Best Large Grants for Nonprofit Organizations in Missouri

Takeda Oncology offers grant funding opportunities aimed at addressing unmet educational and research needs in the medical community. They prioritize support for programs in hematology, thoracic, and gastrointestinal cancers, including lymphoma, leukemia, and previously treated metastatic colorectal cancer. Takeda encourages partnerships that enhance patient outcomes and provide tangible benefits through donations, grants, and sponsorships. Applications must be submitted at least 60 days prior to the program start date for timely review.

The Carl J. Niedzial Memorial Scholarship, established by the Connecticut Community Foundation in 1923, supports members of the CT State Police Credit Union and their immediate families, including grandchildren. As one of the largest scholarship providers in the Greater Waterbury and Litchfield Hills region, the foundation aims to help students achieve their college education dreams by addressing critical community issues and fostering equitable outcomes.

The Mark Wahlberg Youth Foundation, established in 2001 by Mark and Jim Wahlberg, aims to support youth service programs that eliminate barriers to success for inner city youth. By providing financial and community support, the foundation empowers young individuals to achieve their potential and dreams, fostering a nurturing environment reminiscent of the Boys and Girls Clubs of America, where Mark spent his formative years.

The Rachael Ray No-Kill Excellence Grants, funded by the Rachael Ray Foundation, support Best Friends Network partners in maintaining a 90% Save Rate for animals. These grants encourage innovative projects that enhance community partnerships and mentorships, helping organizations achieve sustainable lifesaving outcomes. Eligible organizations can apply for grants up to $60,000, with a focus on scalable programs that benefit animals and promote no-kill initiatives across the United States.

The Dog Enrichment Grant, offered by the Petfinder Foundation, aims to enhance the quality of life for dogs awaiting adoption through enrichment activities and items. Grants are available for play yard renovations (up to $3,000) and interactive items (up to $1,000). Applications are accepted monthly until funds are depleted, and the window closes on November 1. Eligible expenses must be utilized within three months, and reimbursement requests will not be accepted.

Nestlé Purina is dedicated to enhancing the well-being of pets and the communities they serve. Through their event sponsorship program, they support 501(c)(3) tax-exempt pet welfare organizations in the U.S. that focus on the welfare of cats and dogs. Eligible events must be located within 50 miles of their St. Louis headquarters, ensuring that their contributions directly benefit local communities. Purina's commitment to pets and people strengthens the bond between them.

The Security and Preparedness (SAP) Program, supported by the National Science Foundation, promotes fundamental research addressing global and national security issues. It emphasizes intellectual merit and broader impacts, encouraging projects that are methodologically sound and empirically driven. Research areas include international relations, political violence, and peace science, among others. The program also fosters undergraduate research experiences and methodological innovations, while strictly avoiding applied research.

Community Foundation of Northwest Mississippi

The Community Foundation of Northwest Mississippi manages 314 donor-established funds and has disbursed over $48 million to support more than 1,000 charitable organizations and activities recommended by its donors, as well as charitable programs established by the foundation. Established in 2002 with a generous grant from the Maddox Foundation, the Community Foundation is an independent 501(c)3 charitable organization. The Foundation serves Bolivar, Coahoma, DeSoto, Leflore, Marshall, Panola, Quitman, Sunflower, Tallahatchie, Tate, Tunica and Yalobusha counties. 

Win Winogrond Memorial Scholarship

Mark Winogrond has established a scholarship in memory of his older brother, Henry “Win” Winogrond, Jr., who passed away in Clarksdale in 2014. The scholarship will help an outstanding graduate of Coahoma Community College to complete a four-year degree at a college of the recipient’s choice.

Win was a lifelong fan of the blues. In Clarksdale, he restored historic buildings as lodging for national and international travelers making pilgrimages to America’s “Home of the Blues”. Win served with distinction in Vietnam and was awarded a Purple Heart as a decorated member of the Special Forces. He continued to assist the U.S. government throughout a long and distinguished career. He traveled to more than 300 counties. Win was buried, with an honor guard, at Arlington National Cemetery.

The 1687 Foundation Book Ministry was established in response to the 1995 Oklahoma City bombing, aiming to provide Christian literature to those in need, including first responders and at-risk populations. This initiative supports various 501(c)(3) non-profit organizations dedicated to disaster relief, healthcare, and homelessness. By focusing on established ministries, the Foundation ensures that resources effectively reach those who need them most, fostering hope and healing through the power of literature.

Community Foundation of Northwest Mississippi

The Community Foundation of Northwest Mississippi manages 314 donor-established funds and has disbursed over $48 million to support more than 1,000 charitable organizations and activities recommended by its donors, as well as charitable programs established by the foundation. Established in 2002 with a generous grant from the Maddox Foundation, the Community Foundation is an independent 501(c)3 charitable organization. The Foundation serves Bolivar, Coahoma, DeSoto, Leflore, Marshall, Panola, Quitman, Sunflower, Tallahatchie, Tate, Tunica and Yalobusha counties. 

Shapoor Alexander Ghane Memorial Endowment

Shapoor Alexander Ghane was a Navy SEAL and to honor his memory this scholarship fund was established to benefit the children of Navy SEAL members who died in action. 

The Union Plus Scholarship, offered by the Union Plus Education Foundation, supports students from working families pursuing post-secondary education. Since its inception in 1991, over $5.6 million has been awarded to more than 4,000 beneficiaries. Scholarships range between $500 and $4,000 for studies starting in Fall 2025. Applicants must be current or retired union members, their spouses, or dependent children, ensuring access to higher education for diverse families across the U.S. and Canada.

The Aloha Prince Hall Hawaii Foundation Fund offers scholarships to graduating high school seniors from Hawaii who demonstrate financial need and maintain a minimum GPA of 2.7. The fund prioritizes students enrolling full-time in accredited four-year institutions and considers community service and extracurricular activities. Preference is given to previous recipients who continue to meet eligibility criteria. This initiative supports the educational aspirations of Hawaii's youth, fostering academic achievement in post-secondary education.

Wilford Kallmeyer Emergency Responders Grant

The Community Foundation of the Hermann Area works to improve the quality of life for individuals in its service area through thoughtful grantmaking and community leadership. It is governed by a Board of Directors, chosen for their knowledge of the area. Grant decisions are made by the grant committee. 

Funding

The total amount to award is $1,032.00.

Applicants may apply for up to $1,032 in funding for this grant cycle.

The Dr. Hans and Clara Zimmerman Foundation Health Scholarships offer financial assistance to Hawaii residents pursuing education in health-related fields. Established by Dr. Zimmerman, the foundation supports college seniors and graduate students demonstrating financial need and maintaining a minimum GPA of 3.0. Preference is given to past recipients who continue to meet eligibility criteria. This scholarship is part of one of Hawaii's largest scholarship funds, promoting careers in healthcare.

The Children’s Relief Fund 

The Children’s Relief Fund (CRF) is a non-profit organization founded in 1991 by Rose and Frank Fotia. Their son Gregory had multiple disabilities and was the inspiration behind CRF. Our group consists of volunteers who raise money to help fund therapy, equipment, summer programs and other group activities for disabled children in the Hilton Head Island and Bluffton area.

Gregory Fotia Memorial Scholarship

This scholarship is available to high school students and home-schooled students.

Career Fields applicable: Career field that benefits special needs children (e.g. Special Education, Pediatrics, Various Therapies)  

Service Area: All Hilton Head/Bluffton High Schools

Number of Awards: One or two

Duration/Renewal: One year

Financial Need: No

Criteria: A completed online application form and 250-word essay describing education and career choices.  Two character references.

About Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.

Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.

Jeannette Turner Memorial Scholarship

Dorothy Ellen Thew, a lifelong member of the Marion community, left, as part of her legacy, a gift to create three scholarship funds at Marion Community Foundation. A noteworthy person in her own right, Dorothy designated that three scholarship funds be created from her estate to honor beloved members of her family. The Jeannette Turner Memorial Scholarship, created in 2010, honors her aunt’s work as a teacher at the former Silver Street Elementary School.

Ella C. White Memorial Scholarship Fund 

The Ella C. White Memorial Scholarship Fund is committed to empowering students in our community to pursue their dreams through higher education. Since its inception in 1972, the fund has awarded 913 scholarships, totaling an impressive $828,200, to deserving students.

​Focused on supporting graduating seniors from Hilton Head Island High School, Bluffton High School, and May River High School, the fund also offers the potential for continued support throughout college. Scholarship recipients are selected based on financial need, academic achievement, and their commitment to building a brighter future.

Our Scholarships

The Scholarship Committee will consider these criteria in making their selection:

• Academic achievement: Copy of your most recent high school transcript, reflecting last 3 years
• Financial need: Must provide proof of parent(s) income
• Letters of recommendations: one from your guidance counselor and one from a current teacher
• A copy of your award letter from the institution you will be attending.

Scholarship Renewals

The Ella C. White Memorial Scholarship is a renewable scholarship. Students may apply for scholarships for two additional years or up to the third year of college. Students are not eligible to receive scholarships for their final year or senior term of college. To be considered for additional assistance, students must provide their most recent college GPA and demonstrate financial need.

About Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.

Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.

Gary W. Troll Memorial Scholarship

The Gary W. Troll Memorial Scholarship Fund, created in 2002, supports higher education for students who reside in the service area of the Northwest Ohio Educational Service Center, where Gary Troll (1947-2002) served as superintendent.

Recipients of the Troll Scholarship may come from any of the high schools in the Northwest Ohio Educational Service Center’s district, including Marion County—Elgin, Pleasant, Ridgedale, and River Valley; Seneca County—Bettsville, Hopewell-Louden, New Riegel, Old Fort, and Seneca East; and, Wyandot County—Carey, Mohawk, and Upper Sandusky. They will be seniors with a GPA of 2.75 or above.

Community Foundation of the Lowcountry

With more than $125 million invested in the Lowcountry area since 1994, Community Foundation of the Lowcountry is the largest source of unrestricted philanthropic resources dedicated to Beaufort, Colleton, Hampton and Jasper Counties. Throughout our history, we have expanded our services, undertaken important initiatives and altered our course to ensure we’re serving the needs of the Lowcountry. We provide donors and nonprofits the steadfast philanthropic leadership to transform, empower and enhance the communities we serve.

Scholarships

Since 1995, we’ve been a resource for students and parents who are looking for a way to offset the cost of tuition while bypassing the use of student loans.

Heritage Classic Foundation Scholarships

Every year we award Heritage Scholarships to 11 high school seniors who demonstrate outstanding academic achievement, community service and leadership skills. Since the program began in 1993, we’ve distributed $5.75 million in scholarships to 408 students from Beaufort and Jasper Counties.

Ron Brown Scholar Fund

The Ron Brown Scholar Fund is a public 501c3 charity and administers the Ron Brown Scholar Program (RBSP). Established in 1996 by Anthony M. Pilaro to honor the late Secretary of Commerce, RBSP is a college scholarship and leadership program for African American students. Our three initiatives support young people who share Ron Brown’s dedication to individual excellence, leadership, and public service

Ron Brown Signature Scholarship

The Ron Brown Scholarship honors the legacy of Ronald H. Brown through a selective scholarship program that advances higher education for community-minded and intellectually gifted African Americans.

RBSP competitively awards 20 four-year $40,000 scholarships ($10,000 each year) to the most talented and economically-challenged high school seniors who demonstrate a keen interest in public service, community engagement, business entrepreneurship and global citizenship – the four pillars of the late Ronald H. Brown’s mission to uplift people of all races, cultures and ethnicities – especially our disadvantaged youth.

Recipients may use the renewable scholarships to attend an accredited four-year college or university of their choice within the United States. Ron Brown scholarships are not limited to any specific field or career objective and may be used to pursue any academic discipline. Since the Program’s inception in 1996, 683 students have been designated as Ron Brown Scholars.

The Innovative Traffic Safety Enforcement (ITSE) Grant Program aims to develop effective traffic safety enforcement initiatives to reduce motor vehicle crashes caused by risky driving behaviors. It encompasses three evaluation phases, with deadlines from September 2026 to September 2027. This program seeks to fund scalable and repeatable projects that align with the Department of Transportation's mission and executive priorities, enhancing safety across the United States.

About Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.

Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.

Douglas & Elaine Waring Memorial Scholarship

The Douglas & Elaine Waring Memorial Scholarship Fund honors engineer Doug Waring and his wife of 49 years, Elaine. 

Created in 2002, the Waring scholarship supports the education of any Marion County high school student who scored in the upper 50th percentile of the ACT, SAT, or other national standardized test.

About Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.

Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.

Donald S. & Beulah Mae Williams Scholarship

Created by the late Don Williams in 2016, this scholarship fund initially honored his beloved Beulah Mae, devoted farmer, loving housewife, mother, grandmother and great-grandmother. It now memorializes this Prospect farming couple.

The Williams Scholarship supports Marion County students who participated in either FFA or 4-H for three or more years.

About Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County.

Individuals, families, businesses and organizations create permanent charitable funds that help our community meet its needs and challenges. The Foundation invests and administers these funds.

David G. Wilhelm Memorial Scholarship

The David G. Wilhelm Memorial Fund was created in honor of its namesake in 2020. It supports college students pursuing careers in mental and behavioral health services.  

Central Alabama Community Foundation

Established in 1987 by community leaders, the Central Alabama Community Foundation serves the River Region counties of Lowndes, Macon, and Montgomery. CACF was created to provide a permanent charitable resource dedicated to strengthening nonprofits and meeting local needs in the Montgomery area.

Through a variety of funds, CACF supports projects and programs in education, health, human services, cultural arts, recreation, historic preservation, and other civic concerns.

Every year, CACF awards grants to nonprofit projects and programs providing services in Lee, Macon, and Montgomery counties.

Shirley Ann Mesher Scholarship

The Shirley Ann Mesher Scholarship shall provide scholarships to students attending, or planning to attend, or are already enrolled in an accredited junior college, a four-year college or university, or a graduate or professional degree program. Eligible candidates must demonstrate financial need, maintain a cumulative grade point average of 2.0, be of African American or Native American descent. Preference for applicants with a history of participating in community service and who provide at least one letter of recommendation.

Central Alabama Community Foundation

Established in 1987 by community leaders, the Central Alabama Community Foundation serves the River Region counties of Lowndes, Macon, and Montgomery. CACF was created to provide a permanent charitable resource dedicated to strengthening nonprofits and meeting local needs in the Montgomery area.

Through a variety of funds, CACF supports projects and programs in education, health, human services, cultural arts, recreation, historic preservation, and other civic concerns.

Every year, CACF awards grants to nonprofit projects and programs providing services in Lee, Macon, and Montgomery counties.

Ronnie Mendheim Memorial Scholarship

Established in 2005 to honor Ronnie Mendheim’s legacy of helping youth, this scholarship benefits graduating seniors of any high school located in Dothan, Alabama. Selection criteria include academic achievement and school/community activities that demonstrate leadership abilities. Applicants must have a minimum GPA of 2.5 on a 4.0 scale and minimum ACT score of 21.

The Paul Easterling Dixie Youth Scholarship, established by the Central Alabama Community Foundation in 1987, supports graduating seniors from any Autauga County school who have participated in Dixie Youth Baseball. This scholarship honors Paul Easterling's legacy by recognizing students exemplifying sportsmanship both on and off the field. The Central Alabama Community Foundation, dedicated to enhancing local nonprofit efforts, awards annual grants for various community needs, making a positive impact in the region.