Best Operating Grants for Nonprofits in Minnesota

The Therapeutic Giving program by Johnson & Johnson Innovative Medicine focuses on enhancing patient access to treatment in cardiovascular and metabolism areas. Nonprofit organizations classified as 501(c)(3) are eligible to apply for funding. The program emphasizes innovative initiatives that address healthcare disparities and improve patient outcomes through education, advocacy, and support services. Applications are evaluated based on design, capacity, and potential impact, with a preference for programs over event-based funding.

The Minnesota Department of Health is offering funding for innovative HIV Pre-Exposure Prophylaxis (PrEP) programs aimed at reducing HIV transmission in rural communities. With a total of up to $600,000 available, the initiative seeks to increase HIV screenings, referrals, and prescriptions, ultimately promoting health equity and supporting the local END HIV MN plan. Organizations that can effectively implement and evaluate these programs are encouraged to apply.

The Carl and Marilynn Thoma Foundation offers Special Project Funding to support innovative initiatives in the arts, particularly in under-resourced areas. This grant encourages collaborative projects that enhance community engagement and education, focusing on art exhibitions and scholarships in the greater Texas Panhandle. By fostering leadership and creativity, the Foundation aims to empower individuals and organizations to make a lasting impact in the fields of art and art history.

The US Dept. of Health & Human Services, through the Eunice Kennedy Shriver National Institute of Child Health and Human Development, is set to announce a funding opportunity focused on HIV research for pediatric and maternal populations. This initiative aims to foster innovative clinical trials addressing critical research areas in HIV, inviting collaborations from experts in various fields. Applications are not currently solicited, but potential applicants are encouraged to prepare for this opportunity.

The Bay Area Lyme Foundation Grant supports innovative research aimed at improving diagnostics and treatments for Lyme disease. With a revised granting schedule, proposals can be submitted year-round, with reviews conducted three times annually. The foundation welcomes applications from universities, hospitals, and independent entities across the U.S., emphasizing the importance of addressing challenges in diagnosing and treating Lyme disease, especially for difficult cases.

AmeriCorps Seniors RSVP Opportunity

About RSVP

Established in 1971 and now one of the largest senior volunteer programs in the nation, AmeriCorps Seniors RSVP engages people ages 55 and older in a diverse range of volunteer activities. AmeriCorps Seniors RSVP volunteers tutor children, help prepare simple taxes, assist victims of natural disasters, provide nutrition/food support, facilitate opioid and substance abuse education workshops, and serve in their communities in many other ways. AmeriCorps Seniors RSVP volunteers choose how, where, and how often they want to serve, with commitments ranging from a few hours to a maximum of 40 hours per week. While serving, AmeriCorps Seniors RSVP volunteers improve their own lives by staying active and civically engaged. 

Funding Priorities

AmeriCorps Seniors RSVP programming is designed to meet community needs. Applicants may propose activities intended to address community needs by thoroughly explaining the unmet need and activities to be completed by volunteers to address that need. In addition, AmeriCorps is interested in programming that addresses agency priorities. AmeriCorps Seniors RSVP priorities for this funding opportunity are:

• Supporting Older Adults and Caregivers: Provide respite, support groups, system navigation, care coordination, and resources for older adults, including custodial grandparents, and caregivers.
• Helping Older Adults Re-enter the Workforce: Offer job readiness, mentoring, training, and remove barriers to employment for older adults (volunteers provide services, not seek jobs).
• Building Strong Families: Support parents in helping children succeed, mentor parents, connect families to resources, and strengthen community partnerships.
• Preventing and Mitigating Fraud and Scams: Use digital navigators and other strategies to protect older adults from financial fraud and exploitation, including emerging AI-driven scams.
• Reducing Homelessness: Develop or renovate affordable housing, assist people experiencing homelessness in finding and maintaining permanent housing, and address housing needs for vulnerable populations.
• Supporting Behavioral Health Initiatives: Improve mental health, reduce isolation, prevent substance use, provide harm reduction tools (Naloxone, fentanyl test strips), peer support, and recovery services.

Award Funding Requirements

Applicants must construct the budget in the following manner. The federal share of the budget must not exceed $75,000 plus up to $350 for every unduplicated volunteer, whether or not they serve in an outcome-based work plan. 

The Arthur N. Rupe Foundation Grant focuses on promoting positive social change through scholarly studies, education, and public debate. It supports projects related to caregiving, civil debate, and public policy, aiming to enhance the quality of life in America. The foundation prioritizes specific project funding over general operations and does not support individuals or capital campaigns. Grant inquiries are invited through a letter of inquiry process, ensuring alignment with its mission.

The Ralph J. Torraco Scholarship for Therapy Sciences, provided by the UNICO Foundation, awards two scholarships valued at $2,500 each to full-time students pursuing degrees in Therapy Sciences, including physical therapy, occupational therapy, audiology, and speech-language pathology. Eligible candidates must be U.S. citizens with a minimum GPA of 3.0 and continue their studies in the 2026-2027 academic year. This scholarship promotes educational advancement within the community.

May Family Foundation

Eleanor Jean May established the May Family Foundation in 2000, as a gesture of gratitude to the communities that shaped her life. The May Family Foundation is dedicated to identifying programs that strongly resonate with our mission and values as we work together to empower and uplift lives within our communities.

Our foundation provides resources and opportunities that empower young individuals to thrive and reach their full potential. Our goal is to create a brighter future for under-resourced youth in our local communities.

May Family Foundation Mental Health & Counseling Grant

Our foundation strives to be engaged in our local communities beyond grant funding. We support select programs that align with our goals and form a connection through potential volunteering opportunities, site visits, and recognition of successes.

We welcome grant applications for financial support in mental health and counseling:

• Programs and services that improve life for those with physical and mental challenges.
• We support programs that help students deal with a mental health diagnosis and life stressors, to help navigate the changes that occur during early childhood development through college.

The Garden Club of America Board of Associates Centennial Pollinator Fellowship offers funding for research on pollinator decline, specifically targeting bees, bats, butterflies, and moths. This fellowship, established in 2013, supports graduate students in U.S. institutions with annual funding typically around $4,000. It aims to enhance knowledge in pollinator science while fostering a new generation of scientists dedicated to conservation. Recipients may reapply for additional funding in subsequent years.

The Fiscal Year 2026 National Dam Safety Program focuses on rehabilitating high hazard potential dams that do not meet state safety standards. Funded by FEMA, this initiative aims to protect lives and property by providing federal funds to eligible states, which then pass these funds to non-Federal governmental or nonprofit organizations. Rehabilitation involves repairing, replacing, reconstructing, or removing dams to ensure compliance with safety regulations.

The Forest Legacy Program (FLP) invites applications for FY2028 funding to safeguard privately owned forest lands through conservation easements or land purchases. This USDA Forest Service initiative collaborates with State agencies to protect vital forest ecosystems threatened by development. Participants can ensure the preservation of traditional forest uses and public benefits such as clean water, wildlife habitats, and recreational opportunities. For more details, visit the USDA Forest Service website.

This funding opportunity from the Patient-Centered Outcomes Research Institute aims to enhance health decision-making through comparative clinical effectiveness research, focusing on critical areas such as cancer, maternal health, and mental health. The initiative encourages robust observational studies that utilize existing data to derive patient-centered insights. Applications must address specific themes approved by PCORI and demonstrate potential benefits to the U.S. healthcare system, thus ensuring relevance and stakeholder engagement in research efforts.

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

Breast Cancer Screening & Prevention Initiative

The Breast Cancer Screening & Prevention Initiative, supported by the McKesson Foundation and administered by the NAFC, aims to expand access to lifesaving breast cancer screening and prevention services for uninsured and medically underserved. Through this initiative, the NAFC will provide $30,000 grants to members to establish or strengthen breast cancer screening programs in alignment with evidence-based guidelines from the U.S. Preventive Services Task Force and the American Cancer Society. Funding will support activities such as improving patient identification and referral systems, increasing access to mammography services through partnerships or mobile units, strengthening staffing and technology capacity, and providing patient education and case management to ensure follow-through with recommended screenings. By enhancing early detection and preventive care, the initiative seeks to reduce barriers to care and improve health outcomes for women who might otherwise go without critical cancer screening services.

The 15 and the Mahomies Foundation Grants aim to enhance the lives of children by supporting health, wellness, and community initiatives. This private foundation seeks to fund 501(c)(3) non-profit organizations, focusing on charitable causes. Grant requests are reviewed quarterly, and applicants must meet eligibility criteria. However, the foundation does not accept applications from individuals or for non-charitable items such as autographs or game tickets.

The Richard King Mellon Foundation invites proposals for the RKMF Innovative Wood Products and Value Chains Grant, aimed at fostering innovation in wood products and strengthening value chains. With a focus on rural economic development and environmental conservation, the Foundation supports projects that enhance the use of novel wood materials in the built environment. Eligible initiatives may include product development, market strengthening, and demonstration of new technologies to maximize the benefits of these innovations.

The Dr. Bruce D. J. Batt Fellowship in Waterfowl Conservation honors the legacy of Dr. Bruce Batt, a leading figure in waterfowl research. This fellowship offers up to $5,000 annually to graduate students at North American universities conducting vital research on waterfowl and wetlands. Renewable for up to two additional years for PhD students, the fellowship promotes the integration of sound science in conservation efforts, supporting the next generation of waterfowl professionals.

The Sustainable Forests and Communities Grant aims to foster environmentally and economically sustainable forest communities in the U.S., particularly where the Weyerhaeuser Family has interests. It prioritizes projects enhancing the environment, economy, and community through sustainable practices. Eligible organizations must be 501(c)(3) tax-exempt entities operating in forested areas, focusing on integrated approaches that value forest ecosystem services. This initiative encourages local job creation, sustainable economic activities, and innovative partnerships to achieve sustainability goals.

Hennepin County offers up to $106,000 in Aquatic Invasive Species Prevention Grants to support local governments and organizations in projects aimed at preventing the spread of aquatic invasive species. Typical awards range from $5,000 to $25,000, with a maximum of $50,000 available. Eligible recipients include local government agencies, nonprofits, and for-profit companies engaged in activities such as early detection, education, and research to combat invasive species.

The Emergency/Medical Workers Behavioral Health Fund aims to support emergency workers facing trauma and anxiety due to their roles. Established by the HealthWell Foundation, it provides financial assistance for treatment-related costs, including copayments for prescription drugs, counseling, and transportation. In 2024, the Foundation awarded over $1.2 billion to underinsured patients, ensuring no one is denied essential healthcare due to financial barriers. This initiative helps address the critical mental health needs of those who serve on the front lines.

The Family & Neighborhood Stability Grant by the McNeely Foundation aims to enhance the economic vitality and stability of youth and low-income families in East Side St. Paul. The foundation prioritizes organizations that provide financial literacy, supportive housing services, and employment training. It welcomes applications from tax-exempt non-profits and public agencies, focusing on programs that foster community development and individual empowerment. Grants are awarded primarily for program support, with a strong emphasis on data-driven strategies and community partnerships.

The WWT Foundation Grant aims to empower organizations aligned with the foundation's values, focusing on community service, employee engagement, and business impact. Key areas of support include career readiness, STEM education, human services, and health and wellness. Eligible organizations must be located in the U.S. and registered as 501(c)(3). Applications are accepted year-round, allowing for flexible engagement and support for impactful community initiatives.

The Dawn Foods Foundation Corporate Grants program is dedicated to enhancing community well-being through strategic investments in key areas like hunger prevention, education, community vibrancy, and volunteerism. With a strong commitment to improving lives, the foundation supports initiatives that promote health, literacy, and creative arts, while also encouraging team members to engage in volunteer efforts. Though applications for 2025 are closed, opportunities will reopen in 2026.

Young Health Programme

The Young Health Programme (YHP) is a global disease prevention initiative, aiming to provide education for young people to feel empowered to make informed choices about their health and catalyse a global, youth-led advocacy movement.

The programme operates in over 40 countries and partners with more than 60 non-profit organisations, including UNICEF and Plan International. The YHP combines community programmes, research, advocacy, and the development of young leaders, with a focus on underserved communities.

Since its launch in 2010, the YHP has directly reached over 23 million young people, trained over 1 million, and engaged more than 23,000 AstraZeneca employees, who have volunteered their time with more than 140,000 hours.

The YHP aims to prevent the most common non-communicable diseases (NCDs), including cancer, diabetes, heart disease and respiratory disease, by addressing five main risk factors: tobacco use, unhealthy diet, physical inactivity, harmful use of alcohol, and air pollution. Additionally, the programme tackles climate-health impacts to build healthier communities, recognising, as projected in the IPCC Sixth Assessment Report, that children born after 2010 will be the first generation to enter adulthood in a world where the average temperature will reach 1.5°C above pre-industrial levels, and are expected to experience a +2°C rise within their lifetime.1

AstraZeneca Young Health Programme Impact Fellowship 2026

AstraZeneca is looking for passionate, driven young leaders to join their 2026 Young Health Programme (YHP) Impact Fellowship. The Fellowship supports young advocates to create actionable change to: 

• Advance health equity – with a focus on acting early to prevent non-communicable diseases among young people, or supporting young people living with rare diseases.
• Take action on climate and nature – advocating for the mitigation of the harmful effects of climate change on the health and well-being of young people.
• Build health systems resilience – contributing to stronger health systems that prioritise earlier intervention to meet today’s needs and mitigate tomorrow’s disease burden.

Benefits

The selected Fellows will gain access to networks, funding and development opportunities, enabling them to drive a global health movement led by and for young people:

A fully-funded scholarship to attend the 2026 One Young World Summit in Cape Town, South Africa (3–6 November 2026) as well as access to the One Young World Ambassador Network and the Young Health Programme (YHP) Alumni group of other young changemakers working to improve youth health.

Structured learning and development offerings to enable them to scale their impact, including both self-directed and live learning. This includes access to the One Young World Academy, an award-winning mini-MBA programme, mentorship from AstraZeneca colleagues and professional training.

Each selected Fellow will receive a grant of either USD $10,000 or USD $50,000 (if selected as the Lead2030 winner** for Sustainable Development Goal 3, for which applicants will be automatically considered) from AstraZeneca, through their non-profit organisation. Fellows are expected to use the grant to implement a project focused on either (1) advancing health equity (2) taking action on climate and nature (3) building health systems resilience.

The John Lenard Civil Engineering Scholarship, established in 2008 by John Lenard, P.E., F.ASCE, supports undergraduate students pursuing civil engineering with a focus on water supply or environmental engineering. The scholarship aims to assist deserving students in covering tuition expenses. Awarded annually, it is limited to two recipients who demonstrate commitment to their field. The American Society of Civil Engineers, founded in 1852, oversees this scholarship, fostering excellence in civil engineering education.

The Empathy Building Initiative, led by Acton Family Giving, seeks to foster partnerships with organizations aligned with its mission. While currently not expanding its portfolio, it invites inquiries from potential partners. Eligible organizations must hold 501(c)3 status and align with specific giving areas. The initiative focuses on a national or broad reach and evaluates grant applications based on alignment and conversation. For more details, potential partners are encouraged to review the grants list available on their website.

BioMarin offers funding through its donation program focused on improving healthcare and patient advocacy, particularly for rare diseases. Organizations eligible for support include hospitals, accredited providers, and patient advocacy groups. BioMarin prioritizes innovative therapeutic solutions for rare genetic conditions. The company is dedicated to enhancing patient care and education, and it reviews funding requests year-round, although specific deadlines apply for year-end funding. This initiative reflects BioMarin's commitment to addressing unmet medical needs.