Best Large Grants for Nonprofit Organizations in New York

The Thriving Community Impact Fund offers grants ranging from $2,500 to $49,999 to support community health initiatives. Gundersen Health emphasizes collaboration and addressing social needs to foster well-being. Eligible organizations include non-profits, schools, and government agencies. The fund prioritizes projects that align with the Community Health Improvement Plan, focusing on health equity, civic engagement, and neighborhood enhancement. This initiative aims to empower communities and improve health outcomes while fostering corporate social responsibility.

The Thriving Community Impact Fund offers grants up to $2,499 to support local programs that enhance community health and well-being. This initiative by Gundersen Health emphasizes collaboration, focusing on areas such as physical and mental health, poverty alleviation, and neighborhood improvements. Organizations like non-profits and government agencies can apply for funding during a rolling application period, with decisions made monthly. The fund aims to empower communities and address health inequities through impactful partnerships.

The E2 Energy to Educate Grant, offered by Constellation Energy Resources, empowers students from sixth grade to college to tackle current and future energy challenges. With grants up to $50,000, projects can enhance understanding of STEM and energy careers, particularly for underserved communities. Innovation themes include sustainability, nuclear technology, and clean energy solutions, aiming to inspire diverse participation in the energy sector while addressing climate change through advanced technologies.

The Luce/ACLS Dissertation Fellowships in American Art support graduate students conducting research on the history of art and visual culture in the U.S., including Native American art. These fellowships aim to enhance diversity in academia by welcoming applications from PhD candidates at all degree-granting institutions in the U.S. The program offers a stipend of $38,000 plus a travel and research allowance, with a total award of $42,000 for a nine to twelve-month period between July 2025 and May 2027.

The 1928 AGC Founders Fund, established by the Adirondack Garden Club, aims to support nonprofit organizations, including schools, that enhance the Adirondack environment. By providing grants, this fund promotes gardening knowledge, protects native species, encourages civic planting, and conserves natural resources. Applications are welcomed from organizations dedicated to making a positive impact in Clinton, Essex, and Franklin counties, covering a diverse area of 1,824 square miles.

The DCLA Premier Grants provide vital support to first-time applicants, including individual artists and community organizations on Staten Island. These grants focus on projects that foster public engagement and enhance cultural programming across diverse artistic disciplines. Eligible applicants must demonstrate community interest, clear objectives, and a realistic plan for implementation. Priority is given to projects that address under-resourced communities or artistic disciplines, ensuring equitable access to funding and cultural production opportunities.

The Mitsubishi Corporation Foundation for the Americas (MCFA) supports environmental initiatives across the Americas, focusing on biodiversity conservation, environmental education, justice, and sustainable development. They prioritize programs that align with these aims, particularly those involving 501(c)(3) organizations. MCFA seeks to empower marginalized communities, promote ecological stewardship, and encourage sustainable economic practices, ensuring that environmental burdens are shared equitably across all communities.

The Graduate Education Fund: AUKUS Scholarships, established by the American Australian Association, supports American and Australian citizens pursuing full-time graduate studies in security, technology, and diplomacy. With up to $40,000 in funding for tuition and living expenses, this scholarship encourages innovative research in critical fields, particularly in relation to the AUKUS initiative. Applications are open biannually, fostering educational exchange and collaboration between the two nations.

The Field Hall Foundation Small Grants program supports not-for-profits and local governments in Dutchess, Putnam, and Westchester Counties, NY, aiming to enhance the lives of older adults and caregivers. Grants are awarded three times a year through a Letter of Inquiry process. Focus areas include food insecurity, home-based care, and transportation. Priority is given to new projects addressing basic needs, with eligibility criteria including a $1 million budget and a commitment to direct services.

The Bronx Cultural Visions Fund Grant supports the live performing arts in the Bronx by funding new project development for individual artists, collectives, and nonprofit organizations in theater, music, and dance. Grants of up to $20,000 are available for project realization, with an emphasis on emerging and mid-career artists. The program requires participation in cohort meetings and aims to foster long-term relationships within the borough's artistic community.

The Reproductive Scientist Development Program (RSDP) aims to enhance maternal and infant health by supporting early-career researchers in obstetrics and gynecology. This program encourages applicants committed to advancing their careers in academic research. With a focus on health equity and the training of scholars, RSDP seeks to foster impactful research proposals that address critical issues such as prematurity and maternal morbidity. Funded by the March of Dimes and other organizations, it empowers diverse talent in the field.

The Pediatric Scientist Development Program (PSDP) supports early-career pediatricians committed to research. It emphasizes flexible research proposals, fostering scientific inquiry in pediatrics, particularly in areas like prematurity and health equity. Funded by March of Dimes and other organizations, the program aids scholars in gaining vital training and mentorship while contributing to advancing pediatric health outcomes. Applicants must have completed pediatric residency in the USA or Canada and demonstrate a strong commitment to medical research.

The Lynne Goldsborough Yowell Scholarship, managed by the Northern Piedmont Community Foundation, supports students from Madison and Culpeper County public high schools. It is awarded to high school graduates or current college students pursuing an Arts Major, defined as visual arts, music, theater, or culinary arts. Emphasizing academic merit and financial need, this scholarship honors the legacy of Lynne Goldsborough Yowell, a dedicated community advocate.

The NIDA Core "Center of Transformative Science" Grant Program aims to enhance research on substance use, addiction, and HIV by fostering collaboration among NIH-funded researchers. Centers are expected to innovate and extend existing research through shared resources and support for new investigators. This initiative encourages interdisciplinary work and aims to transform the scientific landscape by promoting data sharing and collaborative opportunities. Applications should focus on integrating research within a specific thematic framework to maximize impact.

The NEA Federal Rescue Implementation Network Grant provides up to $100,000 per year for two years to state affiliates for hiring a coordinator to implement the American Rescue Plan in support of public education. This funding is specifically for backfilling a position that must remain filled for at least ninety days, ensuring effective oversight of federal recovery initiatives within the affiliate.

About The Community Foundation

The Community Foundation of Herkimer and Oneida Counties is a community-based social impact investor whose mission is to engage, invest, and lead—working toward a vision of community vibrancy with opportunity for all. Our team of experienced staff and dedicated trustees is committed to boldly leading and supporting transformational community investments. We channel charitable contributions from donors through nonprofit partners that are meeting current community needs and steward community resources responsibly to ensure greater capacity for the future.

Helpful Harvest Grant Round

The Community Foundation of Herkimer and Oneida Counties will host its Helpful Harvest Grant Round to help Herkimer and Oneida County nonprofits address food insecurity this holiday season. The Community Foundation is seeking applications from human service organizations whose primary operation is a food pantry, soup kitchen or shelter that provides pantry items or meals to residents.

The National Institute on Drug Abuse (NIDA) is launching a specialized entrepreneurship program aimed at life science researchers in the field of substance use disorders (SUD). This initiative will equip researchers with essential skills to transform their innovative ideas into viable products, focusing on aspects such as market evaluation, customer discovery, and intellectual property. The course will be delivered in a hybrid format to engage US-based SUD researchers effectively, fostering collaboration and advancing the field.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Multiple sclerosis (MS) health equity

Help with healthcare costs for multiple sclerosis (health equity)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

Health Equity Funds offer help to eligible patients living in areas identified as having increased social and financial needs, as well as higher rates of chronic conditions. Eligibility is determined in part by home address zip code. 

About the disease

Multiple sclerosis (MS) is a potentially disabling disease of the central nervous system in which the insulating covers of the nerve cells in the brain and spinal cord are damaged. MS is a chronic disease that affects the nervous system.

The NINDS Exploratory Clinical Trials for Small Business (R43/R44 Clinical Trial Required) grant supports small businesses in conducting innovative clinical trials relevant to neurological disorders. This funding opportunity encourages investigator-initiated projects evaluating drugs, devices, and therapies aligned with NINDS goals. Applications are accepted only from SBIR Phase II and Fast-Track applicants, with a submission deadline of 5:00 PM local time. Letters of Intent are encouraged 30 days prior to the full proposal deadline.

The AHRQ is inviting proposals for research focused on improving diagnostic safety in ambulatory care settings. This funding opportunity aims to understand the incidence and contributing factors of diagnostic errors that occur across various ambulatory care services. Proposals should address the complexities of diagnostic safety to enhance patient care and outcomes.

Samardzija-Gutesha Family Fund

The Field of Interest Fund reflects the Samardzija-Gutesha family’s values and commitment to giving back. It supports education and hands-on learning in farming, soil health, and water conservation, with a focus on FFA members and associate-level college students.

Scholarships benefit graduating seniors and second-year post-high school students who are originally from DeKalb County high schools with FFA programs.

The Samardzija-Gutesha Family Fund provides scholarships for post-high school students pursuing education in agriculture or conservation, as well as paid internships with local farmers, and conservation professionals. It also supports educational seminars on topics such as sustainable farming and agricultural business, and provides grants to local organizations that align with the donor’s values.

In its first year, the Fund awarded $65,000 in scholarships to eight graduating seniors from DeKalb, Genoa-Kingston, Indian Creek, Somonauk, and Sycamore high schools (pictured above). Each student attending a two-year college received a $5,000 scholarship, while students planning to attend a four-year university received $10,000.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Multiple sclerosis (MS)

Help with healthcare costs for Multiple sclerosis (MS)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Multiple sclerosis (MS) is a potentially disabling disease of the central nervous system in which the insulating covers of the nerve cells in the brain and spinal cord are damaged. MS is a chronic disease that affects the nervous system.

The Garman Family Foundation Grant, administered by the Community Foundation for Greater Buffalo, focuses on enhancing mental health, physical wellness, and education, particularly for women and children. With two annual cycles, it supports organizations in Western New York that hold a 501(c)(3) status. Applications are limited to one grant per year, prioritizing impactful initiatives. However, certain funding areas, such as higher education scholarships and political activities, are excluded from consideration.

The Principal Student Support Services Grant, offered by the School-Based Healthcare Solutions Network, aims to enhance mental health support for students in grades 6-12 at under-resourced public schools. With funding available for hiring mental health professionals and performance-based awards, this initiative addresses critical challenges like chronic absenteeism and behavioral issues. By providing targeted interventions, the grant seeks to improve academic performance and overall well-being among students facing mental health crises.

The National Institute on Aging (NIA) is launching a Notice of Funding Opportunity (NOFO) to establish a national consortium focused on improving care for older adults with multiple chronic conditions. This initiative aims to evaluate the effectiveness of integrated primary care interventions through innovative electronic health record (EHR) platforms. By fostering collaborations among researchers and clinicians, the consortium will work to enhance patient outcomes and streamline population health management, paving the way for future advancements in aging care.

The Chobani Community Impact Fund, managed by The Community Foundation for South Central New York, focuses on combating food and nutrition insecurity. It supports initiatives such as community-based meal programs, nutritional education for mothers and caregivers, and efforts to enhance access to food-related public benefits. Eligible organizations include 501(c)(3) groups benefiting Chenango and Otsego counties, while ineligible requests include funding for capital campaigns and reimbursements for prior costs.

The DOE Computational Science Graduate Fellowship (CSGF) supports U.S. citizens and permanent residents pursuing Ph.D. degrees in computational sciences. Established in 1991, it provides a $45,000 annual stipend, full tuition, and a $1,000 professional development allowance over a maximum of four years. The program encourages interdisciplinary research, offering fellows practical experience in DOE laboratories, enhancing their careers in high-performance computing and scientific research across various fields.