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Best Large Grants for Nonprofit Organizations in Minnesota

Find the perfect Large Grants for Nonprofit Organizations in Minnesota on Instrumentl. 10,000+ Large Grants for Nonprofit Organizations in Minnesota in the United States.

10,000+

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$2.71B

Total funding

$5K

Median grant

10,000+ grants
$2.71B total
$5K median

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9,949 Results based on applied filters

Accelerating Research and Development of Next Generation Malaria Vaccines Against Malaria – A Model for Mosquito-Borne Diseases

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIAID is focused on advancing the research and development of next-generation malaria vaccines, aiming to leverage innovative vaccine design techniques. This initiative not only aims to enhance malaria prevention but also serves as a model for combating other mosquito-borne diseases. By utilizing cutting-edge methods such as structure-based immunogen design and combination vaccines, the program seeks to significantly reduce both parasite infection rates and the overall disease burden associated with malaria.
Malaria Tropical Diseases

HIV/AIDS Clinical Trials Network Leadership and Operations Centers

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Allergy and Infectious Diseases (NIAID) is calling for applications for four Leadership and Operations Centers (LOCs) as part of its HIV/AIDS Clinical Trials Network initiative. These LOCs will guide research on HIV therapeutics, prevention, and treatment strategies across diverse populations. The initiative aims to enhance evidence-based practices and improve health outcomes for individuals affected by HIV, ultimately contributing to the goal of ending the HIV epidemic.
HIV / AIDS

HIV/AIDS Clinical Trials Network Laboratory Centers

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Allergy and Infectious Diseases (NIAID) is launching a funding opportunity for up to four Clinical Trials Network Laboratory Centers (LCs). These LCs will support HIV prevention and treatment strategies by providing necessary laboratory infrastructure and technologies for clinical trials. They will ensure rigorous laboratory testing and oversight, enhance sample integrity, and utilize advanced data management systems to meet evolving demands in HIV research and testing.
HIV / AIDS

QBE Foundation Local Grant Program

Qbe Foundation Inc.
Corporate
United States
Up to US $30,000

QBE Foundation Inc.

The QBE Foundation’s focus is on creating strong, resilient and inclusive communities. We work in partnership with community organizations, working in climate resilience and inclusion – two areas where we believe we can have the greatest impact.

The QBE Foundation is one component that reflects our company’s focus, involvement, and investment in the neighborhoods where we do business, and where our employees live and work. The QBE Foundation also empowers our employees to volunteer with colleagues and community partners to make a difference for those in need. Employees can also coordinate fundraisers that are matched by the foundation.

QBE Foundation Local Grant Program

This program supports high-impact, community-based initiatives aligned to our focus on climate resilience and inclusion.

  • Climate Resilience:
    • Helping communities prepare for, adapt to, and recover from climate-related risks, including preparedness, financial resilience, and risk reduction solutions.
  • Inclusion:
    • Expanding access to opportunity for underserved communities through economic inclusion, workforce pathways, and removing systemic barriers.

Multiple grants of $30,000 will be awarded across our two focus areas.

Financial Literacy Economic Rights, Justice, & Mobility Climate Change Resilience & Equity +1 more

HIV/AIDS Clinical Trials Network Clinical Trials Units

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Allergy and Infectious Diseases (NIAID) is launching a funding opportunity for Clinical Trials Units (CTUs) as part of its effort to combat HIV/AIDS. This initiative aims to support innovative clinical trials and implementation research to improve prevention and treatment strategies. With a focus on both domestic and international research sites, CTUs will play a crucial role in addressing the HIV epidemic and enhancing participant recruitment and retention. This funding opportunity is authorized under the Public Health Service Act.
HIV / AIDS

Jack Kent Cooke Foundation: Young Scholars Program

Jack Kent Cooke Foundation
Private
United States
Unspecified amount

Jack Kent Cooke Foundation

The Jack Kent Cooke Foundation is dedicated to advancing the education of exceptionally promising students who have financial need. Since 2000, the Foundation has awarded $304 million in scholarships to more than 3,400 students from 8th grade through graduate school, along with comprehensive academic advising, career pathway counseling and other support services. The Foundation has also provided $136 million in grants to organizations that serve such students.

The Jack Kent Cooke Foundation’s scholarship programs are designed to encourage and support outstanding students who work hard and have financial need. Our scholarships provide financial assistance and academic support to high school, undergraduate, and graduate students. In addition to the monetary award, students join a thriving network of more than 3,400 Cooke Scholars.

Young Scholars Program

The Cooke Young Scholars Program is a selective five-year, pre-college scholarship for exceptionally promising 7th grade students with financial need. It provides comprehensive academic and college advising, as well as financial support for school, Cooke-sponsored summer programs, internships, and other learning enrichment opportunities.

Program Experience

Educational Advisers support Young Scholars to maximize high school experiences and to go on to thrive at the nation’s top-performing colleges. Our programming and support may include:

  • Identifying an appropriately rigorous high school.
  • Engaging in four-year planning and goal-setting.
  • Funding for academic and extracurricular opportunities, such as music and art lessons, supplemental academic classes and technology.
  • Annual summer programs, including two required Young Scholar programs.
  • Year-round Young Scholars community programming.
  • Networking opportunities with a high-achieving peer community.

Academic Success & Enrichment After School / Summer Educational Programs Career / College Preparation +2 more

AGA-Bern Schwartz Family Fund Research Scholar Award in Pancreatic Cancer (Fund B)

American Gastroenterological Association
Association/Society
North America
US $300,000
The AGA-Bern Schwartz Family Fund Research Scholar Award in Pancreatic Cancer provides $100,000 annually for three years to early-career faculty in digestive disease research. This award aims to support independent careers in pancreatic cancer research by protecting a significant portion of the recipient's time for research activities. Eligible applicants must hold an MD, PhD, or equivalent and work at a North American institution, with AGA membership required. Strong encouragement is given to underrepresented groups.
Pancreatic Cancer

Pediatric Visiting Professorship

Rheumatology Research Foundation
Private
United States
Up to US $4,000
The Pediatric Visiting Professorship, funded by the Rheumatology Research Foundation, aims to recognize exceptional scientific abstracts from pediatric rheumatology fellows at ACR Convergence. This award facilitates knowledge sharing and promotes advancements in rheumatic disease care. The professorship spans two to three days and includes diverse teaching formats. Selected fellows receive a $1,000 honorarium for virtual visits or $1,500 for in-person engagements, along with reimbursement for travel expenses, enhancing the future of pediatric rheumatology education.
Musculoskeletal Diseases Arthritis Medical Education & Professional Training +1 more

AGA-Bern Schwartz Family Fund Research Scholar Award in Pancreatic Cancer (Fund A)

American Gastroenterological Association
Association/Society
North America
US $300,000
The AGA-Bern Schwartz Family Fund Research Scholar Award in Pancreatic Cancer provides $100,000 annually for three years to early-career faculty focused on independent research in pancreatic cancer. This award aims to protect at least 50% of the recipient's time for research activities. Eligible applicants must hold an MD or PhD and be classified as early-career. The award encourages physician-scientists and underrepresented groups in biomedical research to apply, supporting innovative research that can lead to significant advancements in understanding pancreatic cancer.
Pancreatic Cancer

Enhancing Pastoral and Social Ministry Grants

Catholic Extension
Association/Society
Acadia Parish, Louisiana, Accomack County, Virginia +994 more
Unspecified amount
Catholic Extension's Enhancing Pastoral and Social Ministry Grants aim to empower the church to broaden its outreach and foster societal transformation through targeted pastoral and social initiatives. This program supports specific elements of the church's ministerial efforts, including funding for catechetical resources, marriage and family ministries, and social outreach for vulnerable populations. By investing in these areas, Catholic Extension seeks to enhance the church's role in communities, especially following disasters.
Catholicism Family Services Homelessness Services +3 more

Carl Hill Memorial Scholarship

Delaware Community Foundation
Private
United States
US $500

Carl Hill Memorial Scholarship

Awards:

  • One time award of $500.
Education - Higher Education Financial Literacy Business Education +1 more

Music Therapy Grants

Music Movement
Association/Society
United States
US $1,500 - US $2,500
Music Movement offers grants for music therapy aimed at children and young adults with Autism Spectrum Disorder (ASD) and other developmental challenges. Grants typically range from $1,500 to $2,500, providing financial relief to families seeking therapeutic resources. Eligible applicants include legal guardians of children in the U.S. who select qualified therapists. The organization focuses on enhancing communication, social skills, and emotional well-being through music, benefiting diverse communities and promoting personal growth.
Autism Children With Disabilities Music Education

Instrument Donations Program

Music Movement
Association/Society
United States
US $500 - US $1,500 in in-kind support
The Instrument Donations Program by Music Movement supports children and young adults with Autism and learning differences by providing funding for musical instruments. This initiative fosters self-expression, personal growth, and emotional well-being through music. Grants typically range from $500 to $1,500 and are available to applicants within the United States. The program encourages artistic development and enhances social skills, making a significant impact on the lives of those facing developmental challenges.
Music Autism Children With Disabilities

Independent Living Initiatives

Music Movement
Association/Society
United States
US $1,500 - US $5,000
Music Movement's Independent Living Initiatives grant supports individuals with Autism and developmental differences in the U.S. Grants, typically ranging from $1,500 to $5,000, aid in various areas including independent living, camps, and continued education. Applicants must be legal guardians of eligible individuals aged 18 and older. The grant portal will reopen for submissions on March 28, 2026, encouraging early review of guidelines to ensure complete applications.
Music Autism Physical Therapy

Madison Chautauqua Scholarship for the Arts in Memory of Bob Fourhman

Community Foundation of Madison and Jefferson County
Private
United States
US $1,800

In 2025, the Community Foundation of Madison & Jefferson County awarded over $233,000 in scholarships to graduating seniors of the county’s public and private high schools. Nearly 50 different students earned money toward their college costs. Scholarships are available for a variety of applicants. Some are specific to schools, majors, need, or interests.

CFMJC scholarships may be used for tuition and related expenses like fees and required equipment at accredited colleges and universities. Room and board are not covered.

Madison Chautauqua Scholarship for the Arts in Memory of Bob Fourhman

Criteria evaluated:

  • Letter of recommendation and artwork samples

Required materials:

  • Letter of recommendation from a person knowledgeable about your talent and accomplishments in your art form; and
  • An uploaded sample of your work (maximum 3 photos or 1 short video/audio clip)

Scholarship amount:

  • $1,200 | 1 scholarship
Education - Higher Education Adult Education Career / College Preparation +3 more

AHCJ U.S. Health System Reporting Fellowship

Association of Health Care Journalists (AHCJ)
Association/Society
United States
Up to US $7,500

About

Building a community of journalists committed to better health care reporting.

We believe accurate, contextual and balanced health care reporting is more important than ever.

People depend on health care stories to make life-altering decisions every day.

AHCJ U.S. Health System Reporting Fellowship

This opportunity is for U.S.-based journalists.

Issues with the U.S. health care system are often obvious — from large swaths of uninsured residents and junk insurance plans, to high maternal mortality rates and preventable medical errors. But what is at the root of issues like these? What could an equitable health care system look like? 

Through the U.S. Health System Reporting Fellowship, supported by The Commonwealth Fund, you can pursue a significant reporting project related to the U.S. health care system at the local, regional and/or national level.

This fellowship allows mid-career journalists to maintain their regular employment while working on a major project over a 12-month calendar year. You’ll pursue the projects with the support of your newsrooms or arranged outlets, which commit to publish or air the work.

We believe that issues of health equity impact every facet of the health care system, which is why we’re specifically interested in projects focused on health equity. This might include racial disparities within a community, gaps in public health inclusion, unstable housing, insurance access, food insecurity, violence as a health issue, how health care institutions or systems are applying a racial equity lens to their policies and practices or otherwise addressing inequities or disparities, or other examinations of systemic problems that have become so apparent over the last few years.

Guidance is provided by AHCJ mentors through customized seminars on health care systems, conference calls and email consultations. The fellowship covers the cost of attending the seminars and the annual AHCJ conference, as well as a $2,500 project allowance to defray the cost of field reporting, health data analysis and other project-related research. In addition, you will receive a $5,000 fellowship award upon the successful completion of the project.

Journalism Health Disparities & Social Determinants of Health Health Care Access & Delivery +2 more

AHCJ Sunshine Award

Association of Health Care Journalists (AHCJ)
Association/Society
United States
Unspecified amount

About

Building a community of journalists committed to better health care reporting.

We believe accurate, contextual and balanced health care reporting is more important than ever.

People depend on health care stories to make life-altering decisions every day.

Awards, Grants, & Fellowships

Ambitious freelancers who want to tackle an in-depth reporting project often find that the fee from a potential publisher doesn’t come close to covering their costs and time. Grants and fellowships can fill that gap, but freelancers have to know about them in order to apply. In this section, the Freelance Center is compiling a list of non-AHCJ grants, fellowships and awards (for when the hard work is done).

Sunshine Award

Presented by AHCJ’s Right-to-Know Committee

AHCJ’s Right-to-Know Committee established the Sunshine Award at Health Journalism 2026 as a way to elevate the work of journalists like STAT’s Bob Herman who fight for government transparency. We plan to continue this tradition annually from now on. Award winners receive free registration and a one-night hotel stay for our annual conference, a free year of AHCJ membership, a trophy and a certificate.

Journalism Epidemiology & Public Health Health Policy & Advocacy +2 more

Basic Needs and Income Creation

Bank Of America Charitable Foundation Inc
Private
Abbeville County, South Carolina, Ada County, Idaho +198 more
Unspecified amount
The Bank of America Charitable Foundation focuses on improving economic mobility and social progress through partnerships with nonprofits. It prioritizes basic needs, income creation, stable housing, and community empowerment. By supporting vulnerable populations, the foundation aims to enable individuals to achieve their goals and contribute positively to their communities. The foundation emphasizes sustainable progress, ensuring that all community members have access to essential resources and opportunities for growth.
Basic Human Needs Economic Services & Development Employment Services +2 more

Colon Cancer Coalition Get Your Rear in Gear Grants

Colon Cancer Coalition Foundation
Private
Bahamas, El Paso County, Texas +12 more
Unspecified amount
The Colon Cancer Coalition offers the Get Your Rear in Gear Grants to support local programs aimed at improving colon cancer screening and awareness. Open year-round, applications are reviewed biannually in February and August. Grants fund initiatives that educate the public about colon cancer and alleviate the financial burden on patients. By applying, organizations commit to promoting local events that raise funds for these important community programs.
Colon Cancer

Jacquelin Goldman Congressional Fellowship

American Psychological Foundation Inc
Private
United States
US $75,000 - US $90,000
The Jacquelin Goldman Congressional Fellowship offers developmental and clinical psychologists a unique opportunity to gain public policy experience while enhancing the application of psychological knowledge in government. Funded by the American Psychological Foundation, this fellowship supports one fellow annually with a stipend of $75,000 to $90,000, along with health insurance reimbursement and professional development funds. Applicants must demonstrate expertise in child psychology and policy issues, and have strong communication skills.
Psychology Children’s Mental Health Health Policy & Advocacy +1 more

Integrated Specific Pathogen Free Research Models and Human New Approach Methodologies to Advance HIV/AIDS Research (U42 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $212,004 - US $2,725,311
This funding opportunity aims to advance HIV/AIDS research by implementing human new approach methodologies (NAMs) to reduce the reliance on specific pathogen free (SPF) animal models. It emphasizes the integration of NAMs-enabled frameworks for in vitro testing while supporting essential SPF colony resources. The initiative seeks to enhance research rigor and reproducibility through innovative strategies that prioritize human-relevant models, ultimately improving HIV research outcomes and facilitating collaborative development in the field.
HIV / AIDS

Scleroderma-Related Lung Disease— The Debra Lurvey Memorial Research Grant

National Scleroderma Foundation
Private
United States
US $200,000
The Scleroderma-Related Lung Disease— The Debra Lurvey Memorial Research Grant, provided by the National Scleroderma Foundation, aims to support research in scleroderma-related lung disease. With a funding amount of $200,000, the grant encourages established investigators to explore innovative solutions and enhance understanding of this condition, ultimately working towards improving the quality of life for affected individuals and advancing medical knowledge in the field.
Rare Diseases Immune System Diseases Interstitial Lung Disease

Alzheimer’s Association: Center for Dementia Respite Innovation Grant (CDRI)

Alzheimer's Association
Private
United States
US $50,000 - US $100,000
The Alzheimer’s Association's Center for Dementia Respite Innovation Grant (CDRI) supports innovative respite care projects, aiming to improve person-centered dementia care across the U.S. With up to $20 million available over five years, the grant encourages local respite care providers to enhance their services through collaboration and innovative solutions. Recipients will receive training and assistance to ensure their programs are effective and sustainable, addressing the growing need for quality dementia care.
Dementia & Alzheimer’s Disease Caregiver Support / Respite Care

NMDP Barbara Buchbinder Nurse Research Program Grant

National Marrow Donor Program
Private
United States
US $25,000
The NMDP Barbara Buchbinder Nurse Research Program Grant supports pediatric BMT nurses conducting research to enhance transplant experiences and outcomes for children. With only 4% of federal funding allocated to childhood cancer, this program, honoring a dedicated nurse, aims to attract new talent to the field. Each selected Buchbinder Scholar receives a $25,000 award to pursue relevant investigations, emphasizing the importance of supportive care in pediatric allogeneic hematopoietic cell transplants.
Children’s Health & Pediatrics Hematological Systems Cell Biology +1 more

Large Grants for Nonprofit Organizations in Minnesota Highlights

Looking for large grants for nonprofit organizations in Minnesota?


Read more about each grant below or start your 14-day free trial to see all large grants for nonprofit organizations in Minnesota recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in Minnesota

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

300+ Large Grants for Nonprofit Organizations in Minnesota grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

100+ Large Grants for Nonprofit Organizations in Minnesota over $25K in average grant size

100+ Large Grants for Nonprofit Organizations in Minnesota over $50K in average grant size

49 Large Grants for Nonprofit Organizations in Minnesota supporting general operating expenses

200+ Large Grants for Nonprofit Organizations in Minnesota supporting programs / projects

1,000+ Grants on Instrumentl focused on Workforce Preparation & Job Readiness

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in Minnesota?

Most grants are due in the fourth quarter.

Q1
27.8%
Q2
24.1%
Q3
19.9%
Q4
28.3%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in Minnesota?

Grants are most commonly $49,999.

$300 $300 Min.
$49,999 $50 K Median
$524,264 $524.3 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for Minnesota?

Grants are most commonly $118,274.

$118,274

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in Minnesota year over year?

In 2024, funders in Minnesota awarded a total of 56,278 grants.

2022 54,862

2023 52,544

2024 56,278

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in Minnesota given out in Minnesota, the most popular focus areas that receive funding are Education, Human Services, and Philanthropy, Voluntarism & Grantmaking Foundations.

1. Education

2. Human Services

3. Philanthropy, Voluntarism & Grantmaking Foundations

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in Minnesota changing over time?

Funding has increased by -10.55%.

2022 $6,166,461,795

2023 $7,425,303,965
20.41%

2024 $6,642,167,971
-10.55%

Minnesota Counties That Receive the Most Funding

How does grant funding vary by county?

Hennepin County, Olmsted County, and Ramsey County receive the most funding.

County Total Grant Funding in 2024
Hennepin County $2,523,121,165
Olmsted County $1,922,001,946
Ramsey County $1,159,108,356
Washington County $321,318,471
Blue Earth County $287,516,198