Best Large Grants for Nonprofit Organizations in New York

The DFO Research, Education, and Conservation Grant supports projects focused on birds and their habitats, prioritizing initiatives in the Denver area and Colorado's Front Range. Established in 1994, the fund encourages research, education, and conservation efforts with grants typically under $2,000. Recent funded projects include studies on owl habitats and educational programs for young birders. The fund aims to advance knowledge and appreciation of avian species through targeted financial support.

The General Surgery Resident Research Initiation Grant aims to engage General Surgery Residents in research related to colorectal diseases. With an annual funding of $20,000, this grant supports both clinical and laboratory-based research. It is geared towards residents or recent graduates of approved General Surgery programs, prioritizing those with aspirations in Colon and Rectal Surgery. This initiative fosters innovative research to enhance patient care and surgical techniques in the field.

Greater Toledo Community Foundation

Greater Toledo Community Foundation transforms generosity into lasting impact. With over $510 million in assets across 1,000+ funds, we've granted more than $370 million to strengthen education, health, arts, and social services throughout our region.

We connect donors with causes they care about while bringing together leaders, organizations, and resources to tackle our community's biggest challenges. What began with Walter E. Terhune's vision in the 1920s continues today as we help individuals, families, and businesses create positive change that will benefit our region for generations.

Ottawa County Community Foundation Grants

The Ottawa County Community Foundation, Inc. (OCCF) is a public charitable organization created by the citizens of Ottawa County to enrich the quality of life for individuals and families in Ottawa County. Grants from unrestricted funds support a variety of programs in the fields of education, health and social services, economic development, natural resources and the arts.

About National Fish and Wildlife Foundation (NFWF)

The National Fish and Wildlife Foundation (NFWF) works with partners to foster sustainable and impactful conservation solutions so that people and nature thrive together. Chartered by Congress in 1984, NFWF has grown to become the nation’s largest conservation foundation. Since its founding, NFWF has funded more than 23,900 projects that have generated a total conservation impact of more than $12 billion.About Sustain Our Great Lakes Program

Sustain Our Great Lakes is a public–private partnership designed to sustain, restore and protect fish, wildlife and habitat in the basin by leveraging funding, building conservation capacity, and focusing partners and resources toward key ecological issues. The program achieves this mission, in part, by awarding grants for on-the-ground habitat restoration and enhancement.Funding priorities for this program include:

• Habitat Restoration to Conserve Species and Improve Water Quality
• Expand and Maintain Nature-Based Solutions in Great Lakes Communities
• Invasive Species Control to Protect and Enhance Restored Habitat
• Activate Restored Habitats and Natural Areas

Our Mission and Vision

The Wright Foundation for Sustainability and Innovation exists to foster innovative sustainability initiatives that make a positive impact on our planet. We want to find solutions to the complex challenges facing our world today.

Our vision is to facilitate positive action toward sustainable and innovative solutions in agricultural and environmental sectors that reduce carbon footprints and minimize risk for our communities.

Grant Programs

Wright Foundation for Sustainability and Innovation administers projects directly funded by donors that help reduce carbon footprints through carbon positive practices and emission offsetting. The foundation holds open application periods for projects in the contiguous United States, Puerto Rico and Canada that focus on reducing environmental risk through regenerative agricultural practices, habitat restoration and using natural energy sources to make our communities more sustainable.

Reducing Carbon Footprints

The foundation supports projects that work to reduce carbon footprints through the following initiatives.

Habitat Reclamation

• Restoration of habitats creates spaces for native flora and fauna and microorganisms to survive. Natural landscapes are integral to functioning ecosystems and increasing biodiversity, not to mention creating habitats for pollinator species like bees and butterflies that we so desperately need for agricultural success.

Regenerative Agriculture

• Regenerative agricultural practices have a far-reaching impact on the industry and our lives. We aim to reduce carbon emissions by fostering projects that innovate row crop sustainability and dairy, beef, pork and poultry operations to create practices that are sustainable for years to come.

Renewable Energy

• We care about carbon positive practices that harness renewable resources like solar, wind and biomass for improved efficiencies and overall reduction in use. Organic matter often sourced from agricultural production, garbage and tree pruning can be converted to energy in various ways, recycling it back into the agricultural operation that created it or fueling our communities.

Soil

• Soil sequestering practices have wide-reaching benefits like restoring and building organic matter in the soil and increasing biodiversity. It boosts water infiltration and retention and reduces erosion. Through practices like no till, applying organic matter like manure and biochar, and planting cover crops, we improve soil health as well as take CO2 out of the atmosphere.

Tree Planting

• Planting trees is a simple act that makes a huge impact in our urban, suburban and rural communities. They provide shade, release oxygen and improve air quality, improve soil quality and biodiversity, all of which contributes to offsetting carbon emissions.  

• Water
• We want to find ways to protect and restore the integrity of our water resources. We aim to fund projects focused on practices that create efficiencies and reduce the agricultural production impact on water quality and benefit our communities by conserving one of our most important natural resources. 

John Harsch Regenerative Agriculture Grant

Funding for projects adopting best regenerative agricultural management practices that impact one or several of these areas:

• Improve water quality
• Reduce soil erosion
• Increase soil health index
• Reduce synthetic fertilizer use
• Increase effective manure use as a fertilizer
• Increase biodiversity
• Reduce methane and nitrous oxide emissions

This funding opportunity encourages applications for clinical observational studies focused on musculoskeletal, rheumatic, and skin diseases. It aims to gather essential data for designing future clinical studies, enhancing understanding of disease symptoms, progression, and patient outcomes. Observational studies supported by this initiative will contribute to the development of objective biomarkers and effective outcome measures. Applicants are invited to address key challenges in clinical project design, ensuring a robust foundation for subsequent clinical trials.

The Jobs Plus NOFO for FY2026, issued by the US HUD's Office of Public and Indian Housing, aims to enhance job opportunities for public housing residents. This initiative encourages innovative programs that prepare individuals for employment in high-demand fields, ultimately fostering economic stability within communities. By focusing on workforce development, this funding opportunity seeks to empower residents through education and training, paving the way for long-term success and self-sufficiency.

The Nonprofit Resource Training Grant offers up to $1,000 for tax-exempt organizations to send employees to essential training and conferences. This initiative supports community-based groups that serve low- to moderate-income populations and align with The Ready Commitment. By enhancing employee skills, the grant aims to strengthen nonprofits and their impact in the community, ensuring they provide valuable services effectively.

The Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61 Clinical Trial Required) aim to support clinical trials that can be completed within a limited timeframe. This funding opportunity encourages a variety of exploratory studies that align with the NIAMS mission, focusing on interventions such as drugs, biologics, devices, and various therapies. Applications are due by 5:00 PM local time of the applicant organization.

The American Heart Association is seeking proposals to study the prevalence and treatment of cardiovascular, kidney, and metabolic diseases among cancer patients and survivors. Given the over 16.7 million cancer survivors in the U.S., this research aims to highlight critical health disparities, identify treatment modalities, and explore shared risk factors. Applications focusing on underrepresented populations and utilizing real-world data sources are especially encouraged, aiming to improve health outcomes in this vulnerable group.

The Limited Competition Small Grant Program for NIDDK K01/K08/K23/K25 recipients offers funding opportunities for pilot studies and feasibility research. This program aims to support researchers transitioning to independent investigator roles by providing resources for small projects that can yield preliminary data for future R01 applications. Key deadlines for applications range from February 2025 through January 2028, with specific dates for standard, renewal, and AIDS-related applications.

The Union Home Foundation Grant provides financial support to nonprofit organizations that promote economic self-sufficiency through financial literacy and housing initiatives. Established in 2015, this grant has awarded over $2 million to various nonprofits across the U.S. Grants typically start at $1,000 and are available for a one-year period. Organizations must be 501(c)(3) tax-exempt and can only apply once per year, following specific eligibility criteria.

The HEAL Initiative: Pain Research Enhancement Program (PREP) supports R15-eligible Principal Investigators in conducting innovative pain research. This program encourages interdisciplinary partnerships and aims to enhance the research environment for health professional trainees. Key application deadlines include November 19, 2024, and October 28, 2025, with specific dates for AIDS-related applications. By fostering collaboration, the initiative seeks to advance understanding and treatment of pain.

The Melanoma Research Resident and Fellowship Grant offers $10,000 to support early-career residents and fellows in conducting clinical or laboratory research focused on melanoma. This grant encourages innovative approaches to understanding prevention, detection, and treatment of melanoma, including special emphasis on ocular melanoma. Eligible candidates must have a qualified mentor and conduct research at a U.S. institution. This initiative aims to enhance the landscape of melanoma research and foster the next generation of researchers.

The USDA Forest Service's Invasive Species Program funding opportunity invites proposals aimed at enhancing invasive species prevention. By leveraging existing research and knowledge, projects can create actionable solutions to protect American agriculture. This initiative seeks to connect scientific insights with practical regulatory improvements, thereby reducing the introduction and establishment of new invasive pests. Previous research, including horizon scanning and monitoring sentinel trees, serves as a foundation for developing effective strategies.

The Applied Materials Momentum Fund offers emergency financial assistance to students facing unexpected financial obstacles while pursuing degrees in engineering. This initiative supports basic needs such as food, housing, and transportation, ensuring that students can continue their education without interruption. It aims to empower women engineers and underrepresented groups in the semiconductor industry, fostering a diverse and resilient workforce for the future.

The Applied Materials Momentum Fund - Bridge Grants aim to support students facing financial obstacles in completing their computing degrees. This initiative fosters diversity in the semiconductor industry by encouraging women engineers and providing them with career-building opportunities. Eligible candidates include U.S. citizens, DACA recipients, and F1 visa holders pursuing engineering majors. The fund not only alleviates financial stress but also opens doors to internships and full-time positions at Applied Materials, thus enhancing educational progress and career advancement.

The Applied Materials Momentum Fund is dedicated to enhancing educational opportunities for students in the semiconductor industry, particularly supporting women engineers. This initiative provides essential financial assistance through various grant types, including emergency mini-grants and larger Last Mile grants, aimed at helping students overcome financial barriers in their pursuit of degrees. By fostering diverse and resilient teams, the fund contributes to innovation and growth in technology and engineering fields.

The BJA FY 2026 Smart Reentry Demonstration Program aims to support state, local, and tribal governments in implementing effective reentry strategies for individuals transitioning from correctional facilities back to their communities. This program encourages comprehensive interventions designed to reduce recidivism by addressing various reentry needs, as outlined in the Second Chance Act. Applications are due by October 1, 2026, at 8:59 PM ET, and are submitted through JustGrants.

The Affirm Cares Employee Foundation Grant, established by Affirm, aims to support non-profit organizations making a significant impact in financial literacy, community enrichment, and technology education. Grants range from $1,000 to $10,000, focusing on sustainable initiatives that empower communities and alleviate housing insecurity. Eligible applicants must be 501(c)(3) designated non-profits operating within the U.S. The foundation prioritizes measurable outcomes in its funding efforts, fostering civic engagement and vibrant communities.

The NIAID Career Transition Award (K22) supports postdoctoral fellows transitioning to independent research positions, fostering their development into successful biomedical scientists. Key deadlines for applications span from February 2025 to June 2027, including specific dates for standard, renewal, and AIDS-related grants. This initiative, funded by the NIH, aims to enhance the career trajectory of emerging researchers in clinical and biomedical fields, ensuring a robust pipeline of innovative scientific talent.

The NYSCA Encore Grants are designed to support returning Staten Island-based 501(c)(3) nonprofit organizations in presenting significant artistic and cultural programming across various disciplines. Eligible projects must focus on cultural expression and be accessible to the community, emphasizing artistic significance and addressing under-resourced disciplines. The grant is funded by the New York State Council on the Arts and aims to enhance local cultural production and community engagement.

The AUKUS Scholarship, part of the Graduate Education Fund, supports American and Australian graduate students in security, technology, and diplomacy fields. Applicants must be citizens or permanent residents, with an offer from an accredited institution. The scholarship provides up to $40,000 for tuition, travel, and living expenses. Applications are due in March for Australia to USA and in September for USA to Australia. This initiative strengthens ties and promotes research in critical areas.

The Unity for Humanity Grant invites innovative creators to submit impact-driven projects that utilize real-time 3D technology. This annual grant provides funding, technical support, and marketing resources to help bring visionary ideas to life. Projects must align with UN Sustainable Development Goals and demonstrate measurable impact. Eligible submissions include prototypes across various genres, fostering a more inclusive and sustainable world. Join us in empowering changemakers to make a positive global difference.

The DCLA Art Fund Grants, offered by Staten Island Arts, support individual artists and collectives in creating culturally significant work. Open to all artistic disciplines, projects must include a public component. Emphasizing community engagement, the grants prioritize under-resourced disciplines and communities. With funding from the Greater New York Arts Development Fund, these grants aim to enhance cultural programming and education, fostering a vibrant arts scene on Staten Island.

The Barnabas McHenry Hudson River Valley Awards support exceptional young leaders in environmental conservation, historic preservation, and the arts. Awarded annually, these prestigious grants of up to $5,000 encourage students to engage in impactful projects with local nonprofits. Since 2007, the awards have honored the legacy of Barnabas McHenry, fostering a new generation of environmental advocates and cultural stewards dedicated to enhancing the Hudson Valley's unique resources.

About Us

Overview

The Alaska Community Foundation connects people who care to the causes that make a difference and matter most to them. We encourage and nurture philanthropy through building and managing permanent endowments, convening stakeholders, working with partners to strengthen Alaskan communities, and providing donors with flexible giving options that are strategic to their philanthropic objectives. ACF also manages the Pick.Click.Give. program.

Mission

Inspiring the spirit of giving and connecting people, organizations, and causes to strengthen Alaska’s communities now and forever.

Vision

ACF envisions an Alaska where communities come together and have resources to thrive.

Stassel Education Scholarship Fund

The Stassel Fund was established in memory of Fred L. and Jean N. Stassel who came to Alaska on their honeymoon in 1949, making Anchorage their home for over 60 years until they passed away in 2017 and 2011 respectively. Here they raised 6 children, celebrated Alaska's statehood in 1959, survived the 1964 earthquake, and became active in the community and state. The Fund honors their dedication to education and service to others focusing on creating opportunities for all Alaskans, especially the vulnerable and most in need. Fred and Jean valued education, hard work, integrity, justice, respect, and care for all people. They were both educators, commercial fishers, and very active in social services through the United Methodist Church and other organizations. Fred was very influential in establishing the now-named Credit Union 1, and Jean was active with The League of Women Voters. They would be honored to know that deserving Alaskans were able to pursue their educational goals with the help of scholarships from the Stassel Education Fund.