Best St. Louis Grants for Nonprofits in Missouri

Community Foundation of the Ozarks

The Community Foundation of the Ozarks (CFO) provides philanthropic leadership to build stronger communities. Our mission is to enhance the quality of life in our region through resource development, community grantmaking, collaboration and public leadership.

We help donors achieve their philanthropic goals through professional management and investment of charitable funds. We work with nonprofit organizations to help them fulfill their missions through fund administration, grantmaking and learning opportunities. We award scholarships to deserving students to help them achieve their educational goals.

Cardinals Fly Together Fund — School Matching Grants

The Springfield Cardinals Fly Together Fund has been created to provide grants to area schools to give students the opportunity to attend a Springfield Cardinals (AA Affiliate of the St. Louis Cardinals) home baseball game. Educational Day Field Trips are an excellent opportunity to incorporate learning through various pre-game educational topics along with the experience of attending a live sporting event.   

Matching grants may be awarded as full or partial requests to provide an amount equal to the amount contributed by the school for a Springfield Cardinals educational day field trip. For example, a full grant will cover 50% of the ticket cost for tickets requested through the grant. A partial grant will cover 25% of the ticket cost for tickets requested through the grant. (Transportation costs and food & beverage expenses are the responsibility of the school and not included in the grant.)

Mission

The Social Science Research Council (SSRC) is an independent, international, nonprofit organization founded in 1923. The Council fosters innovative research, nurtures new generations of social scientists, deepens how inquiry is practiced within and across disciplines, and mobilizes necessary knowledge on important public issues.

Driving University Impact: Expanding the Public Exchange Network

With generous support from the William and Flora Hewlett Foundation, the Social Science Research Council is pleased to invite U.S. R1 research universities in SSRC’s College and University Fund for the Social Sciences to apply for funding to join the Public Exchange Network. Public Exchange is a new network that turns university research expertise into real-world action and impact. Foundedat the University of Southern California in 2020 and expanded to Washington University in St. Louis in 2025, Public Exchange connects researchers with government, nonprofit, and industry partners to tackle pressing challenges—from disaster recovery and climate solutions to food insecurity and homelessness prevention. Since its founding, Public Exchange has developed high-impact collaborations between 48 partners and 142 researchers including:

• CLEAN LA and CLEAN STL: One of the largest free soil testing programs for lead in Los Angeles County following the January 2025 wildfires, and a related program in St. Louis to test soil and air for contaminants following the May 2025 EF-3 tornado;
• The California Solar Canal Initiative: An ambitious public-private research collaboration to advance solar panel infrastructure along California’s 4,000 miles of open aqueduct, conserving water and generating renewable energy;
• Food Base LA: LA County’s first food systems data dashboard, helping LA County and non-profit partners target distribution of millions of pounds of food and related resources to families experiencing food insecurity;
• ShadeLA: A people-powered campaign to cool Los Angeles ahead of the 2028 Olympics and Paralympics by advancing natural and built shade cover in the region.

Partners have included the City and County of Los Angeles, the State of California, the City of St. Louis, Yelp, Solar AquaGrid, the United Nations Foundation, Keck Medicine of USC, the Southern California Association of Governments, Santa Clarita Valley Water Agency, the Sustainable Entertainment Alliance, the Los Angeles Regional Food Bank, Department of Angels and many more. In addition to real-world impact positively affecting millions of lives, Public Exchange collaborations have resulted in over $18m in research funding, some helping to incubate new centers or areas of research, more than 40 academic journal publications, hundreds of media hits, and dozens of student career opportunities. 

The Public Exchange Model

Public Exchange is a partner-driven program, working collaboratively with external partners to: (1) define a research scope, timeline, and deliverables; (2) identify the right team of multidisciplinary academic experts to analyze the problem; (3) provide project management from concept and strategy development to project outputs and tools delivery; and (4) manage the public and stakeholder engagement related to the project, as well as communications and design needs. Public Exchange staff are not researchers, but come from government, industry, and non-profit backgrounds, uniquely equipping project teams to understand partners’ needs and lead projects to action. Staff oversee activities including partnership and proposal development, funder cultivation, research translation, dissemination, and communications, impact and scaling strategy, administrative support, cross-sector convening, and more, to maximize the real-world impact of university expertise. Public Exchange builds results-driven teams that deliver measurable impact and lasting solutions for partners.

How the Public Exchange Network Works

No single university – even a large R1 – has enough faculty expertise available to meet the needs of every partner. The Public Exchange Network was designed to help universities work together seamlessly to build robust partnerships and generate more collective impact. Universities joining the network are independent but affiliated members, with full control over their own program and project portfolios. As a national network with local, on-the-ground capacity, Public Exchange Network members can also share approaches that work, scale solutions to common problems, and build cross-regional partnerships together. 

As an institutional partner in the Public Exchange Network, universities will build capacity to develop, test and implement solutions to the most urgent problems in their regions and beyond. Universities joining the Public Exchange Network get:

• The tools, templates and training they need to start right away;
• A shared brand they can plug into on day one;
• A network of faculty, past and potential partners and philanthropic relationships, benefitting everyone in the network. 

SSRC Public Exchange Network Expansion Grants

Public Exchange Network Expansion grants will cover 75-80% of the minimum estimated annual costs for two years to launch a new Public Exchange. To launch a Public Exchange, universities must have the following in place: (1) a staff executive director with experience launching and leading social impact partnerships, (2) a project seed fund, and (3) a modest operations budget. We also recommend some in-kind project management support from an existing university staff member. The grant includes a two-year Public Exchange Executive Director (ED) compensation subsidy of $300,000 to launch the Public Exchange on campus, and a 2-year license to use the Public Exchange brand. New Public Exchange Network members will also receive ongoing support and guidance from current Public Exchange leadership and staff at USC and WashU, including recruitment support and intensive training for hiring and onboarding an executive director, a sub-site on the Public Exchange website, incubation and project management support from current Public Exchange staff, and a suite of tools for developing and implementing Public Exchange projects.

In addition, every university in the Public Exchange Network benefits from central communications support (currently housed at USC), and access to a collaborative network of project partners, researchers, and funder relationships. Separately, SSRC will select a local research fellow to study and document how the Public Exchange model develops within and between host institutions during the grant term, and how the Public Exchange Network universities work together to effect larger-scale change. 

Expectations

Institutions selected to join the Public Exchange Network are expected to:

• Hire an Executive Director who can launch and lead efforts to incubate social impact projects with public and private sector partners;
• Have in place before public launch: (1) an executive director, (2) a seed fund, (3) a modest operations budget, and (4 – recommended) some in-kind project management support. 
• Develop and sustain at least three high-impact research partnerships during the two-year grant tenure;
• Invest modest resources during the grant term that demonstrate commitment to continuing the Public Exchange model after the end of philanthropic support. This is estimated at approximately $85-$90k annually (with some variation considering local labor markets) to support an operations and project seed fund and any additional capital needed for the Executive Director hire beyond the subsidy. 
• Coordinate with the SSRC research fellow who will examine the impact of Public Exchange at their university and across the network. 
• Work with faculty across their university. Public Exchange can live anywhere within a university at the school or central level. The majority of Public Exchange projects to date at USC and WashU have included researchers from two or more schools, and grantees must be able to work with faculty university-wide. 

United Way of Greater St. Louis

Our Mission: The United Way of Greater St. Louis mission is to mobilize the community with one goal in mind – helping people live their best possible lives. We unite people, resources and funding to help build strong and equitable communities where everyone can thrive.

Safety Net

United Way’s Safety Net is a collaborative network of agencies that deliver an array of essential direct services to address the region’s most pressing needs, helping families and individuals remain and work toward stability. Safety Net agencies provide direct services that address basic, urgent needs – such as access to food and housing— as well as supports that help move individuals and families toward stability, including education, health and well-being, workforce access, and financial mobility.

Safety Net Funding

United Way of Greater St. Louis is now accepting applications for its Safety Net Funding cycle and invites all eligible agencies across its 16-county region in Missouri and Illinois, including those not currently receiving United Way funding, to apply. United Way equips 160 local nonprofits with vital funding and training resources to support measurable impact across its five impact areas. Organizations selected will receive a three-year contract and become part of the UWGSL member agency network.

United Way’s Impact Areas

• Basic Needs 
• Community Stability and Crisis Response 
• Early Childhood and Youth Success 
• Health and Wellbeing 
• Jobs and Financial Mobility 

While needs are great across the five impact areas, United Way will use data derived from its landscape analysis of community needs to inform how service areas will be prioritized to ensure the region has access to a strong and resilient network as needs arise.