Best Large Grants for Nonprofit Organizations in New York

The Indigo Oak Fund, a Colorado-based private foundation, focuses on empowering women and children through various initiatives. By funding organizations that address issues such as domestic abuse, food insecurity, and gender equity, the Fund aims to improve lives and foster lifelong learning. Their mission emphasizes recognizing individual potential and ensuring equal opportunity for all, making a significant impact in communities across Colorado and the Bay Area.

The National Institute on Drug Abuse (NIDA) invites applications for longitudinal cohort studies focusing on HIV and substance use. This initiative aims to foster multidisciplinary research addressing HIV-associated co-morbidities and substance use disorders. The program encourages collaboration with a NIDA-funded Coordinating Center to enhance research agendas that align with NIH-HIV priorities, ensuring impactful policy and practice outcomes in the field of HIV/AIDS and substance use.

The Downing-Nix Trust Grant provides funding for organizations engaged in research on muscular dystrophy, maintaining treatment wards in Atlanta hospitals, offering veterinary medicine scholarships, and supporting shelters for small animals. Organizations must qualify as 501(c)(3) charities. Applications are accepted year-round, but submissions by April 15 are required for annual meeting reviews. Priority may be given to hospitals and veterinary schools within Atlanta, GA.

The NCAA Postgraduate Scholarship for Fall Sports offers up to 126 scholarships annually, valued at $10,000 each, to student-athletes who excel academically and athletically. Eligible candidates must be in their final year of intercollegiate competition and maintain a minimum GPA of 3.20. Scholarships are awarded three times a year, with 21 available for men and 21 for women across various sports. This initiative promotes graduate education and recognizes the achievements of outstanding student-athletes.

The Southern NM Down Syndrome Families Scholarship Fund Endowment aims to provide financial support for individuals with Down syndrome pursuing post-secondary education or life skills training at accredited institutions. Managed by the Community Foundation of Southern New Mexico, this scholarship embodies the mission of improving quality of life and fostering educational opportunities for diverse communities. It encourages applicants from various backgrounds, including those with disabilities, to achieve their academic and personal goals.

The Gospel Fest Music Arts Scholarship, established by Vicki Hill of WTLZ-FM, aims to support Saginaw County students pursuing degrees in Musical Arts. This initiative is part of a larger effort by the Saginaw Community Foundation to enhance local education through scholarships and grants. The annual Gospel Fest, attracting up to 2,000 attendees, serves as a vibrant community event promoting peace and cultural unity through music, showcasing both local and national talent.

The Dr. Carol J. Chrisman Nursing Scholarship, offered by the Ashland County Community Foundation, supports registered nurses and nursing students from Ashland County pursuing advanced degrees at Ashland University. This scholarship honors Dr. Chrisman's legacy in nursing and community health, encouraging local nurses to further their education. Eligible applicants include full-time nursing students and those employed in public health within the area, with prior recipients allowed to reapply once.

Brave Beginnings Grants, under the Will Rogers Motion Picture Pioneers Foundation, focus on enhancing neonatal care by providing vital equipment to hospitals. Since 2006, the program has awarded approximately $1 million annually to Neonatal Intensive Care Units (NICUs) across the U.S. Following a suspension due to COVID-19, the 2026 grant cycle is now open, with applications due by February 13, 2026. This initiative aims to ensure the availability of lifesaving equipment for newborns in critical need.

The T32 Training Program for Institutions That Promote Diversity aims to increase the involvement of individuals from underrepresented backgrounds in research related to cardiovascular, pulmonary, hematologic, and sleep disorders. This initiative seeks to support institutions dedicated to serving health disparity populations, ensuring they develop robust training programs. While trainees cannot lead independent clinical trials, they can gain valuable experience under the guidance of mentors, ultimately contributing to improved health outcomes for underserved communities.

The Fiscal Year 2027 National Sea Grant College Program Dean John A. Knauss Marine Policy Fellowship offers an opportunity for students to engage in marine policy through a fellowship funded by the National Oceanic and Atmospheric Administration (NOAA). With anticipated funding for at least 35 applications, each receiving $97,200, this program encourages applicants to connect with their local Sea Grant program for support. Early registration with SAM.gov, Grants.gov, and eRA Commons is crucial for eligibility.

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The Middle Run Foundation is a family-governed foundation based in Newark, Delaware. The Board of the foundation is chaired by Sarah Ives Gore, its founder, and includes her children, grandchildren, and non-family members who bring experience and expertise to our work.

About

Purpose:

The purpose of the foundation is to fund and support non-profit programs which focus on building healthy, self-sufficient families.

Apply

The Middle Run Foundation makes grants up to $500,000 annually with individual grants ranging from $5,000 to $50,000.

The Agriculture and Food Research Initiative (AFRI) focuses on enhancing education and workforce development in food and agricultural sciences. It invites applications for various grants aimed at professional development, non-formal education for youth, community college training, and fellowships for both predoctoral and postdoctoral candidates. The program, managed by the USDA's National Institute of Food and Agriculture, emphasizes the cultivation of skills necessary for the future workforce in agriculture, with multiple deadlines for submissions.

The Hearst Foundation's Health Grant aims to support nonprofits that enhance healthcare access for underserved populations in the U.S. Focused on improving skills and increasing healthcare practitioners, the grant also emphasizes public health and medical research. With a history of funding significant projects, the foundation prioritizes programs that address the complex needs of low-income, rural, and elderly communities. This commitment ensures a sustainable impact on national health outcomes while supporting innovative healthcare delivery systems.

Our Mission and Vision

The Wright Foundation for Sustainability and Innovation exists to foster innovative sustainability initiatives that make a positive impact on our planet. We want to find solutions to the complex challenges facing our world today.

Our vision is to facilitate positive action toward sustainable and innovative solutions in agricultural and environmental sectors that reduce carbon footprints and minimize risk for our communities.

Grant Programs

Wright Foundation for Sustainability and Innovation administers projects directly funded by donors that help reduce carbon footprints through carbon positive practices and emission offsetting. The foundation holds open application periods for projects in the contiguous United States, Puerto Rico and Canada that focus on reducing environmental risk through regenerative agricultural practices, habitat restoration and using natural energy sources to make our communities more sustainable.

Reducing Carbon Footprints

The foundation supports projects that work to reduce carbon footprints through the following initiatives:

• Habitat Reclamation: Restoration of habitats creates spaces for native flora and fauna and microorganisms to survive. Natural landscapes are integral to functioning ecosystems and increasing biodiversity, not to mention creating habitats for pollinator species like bees and butterflies that we so desperately need for agricultural success.

• Regenerative Agriculture: Regenerative agricultural practices have a far-reaching impact on the industry and our lives. We aim to reduce carbon emissions by fostering projects that innovate row crop sustainability and dairy, beef, pork and poultry operations to create practices that are sustainable for years to come.

• Renewable Energy: We care about carbon positive practices that harness renewable resources like solar, wind and biomass for improved efficiencies and overall reduction in use. Organic matter often sourced from agricultural production, garbage and tree pruning can be converted to energy in various ways, recycling it back into the agricultural operation that created it or fueling our communities.

• Soil: Soil sequestering practices have wide-reaching benefits like restoring and building organic matter in the soil and increasing biodiversity. It boosts water infiltration and retention and reduces erosion. Through practices like no till, applying organic matter like manure and biochar, and planting cover crops, we improve soil health as well as take CO2 out of the atmosphere.

• Tree Planting: Planting trees is a simple act that makes a huge impact in our urban, suburban and rural communities. They provide shade, release oxygen and improve air quality, improve soil quality and biodiversity, all of which contributes to offsetting carbon emissions. 

• Water: We want to find ways to protect and restore the integrity of our water resources. We aim to fund projects focused on practices that create efficiencies and reduce the agricultural production impact on water quality and benefit our communities by conserving one of our most important natural resources. 

Tree Canopy Improvement Grant

Funding for projects in tree canopy improvement efforts:

• Increasing tree species diversity
• Planting in urban and suburban areas and green spaces

The Juliette Low’s Amazing Girls Scholarship, established in 2011 by the East Texas Communities Foundation, is aimed at female graduating seniors from Smith County who have been active in Girl Scouts. This scholarship supports educational pursuits for students attending any college in the U.S. Applicants must demonstrate financial need and have a minimum GPA of 3.00. The award amount is $1,000, and preference is given to recipients of the Girl Scout Gold Award. Reapplication is encouraged.

The Partners in Arts Scholarship, administered by the East Texas Communities Foundation, supports graduating seniors from Smith County who have engaged in performing or visual arts and plan to pursue a related major in college. This scholarship highlights the importance of arts education and aims to empower students to achieve their academic goals. Eligible applicants must demonstrate a commitment to the arts and meet specific criteria, ensuring that funding is awarded to deserving candidates.

The Furer-Barag-Wolf Post 126 Jewish War Veterans Scholarship Award supports children or grandchildren of JWV Post 126 members, providing merit-based assistance for college or vocational education. Eligible applicants must reside in specific counties in New Jersey or be related to a JWV member. The scholarship covers tuition, books, and living expenses and is open for reapplication annually. This initiative by the Jewish Community Foundation fosters educational opportunities for deserving students.

Morgan Stanley Alliance for Children’s Mental Health Innovation Awards aim to fund innovative mental healthcare solutions for children in the U.S. This initiative invites U.S.-based 501(c)(3) charities with revenues under $5 million to submit projects. With up to $550,000 in grants, the program focuses on addressing critical mental health issues among youth, fostering equity in access to care, and supporting nonprofits led by young leaders. Awards include up to $100,000 for general and $50,000 for Next Gen projects.

The CDC's National Center for Injury Prevention and Control invites research proposals aimed at reducing suicide and interpersonal violence among youth aged 10 to 24. This funding opportunity encourages the evaluation of pre-existing primary prevention strategies that have not yet been rigorously assessed. Proposed approaches may include community programs and policies designed to enhance social connectedness, mitigate harmful online behaviors, and address technology-facilitated interpersonal violence.

The See, Test & Treat Grant offers vital funding for cancer screening and health education programs targeting medically underserved communities. This pathologist-led initiative aims to reduce healthcare barriers, empower preventive care, and connect patients with local resources. Eligible organizations can apply for up to $50,000 over three years, fostering sustainable health improvements. The program emphasizes same-day results for screenings and culturally appropriate education, ensuring equitable access to essential healthcare services.

The Diversity Mentorship Grant Program aims to enhance ethnic diversity in dermatology by providing mentorship to underrepresented medical students. Participants receive 160 hours of hands-on experience with a dermatologist, fostering a deeper understanding of the field. A stipend of $1,500 is available for travel and living expenses. Applications are open until November 1 for the upcoming year, encouraging students from diverse backgrounds, including Black, Hispanic, and Native American groups, to apply.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Eosinophilic esophagitis

Help with healthcare costs for eosinophilic esophagitis

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Eosinophilic Esophagitis (EoE) is a disorder of the esophagus and is increasingly recognized as a major cause of swallowing difficulties in children and adults. It is a chronic disease of the immune system and can be triggered by a food allergy, acid reflux, or an airborne allergy. An allergic trigger causes the immune system to overact which causes many white blood cells, or eosinophils, to collect in the esophagus. This causes the esophagus to become inflamed and not contract properly. The esophagus can also narrow and develop rings or abscesses. This condition can become worse over time.

The Imagine Learning Foundation's Signature Grant Program aims to enhance the well-being of learners by supporting social and emotional learning (SEL) initiatives. By bridging classroom and community efforts, it fosters healthier environments for youth, families, and educators. The program prioritizes funding for organizations addressing critical issues like chronic absenteeism and housing insecurity. In 2024, the foundation will allocate over $400,000 to impactful projects, furthering its mission to cultivate supportive learning experiences both in and out of the classroom.

The Walking Classroom Grant Program, offered by the Alliance for a Healthier Generation, enables classroom teachers in public schools to receive donated materials for their students. This innovative program promotes physical activity while maintaining instructional time through engaging podcasts. Ideal for grades 3-8, it enhances cognitive function and retention. Schools with the greatest need, both socioeconomically and academically, are prioritized, ensuring that all students can benefit from this unique educational approach.

The Richard S. Shineman Foundation Strategic Grants focus on enhancing community well-being in Oswego County. Established in honor of Dr. Richard S. Shineman, the foundation supports projects in various areas, including arts, civic benefit, education, and health services. Organizations classified as tax-exempt under 501(c)(3) are encouraged to apply for grants exceeding $10,000, which are reviewed biannually in May and November. A Letter of Inquiry is required for consideration.

The Richard S. Shineman Foundation Community Enrichment Grants support organizations in Oswego County that enhance community well-being. Focused on arts, education, civic improvement, and health services, these grants empower projects that address local needs. With a funding limit of $2,499 and quarterly review cycles, the foundation aims to foster sustainable development and improve the quality of life in the region. Eligible applicants must be tax-exempt organizations or have a fiscal sponsor.

The Mexican Scholarship, established by the former Consulate of Mexico in Indianapolis, aims to support students of Mexican descent in pursuing higher education. Funded by the Central Indiana Community Foundation, this scholarship is open to Indiana residents enrolled in accredited colleges or vocational schools. Applicants must demonstrate financial need, maintain a GPA of 3.0 or higher, and preference is given to those of Mexican heritage. Award funds can be utilized for tuition, fees, and essential educational expenses.