Best Seed Grants for Nonprofits in Missouri

The US Acute Care Solutions Scholarship Fund, established by Stark Community Foundation, supports the dependent children of non-physician employees of US Acute Care Solutions and its affiliates. Eligible applicants must be accepted into or attending a college, university, nursing school, or vocational program, with a minimum GPA of 3.0. This initiative highlights the Foundation's commitment to empowering future generations through education and community service involvement.

The OJJDP FY 2026 Mentoring for Youth Impacted by Opioids and Other Substance Use program aims to provide high-quality mentoring services to youth affected by substance use. This funding opportunity supports various mentoring formats, including one-on-one, group, and peer mentoring, to assist those currently using substances or at risk due to familial influences. The initiative seeks to enhance the well-being of these youth through supportive relationships and guidance.

The Capacity Building Grant - Comprehensive Organizational Assessment & Reports (COAR) Grant Program by the Marillac Mission Fund aims to enhance nonprofit infrastructure and leadership. This initiative supports organizationally-ready nonprofits by providing funding for core capacity building, fostering sustainable practices to better serve vulnerable populations in the St. Louis area. The program emphasizes organizational assessments to evaluate strengths and weaknesses, ultimately facilitating growth and positive change.

The Marillac Mission Fund provides funding for capacity building grants aimed at enhancing the effectiveness of nonprofits focused on vulnerable populations. Eligible organizations must have a history of receiving MMF funding and be located in the St. Louis area. Grants can support various improvement activities including strategic planning and resource development, with a maximum award of $25,000 per year. This program seeks to empower nonprofits to better serve their communities and advocate for those in need.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Help with healthcare costs for Paroxysmal Nocturnal Hemoglobinuria (PNH)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Paroxysmal Nocturnal Hemoglobinuria (PNH), also known as Marchiafava– Micheli syndrome, is a rare disease that is characterized by impaired bone marrow function and destruction of red blood cells. PNH is a rare disease that affects the circulatory system.

The Career Development Bridge Funding Award from the Rheumatology Research Foundation aims to support early and mid-career researchers facing funding challenges. This program provides $200,000 over two years to help investigators refine their NIH or equivalent grant applications while pursuing innovative research in rheumatic diseases. By fostering the next generation of rheumatologists, the foundation seeks to enhance patient care and advance treatment options for those affected by these conditions.

The Periodic Paralysis Grant, offered by the Patient Advocate Foundation, assists individuals diagnosed with periodic paralysis in managing out-of-pocket healthcare costs. Eligible applicants must be in treatment or planning to begin treatment for this rare muscle disease. The fund covers various expenses, including medication copays and insurance premiums, ensuring that patients can afford essential care. With a mission to empower and support patients, this grant plays a crucial role in navigating healthcare challenges.

The Hypercholesterolemia Grant by the Patient Advocate Foundation offers financial assistance to individuals diagnosed with hypercholesterolemia, helping cover out-of-pocket healthcare costs such as medication copays and insurance premiums. This nonprofit aims to improve patient access to necessary care while supporting over 3.8 million patients since its inception. Eligible applicants must have health insurance and meet specific income requirements to receive assistance in managing their healthcare expenses effectively.

Mission

The Fish Family Foundation of Maine is a faith based charitable organization located in Bangor, Maine. Founded in 2007, our mission is to provide resources for many initiatives including, but not limited to, missions, education scholarships, ministries, medical research, and employment creation. The Fish Family Foundation of Maine is primarily funded by the family. However, contributions from like minded individuals and organizations is appreciated. The Fish Family Foundation of Maine has a balanced strategy of making funds available for immediate needs, while also investing to build a perpetual earning endowment ensuring the Foundation's successful future.

Missions:

We support needs of missionary organizations including sponsorships for young people who wish to attend youth group sponsored mission trips. We ordinarily make one time contributions but on occasion have made up to a three year commitment. 

Education/Scholarships:

The Foundation makes scholarships available to Colleges, Universities, and other Schools for student enrollment and expenses. We also consider new construction, existing renovation, equipment, and support material contributions.

Independent Churches and Ministries:

We accept a wide variety of requests, including, but not limited to: materials, equipment, new construction, renovations, programs, and services. 

Medical Research:

We support medical research opportunities close to our hearts and organizations that our family and friends have experienced. 

Job Creation:

We Support organizations that fund entrepreneurs in impoverished areas to start small businesses providing services and employment to the community.

Requests are considered by the trustees the first week of each month. Foundation payments are made by paper check in US dollars and are reported to the appropriate tax agencies. While we certainly wish that we could contribute to all the applications that meet our funding criteria, there are times when when available funding is limited and we are not able to contribute to some very worthy causes. If we are not in a position to help in the timeline requested, we will keep the information on file for possible consideration in the future. 

The Pediatric Rheumatology Fellow Research Award, offered by the Rheumatology Research Foundation, recognizes exemplary scientific abstracts from pediatric rheumatology fellows at ACR Convergence. With a $1,500 award and an additional $1,000 for travel expenses, this initiative aims to promote innovative research and enhance educational opportunities for future rheumatologists. The program underscores the importance of developing a skilled workforce to improve access to specialized care for patients with rheumatic diseases.

The Hyperkalemia Grant, provided by the Patient Advocate Foundation, offers crucial financial assistance to patients struggling with hyperkalemia. This grant covers out-of-pocket healthcare costs, including medication copays and health insurance premiums. Eligible applicants must have a confirmed diagnosis and meet specific income and residency requirements. Since its inception, the foundation has supported millions of patients, ensuring they can access the necessary treatment and resources for their health needs.

The Virtual Living Room Grant Program aims to create welcoming spaces for veterans in rural communities, providing access to advanced medical technologies via telehealth. By establishing these rooms in accessible locations, veterans can connect with VA resources without the burden of travel, ensuring they receive essential care in a comfortable environment. This initiative not only supports health access but also fosters community engagement and enhances the quality of life for our nation's heroes.

The Les Paul Foundation Grant supports innovative music education and medical research related to hearing loss. Eligible organizations must be U.S.-based public charities under 501(c)(3) and avoid religious, political, labor, or business affiliations. The foundation prioritizes projects that enhance music production, performance, and STEM/STEAM initiatives, particularly those benefiting individuals in challenging situations. Proposals must detail how they will share Les Paul's legacy in their work.

The Rural Communities Opioid Response Program - Evaluation aims to assess the effectiveness of behavioral health strategies in rural settings. By developing evaluation tools and resources, this initiative seeks to empower local communities in their health initiatives, ensuring that future programs are informed by comprehensive evaluations. Funded by the Health Resources and Services Administration, the program highlights the importance of tailored approaches to address opioid-related challenges in rural areas.

This grant aims to enhance global polio eradication efforts through innovative modeling approaches. It focuses on developing effective strategies for cVDPV2 outbreak response and optimizing surveillance following global WPV eradication. The initiative also seeks to build a skilled public health workforce in statistical and mathematical modeling, assess economic impacts of response strategies, and foster capacity among students to address polio and other vaccine-preventable diseases.

The Scientist Development Award from the Rheumatology Research Foundation supports early career professionals in rheumatology research. This award provides funding for salary and research training, aiming to enhance the skills of trainees and ensure a robust workforce in rheumatology. With a maximum of $75,000 per year, this initiative encourages innovative research and mentorship opportunities to improve treatment options for patients with rheumatic diseases.

The BJA FY 2026 Tribal Justice Training and Technical Assistance Program aims to enhance Tribal justice systems through specialized technical support. This funding opportunity addresses critical issues such as violent crime and substance-use related crime, including opioids. By assisting federally recognized Indian Tribes, the program promotes the development of sustainable legal and corrections infrastructure while fostering collaboration with federal, state, and local partners. Applications are due by October 28, 2026, at 8:59 p.m. ET.

The Marillac Mission Fund offers responsive grants primarily for established organizations addressing poverty and vulnerability in the St. Louis area. Focus areas include support for older adults living independently, immigrants and refugees, veterans (existing grantees only), and human trafficking prevention. Grant types include program/project funding and general operating support, with a preference for organizations demonstrating alignment with Catholic moral teachings and serving specific populations. Applications are currently limited to existing grantees in designated focus areas.

The Richard S. Reynolds Foundation, established in 1955 in Richmond, Virginia, supports diverse community initiatives in education, healthcare, the arts, and the environment. With over $71 million granted to date, it aims to strengthen communities and foster future generations. The foundation prioritizes requests from IRS-recognized 501(c)(3) organizations while typically avoiding contributions to annual operational costs. Its commitment to impactful projects ensures a lasting positive influence both locally and globally.

Melton Foundation

The Melton Foundation is an international 501(c)(3) non-profit organization registered in the USA, and a leading proponent of Global Citizenship education and practice worldwide. Established nearly thirty years ago with the credence that collaborations across boundaries can forge sustainable solutions to the world’s most pressing challenges, today, our programs reach millions of young leaders, having crystallized into a network of over 750 life-long Melton Fellows spread across 40+ countries. Our primary operations are in Chile, China, Germany, Ghana, India, and the United States of America, with legal subsidiaries in Bangalore, India; Jena, Germany; Temuco, Chile; and Accra, Ghana. 

Through our fellowship and collaborative programs we promote and enable global citizenship as a way for individuals and organizations to work together across boundaries of place and identity to solve challenges in an interconnected world.

Melton Foundation Action Grants

The Melton Foundation offers grants year-round to support Melton Fellows in developing skills, perspective and wider networks to further their capacity as global citizens and contribute towards building an equitable, sustainable, and peaceful world.

In almost 10 years of granting, more than 100 Fellows’ initiatives have been awarded with a Melton Foundation grant to

• Build awareness and/or further awareness raising around global issues and the Sustainable Development Goals (SDGs),
• Develop individual and collective responsibility for sustained, collaborative action,
• Grow capacity to collaboratively drive and sustain social impact at the local and/or global level,
• Further the design, implementation and evaluation of collaborative actions that embody the spirit of global citizenship practice and further social impact, or
• Support coordinated social-impact efforts in a particular or across (emerging) Melton Foundation Hub regions to promote global citizenship practice (s) and the organization’s mission.

The Ai2 Predoctoral Young Investigators Program offers predoctoral candidates a unique opportunity to engage in advanced research through collaboration with experienced mentors. Participants can co-author papers and benefit from a generous travel budget, along with support for visa acquisition. This program is designed for candidates preparing to enter a PhD program in the next 1-2 years, providing essential resources and experiences to facilitate their academic journey.

The Pittsburgh Foundation

Established in 1945, The Pittsburgh Foundation is one of the nation’s oldest community foundations and as of 2022 is the 18th largest of more than 750 similar foundations across the United States.

As a community foundation, its resources comprise endowment funds established by individuals, businesses and organizations with a passion for charitable giving and fulfilling the Foundation’s mission of improving quality of life for all in the region. The Foundation currently manages about 2,500 individual donor funds and, together with its supporting organizations and its affiliate, The Community Foundation of Westmoreland County, has assets of $1.386 billion (2022). Grantmaking benefits a broad spectrum of basic needs and development opportunities within Pittsburgh and beyond.

Scholarships

The Pittsburgh Foundation and The Community Foundation of Westmoreland County provide scholarship opportunities for local students to pursue their educational goals. Scholarships are available for graduating high school seniors, undergraduates, graduate, medical and professional school students who are attending community colleges, four-year universities and career/technical schools.

Daniel R. Miller (Fretts) Memorial Scholarship Fund

The Daniel R. Miller (Fretts) Memorial Scholarship Fund was established to provide scholarship assistance for vocational and higher educational opportunities for Scottdale Borough/East Huntingdon Twp. youth. The fund was endowed by Daniel R. (Bob) Miller’s daughter Karen to honor the memory of her father and the Miller & Fretts families of the Scottdale Area. Bob Miller, for whom this scholarship is named, was born and raised in Scottdale. He believed that the core values instilled in him by his immediate Miller and Fretts relatives in the Scottdale area were a contributing factor to his later successful business career and other lifetime experiences.

The purpose of the scholarship is to provide scholarship assistance to a graduating senior from Southmoreland High School who wishes to pursue a career in a traditional trade or modern equivalent (engineering, architecture, design etc.).

Award Type: Single Year Award. Previous recipients are encouraged to re-apply.

About BlackRock

We’re a global asset manager and technology provider dedicated to helping more and more people experience financial well-being. We help millions of people invest to build savings that serve them throughout their lives. The BlackRock Foundation which funds and partners with organizations that strengthen financial security for more people,

BlackRock Future Builders

BlackRock Future Builders is a $100 million philanthropic initiative funded by The BlackRock Foundation to expand economic opportunity and power the next generation of America’s skilled trades workers. Through this Request for Proposals (RFP) process, The Foundation seeks to support U.S. nonprofit organizations (i.e., registered 501(c)3 organizations) delivering or supporting high‑quality skilled trades training.

This competitive grant opportunity operates in parallel to other BlackRock Future Builders partnerships and is intended to surface additional, regionally grounded solutions across the skilled trades ecosystem. Organizations may propose direct worker training programs or capacity‑building efforts that enable systems to function more effectively and at greater scale. This first round RFP will be administered by Jobs for the Future (JFF), a national nonprofit that transforms U.S. education and workforce systems.

Focus Areas and Solutions

Applicants may propose worker training or capacity‑building solutions aligned to skilled trades workforce development.

• Worker training interventions may include direct service proposals such as pre-apprenticeship or career navigation programs, workforce training programs, apprenticeship programs, or wraparound participant supports that are supportive of training persistence and completion.
• Capacity-building interventions are organizational and system-focused, rather than in direct service of participants, and may include, but are not limited to, proposals such as ecosystem-building, demonstration projects, technology or tool adoptions, or research, among others.

Helen Frankenthaler Foundation

The Helen Frankenthaler Foundation supports the artist’s legacy through a variety of initiatives, including exhibitions, loans of artworks, research and publications, conservation, grants, educational programs for the public and the scholarly community, and the publishing of a catalogue raisonné. It is dedicated to promoting greater public interest in and understanding of the visual arts.

Established and endowed by the artist during her lifetime (1928-2011), the Foundation became active in 2013, on the closing of Frankenthaler’s estate. As the principal beneficiary of Frankenthaler’s estate, the Foundation maintains an extensive collection of her work in a variety of mediums, as well as her collection of works by other artists and original papers and materials pertaining to her life and work.

Frankenthaler Climate Initiative

The Frankenthaler Climate Initiative (FCI) is a pioneering grantmaking program established by the Helen Frankenthaler Foundation. Since its inception in 2021, FCI has distinguished itself as the foremost private national initiative in the United States dedicated to combating climate change specifically within the visual arts sector.

FCI provides visual arts institutions with up to $100,000 to undertake ambitious sustainability and energy efficiency initiatives that directly address carbon reduction and energy efficiency. The scope of its support is broad, encompassing everything from modest, rapid-response projects to comprehensive efficiency audits and feasibility studies, and extending to financial contributions for significant infrastructural renovations and strategic planning for new buildings and major initiatives.

Building on the core values of the Helen Frankenthaler Foundation, the initiative aligns a commitment to environmental stewardship with a belief in the vital importance of the visual arts and arts education. Through strategic funding and partnerships focused on tangible infrastructure, FCI aims to catalyze a sector-wide shift toward zero carbon operations, promoting a future where the visual arts thrive—while contributing to a more sustainable and ecologically conscious world.

Who We Fund

FCI funds nonprofit institutions in the United States and its territories whose primary focus rests in the visual arts. The visual arts includes but is not limited to painting, drawing, sculpture, printmaking, photography, and installations in clay, glass, metal, wood, fiber, paper, film, and mixed media.

Most of our grantees are art museums, nonprofit galleries, archives, noncollecting institutions, art schools, university museums, and artist-endowed foundations.

What We Fund

FCI funds energy efficiency and clean energy generation projects.

FCI meets arts institutions at every stage of the work, through four kinds of grants:

• Catalyst — first actions and stand-alone projects with a quick turnaround
• Scoping — energy audits and assessments that establish a baseline
• Technical Assistance — detailed planning for technically demanding projects
• Implementation — comprehensive capital work addressing a building's environmental impact at multiple levels

Technical Assistance Grants

Technical Assistance grants support projects that have finished initial assessments, and need procurement and financing support for an identified efficiency project. This may include providing designs, specifications, or fees for working with energy services companies (ESCOs) for project support. These grants also support more complex studies or analysis required for pursuing major implementation projects. At the conclusion of a Technical Assistance grant, the applicant should be sufficiently informed to implement a project.

The Aspiring Educators CREATE Grants, funded by the National Education Association Staff Organization, offer up to $2000 to strengthen the AE Program and foster impactful partnerships. Grants focus on areas such as Educator Quality, Community Engagement, Political Action, and Social Justice. Eligible organizations include state AE chapters, and submissions are accepted three times a year. This initiative encourages aspiring educators to develop their skills and contribute meaningfully to their communities.

The CHEERS Open Period 1 invites white papers focused on enhancing operational medicine and support for Airmen and Guardians. Managed by the Air Force Research Laboratory and USAFSAM, this opportunity aims to address future demands in Aerospace Medicine, Occupational Health, and Public Health. Proposals should align with the objectives outlined in the Continuing Human Enabling, Enhancing, Restoring and Sustaining announcement. This initiative emphasizes innovative solutions to support the Department of Defense's mission.

The SHAPE America Major of the Year Award recognizes exemplary undergraduate students in health, physical education, recreation, and dance. This prestigious accolade aims to highlight nominees who demonstrate academic excellence and commitment to service within their communities. Faculty members from colleges and universities are encouraged to nominate one outstanding student per major, ensuring that the next generation of health educators is celebrated for their achievements and contributions to the field.