Best Large Grants for Nonprofit Organizations in New York

The National Institutes of Health (NIH) is inviting applications for the Screening, Brief Intervention, and Referral to Treatment or Prevention (SBIRT/P) program. This funding opportunity aims to explore innovative methods for addressing alcohol, tobacco, and other drug use among adults facing health disparities. The initiative seeks research proposals that will implement and evaluate SBIRT/P strategies in collaboration with healthcare and community partners. This approach is crucial for enhancing public health and ensuring effective interventions.

Asia-Pacific Network for Global Change Research

The Asia-Pacific region, home to over half the world's population, faces challenges due to its development goals, which strain natural resources, communities, and cultural heritage. These issues are exacerbated by adverse environmental changes. While research has shed light on these problems, it's clear that more challenges lie ahead. The Asia-Pacific Network for Global Change Research (APN) is well-positioned to generate new knowledge and solutions for these evolving global change and sustainability issues by supporting collaborative research and scientific capacity development activities, particularly those aimed at training the next generation of early career professionals.

APN 2025 Call for Proposals: CRRP 

Through the competitive Collaborative Regional Research Programme (CRRP), we promote regional research that has potential to improve our understanding of global change and its implications while contributing to a sound scientific basis for policymaking in areas affected by global change. Under this pillar, APN supports collaborative research that contributes to the evolving science-policy arena, including the UNFCCC Paris Agreement, IPCC, IPBES, post-2015 Sustainable Development Goals, Sendai Framework for Disaster Risk Reduction and the UN Decade of Ocean Science as well as ongoing and new global change and sustainability research programmes.

Activities of interest under the CRRP Programme

APN promotes regional collaborative research that improves understanding of the physical, biological and human dimensions of change in the Earth system and advances actionable science that informs decision-making. APN accepts proposals that engage at least 3 member/approved countries in the region, and prioritise collaboratively designed, actionable research with non-academic stakeholders. Proposals must address one or more of the following activities:

• Collaborative research on global change and sustainability that particularly addresses GAPS, ANALYSIS, SYNTHESIS and ASSESSMENT work.
• Collaborative research that develops PATHWAYS and MECHANISMS to achieve sustainable development, and develop adaptation strategies.
• Collaborative PLACE-BASED INTEGRATIVE RESEARCH, particularly from developing countries.
• Collaborative research that is CO-DESIGNED to contribute to the Paris Agreeemnt, Sustainable Development Goals, Sendai Framework for Disaster Risk Reduction, Post-2020 Global Biodiversity Framework, UN Decade of Ocean Science (2021-2030), and the accumulation of scientific knowledge at IPCC, IPBES, etc.

The Jazz Touring Network (JTN) fosters the presentation of jazz across the mid-Atlantic region, supporting both novice and experienced presenters. Through an open and competitive application process, JTN members engage in professional development and collaborate on annual jazz tours. Eligible organizations must be located in specific states and maintain a strong history of presenting touring artists. The JTN prioritizes diversity and inclusivity, ensuring that programming reflects the vibrant landscape of contemporary jazz.

The FJ Brotherton Charitable Trust Grant aims to support charitable organizations, focusing on arts, education, and social services primarily in the northeastern United States. Established in 2024, the Trust continues the legacy of the Fred J. Brotherton Charitable Foundation. It emphasizes funding for programs that assist the needy or disabled, while adhering to strict eligibility criteria, including a requirement for tax-exempt status under I.R.C. Section 501(c)(3).

The Youth Safe Spaces Program aims to address the mental health challenges faced by youth, particularly those aged 12-24, by creating safe spaces for interaction and community engagement. With funding from the New York State Office of Mental Health, this initiative seeks to foster positive relationships, cultural sensitivity, and provide necessary resources. The program will support 3-5 pilot projects, each receiving $250,000 or $500,000 over five years, to enhance mental wellness and community participation among high-risk populations.

The Big Bets Fellowship: Economic Opportunity in the United States is a transformative 4-month program designed to empower emerging leaders to tackle economic challenges head-on. With a focus on innovative solutions for job creation, affordable housing, and equitable access to resources, the fellowship equips participants with essential skills and a supportive network. The initiative aims to drive systemic change and promote sustainable economic prosperity, addressing inequalities while fostering resilient communities across the nation.

The Smart Growth Community Planning Program, managed by the New York State Department of State, aims to enhance community planning by integrating Smart Growth principles. This program supports the development of comprehensive plans and zoning codes that prioritize equity, economic development, environmental stewardship, and energy efficiency. By fostering inclusivity and sustainability, it empowers communities to create vibrant, livable spaces that cater to diverse populations and promote long-term resilience.

The Corporate Giving Program by the Franklin P. and Arthur W. Perdue Foundation focuses on supporting nonprofit organizations within specific states. They prioritize initiatives that enhance community welfare, especially in agriculture, education, health, and environmental sustainability. Organizations must have 501(c)(3) status to apply, and preference is given to those involving Perdue associates. Ineligible requests include those from religious, political, or individual-focused groups. This program emphasizes broad community benefits over organizational affiliations.

The Brownfield Opportunity Area Program in New York aims to revitalize underutilized and contaminated properties, enhancing community investment and growth. Managed by the New York State Department of State, the program provides grants and technical assistance to develop strategic redevelopment plans. This initiative targets areas with known contamination, especially in disadvantaged communities, transforming them into valuable assets that promote economic development and improve quality of life for residents.

The MacDowell Fellowship supports artists by providing a nurturing environment for creative work. This prestigious opportunity awards around 300 artists annually across various disciplines, including architecture, literature, and visual arts, based solely on artistic excellence. There are no residency fees, and financial assistance is available for travel and living expenses. MacDowell encourages applications from artists of diverse backgrounds, fostering inclusivity in the arts community.

The Ralph C. Wilson, Jr. Foundation, established in 2015, focuses on community transformation in Southeast Michigan and Western New York. With a spend-down structure by 2035, the foundation prioritizes collaborative investments in key areas like active lifestyles, success preparation, caregiver support, and economic development. Emphasizing urgency and innovation, it seeks to create lasting impacts by fostering partnerships and supporting visionary projects that address significant community needs.

The Pinetop Assistance League (PAL) Grant provides crucial financial support to elderly blues musicians, ensuring their well-being during emergencies. This grant, part of the Pinetop Perkins Foundation's mission, offers assistance for medical expenses, home care, and essential living costs. Eligible applicants must be professional artists aged 50 or older with a household income below $35,000. By addressing these needs, PAL plays a vital role in preserving the legacy and care of blues musicians.

The J.W. Couch Foundation Grant focuses on supporting Wildlife Conservation nonprofit organizations that align with their mission of community betterment and environmental protection. The foundation seeks partnerships with organizations that promote animal wellbeing, early childhood education, teacher support, and outdoor activities. Eligible applicants must be registered 501(c)3 nonprofits or for-profit entities aligned with their charitable programs. This grant emphasizes collaboration and community engagement to create lasting impacts.

Our Programs

For over 25 years, Glynwood Center for Regional Food and Farming has been a leader in building a resilient and equitable food system in New York’s Hudson Valley. Through four interconnected strategies, we strengthen our region’s food system while serving as a national model for transformative, regionally-based solutions.

Core Strategies

Our strategic approaches are not standalone efforts, but a dynamic, interwoven framework that collectively advances our vision of a resilient and equitable regional food system. By incorporating all four strategies into every one of our programs, we create comprehensive solutions that amplify our impact across the agricultural landscape.

Offering a robust foundation in regenerative agricultural practices through in-field and classroom instruction. 

The County Agricultural and Farmland Protection Planning Grant, offered by the New York State Department of Agriculture and Markets, provides funding to counties for the development or updating of agricultural and farmland protection plans. Eligible counties can receive up to $50,000 or 50% of total project costs. This initiative supports local governments in creating planning documents that foster a favorable environment for agriculture and safeguard the farmland base, ensuring sustainable agricultural practices.

The Park & Trail Partnership Grants program supports the hiring of permanent staff to enhance the professionalism and sustainability of organizations dedicated to New York's parks and trails. Grants, up to $100,000 over two years, require a 20% cash match and aim to improve staffing capacity for better community outreach and operational stability, ultimately fostering increased volunteer engagement and fundraising efforts.

The Park & Trail Partnership Grants provide up to $150,000 in matching funds to enhance the stewardship and public access of New York's parks and historic sites. Funded by the NYS Environmental Protection Fund, these grants support projects that improve public engagement, sustainability, and visibility for nonprofit organizations. Eligible applicants include 501(c)(3) organizations focused on preservation and education. Projects must promote community involvement and can include interpretive signage, marketing plans, and shared consultant services.

The Park & Trail Partnership Grants: Step Up Grants program provides up to $20,000 in matching funds to support organizations in securing 501(c)(3) status and enhancing their operational capacity. Funded by the NYS Environmental Protection Fund, this initiative aims to promote the stewardship and sustainability of New York's parks and trails, while also fostering volunteer and fundraising efforts. Eligible applicants must be registered charities and demonstrate commitment to supporting public lands.

The Therapeutic Giving program by Johnson & Johnson focuses on funding initiatives that enhance patient access to treatment and advance health equity, particularly in immunology. Eligible nonprofit organizations can apply for support aimed at improving health outcomes through innovative programs. The initiative prioritizes measurable impacts over fundraising activities, emphasizing the importance of addressing healthcare disparities and promoting disease awareness efforts for diseases like rheumatoid arthritis and psoriasis.

About Us

Our mission statement

The mission of Empire State Development (“ESD”) is to promote a vigorous, inclusive and growing state economy, encourage business investment and job creation, and support diverse, local economies across New York State through the efficient use of loans, grants, tax credits, real estate development, marketing, and other forms of assistance. 

New York State Empire State Development

Regional Council Capital Funds (formerly ESD Grant Funds)

Funding Available: Up to $60 million

Empire State Development (ESD) has $60 million of capital grant funding available for the State's Regional Economic Development Council Initiative, which helps drive regional and local economic development across New York State in cooperation with ten Regional Economic Development Councils ("Regional Councils"). The $60 million available includes $8 million for tourism projects, formerly offered though the Market New York Capital Grant program. Grant funding is available for capital-based economic development projects intended to create or retain jobs; prevent, reduce or eliminate unemployment and underemployment; increase business or economic activity in a community or Region; and/or expand, construct, restore or renovate New York State tourism destinations and attractions.

Grant funding will be allocated among the ten regions, each represented by a Regional Council. Funding decisions will be based on each Regional Council's strategic plan and subsequent progress reports that set out a comprehensive vision for economic development and specific strategies to implement that vision, coupled with New York State's economic growth priorities. Funding will be awarded by the New York State Urban Development Corporation (d/b/a Empire State Development) at its discretion.

The Tribal Wildlife Grants (TWG) program, offered by the US Department of the Interior's Fish and Wildlife Service, provides vital technical and financial assistance to federally recognized Tribes. This funding supports various conservation activities, including habitat protection, species monitoring, and wildlife management, helping to preserve both culturally significant species and ecosystems. TWG grants empower Tribes to implement their conservation priorities effectively and sustainably.

The Park & Trail Partnership Grants program provides up to $100,000 to enhance the preservation and promotion of New York State's parks and trails. This capacity-building initiative supports organizations in improving their effectiveness and sustainability while promoting outdoor recreation and tourism. Eligible projects include strategic planning, training, and membership expansion. A 10% match is required, fostering collaboration among non-profits, ensuring diverse support for public lands.

The Wabtec Direct Grant Program focuses on creating sustainable impacts in local communities by funding 501(c)(3) non-profit organizations. Emphasizing education and environmental stewardship, the program supports initiatives that improve literacy, academic outcomes, and workforce readiness. Grants range from $1,000 to $10,000, prioritizing organizations that engage local Wabtec employees in volunteerism. The program promotes equitable access and non-discrimination while ensuring measurable results in funded projects.

The David, Helen and Marian Woodward Fund (Watertown) provides grants to 501(c)(3) organizations in New York and New England. Established in 1974 by Marian Woodward Ottley, the fund aims to fulfill her vision of improving the world for future generations. The fund prioritizes arts, education, health, and human services, with a historical preference for Connecticut organizations. It also considers the religious affiliations of applicants, reflecting Mrs. Ottley's charitable legacy.

The James M. Cox Foundation Grant offers support to nonprofit organizations focused on conservation, early childhood education, family empowerment, and health. Organizations must be 501(c)(3) tax-exempt and located in areas where Cox Enterprises operates. Grant applications are accepted year-round, with deadlines before Trustee meetings. Preference is given to organizations with a history of local engagement. This foundation embodies the philanthropic spirit of its founder, James M. Cox, by giving back to the community.

Clean Energy Career Pathways Training (PON 6121)

NYSERDA is seeking proposals for Clean Energy Career Pathways projects. These projects must include clean energy technical training as well as career preparation, wraparound services, and job placement support to prepare new workers for entry-level clean energy careers. Projects funded under this solicitation are intended to build or expand training infrastructure and capacity to build an equitable and inclusive pipeline of skilled talent for New York’s clean energy labor market. All training funded under this solicitation must be industry-driven and meet a demonstrated business need.

Total funding for this solicitation is $30 million, with up to $1.5 million per project. Additional funds may be added to this solicitation, if available, at NYSERDA’s discretion.

Funding is available for training that advances skills in the following clean energy technology areas: energy efficiency and building electrification; renewable energy; energy storage; smart grid; and electric vehicle charging stations (installation, operation and maintenance). 

The Environmental Grantmaking Program at the Educational Foundation of America (EFA) aims to support projects that facilitate a transition to a net-zero electricity system. Focused on reducing greenhouse gas emissions, the program emphasizes initiatives that enhance access to affordable clean energy, accelerate regional transitions, and strengthen financial investment in electric utilities. Eligible applicants include 501(c)3 public charities, academic institutions, and government entities committed to sustainable energy solutions.