Best Operating Grants for Nonprofits in Missouri

BOK Charitable Contributions aims to enhance community life and economic wellbeing across several states, focusing on four key pillars: United Way, economic development, education, and basic needs. The foundation supports organizations that address poverty, education, and community health. Their strategic approach ensures impactful contributions, and they welcome grant applications year-round. BOK Financial's commitment is evident in its partnerships with local nonprofits, fostering sustainable growth and development in the regions they serve.

The Water & Waste Disposal Loan & Grant Program in Missouri provides essential funding for rural households and businesses to access clean drinking water, sanitary sewage disposal, solid waste management, and storm water drainage. This program aims to support areas that cannot secure commercial credit, helping eligible applicants such as local governments and nonprofits. Funds can be used for construction, improvements, legal fees, and equipment, ensuring a sustainable and reliable infrastructure for communities.

The Employees Community Fund (ECF) of The Boeing Company supports charitable organizations in the St. Louis area through grants focused on Health and Human Services, Education, Arts & Culture, and Civic Engagement. Applications for 2024 will be accepted from April 1 to June 30, with odd-numbered years prioritizing health initiatives. ECF has invested over $165 million in the community, empowering employees to make a significant impact through collaborative giving.

The Helen S. Boylan Foundation, established in 1982, aims to enhance community life in Carthage, Missouri, the Greater Kansas City Area, and Lindale, Texas. It provides quarterly grants to non-profit organizations focused on arts, education, health, and wellness. The foundation prioritizes innovative projects and multi-year funding for initiatives benefiting local citizens. Eligible recipients include 501(c)(3) nonprofits, while grants for individuals or sectarian activities are excluded. Proposals should focus on new initiatives or capital improvements.

The Penn National Gaming Foundation Grants support various community initiatives across North America, emphasizing education, health services, and cultural affairs. Launched post-Hurricane Katrina, the foundation aids local nonprofits, enhancing community development, public safety, and veteran support. The grants cater to organizations that address the needs of children, senior citizens, and disadvantaged populations, ensuring a broad impact in areas where Penn National Gaming operates. This commitment reflects the foundation's dedication to uplifting communities and fostering resilience.

The Research Foundation is launching community grants to enhance health access and equity in Kansas City, particularly for Jackson County residents. Eligible nonprofit organizations can receive support for programs that align with the foundation's priorities, including a 10% allowance for indirect costs. The focus is on health-centric missions, ensuring the funding promotes care access and workforce retention in the healthcare sector, while adhering to the foundation's guidelines.

The Community Foundation of Central Missouri (CFCM) offers the Impact Grant, a $5,000 funding opportunity designed to significantly address critical issues in mid-Missouri. This grant focuses on human capacity development for disadvantaged individuals or arts initiatives. Eligible applicants must be 501(c)(3) organizations based in central Missouri and operational for at least five years. Projects may target equal opportunity, education, and senior services, among others, adapting to community needs over time.

The Cigna Foundation is dedicated to enhancing veteran mental health through strategic partnerships with nonprofit organizations. This initiative targets the alarming issue of homelessness among veterans, with nearly 40,000 veterans without shelter nightly and 1.5 million at risk. By funding evidence-informed programs, the foundation aims to increase access to permanent housing, improve affordability, and provide essential wraparound services, ultimately fostering mental health stability and resilience within veteran communities.

The Arts and Healing Initiative aims to support arts, social service, and health organizations in implementing arts-based wellness programs. This initiative will enhance the healing process and improve the quality of life for individuals and their families in the St. Louis region. With a strong backing from the Arts and Education Council, the initiative continues a legacy of over $100 million in grants aimed at fostering community health through the arts.

The Kerr Foundation Inc. offers grants to 501(c)3 organizations, focusing on education, arts, health, and human services. Priority is given to Oklahoma entities, but applications from neighboring states and Washington D.C. are also accepted. The foundation supports various project types, including capital, program, and operating expenses. Note that back-to-back grants are not allowed, enforcing a three-year gap for reapplication after funding. This ensures a broad and impactful reach for community development.

The Dana Brown Charitable Trust Grant supports organizations in the St. Louis area that aid financially disadvantaged children, focusing on health, education, and welfare. It encourages programs that expand children's knowledge of nature and wild animals. The Trust favors collaborative, high-impact projects and prioritizes immediate needs over long-term funding. Notably, individual grants are not awarded directly to individuals, and only one Letter of Intent is permitted per year.

The L-A-D Foundation Grant Program, established in 1962, is dedicated to conserving the natural and cultural resources of the Missouri Ozarks. Through partnerships and community support, the Foundation has awarded over $600,000 in grants to eligible 501(c)(3) organizations. Projects may focus on conservation education, community engagement, and innovative initiatives within a 12-county service area. The program encourages applications that align with its mission to enhance ecological and cultural sustainability.

The Bayer Fund Health & Wellness Grant Program aims to support organizations that provide education and resources for patients and caregivers facing cancer and cardiovascular diseases. Grants focus on assisting communities, particularly the African American population, in managing these health issues. Funding covers educational services, disease awareness, and access to care, with all activities to commence post-funding decisions. Eligible organizations must hold a 501(c)(3) status and operate within 55 miles of Bayer sites.

The Christine and Katharina Pauly Charitable Trust Grant supports educational, health, and human services for underserved populations in Springfield, Missouri. Established in 1985, it prioritizes programs benefiting children and older adults, focusing on systemic school improvement, effective healthcare delivery, and strengthening community safety nets. Grants typically last one year, with special consideration for organizations with operating budgets under $1 million. This trust aims to enhance the quality of life for vulnerable populations in the region.

The Emergency Community Water Assistance Grants in Missouri provide vital funding for eligible rural communities to prepare for or recover from emergencies affecting safe drinking water. This program, supported by USDA Rural Development, enables grants for water transmission lines and source construction, ensuring access to reliable water in the wake of disasters like floods and droughts. By fostering partnerships and encouraging sustainable practices, it aims to enhance water security and support community resilience.

Toyota Motor Manufacturing, Missouri, Inc. (TMMMO) Grants aim to enhance community quality of life through strategic partnerships with nonprofits. By focusing on STEM education and workforce readiness, Toyota seeks to create inclusive opportunities that empower individuals and foster sustainable growth. The program emphasizes a holistic approach, engaging volunteers and leveraging Toyota's expertise to maximize social impact in Missouri. Eligible applicants include 501(c)(3) organizations, public schools, and municipal entities, while maintaining a commitment to non-discrimination.

The Neighborhood Assistance Program (NAP), administered by the Missouri Department of Economic Development, provides tax credits to incentivize donations for community projects. Aimed at enhancing community service, education, and revitalization, NAP offers up to $16 million in credits, with a maximum of $500,000 per project. Eligible applicants include nonprofits and businesses, while donors can receive credits up to 70% for their contributions. Attend the virtual workshop on April 1, 2025, to learn more about applying.

The Zero KC Grant is a vital initiative by the City of Kansas City aimed at addressing homelessness through innovative funding. By fostering collaboration among local agencies, the grant seeks to create a comprehensive system of services, including outreach, transportation, and permanent housing. It encourages partnerships to effectively support individuals facing barriers to housing, such as mental health issues and substance use disorders. This initiative not only addresses immediate needs but also promotes long-term solutions, ensuring that every Kansas Citian has access to safe shelter.

The Policy Campaign Grants by the Deaconess Foundation empower organizations to drive systemic change through policy advocacy and grassroots efforts. With funding up to $100,000, these grants aim to support urgent campaigns that enhance voter engagement and community organizing. By strengthening local movements, the foundation seeks to address racial and structural inequities in Eastern Missouri and Southern Illinois, fostering a path towards liberation and community well-being.

The Elevance Health Foundation's Behavioral Health Grant aims to address significant challenges in mental health and substance use disorders. With a commitment of up to $90 million over three years, the Foundation seeks partnerships with nonprofits to enhance treatment access, promote prevention strategies, and alleviate loneliness among affected individuals. This initiative emphasizes innovative solutions and measurable outcomes, targeting both national and local programs, particularly in states with pressing health disparities.

Enterprise Community Partners

Enterprise Community Partners (Enterprise) is a national nonprofit that exists to make a good home possible for the millions of families without one. We support community development organizations on the ground, aggregate and invest capital for impact, advance housing policy at every level of government, and build and manage communities ourselves. Since 1982, we have invested $80.9 billion and created 1 million homes across all 50 states, the District of Columbia, Puerto Rico and the U.S. Virgin Islands – all to make home and community places of pride, power and belonging.

Midwest Asset Management University Program

Operating, maintaining, and preserving affordable housing is complex and requires a specialized set of skills and a deep organizational commitment to asset management. Today, affordable housing providers face a variety of economic, operational, and compliance challenges, including rising operating costs, rental arrears, staffing shortages, and an aging portfolio.

Enterprise is launching its first Asset Management University (AMU) Program in the Midwest (Illinois, Indiana, Wisconsin, Missouri, and/or Minnesota) in March 2026 to support mission-aligned, affordable housing providers in meeting these challenges in their efforts to provide housing stability to residents and preserve the long-term affordability of properties.

The Midwest AMU is a comprehensive, five-month training program that seeks to strengthen the asset and property management capabilities of participating housing providers, improving organizations’ capacity to oversee the financial, physical, and operational health of their housing portfolios.

Midwest Asset Management University Cohort 

Enterprise is excited to offer this application for participation in the Asset Management University (AMU) Cohort (the “Cohort”). Up to fifteen (15) eligible organizations will be selected for this Cohort and will receive access to online training offered by the Consortium of Housing and Asset Management (CHAM), peer learning opportunities, and post-training technical assistance.

The Jelley Family Foundation Endowment for Children's Education Fund, established in 2013 by Dr. Carl Jelley, supports educational initiatives for children in Eastern Jackson County, Missouri. With an average grant award of $5,000-$8,000, and a maximum of $10,000, the foundation encourages innovative proposals focusing on at-risk youth. Eligible organizations include 501(c)(3) nonprofits and public education institutions, with a new 3-year funding rule starting in 2024 to enhance sustainability in educational projects.

Who We Are & What We Do

On November 26, 1997, a small group of citizens with an abundance of enthusiasm embarked on a mission to secure the quality of life in our region now and forever. By yearend, they had a modest $1,050. Through commitment and vision, the Quincy Area Community Foundation expanded and grew to become the Community Foundation Serving West Central Illinois & Northeast Missouri. 

Serving 12 counties on both sides of the Mississippi River, we operate as a bridge between our donors’ charitable visions and the nonprofit organizations that bring those visions to life. 

Robert & Barbara Girouard Endowment

About the Fund

Enlisting in the United States Air Force was one of the best decisions Robert (Bob) and Barbara (Barb) Girouard ever made. In fact, the two met at Iraklion Air Station in Crete, Greece and credit the military for creating an “avenue of success”.

“We have been so incredibly blessed. Serving in the Air Force gave us job opportunity, education and lifelong friends that we never imagined we would have growing up, so now we feel it is time to give something back,” said Barb.

When Bob and Barb were looking to make a difference in the community where they have spent their adult life, they decided to create an endowment fund at the Community Foundation to support veterans in West Central Illinois and Northeast Missouri by establishing the Robert and Barbara Girouard Endowment.

Grant Purpose

The Robert & Barbara Girouard Endowment provides financial support to postsecondary and vocational training institutions for the support of Veterans’ education. Grants may be used to provide financial assistance for honorably discharged Veterans, including tuition, books, fees, and related expenses for honorably discharged Veterans or for the support of educational or vocational training and programs offered to Veterans.

The THCF Community Grants program offers funding for up to three years for eligible 501(c)(3) nonprofits and local government organizations in Eastern Jackson County. Proposals can focus on areas such as arts, education, community betterment, and health services. Notably, applicants may only seek funding from one grant program, either Community Grants or the Jelley Family Foundation Grants, starting in 2024. This initiative aims to foster community growth and support diverse local projects.

United Way of Greater St. Louis

Our Mission: The United Way of Greater St. Louis mission is to mobilize the community with one goal in mind – helping people live their best possible lives. We unite people, resources and funding to help build strong and equitable communities where everyone can thrive.

Safety Net

United Way’s Safety Net is a collaborative network of agencies that deliver an array of essential direct services to address the region’s most pressing needs, helping families and individuals remain and work toward stability. Safety Net agencies provide direct services that address basic, urgent needs – such as access to food and housing— as well as supports that help move individuals and families toward stability, including education, health and well-being, workforce access, and financial mobility.

Safety Net Funding

United Way of Greater St. Louis is now accepting applications for its Safety Net Funding cycle and invites all eligible agencies across its 16-county region in Missouri and Illinois, including those not currently receiving United Way funding, to apply. United Way equips 160 local nonprofits with vital funding and training resources to support measurable impact across its five impact areas. Organizations selected will receive a three-year contract and become part of the UWGSL member agency network.

United Way’s Impact Areas

• Basic Needs 
• Community Stability and Crisis Response 
• Early Childhood and Youth Success 
• Health and Wellbeing 
• Jobs and Financial Mobility 

While needs are great across the five impact areas, United Way will use data derived from its landscape analysis of community needs to inform how service areas will be prioritized to ensure the region has access to a strong and resilient network as needs arise.

Community Foundation of the Quincy Area

My Community Foundation (also known as The Community Foundation Serving West Central Illinois & Northeast Missouri) is a tax-exempt 501(c)(3) nonprofit organization dedicated to improving quality of life in the communities it serves by connecting compassionate donors with meaningful causes. The foundation works with individuals, families, businesses, and nonprofit partners to gather charitable contributions, grow those funds through professional investment strategies, and grant the earnings in ways that address local needs now and into the future. It builds and manages permanent endowments tailored to donors’ goals, ensuring their philanthropic visions—whether honoring a loved one, establishing a legacy, or supporting community needs—are realized. Serving a 12-county region across West Central Illinois and Northeast Missouri, the foundation acts as a steward of charitable assets, helping donors make a lasting impact through customized giving opportunities, community grants, and strategic support for nonprofit organizations.

AgForward Program for Agricultural Education

AgForward Program for Agricultural Education provides grant funding to support education, innovation, and workforce development in the field of production agriculture. Grants from the fund will promote and benefit education relating to production agriculture at any educational level throughout the Community Foundation’s service area. Funded programs must directly involve and/or impact students. Grants must be for project or program support. Grants may not be used for scholarships or general operating support.

Priority will be given to applicants whose proposals demonstrate one or more of the following:

• Educational projects and programs that seek to advance the field of production agriculture in the Community Foundation’s service area.
• Programs to encourage or inspire agricultural careers and/or to develop a skilled agricultural workforce at any education level.
• The development of and training in technologies and techniques that will enable agriculture to be more productive, efficient, and safe.

The Elevance Health Foundation's Food as Medicine Grant aims to enhance access to nutritious foods and improve health outcomes for individuals facing diet-related conditions. This initiative invites qualified nonprofits to submit proposals focused on scalable solutions that address food insecurity and promote health equity. The foundation prioritizes programs that demonstrate measurable outcomes and support whole-person health, particularly for populations at high social risk. Grants will be awarded for a term of 1-3 years, with funding based on program needs.