Best Large Grants for Nonprofit Organizations in New York

The Horton PhD Research Grant supports up to three Ph.D. students annually in hydrology and related fields, funded by the Robert E. Horton Fund. It provides a maximum of $10,000 for research and travel, along with $500 for U.S. and Canadian applicants participating in AGU's annual meeting. Eligible students must be active AGU members, enrolled for the award's duration, and meet all application requirements. This grant promotes excellence in hydrological sciences.

The Enterprise Mobility™ Philanthropic Giving program focuses on enhancing community engagement through grants aimed at supporting health, education, arts, and disaster relief initiatives. Only Enterprise Mobility team members and their spouses or domestic partners who volunteer with a nonprofit can apply for funding. The program prioritizes sustainable projects that uplift local communities and address pressing social issues, fostering a culture of responsibility and giving back to society.

The NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Not Allowed) invites proposals for high-risk, multi-center observational studies on diseases relevant to NIDDK's mission. Applicants are encouraged to consult with NIDDK staff and must complete planning activities before submission. Key deadlines for applications span from February 2025 to October 2026, with optional Letters of Intent due 30 days prior to full proposals.

The See, Test & Treat Grant offers funding for a pathologist-led cancer screening program aimed at underserved communities. With a focus on health education, the program provides vital cervical and breast cancer screenings, ensuring same-day results and follow-up care. Eligible institutions can apply for funding up to $20,000 for single-year projects or up to $50,000 over three years. This initiative addresses health disparities, empowers communities, and enhances the visibility of pathology in healthcare.

The Live Más Scholarship, offered by the Taco Bell Foundation, supports students aged 16-26 pursuing higher education and workforce readiness. Emphasizing passion and impact, applicants showcase how their interests drive positive change in their communities. The foundation is dedicated to breaking down educational barriers, fostering creativity across various fields including arts, technology, and entrepreneurship. This initiative empowers young dreamers to turn their aspirations into actionable goals, creating meaningful contributions to society.

The AWWA Jacobs Holly A. Cornell Scholarship, established in 1990, supports graduate students pursuing water supply and treatment studies. Sponsored by Jacobs/CH2M, this $10,000 scholarship is aimed at first-generation college graduates or those who have faced economic disadvantages and significant educational barriers. AWWA, the largest organization of water supply professionals, emphasizes the importance of investing in the future of the water industry through such scholarships.

The Kalamazoo Valley Chapter's Stanley Weber Projects Fund honors a dedicated member by supporting projects that enhance coldwater fisheries and their habitats. Offering grants up to $5,000 annually, the fund prioritizes non-profit initiatives that foster conservation, restoration, and public education while promoting volunteer engagement. Recognition through plaques or media announcements is requested for grant recipients, ensuring the legacy of Stanley Weber continues to impact the community positively.

The AWWA Scholarship Program, specifically the Woodard & Curran Scholarship, offers a $5,000 merit-based award annually to undergraduate or graduate students focused on water-related fields. This initiative aims to support historically marginalized communities, including women and BIPOC students, promoting equity in the water industry. With clean water being essential for community health, this scholarship reflects AWWA's commitment to nurturing the next generation of water professionals.

Wilson Ornithological Society

The earliest stages of the Wilson Ornithological Society’s development began with the formation of the “Young Ornithologists’ Association,” initiated in 1886 under the leadership of L. O. Pindar and J. B. Richards. They began as a corresponding group of naturalists interested in birds, with notes published in The Oölogist.

Soon after, the Society acquired a constitution and established itself in December 1888 as the Wilson Ornithological Chapter of the Agassiz Association. The fledgling group was named in honor of Alexander Wilson, considered the Father of American Ornithology. Its original purpose was “the study of birds, their nests, and eggs.”

Over the subsequent decades, the group—eventually becoming known as the Wilson Ornithological Club—published its proceedings and articles under a series of diverse titles, culminating in The Wilson Bulletin after 1894 and, most recently, The Wilson Journal of Ornithology. The Club adopted its Constitution and Bylaws in 1930 and became the Wilson Ornithological Society in 1955.

Early Professional Avian Conservation and Community Impact Award

The Early Professional Avian Conservation and Community Impact Award recognizes outstanding contributions by Wilson Ornithological Society (WOS) members working in applied, non-research careers that advance the conservation of birds and their habitats. This award also celebrates professionals whose work fosters a stronger and more inclusive conservation community, through management, education, communication, advocacy, or community engagement.

Purpose

This award highlights the diverse pathways through which people contribute to lasting ornithology and avian conservation beyond academic research. It honors those whose efforts build bridges between science, management, and the public; inspire action for birds; provide mentorship or leadership to build capacity; and promote equity, inclusion, and accessibility within the bird conservation community.

Examples of Qualifying Contributions

• Developing and implementing habitat management or conservation plans.
• Creating tools, educational materials, or outreach programs that promote bird conservation.
• Leading advocacy, communications, or storytelling that inspires conservation action.
• Building partnerships or community engagement initiatives that strengthen conservation impact.
• Advancing conservation policy or planning at local, regional, or national scales.

Award and Presentation

The recipient will be recognized at the 2026 Wilson Ornithological Society Annual Meeting, where they will be invited to share their work with attendees. The award includes:

• A monetary honorarium
• An original piece of artwork from an early-career artist
• Coverage of meeting registration, travel, lodging, and per diem expenses

About Pfizer External Research & Grants

Pfizer External Research & Grants (ER&G) supports independent research, education, and QI initiatives to improve patient outcomes in areas of unmet need. Competitive grants are awarded through transparent RFPs reviewed by independent expert panels.

About ASCP

American Society for Clinical Pathology (ASCP) is the world’s largest professional membership organization for pathologists and laboratory professionals, with more than 100,000 members. ASCP provides excellence in education, certification, and advocacy on behalf of patients and the laboratory workforce. With a portfolio of more than 900 educational activities, ASCP is the worldwide leader in providing CME/CMLE credit for the entire laboratory team.

Quality Improvement in Molecular Testing Pathways for Metastatic Colorectal Cancer (mCRC)

The American Society for Clinical Pathology (ASCP), in collaboration with Pfizer Inc. and with participation from the American Society of Clinical Oncology (ASCO, invites proposals for pathology-centric Quality Improvement (QI) initiatives aimed at optimizing molecular testing pathways in the management of metastatic colorectal cancer (mCRC). This grant opportunity seeks to fund sustainable projects that improve biomarker testing practices, strengthen targeted therapy selection, and support care teams in implementing patient-centered protocols. 

The overarching goal of this program is to advance diagnostic excellence and improve treatment decision-making for patients with mCRC.

The Healthy American Forests Initiative, led by the National Fish and Wildlife Foundation (NFWF), aims to enhance forest health and resilience through targeted funding. This initiative anticipates awarding 10-15 grants ranging from $250,000 to $2 million, supporting projects up to 2 years in duration. A 20% non-federal match is required, and interested applicants are encouraged to collaborate with NFWF and Native Americans in Philanthropy for potential match funding.

The Arthritis National Research Foundation supports early career researchers in their quest to advance understanding and treatment of arthritis and related autoimmune diseases. Annually, the foundation grants 10 to 20 awards of $125,000 each for two years. Focus areas include osteoarthritis, rheumatoid arthritis, lupus, and more. Eligible investigators must hold an M.D. or Ph.D., be affiliated with a U.S. nonprofit research institution, and commit significant research time. Applications from prior grant recipients or those with certain NIH grants are ineligible.

The Mike & Sofia Segal Foundation Grant provides vital funding to nonprofit organizations focused on intellectual freedom, medical research for rare diseases, Jewish heritage preservation, elder care, and climate change initiatives. By supporting innovative projects that align with their mission, the foundation aims to uplift communities and foster meaningful societal contributions. Organizations must be 501c-3 compliant and demonstrate a clear plan for engagement with beneficiaries and measurable objectives to be eligible for funding.

The Oak Foundation's Housing and Homelessness Grant Program aims to reduce homelessness and improve housing conditions by supporting organizations that empower renters and advocate for equitable housing. The program focuses on enhancing renter rights, increasing the availability of affordable homes, and preventing homelessness through community-driven strategies. By addressing structural issues such as poverty and discrimination, the foundation seeks to create lasting change in housing accessibility for marginalized populations in both the US and UK.

The Higher Education Challenge Grants Program, managed by the USDA's National Institute of Food and Agriculture, aims to enhance institutional capacities in food and agricultural sciences education. This initiative focuses on improving curriculum, faculty, and student recruitment for master's and doctoral programs, particularly in veterinary medicine. By strengthening these educational frameworks, the program seeks to ensure the availability of skilled professionals in critical agricultural sectors.

Mental Health

Overview

Our vision for adults living with mental illnesses is that they are engaged and supported members of the community

We recognize advocacy at the state and federal levels is essential to achieving meaningful change, so we partner with organizations from across the United States to raise awareness of critical mental health issues and to press for increased public funding.

Our Goals

Through our investments and advocacy, we hope to accomplish the following:

• There is a strong, well-trained mental health workforce capable of meeting community need.
• Adults affected by serious mental illnesses have access to high-quality medical treatment and support services that enhance their quality of life.
• Mental health services are well funded by public and private investment.

The Research Foundation of the American Society of Colon and Rectal Surgeons offers a Career Development Award to support early career investigators in colorectal surgery. With a funding of $75,000 per year for two years, this award emphasizes mentorship and career growth. Applicants must be within five years of their first faculty position and demonstrate innovative research in colon and rectal diseases. The award aims to enhance academic careers while fostering advancements in surgical techniques.

The Applied Drug Policy Research Experiences project aims to provide graduate students and recent post-graduates with hands-on research opportunities to support the National Drug Control Strategy. Through rigorous studies and data analyses, this initiative will explore the evolving dynamics of illicit drug supply and usage, assisting public health and safety officials in anticipating drug-related issues and crafting effective responses to safeguard the American public.

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

Medication Therapy Management (MTM) Initiative

The Medication Therapy Management (MTM) Initiative, supported by the McKesson Foundation and administered by the NAFC, aims to improve medication access, adherence, and patient understanding among uninsured and medically underserved populations. Individuals without health insurance often face significant barriers to obtaining prescription medications and receiving the counseling necessary to manage chronic conditions effectively. Through this initiative, NAFC will provide $30,000 grants to member free and charitable clinics and pharmacies to establish or expand Medication Therapy Management programs aligned with recommendations from the American Pharmacists Association. Funding will support activities such as staff certification in MTM, development of standardized protocols, and patient education to help individuals better understand their medications, manage side effects, and support overall treatment plans. By strengthening pharmacist-led care and improving communication between providers and patients, this initiative seeks to enhance medication adherence, improve chronic disease management, and advance better health outcomes for vulnerable patient populations.

Common Waters: Strengthening Community-based Coastal and Riverine Stewardship

Opportunity Overview

Projects supported by this RFP must be community-based stewardship initiatives (including but not limited to stewardship driven by Indigenous and descendant communities); they should be led by an individual with a strong connection to and/or an existing track record of work in the community(ies) where the project will take place, or by a member of the community themselves, and be designed in response to community needs. Projects can focus on a wide range of specific issues, including (but not limited to) local conservation and ecosystem restoration, climate change adaptation and resilience, or sustainable fishing/agriculture. The RFP will prioritize projects in National Geographic-Lindblad Expeditions destinations, including the Arctic, Asia, Baja California, Costa Rica and Panama, Europe and the Mediterranean, Patagonia, the Peruvian Amazon, the Pacific Northwest, Southeast Alaska and British Columbia, the South Pacific, and the United Kingdom and Ireland. For more detailed information on targeted areas within these regions, please refer to the targeted areas document.

J. C. & L. A. Duke Employees' Assistance Fund

Grants from the Duke Fund are designed to:

• Help recipients achieve self-sufficiency and/or return to the workplace.
• Provide transitional assistance.
• Improve the quality of life for the employee and their family.

Selection Criteria

The applicant must have experienced a combination of the following factors:

• Financial hardship as a result of a catastrophic illness or accident.
• Lack or depletion of benefits available through the 3M Benefit Plan, personal benefit plans and/or other resources.
• In addition, the applicant must be able to demonstrate that a grant will substantially assist them in overcoming all or a portion of the adversity. Awards will be made without regard to race, creed, color, gender, individual marital status, religion or national origin.

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

NAFC Capacity Fund

The NAFC Capacity Fund supports investments that strengthen clinic and pharmacy infrastructure and organizational effectiveness. This funding is designed to help NAFC members build the systems, tools, and capabilities needed to operate more efficiently, improve quality, and expand their ability to serve patients over time.

The Research Foundation of the ASCRS offers the Limited Project Grant to support innovative research in colon and rectal surgery. With funding up to $25,000 for one year, this grant aims to foster investigator-initiated, hypothesis-driven projects conducted in the U.S. or Canada. Successful applicants may secure further funding from national agencies. ASCRS membership is required for principal investigators, ensuring a dedicated approach to advancing colorectal health and surgical techniques.

The ASTR Targeted Research Area Grant supports projects by scholars focusing on under-represented areas in theatre, dance, and performance studies. This includes research on Asian, African, Latin American, and Middle Eastern disciplines, as well as pre-1900 studies and essential translations. The grant, offering up to $3000, encourages recipients to publish their findings and collaborate with Theatre Survey editors. Eligibility extends to scholars with terminal degrees and graduate students, provided they are ASTR members.

The FY26 Bureau of Land Management Wildlife Resource Management Program aims to enhance wildlife resource management on public lands across the nation. With a focus on habitat protection, species reintroduction, and collaborative conservation efforts, the program addresses critical ecological needs while supporting the social and economic well-being of communities. Key initiatives include habitat treatments, monitoring efforts, and partnerships with state agencies to ensure effective management and recovery of priority wildlife species.

The NIDA Research Education Program (R25) aims to enhance the training of a workforce skilled in biomedical, behavioral, and clinical research, particularly regarding substance use disorders. This program supports educational activities that prepare clinicians and clinical researchers. Applications are due by 5:00 PM local time, with optional Letters of Intent encouraged 30 days prior to the full proposal deadline. This initiative does not fund non-research-related clinical training.

The Eugene Salvati, MD, Limited Project Grant, offered by the Research Foundation of the American Society of Colon and Rectal Surgeons, supports clinical research in colorectal surgery. This grant aims to honor Dr. Salvati's legacy by funding innovative projects that improve patient care. With a maximum funding of $25,000 for one year, it emphasizes investigator-initiated research conducted within the U.S. or Canada, encouraging collaboration among ASCRS members and adherence to ethical review board protocols.