Best Large Grants for Nonprofit Organizations in Missouri

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing organ transplantation outcomes through the Clinical Trials in Organ Transplantation in Children and Adults (CTOT-CA) program. This initiative supports multicenter clinical trials and mechanistic studies related to heart, lung, kidney, liver, and intestinal transplants, as well as non-hematopoietic cellular transplantation. By exploring immune mechanisms and innovative therapies, the program aims to enhance the success and efficacy of organ transplantation.

GBA1 Parkinson's Disease Research Catalyst Program

The GBA1-PD Research Catalyst Program seeks to build a deeper, globally integrated understanding of GBA1-associated Parkinson’s disease by aligning efforts across geographies and maximizing the value of shared datasets and research assets. Funding will support hypothesis- driven projects with an emphasis on integrative, cross-cohort analyses and the systematic characterization and standardization of models to enable broad use by the research community.

Funding

Duration: 12 to 24 months

Award Amount: Up to $300,000. Requested support should be commensurate with work proposed.

These budgets include direct and indirect costs. For academic and for-profit institutions, no more than 15% or 10%, respectively, may go to indirect costs. 

The NIMH Career Transition Award (K22) supports tenure-track intramural investigators at NIMH in their transition to independent research faculty positions. This program aims to foster innovative research in mental health, encouraging applicants with a strong record of research excellence. Key deadlines for applications vary, including those for standard and renewal submissions, emphasizing the importance of timely applications to secure funding and advance mental health research initiatives.

This initiative aims to support research interventions targeting disparities in liver diseases and liver cancer among underserved populations in the U.S. It encourages innovative approaches to reduce health inequities and improve health outcomes. The funding opportunity is available through various deadlines for both standard and renewal applications, promoting multi-level strategies to address these critical health issues effectively.

The Gina M. Finzi Memorial Student Summer Fellowship Program, funded by the Lupus Foundation of America, aims to engage students in lupus research across various disciplines. Six awards of $4,000 each will be granted for projects spanning 10 weeks between May and September 2026. Eligible applicants include undergraduate and graduate/medical students, with specific allocation preferences. This initiative promotes valuable research experiences under the guidance of established faculty at accredited institutions.

The Cystic Fibrosis Foundation offers Postdoctoral Research Fellowship Awards to support research training in cystic fibrosis. The program provides up to $66,000 in salary support for the first year and $67,000 for the second year, along with $9,000 for research and travel expenses. Applicants focusing on CFTR protein function restoration or gene correction strategies are encouraged to apply. Open to U.S. citizens and residents, preference is given to recent graduates beginning their research careers.

The Updated National Dislocated Worker Grant Program Guidance informs workforce development systems about the policies and priorities for using National Dislocated Worker Grant funds. This guidance outlines grant types, funding approaches, performance periods, cost limitations, and application requirements. It emphasizes the critical role of DWGs in supporting economic recovery, community resilience, and equitable workforce development, ensuring that these funds effectively contribute to creating good jobs and enhancing local economies.

About

Central Carolina Community Foundation is a nonprofit organization that helps generous people give back to the Midlands of South Carolina in ways that matter. Since 1984, we’ve been a trusted partner, helping individuals, families, and businesses make smart, meaningful contributions that support local nonprofits, scholarships, and community projects.

Estelle Jones Non-Traditional Students Scholarship ($2,000)

This renewable scholarship is designed to support students who are residents of Richland County School District One. 

Transportation Assistance Grant

The Transportation Assistance Grant program was established to help members of the MS community remain as independent as possible, and ensure all people with MS have the transportation necessary to get the best medical care.

The program provides funding for reasonable paratransit fees. In partnership with Lyft and Uber, the program can also provide funding for transportation to and from appointments for MS care, limited to neurologist visits and infusion centers, at no cost to the person with MS.

The APRA AMCOS Global Professional Development Award, offered by the American Australian Association, provides US$10,000 to an emerging or mid-career Australian artist for career development in the United States. This includes opportunities for recording, collaboration, and travel. Applicants must be APRA AMCOS members and demonstrate how their project enhances cross-cultural exchange. The scholarship supports artistic growth in various fields, fostering connections between Australia and the USA.

About Legacy Foundation

Legacy Foundation is the community foundation for Lake County, Indiana. We connect people, knowledge, and funding to build an equitable, accessible, and inclusive Lake County, now and for generations to come.

Legacy Foundation is supported by a broad base of individuals, families, and businesses connected by the desire to improve Lake County, Indiana. With a growing portfolio of over 300 funds and approximately $80 million in assets, Legacy Foundation is a trusted source for philanthropic giving in the region.

For over 30 years, Legacy Foundation has been empowering people, providing strategic leadership, and impactful philanthropic support to create an equitable Lake County where all people thrive.

Mission Statement

Transforming Lake County by providing strategic leadership and impactful philanthropic support to ensure equitable opportunity for all communities that we serve.

Vision Statement

Create an equitable Lake County where all people thrive.

Cenifax Scholarship

Use the chart below to see which scholarships are the best fit for you! You must complete the Legacy Universal Application to apply.

Scholarship eligibility requires students to attend an accredited 2 or 4 year public or private institution of higher learning. All scholarships are for full-time students, unless otherwise noted. Renewable awards are for 4 years of undergraduate study and cannot be used for post graduate coursework; all awards are paid directly to the school or may be used for book reimbursement.

The DoW Bone Marrow Failure Idea Development Award supports innovative, high-impact research aimed at understanding and curing bone marrow failure diseases. This grant is available to both Established Investigators and Early-Career Investigators, with no preliminary data required for applications. Reviewers assess proposals based on specific criteria tailored to the investigator's career stage. The focus is on achieving interpretable results that contribute significantly to the field.

The Classics for Kids Matching Grant Program, established by the Classics for Kids Foundation, aims to enhance music education for at-risk and rural youth by providing matching grants for fine stringed instruments. Since 1998, over $2 million has been allocated to support more than 300 programs across all 50 states. Schools and non-profits demonstrating need and commitment are encouraged to apply, fostering lifelong benefits of music participation and education.

The CART Fund Grant supports innovative Alzheimer’s Disease research projects in the U.S. with funding up to $500,000 for a two-year period. It invites full-time faculty from public and private institutions to submit Letters of Intent, emphasizing novel concepts that advance biomedical knowledge. Selected finalists will be invited to apply for standard grants. The initiative aims to foster groundbreaking research initiatives lacking extensive preliminary data, ensuring a focus on projects with transformative potential.

The DoW Bone Marrow Failure Investigator-Initiated Research Award supports innovative research aimed at advancing the understanding and treatment of bone marrow failure. This funding opportunity encourages applications for translational and clinical studies, requiring preliminary data to strengthen proposals. Unique features include the ability for a partnering Principal Investigator to contribute to the research, thereby fostering collaboration while maintaining a focus on significant advancements in patient care.

The FY26 Bone Marrow Failure Research Program's Resource Development Award aims to create a multiomic atlas from human bone marrow failure samples. This resource will be open-access, providing essential data for researchers and clinicians to enhance their understanding of bone marrow failure diseases. A comprehensive Data Resource Sharing Plan is required to ensure timely availability of the developed resource, fostering collaboration within the scientific community.

The OJJDP FY 2026 Internet Crimes Against Children (ICAC) Task Force Program Support aims to fortify a national network of 61 multiagency task forces dedicated to combating child sexual exploitation facilitated by technology. This funding opportunity enhances training, prevention, and outreach efforts while fostering collaboration among law enforcement entities. Applications are due in JustGrants by November 9, 2026, at 8:59 p.m. ET, ensuring timely support for critical initiatives to protect children.

The Earthwatch Institute's Teach Earth Fellowship connects K-12 teachers with scientists through immersive research expeditions. Celebrating 50 years, this program empowers educators to inspire students with hands-on environmental science experiences. Teachers gain confidence, collaborate with peers, and develop impactful curricula. The fellowship includes workshops, networking opportunities, and resources to enhance environmental education in classrooms. Participants return with renewed purpose, ready to engage their communities in conservation efforts.

The Risk and Protective Factors of Family Health initiative invites research proposals to explore family health and resilience, addressing health disparities in minority communities. Key submission deadlines are set for various dates from February 2025 to February 2027. This program is supported by the National Institutes of Health, highlighting the importance of family well-being as a critical area for advancing health equity. Proposals should focus on interventions that improve family health outcomes.

The FY26 Parkinson’s Research Program Investigator-Initiated Research Award supports innovative, multidisciplinary research projects aimed at advancing the understanding and treatment of Parkinson’s disease. The award encourages collaboration among multiple principal investigators, requiring preliminary data and allowing clinical trials to enhance research outcomes. This initiative is vital for fostering impactful discoveries within the four specified focus areas of the program, ultimately improving patient care and management.

The NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required) grant invites applications for mid-phase clinical trials focusing on natural products such as botanicals and dietary supplements. It aims to advance scientific knowledge by determining optimal dosing and patient responses. Applicants must provide preliminary data demonstrating bioavailability and measurable impacts on target engagement. This initiative will not support efficacy trials for cancer treatments and encourages early contact with NCCIH scientific contacts.

The NCCIH Natural Product Early Phase Clinical Trial Award supports innovative clinical trials of natural products, such as botanicals and dietary supplements, with a strong scientific basis. Applications are encouraged to explore optimal delivery methods and combinations with other treatments. Funding is available for up to three years to assess the impact on target engagement and clinical outcomes, aiming to translate basic science findings into practical clinical applications.

The NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33) invites research proposals for early phase clinical trials of natural products, including botanicals and dietary supplements, emphasizing scientific validity for further testing. Applicants may receive up to three years of funding for pharmacokinetics and bioavailability studies, with potential for an additional three years to evaluate clinical outcomes. This initiative aims to optimize natural product delivery through innovative study designs.

The FY26 Parkinson’s Research Program (PRP) Early Investigator Research Award supports early-career researchers in Parkinson’s disease (PD) research. It offers two funding levels: Level 1 for fellows requiring a Mentor and Level 2 for independent investigators. The PI must show potential in PD research, with Level 1 emphasizing mentorship and Level 2 needing preliminary data. Research must align with one of the four FY26 PRP Focus Areas, excluding clinical trials.

Camillo Family Scholarship 

Benefiting dependents of Camillo Properties, Camcorp Entities, or LCI Services employees.

The Camillo Family Scholarship was created to provide dependents of employees of Camillo Companies (Camillo Holdings, LCI Services, Legend Homes, Millmark Capital, and SimplyHome) with scholarships to further their education.

This is a renewable scholarship, meaning recipients can renew the award and claim up to 4 years of funding if they meet the GPA and enrollment requirements and complete the renewal application for each academic year they plan to be enrolled.

Multiple scholarships awarded for the 2026-27 academic year. Award amount varies by college/degree type:

• 4-Year College/University - The scholarship is comprised of up to four annual awards of $5,000, for a total award of up to $20,000. The four annual awards may be received over a period of up to five years.
• 2-Year College/Trade School - The scholarship award is comprised of up to two annual awards of $2,500, for a total award of up to $5,000. The two annual awards may be received over a period of up to three years.

What can the scholarship be used for?

The scholarship will be mailed directly to the student's college to be used towards tuition, required academic fees, and/or book expenses. 

Scholarship funding cannot be distributed directly to the student. 

About Legacy Foundation

Legacy Foundation is the community foundation for Lake County, Indiana. We connect people, knowledge, and funding to build an equitable, accessible, and inclusive Lake County, now and for generations to come.

Legacy Foundation is supported by a broad base of individuals, families, and businesses connected by the desire to improve Lake County, Indiana. With a growing portfolio of over 300 funds and approximately $80 million in assets, Legacy Foundation is a trusted source for philanthropic giving in the region.

For over 30 years, Legacy Foundation has been empowering people, providing strategic leadership, and impactful philanthropic support to create an equitable Lake County where all people thrive.

Mission Statement

Transforming Lake County by providing strategic leadership and impactful philanthropic support to ensure equitable opportunity for all communities that we serve.

Vision Statement

Create an equitable Lake County where all people thrive.

Anderson Foundation Scholarship

Use the chart below to see which scholarships are the best fit for you! You must complete the Legacy Universal Application to apply.

Scholarship eligibility requires students to attend an accredited 2 or 4 year public or private institution of higher learning. All scholarships are for full-time students, unless otherwise noted. Renewable awards are for 4 years of undergraduate study and cannot be used for post graduate coursework; all awards are paid directly to the school or may be used for book reimbursement.

The Advanced Rehabilitation Research Training (ARRT) Program, funded by the US HHS: Administration for Community Living, aims to enhance the capabilities of individuals with advanced degrees in conducting high-quality research focused on health and function outcomes for people with disabilities. The program offers advanced training opportunities over a 36-month period, specifically targeting rehabilitation researchers, including those with disabilities, to foster multidisciplinary approaches in disability and rehabilitation research.