Best Large Grants for Nonprofit Organizations in Missouri

The CDC is allocating funds through NOFO DD-27-0028 to enhance maternal child health surveillance and partnerships. This initiative targets public health challenges such as alcohol use during pregnancy and fetal alcohol spectrum disorders (FASDs). It aims to improve clinical surveillance systems, data quality, and timely reporting, while fostering national partnerships to prevent FASDs and support affected infants and children. The approach focuses on translating high-quality surveillance data into actionable prevention strategies.

The Public Policy & Public Health Award by the American Lung Association aims to foster innovative research addressing critical public health issues impacting lung health. This grant, with a maximum award of $50,000 per year for up to two years, supports researchers in various disciplines to evaluate existing policies and propose new ideas. It encourages efforts to improve air quality and tackle lung disease, aligning with the mission of enhancing public health through informed policy-making.

The Small Grants for New Investigators program aims to enhance participation in health-related research by supporting new investigators from diverse backgrounds. This initiative encourages projects in the scientific areas of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Eligible applicants may receive funding for small research projects, promoting research independence and innovation while addressing the underrepresentation in biomedical research.

Cattaraugus County Trappers Memorial Scholarship

Created by the Cattaraugus County Trappers Association, this scholarship will be awarded to a graduating high school student who plans to pursue a degree in Natural Resources Conservation, Fish & Wildlife Management, Forest Management or similar area of study at a 2- or 4-year college. Financial need will be considered. Applicants must include list of outdoors sports in which they participate, a statement on importance of the role of sportsmen in conservation and management of fish and wildlife and natural resources, and information on career path in their goal statement.

The Kauffman Foundation's Collective Impact Grant - Planning supports coalitions of high-capacity organizations aiming for systems-level change in the Kansas City area. Grants of up to $500,000 are available to facilitate nine months of planning for collaborative initiatives. Eligible applicants include both established and emerging coalitions, focusing on education, employer connections, and equitable access. This initiative aligns with the foundation's strategic priorities to enhance economic mobility for Kansas Citians.

The Wayne C. Kaufmann Charitable Foundation aims to enhance community welfare and support organizations that provide educational and health services, particularly for disadvantaged individuals. Key focus areas include maternal health, K-12 STEM education, mental health for veterans, support for children with Down Syndrome, and addressing violence against women and children. The foundation gives priority to Lutheran-affiliated organizations and encourages projects that empower communities.

The Tribal Colleges Research Grants Program (TCRGP) aims to enhance research capacity at Tribal colleges, focusing on agriculture, natural resources, and human sciences. By fostering leadership skills and knowledge, the program prepares students for competitive careers in agriculture and related fields. Projects involving innovative agricultural technologies, such as AI and data science, are encouraged. TCRGP also emphasizes training opportunities for undergraduate students to equip them for success in a digital society and explore pathways in AI for food and agricultural sciences.

The Patient-Centered Outcomes Research Institute (PCORI) intends to release an Implementation of Findings From PCORI's Research Investments PCORI Funding Announcement (PFA) on Aug. 4, 2026, seeking to fund implementation projects that promote the uptake of peer-reviewed findings from specific PCORI-funded patient-centered comparative clinical effectiveness research (CER) in the context of the body of related evidence. This PFA is an open competition opportunity for principal investigators to propose implementation projects that move evidence toward practical use in improving health care and health outcomes. Applicants may propose projects with budgets up to $1.8 million in total direct costs.

PCORI seeks to fund implementation projects that incorporate active, multicomponent strategies that will lead to uptake and integration of evidence generated by PCORI-funded research in practice settings. Implementation should target specific end users with a clear interest in — and ability to benefit from — the evidence. Proposed implementation projects will adapt findings as needed to facilitate uptake in the proposed settings and accomplish scale-up to reach larger numbers and/or scale-out to reach broader populations and settings. Applicants must demonstrate commitment and buy-in — including from leadership as well as frontline staff critical to the success of the project — from proposed implementation sites across multiple health systems, such that they provide a supportive context and infrastructure for undertaking the proposed project. In addition, projects should involve regional and national stakeholder organizations positioned to extend uptake in broader venues.  

Applications must be guided by an established conceptual model or framework and, where possible, by evidence regarding effective strategies for implementing evidence-based practices and interventions. Additionally, applications must include a rigorous evaluation plan that documents the successful execution of the implementation approach and the impact of the project on health care and health outcomes as feasible and appropriate within the project scope.

The Bank of America Foundation Sponsorship Program aims to enhance economic mobility and social progress in low- and moderate-income communities through partnerships with nonprofit organizations. This initiative focuses on critical areas such as workforce education, basic needs like food and housing, and community development. The Foundation invested $350 million last year and encourages employee volunteerism and giving, supporting nonprofits in various sectors, including arts, culture, and diversity initiatives.

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

The NRA Foundation Supports Freedom, Family, and the Future of the Shooting Sports

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans.

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans. These activities are designed to promote firearms and hunting safety, to enhance marksmanship skills of those participating in the shooting sports, and to educate the general public about firearms in their historic, technological and artistic context. Funds granted by The NRA Foundation benefit a variety of constituencies throughout the United States including children, youth, women, individuals with physical disabilities, gun collectors, law enforcement officers, hunters and competitive shooters.

Women's Wildlife Management Conservation Scholarship

The Women’s Wildlife Conservation Scholarship, established by the NRA Women’s Policies Committee, is a renewable one-year $5,000 scholarship available to full-time college sophomores, juniors, or seniors. Thank you for your interest in the field of wildlife management, forestry, parks, or fish and wildlife conservation.

Scholarship Value

$2,500 per semester for up to two semesters. Recipients must maintain qualifications listed above to receive second installment.

The Jelley Family Foundation Endowment for Children's Education Fund, established in 2013 by Dr. Carl Jelley, supports educational initiatives for children in Eastern Jackson County, Missouri. With an average grant award of $5,000-$8,000, and a maximum of $10,000, the foundation encourages innovative proposals focusing on at-risk youth. Eligible organizations include 501(c)(3) nonprofits and public education institutions, with a new 3-year funding rule starting in 2024 to enhance sustainability in educational projects.

We support community programs that promote health, education, and human dignity.

The Alfred H. Lander and Janet L. Lander Family Charitable Foundation is a qualified 501(c)(3) private operating foundation that conducts charitable work that meets our mission statement. The Foundation seeks to uplift individuals and families through community programming in the following three areas:

• Programs promoting and supporting the physical and mental health of the community through fitness opportunities and access to services, resources, and qualified care providers.
• Educational programs providing a strong foundation for learning at all ages and levels, including those that improve workforce placement and success.
• Programs assisting individuals and families in meeting basic needs and include a pathway for upward mobility.

The Kauffman Foundation's Capacity Building Grant aims to enhance the organizational effectiveness of nonprofits through leadership development, strategic planning, and technology improvements. With funding between $100,000 and $250,000, this grant focuses on strengthening internal capacities rather than supporting specific programs. Organizations aligned with the foundation's strategic priorities and those demonstrating a capacity gap are encouraged to apply for these short-term, impactful grants.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5428 - Establish Standardized Guidelines for Embedding O&M Considerations into the Design Process

Grant Information

• To provide provisions that address common, recurring design issues that drive operations and maintenance (O&M) time and material, including but not limited to standardization of spare parts and consumables, support for condition based and predictive and preventive maintenance, and maintain-in-place design strategies.
• To develop standardized design guidance to measurably reduce lifecycle O&M labor hours for municipal water and wastewater treatment facilities, pumping stations, etc., once required process performance and regulatory compliance are achieved.

The Health Access Heroes Awards, initiated by Sun Life Financial, aims to enhance health access and outcomes for underserved communities. This initiative highlights the crucial connection between oral health and diabetes, focusing on prevention and management. It recognizes impactful nonprofits and unsung heroes who contribute significantly to community health. Selected awardees will receive a $10,000 donation to support their charitable efforts, promoting diabetes awareness, management, and overall health equity.

The JTMF Foundation Grant focuses on improving the lives of individuals in need, particularly in the Pacific Northwest. By partnering with organizations addressing immediate needs and long-term challenges, the foundation supports children, older adults, veterans, and individuals with intellectual and developmental disabilities. Guided by Catholic values, JTMF aims to empower communities while seeking innovative solutions to societal issues. Organizations that align with these focus areas are encouraged to connect, fostering a collaborative effort towards meaningful impact.

The CDC's K01 Mentored Research Scientist Development Award aims to support new investigators in conducting vital research to prevent interpersonal violence and suicide among children and adolescents. This grant encourages proposals that address critical public health issues, including adverse childhood experiences and youth violence, while fostering research independence. Applicants are expected to explore the impact of technology on violence and demonstrate the relevance of their findings to prevention efforts.

The REPI Challenge, initiated by the DOD's REPI Program, aims to protect critical testing and training capabilities through funded projects. Since 2012, over $193 million has been allocated to 69 initiatives, leveraging more than $512 million in partner contributions. The upcoming 2026 REPI Challenge will focus on strategic mission safeguarding, with up to $20 million available for preventing land use conflicts and enhancing military resilience, thus ensuring the longevity of vital defense capabilities.

BMO Gives is committed to fostering positive societal impact through community support and charitable initiatives. It focuses on enhancing community and economic resilience, as well as environmental sustainability. Eligible applicants must be registered charities or non-profits operating in Canada or the U.S. and align with BMO's corporate values, which promote inclusivity and non-discrimination. The program aims to support projects that address significant societal needs and empower local communities.

The Stray Dog Institute Grants aim to transform food systems by providing funding and support to nonprofits focused on animal welfare, environmental advocacy, and food justice. With grant amounts typically ranging from $2,500 to $10,000, the Institute prioritizes pragmatic solutions that foster dignity, justice, and sustainability. By addressing systemic issues in food production, they promote a compassionate approach that respects both people and animals. This initiative seeks to create a sustainable future for all stakeholders in the food system.

The CREST program by the NSF aims to bolster research capabilities at minority-serving institutions (MSIs) through education and research integration. It specifically supports STEM doctoral programs and encourages proposals in high-priority areas such as AI and climate change. By enhancing the institutional capacity, the program seeks to increase the number of underrepresented doctoral graduates in STEM fields, thereby fostering diversity and innovation in scientific research.

About

The Portland Cement Association (PCA), founded in 1916, is the premier policy, research, education, and market intelligence organization serving America’s cement manufacturers. PCA supports sustainability, innovation, and safety while fostering continuous improvement in cement manufacturing, distribution, infrastructure, and economic growth.

ACA Education Foundation Fellowship

The American Cement Association Education Foundation funds a wide variety of educational activities that will increase public knowledge regarding appropriate uses of cement and concrete. Within that global goal is a specific purpose to:

Advance general scientific understanding of cement and concrete by providing scholarships, fellowships, grants, and other support for the study of engineering and the physical sciences relating to the production and use of cement and concrete.

The support provided by the Education Foundation is used to identify and attract outstanding candidates in the field of engineering and the physical sciences and provide them with the necessary support to complete their studies. Additionally, this support is intended to provide candidates an opportunity for productive work in the cement and concrete industries.

Sustainability and Resilience

• Estimating the impact of optimized use of recycled materials, including alternative fuels and raw materials in clinker manufacture, in hydraulic cements, and in concretes, to improve the CO2 footprint, improve life-cycle performance, reduce the burden on landfills, and improve the circular economy.
• Improving recognition of concrete system performance through better use of life cycle assessments (LCAs) and environmental product declarations (EPDs) to account for both service impacts and embodied impacts of construction.
• Other research investigating the optimization of cement and concrete for sustainable and resilient concrete construction, including use of novel approaches to optimize the clinker-to-cement ratio of cement blends, or to optimize design of structural concrete.

Cement Manufacturing

• Improving raw mix burnability using mineralizers, alternative raw materials, or other means.
• Advanced grinding technology for raw materials or cements.
• Optimizing performance by separate grinding and blending of cement ingredients.
• Advancement of carbon capture, utilization, and storage (CCUS) technology, including novel approaches to capture CO2 from cement kiln emissions, beneficially utilize the captured carbon, or transport and store it.

Testing and Tools

• Quantitative method to characterize the reduction in CO2 footprint of cement manufacture using alternative fuels.
• Method or method(s) for quantitative determination of CO2 uptake in fresh and/or hardened concrete, mortar, or paste, in either laboratory or field exposures or both.
• Updated software tools with consideration of blended cements for mass concrete, crack prediction, and service life prediction of transportation structures.
• Novel non-destructive test (NDT) techniques to assess finishing timing of flatwork, especially when using concrete mixtures containing newer cementitious materials or other ingredients that may affect concrete performance.
• New or novel test methods for assessing the finishability, pumpability, bleed rate, set time, and sensitivity to early age curing that may be different for blended cements compared to traditional portland cements.

The CDC's National Centers of Excellence in Youth Violence Prevention (YVPCs) aim to expand the evidence base for preventing youth violence among individuals aged 10 to 24. This initiative supports rigorous evaluations of prevention approaches, community engagement, and training for early career researchers. By establishing partnerships and focusing on communities with above-average youth violence rates, the YVPCs seek to enhance collaborative efforts and effectively disseminate research findings to inform future prevention strategies.

The Vineyard Family Foundation

The Vineyard Family Foundation is the product of decades of work across three generations and five states. Having enjoyed the benefits of our hard work and community patronage, the Vineyard family has chosen to provide to others what so many have graciously provided to us. 

What Sets Us Apart

The Vineyard family has always been committed to its communities. Whether supporting Boys & Girls Clubs, pediatric hospitals, the Ronald McDonald House, arts organizations, or youth recreation leagues, the family has taken a great interest in the care, health, and education of children and the families that nurture them. We take great pride in personally administering our Foundation’s charitable giving, resulting in fewer expenses and more funding for those organizations aligned with the Foundation’s purpose.

Grants

• Supporting Our Communities and Their Families
• Working Towards the Health, Education, and Overall Well-Being of Parents and Their Children

You are steps away from creating an opportunity to receive full or partial funding of your charitable organization. So that you use your time wisely, we offer the following advice for your efforts:

• As a family foundation, we are prohibited from funding individuals or any entity that is not an IRS-recognized Section 501(c)(3) tax-exempt entity or a Section 509(a)(1), (2), or (3) support organization. Thus, while we cannot award a scholarship to an individual, we can fund a 501(c)(3) charity that provides such scholarships.

• If you qualify as a Section 501(c)(3) tax-exempt organization or a support organization pursuant to Section 509(a)(1-3), we will need the IRS Determination Letter confirming as much, as well as a statement signed by your organization’s President or Chief Executive Officer verifying that your organization’s purposes, structure, and operations have not changed substantially since the date of the IRS’s Determination Letter.

• If you are a “supporting organization” under IRS Code section 509(a)(1-3), please provide a list of the public charities that you support. Please also advise whether you are a Type I, Type II, or Type III supporting organization. If you are a Type III supporting organization, please advise whether you are “functionally integrated” with your supported public charity and provide an explanation of that relationship.

Supported Charities

The Vineyard family has historically provided funding for family-related charities such as the Ronald McDonald House, the Boys & Girls Clubs of America, pediatric hospitals, autism-related organizations, and youth recreational leagues. The Foundation looks forward to continuing this support and extending itself to educational, research, and cultural experiences that focus on the needs of children and their parents.

The B.W. Bastian Foundation Grant supports organizations committed to equality for all Americans, including the LGBTQ+ community. Grants typically range from $100 to $15,000, and applicants must have 501(C)3 tax status. Funding is primarily for projects in the Intermountain West and may include general operating support or specific programs. Organizations should first inquire before applying, especially if requesting more than previous grants. The foundation does not fund individuals or lobbying efforts.

The PCA J.P. Gleason Research Fellowship Program, offered by the Portland Cement Association, supports graduate students in engineering and physical sciences. The program aims to enhance public understanding of cement and concrete uses while addressing urgent sustainability challenges. Each fellowship provides a $35,000 grant to cover educational expenses, fostering research that optimizes cement manufacturing and promotes environmental sustainability, particularly in the context of climate change.