groundwater or drinking water.
  • Examples include:
    • stormwater practices,
    • agricultural conservation practices,
    • feedlot related practices,
    • lakeshore and stream bank stabilization,
    • stream restoration, and
    • SSTS upgrades.
• Drinking Water
  • This grant makes an investment in land treatment projects and practices that will protect or improve drinking water sources.
  • Surface water (streams, rivers, and lakes) and groundwater (aquifers) can both serve as sources of drinking water.

The Soil and Water Stewardship Scholarship, sponsored by the Community Foundation of Northern Illinois, provides financial support to students pursuing careers in natural resources. Applicants must reside in specific Illinois counties and plan to enroll in a full-time program related to fields such as ecology, hydrology, and conservation. Academic performance is a key consideration in the selection process. For more details, contact the Winnebago County Soil & Water Conservation District.

The Green Partners Grant by Hennepin County aims to empower organizations to foster environmental stewardship among residents. This program provides funding for initiatives that engage both youth and adults in sustainable practices. Key focus areas include waste reduction, composting, and enhancing biodiversity through habitat creation. Three grant types are available: Environmental Action, Youth Environmental Leadership, and Youth Environmental Education. Eligible applicants include schools, nonprofits, and park districts, with funding amounts varying based on previous awards.

The OECD Conference Sponsorship aims to enhance scientific knowledge and provide essential information to influence policy decisions on sustainable resource use in food, agriculture, forestry, and fisheries. It supports international events that showcase innovative research and developments, inviting applications from scientists in these fields. The event sponsorship encourages collaboration among policymakers, industry, and academia, ensuring that research insights are effectively communicated and utilized in decision-making processes.

The RNRF Rapid Response Grants provide essential funding up to $50,000 for projects adversely affected by the loss of federal support. The program aims to foster collaboration among organizations working towards sustainable environmental, social, and economic practices. Eligible applicants must be 501(c)(3) organizations in the U.S. and demonstrate multidisciplinary collaboration with RNRF member organizations, ensuring impactful outcomes in critical focus areas such as air quality, biodiversity conservation, and renewable energy.

The RNRF Planning and Small Grants program provides funding up to $50,000 to support projects that enhance collaboration among community partners in addressing critical environmental issues. Eligible applicants must be 501c3 organizations in the U.S. and demonstrate multidisciplinary cooperation. Projects should align with RNRF's mission and focus areas, including air quality, biodiversity, and renewable energy. The initiative aims to create sustainable and impactful outcomes by bridging research and practical implementation.

The RNRF Implementation/Collaboration Grants support innovative projects that enhance collaboration among stakeholders to address critical challenges in environmental, social, and economic systems. Offering up to $200,000 for initiatives lasting 12 months or more, these grants aim to implement evidence-based practices and facilitate multidisciplinary teamwork. Eligible applicants must be from 501c3 organizations in the U.S., ensuring alignment with RNRF's mission and focus areas, fostering sustainable and impactful outcomes.

The Siletz Tribal Charitable Contribution Fund, established by the Confederated Tribes of Siletz Indians, has distributed over $16.3 million in grants since 1999. It supports charitable organizations and local governments in eleven Oregon counties, as well as Native American initiatives across the U.S. The fund prioritizes education, health, public safety, addiction prevention, housing, arts, and environmental preservation, ensuring the Tribe's commitment to community support and cultural heritage.

The Regional Conservation Partnership Program (RCPP) Classic for FY 2026 encourages collaboration between the NRCS and partners to address critical natural resource concerns through innovative projects. By co-investing with partners, the program aims to enhance conservation efforts on farms and private lands, ensuring equitable access to NRCS services. Selected proposals will be based on their potential impact and effective partnership management, ultimately improving environmental outcomes across designated Critical Conservation Areas.

The Stantec Community Engagement Grant is dedicated to enhancing the quality of life in communities where Stantec operates. Focused on arts, education, environment, and health and wellness, the grant supports initiatives that foster sustainable development and responsible practices. Organizations seeking funding must align with Stantec's values, emphasizing ethical practices and community impact. Preference is given to projects located near Stantec offices, ensuring a more significant local impact through their contributions.

The grant aims to enhance access to newborn hearing and pulse oximetry screenings in out-of-hospital settings across Minnesota. By providing portable screening equipment, it seeks to ensure timely identification and intervention for infants who are Deaf or Hard of Hearing (DHH) and those with critical congenital heart disease (CCHD). This initiative aligns with state mandates to improve newborn health outcomes and connect families with essential services.

The Big Ten Academic Alliance Smithsonian Fellowship offers unique research opportunities for graduate students from member universities. Eligible candidates can conduct research at the Smithsonian in diverse fields such as anthropology, ecology, and history of science. The fellowship provides a stipend of $45,000 per year, with additional research allowances, and supports both U.S. and international students. This initiative fosters collaboration among leading academic institutions to advance knowledge and innovation.

ServeMinnesota provides annual grants to support nonprofits, local governments, institutes of higher education, and Indian Tribes in hosting AmeriCorps programs. Grantees must use research-based measures of program outcomes to generate valid and reliable data that are available to ServeMinnesota for evaluation and public reporting purposes.

AmeriCorps improves lives, strengthens communities, and fosters civic engagement through service and volunteering. AmeriCorps brings people together to tackle some of the country’s most pressing challenges through national service and volunteerism. AmeriCorps members serve with organizations dedicated to the improvement of communities and those serving.

AmeriCorps grants are awarded to eligible organizations that engage AmeriCorps members in evidence-based or evidence-informed interventions to strengthen communities. An AmeriCorps member is a person who does community service through AmeriCorps. Members may receive a living allowance and other benefits. After successful completion of their service, members earn a Segal AmeriCorps Education  Award they can use to pay for higher education expenses or apply to qualified student loans.

For this funding opportunity, AmeriCorps will prioritize consideration from organizations that:

Serve Communities:

•  Serve communities with concentrated poverty, rural communities, tribal communities, and historically underrepresented and underserved individuals. These may include people of color, immigrants, refugees, people with disabilities, LGBTQIA+ individuals, people with arrest or conviction records, religious minorities, etc.;
• Implement programs for or expand access to high-quality youth mental health and substance use recovery services and prepare AmeriCorps members to enter behavioral health careers. These may include individuals with lived experience with substance use and mental health challenges to support youth mental health efforts and continued AmeriCorps work on the opioid epidemic;
• Focus on improving the quality of life for veterans, active-duty members of the Armed Forces, and their families by recruiting veterans, military spouses, and their older children into national service;
• Promote environmental stewardship to help communities (especially underserved households and communities) to be more resilient by reducing greenhouse gas emissions, conserving land and water, increasing renewable energy use and improving at-risk ecosystems;
• Support civic bridgebuilding programs and projects to reduce polarization and community divisions; and providing training in civic bridgebuilding skills and techniques to AmeriCorps members;

The Electric Vehicle Fast Chargers Grant, provided by the Minnesota Pollution Control Agency, allocates approximately $1.89 million to install fast-charging stations in strategic locations throughout Minnesota. This initiative aims to facilitate long-distance travel for EV drivers and promote the adoption of electric vehicles, ultimately reducing greenhouse gas emissions and improving air quality, especially in communities disproportionately affected by vehicle pollution.

The Esther Tomljanovich Strategic Initiatives grant from the Medica Foundation supports transformative projects aimed at advancing health equity. With a funding capacity of up to $200,000 over two to three years, the initiative focuses on innovative proposals in healthcare workforce development, women's health, aging services, dental programs, and housing stability. Grantees are expected to demonstrate measurable outcomes and foster collaboration within their communities, emphasizing the importance of addressing unique health needs.

Sanofi Philanthropic Donations support non-profit organizations aligned with Health Equity, STEM Education Equity, and Local Communities. Applications are accepted year-round, with a review process of 8 to 16 weeks. The initiative focuses on improving healthcare access, fostering innovation, and addressing social determinants of health. Sanofi emphasizes collaboration and sustainable solutions, advocating for equal opportunities in health and education, and nurturing future talent to tackle medical challenges.

The ALDI Community Gift Card Program provides financial support ranging from $100 to $1,000 to eligible nonprofits and schools that focus on after-school and out-of-school youth programs, as well as food banks. This initiative aims to empower organizations dedicated to child development and combating food insecurity. By applying, you can gain access to essential resources to further your mission and make a positive impact in your community.

The Norman E. Borlaug International Agricultural Science and Technology Fellowship Program FY2026, funded by the USDA's Foreign Agricultural Service, aims to enhance agricultural research and education collaborations between U.S. institutions and researchers from emerging markets. This initiative not only strengthens trade relations but also fosters global partnerships in agricultural science, ultimately benefiting U.S. prosperity through expanded markets and innovative research solutions.

The PNC Foundation aims to enhance the lives of individuals in local communities through partnerships with nonprofit organizations. Their focus includes promoting educational opportunities, particularly for early childhood education, and supporting economic development initiatives. Grants are available for organizations that benefit low- to moderate-income families and enhance community growth. The foundation prioritizes programs that foster sustainability and diversity, ensuring a lasting impact on the communities they serve.

The Pentair Foundation, a corporate philanthropy initiative, focuses on creating sustainable communities through water solutions and STEM education. With over $80 million in contributions since 1998, the foundation emphasizes ecological resilience, water quality improvement, and youth engagement in science and technology. They prioritize grantmaking in specific U.S. states and international regions, fostering vibrant communities and encouraging employee volunteerism. Initiatives are invitation-only, ensuring a targeted approach to impactful philanthropy.