Best Large Grants for Nonprofit Organizations in Minnesota

2026 ASPCA Grants for Shelters and Spay/Neuter Clinics

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) is offering up to $14 million in grants to support shelters and spay/neuter clinics in meeting the needs of vulnerable animals throughout the United States, including addressing the shortfall in available spay/neuter surgeries. We will fund qualified proposals that support:

• Critical shelter infrastructure
• Strengthening shelter essentials
• Increasing the number of spay/neuter surgeries year-over-year 
• Major capital projects that increase spay/neuter capacity
• Special projects that increase spay/neuter capacity

Shelter Grants

Critical Shelter Infrastructure

Only one application per agency/organization will be considered. 

Applicants may choose only one of the five funding categories. Our interest is in meeting your most pressing needs in one of the offered categories; we do not have our own preference for funding one category over another. We will fund the most compelling proposals, regardless of category chosen.

The American Urological Association's Research Scholar Award offers $40,000 annually for one or two years of mentored research training. This program aims to attract promising young investigators into urologic research, providing essential support to clinical and postdoctoral fellows within five years of completing their doctorate or residency and early career faculty within their first five years. This funding opportunity is crucial for fostering the next generation of urologic researchers.

The American Urological Association Rising Stars in Urology Research Award supports physician-scientists in their journey to become independent researchers in urology. By providing supplemental salary support for up to five years, the program ensures awardees maintain protected research time while receiving competitive compensation. This initiative encourages promising researchers to compete for further funding and enhances their training in urologic research, ultimately advancing the field and improving patient care.

2026 ASPCA Grants for Shelters and Spay/Neuter Clinics

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) is offering up to $14 million in grants to support shelters and spay/neuter clinics in meeting the needs of vulnerable animals throughout the United States, including addressing the shortfall in available spay/neuter surgeries. We will fund qualified proposals that support:

• Critical shelter infrastructure
• Strengthening shelter essentials
• Increasing the number of spay/neuter surgeries year-over-year 
• Major capital projects that increase spay/neuter capacity
• Special projects that increase spay/neuter capacity

Shelter Grants

Strengthening Shelter Essentials

Only one application per agency/organization will be considered. 

Applicants may choose only one of the five funding categories. Our interest is in meeting your most pressing needs in one of the offered categories; we do not have our own preference for funding one category over another. We will fund the most compelling proposals, regardless of category chosen.

2026 ASPCA Grants for Shelters and Spay/Neuter Clinics

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) is offering up to $14 million in grants to support shelters and spay/neuter clinics in meeting the needs of vulnerable animals throughout the United States, including addressing the shortfall in available spay/neuter surgeries. We will fund qualified proposals that support:

• Critical shelter infrastructure
• Strengthening shelter essentials
• Increasing the number of spay/neuter surgeries year-over-year 
• Major capital projects that increase spay/neuter capacity
• Special projects that increase spay/neuter capacity

Spay/Neuter Grants

Increasing Spay/Neuter Surgeries

Only one application per agency/organization will be considered. 

Applicants may choose only one of the five funding categories. Our interest is in meeting your most pressing needs in one of the offered categories; we do not have our own preference for funding one category over another. We will fund the most compelling proposals, regardless of category chosen.

2026 ASPCA Grants for Shelters and Spay/Neuter Clinics

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) is offering up to $14 million in grants to support shelters and spay/neuter clinics in meeting the needs of vulnerable animals throughout the United States, including addressing the shortfall in available spay/neuter surgeries. We will fund qualified proposals that support:

• Critical shelter infrastructure
• Strengthening shelter essentials
• Increasing the number of spay/neuter surgeries year-over-year 
• Major capital projects that increase spay/neuter capacity
• Special projects that increase spay/neuter capacity

Spay/Neuter Grants

Spay/Neuter Major Capital Projects

Only one application per agency/organization will be considered. 

Applicants may choose only one of the five funding categories. Our interest is in meeting your most pressing needs in one of the offered categories; we do not have our own preference for funding one category over another. We will fund the most compelling proposals, regardless of category chosen.

The ASPCA is offering up to $14 million in Spay/Neuter Grants for shelters and clinics across the U.S. to enhance spay/neuter services for vulnerable animals. Proposals can address critical infrastructure needs and major capital projects to increase spay/neuter capacity. Only one application per organization is permitted, and applicants must choose one funding category. The focus is on compelling proposals that meet the most urgent needs.

The AUA Data Research Grant Program, funded by the American Urological Association Inc, aims to enhance urologic research by fostering a diverse group of dedicated professionals. This initiative focuses on bridging knowledge gaps in urology care and cultivating physician scientists through access to comprehensive data sources and mentorship from AUA Data Committee experts. By supporting innovative research, the program contributes significantly to the advancement of patient care in urology.

The Find Your Light Foundation is committed to providing every child with access to quality arts education. By focusing on direct support for exceptional programs, along with education, advocacy, and outreach, they aim to highlight the importance of arts in youth development. Grants are awarded to arts education initiatives in low-income areas across North America, typically ranging from $5,000 to $15,000, with awards issued in the Summer and Winter each year.

Who We Are

The Unitarian Universalist Funding Program (UUFP) is a denominational grantmaking program of the Unitarian Universalist Association. Inspired by the richness and diversity of our liberal religious tradition, the mission of the UUFP is to promote the influence of Unitarian Universalist principles through grantmaking.

With funds generously provided by the Unitarian Universalist Veatch Program at Shelter Rock, the UUFP awards grants to Unitarian Universalist (UU) and non-UU projects and organizations. Grants are made that:

• Support the work of social justice.
• Strengthen Unitarian Universalist institutions.
• Transform gratitude for being into generosity of living.

Get Out The Vote - 2026

The Fund for UU Social Responsibility has increased funding for grants to UU congregations and organizations working to Get Out The Vote in 2026. Grants of up to $1,000 will be made on a rolling basis until funds are depleted.  

Please note that funds must go to a UU congregation or organization for the work by UUs of the organization. The funds may not be passed through to another organization. Collaboration and partnerships are encouraged.

UU congregations and organizations frequently support the democratic process in an election cycle in a non-partisan* manner by participating in voter registration drives, organizing to stop voter suppression, providing non-partisan educational materials or forums for voters, or by volunteering to help registered voters get to the polls on election day.

About USA Track & Field Foundation Inc

The USA Track & Field Foundation was established in 2002. Our Foundation provides a means to attract and guide funds to new and innovative track & field programs, with an emphasis on providing opportunities for youth and elite athletes.

Mission: 

To support the development of emerging elite athletes, while fostering integration within the broader track & field community. To facilitate the physical, educational, social and character development of youth track & field athletes and to help prepare them to mature and succeed in adult life.Team and Club SupportThe USA Track & Field Foundation may be able to provide support to certain Elite Track & Field / Running clubs in the US.

The NIOSH Exploratory/Developmental Grant Program (R21) aims to enhance understanding of occupational diseases and injuries. It focuses on identifying risks, developing prevention strategies, and translating scientific discoveries into effective measures. Applicants are encouraged to describe the health burdens addressed, outline research activities, and demonstrate potential impacts on occupational safety. This initiative supports innovative concepts, model systems, and technologies that can significantly improve workplace health outcomes.

About Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.

Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.

Donald S. & Beulah Mae Williams Scholarship

Created by the late Don Williams in 2016, this scholarship fund initially honored his beloved Beulah Mae, devoted farmer, loving housewife, mother, grandmother and great-grandmother. It now memorializes this Prospect farming couple.

The Williams Scholarship supports Marion County students who participated in either FFA or 4-H for three or more years.

About Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.

Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.

David G. Wilhelm Memorial Scholarship

The David G. Wilhelm Memorial Fund was created in honor of its namesake in 2020. It supports college students pursuing careers in mental and behavioral health services.  

The AFSA 2nd Chance College Scholarship Contest, sponsored by the American Fire Sprinkler Association, aims to support educational pursuits for students with a high school diploma or GED. Open to U.S. citizens and legal residents, the contest encourages applicants to enroll in a college or trade school for the Spring 2019 session. Notably, selection is not based on financial need or GPA, ensuring a fair opportunity for all eligible participants.

The Sullenberger Award for Courage, presented by the U.S. Air Force Academy Association & Foundation, recognizes exemplary acts of bravery by graduates of the Academy. This prestigious award honors those who demonstrate outstanding leadership and service, reflecting the core values of integrity, service before self, and excellence. Nominations can be submitted by anyone, and the award celebrates acts that positively impact the Academy and its legacy.

The Security and Preparedness (SAP) Program, supported by the National Science Foundation, promotes fundamental research addressing global and national security issues. It emphasizes intellectual merit and broader impacts, encouraging projects that are methodologically sound and empirically driven. Research areas include international relations, political violence, and peace science, among others. The program also fosters undergraduate research experiences and methodological innovations, while strictly avoiding applied research.

The NSF State and Regional AI Infrastructure Hubs program seeks to enhance access to computational resources essential for AI-driven scientific exploration. By forming flexible consortia among government, academia, and industry, these hubs aim to foster innovation and workforce development in AI. The initiative aligns with national R&D priorities, emphasizing the critical role of AI in advancing scientific discovery and expanding infrastructure to support this mission across various disciplines.

The Golden Trowel Award, presented by the Archaeological Institute of America, recognizes the local society with the highest proportional membership increase over the past year. This prestigious award highlights the vital role that local societies play in promoting archaeology and supporting the AIA's mission. By fostering community engagement and growth, the award encourages societies to enhance their programs and initiatives, ultimately enriching the field of archaeology.

The National Foundation for the Centers for Disease Control and Prevention offers funding to support administrative expenses that bolster CDC's mission. This initiative enhances partnerships to address health threats both domestically and globally. Projects funded through this grant align with CDC's strategic goals, focusing on measurable outcomes such as program support and participation from various CDC Centers and Offices. Importantly, this grant only supports non-research activities.

The Rotary Club of Portsmouth's Helping Professions Grant provides essential financial support to residents of the Seacoast looking to enter or advance in direct care professions. With scholarships and grants of up to $5,000, this initiative aims to address the growing shortage of skilled caregivers, ensuring quality care for families and individuals in the community. Eligible applicants can pursue training in various in-demand roles, enhancing their skills and career prospects.

The Robert H. N. Ho Family Foundation Buddhism Public Scholars Fellowships offer recent PhD graduates in Buddhist Studies the opportunity to work at host institutions such as museums and libraries. Scholars will engage in meaningful roles, receiving competitive compensation and health benefits. Starting in September 2026, this initiative aims to foster partnerships that enhance the understanding and dissemination of Buddhist traditions, benefiting both scholars and cultural organizations globally.

The Rachael Ray No-Kill Excellence Grants, funded by the Rachael Ray Foundation, support Best Friends Network partners in maintaining a 90% Save Rate for animals. These grants encourage innovative projects that enhance community partnerships and mentorships, helping organizations achieve sustainable lifesaving outcomes. Eligible organizations can apply for grants up to $60,000, with a focus on scalable programs that benefit animals and promote no-kill initiatives across the United States.

The ASPB Excellence in Education Award, established in 1988, honors exceptional teaching and mentoring in plant biology. It recognizes individuals, regardless of society membership, who demonstrate outstanding contributions in education, curricular development, or creation of effective teaching resources. This monetary award emphasizes the importance of quality education in advancing plant science, reflecting the mission of the American Society of Plant Biologists to promote growth and development in the field.

The NCCIH Multi-Site Feasibility Clinical Trials program invites applications for innovative clinical trials in mind and body interventions. Funded by the NIH, this initiative aims to gather essential data for future efficacy studies, focusing on feasibility, recruitment, and participant retention across multiple sites. With deadlines from February 2024 to October 2026, researchers are encouraged to submit proposals that demonstrate scientific necessity and potential public health impact through rigorous trial design.

The Feasibility Clinical Trials of Mind and Body Interventions grant aims to support trials that investigate complementary health approaches for high-priority conditions identified by NCCIH. This funding opportunity focuses on generating vital data necessary for planning future clinical efficacy studies. Applicants must demonstrate the feasibility and acceptability of interventions, ensure proper recruitment and retention strategies, and refine protocols to significantly impact public health. A Plan for Enhancing Diverse Perspectives is also required.

The Council of Independent Colleges

Founded in 1956, the Council of Independent Colleges (CIC) is an association of nonprofit independent colleges and universities, state-based councils, and higher education affiliates that works to support college and university leadership, advance institutional excellence, and enhance public understanding of independent higher education’s contributions to society.

CIC is the major national organization that focuses on providing services to leaders of independent colleges and universities and state-based councils. CIC offers conferences, seminars, publications, and other programs and services that help institutions improve educational quality, administrative and financial performance, student outcomes, and institutional visibility.

NetVUE Grant Programs

NetVUE offers a variety of grants to member institutions, supporting programming for students and professional development for faculty members and staff. Grants support projects ranging from one to four years in length. Grant programs are tailored to differing circumstances among member institutions, including their particular areas of interest, their bandwidth and capacity for administering projects, and the depth of their previous engagement with vocational exploration and discernment. NetVUE grants are administered by the Council of Independent Colleges, with generous support from Lilly Endowment Inc.

NetVUE Grants for Reframing the Institutional Saga

Many NetVUE member colleges and universities have strong historical ties to a specific religious tradition, a particular educational philosophy, or a pioneering educator. These elements of an institution’s heritage are important, but their significance may not always be clear in the midst of changes in the institution’s demographic profile, surrounding community, and founding organizations. These changes can influence student recruitment and retention, curriculum design, and the composition of faculty. The purpose of this grant program is to enable institutions to produce an updated account of their history and mission in light of their current context.