Best Large Grants for Nonprofit Organizations in New York

Mother Cabrini Health Foundation provides New York health and human services nonprofits with large grants of more than US $75,000 for direct service programs improving care for vulnerable residents. Eligible 501(c)(3) public charities with budgets of $750,000+ that primarily serve poor or underserved New Yorkers, including priority groups like immigrants, veterans, youth, and older adults, may apply.

Nonprofit organizations, community councils, and municipal agencies serving Tompkins County community needs can apply for United Tompkins Community Impact Fund grants supporting food security, health, housing, mental health, and youth success. Grants from United Way of Tompkins County help New York nonprofits sustain or expand impactful, outcomes-driven programs over a two-year funding cycle.

Tax-exempt 501(c)(3) and 509(a) organizations working in education, human services, conservation, health, or cultural programs can apply for McGraw Foundation support, including general operating, project, or occasional capital funding. Grants typically range from US $2,000 - US $10,000 and are generally limited to organizations in the greater Chicago area, which may include New York-based groups with relevant Chicago operations.

Graduate students conducting research on drinking water quality, environmental science, or public health can receive US $3,000 to advance work with timely, actionable outcomes for the water industry. Focused on water-related research, American Water Works Association invites students whose work may benefit New York communities and beyond to apply for the Dr. Philip C. Singer Scholarship.

With a mission to support environmental sustainability, American Honda Motor provides New York nonprofits and schools with US $25,000 - US $100,000 for programs in decarbonization, clean energy, and efficient use of natural resources. Eligible 501(c)(3) organizations and public or private schools must primarily benefit communities near Honda’s U.S. operations.

Nonprofit 501(c)(3) organizations or fiscally sponsored groups advancing environmental and climate justice can seek funding for grassroots organizing, advocacy, and movement-building in New York. Scherman Foundation supports BIPOC-led efforts on renewable energy, environmental justice, green jobs, mass transit equity, and climate resilience, with some support also available for groups in New Jersey and Pennsylvania.

Nonprofit charitable organizations in New York working on community development, education, workforce preparation, or financial literacy can apply for KeyBank Foundation’s grants of US $10,000 - US $25,000. Grants from KeyBank Foundation help strengthen affordable housing, small business growth, academic success, and job readiness within communities it serves.

Nonprofit organizations and fiscally sponsored groups in Nassau and Suffolk Counties can apply for $5,000 - $50,000 to support projects in arts, community development, education, environment, mental health for veterans, hunger, technical assistance, and youth development. Grants from The New York Community Trust help New York nonprofits pursue innovative, long-term solutions rather than general operating or capital needs.

Nonprofit organizations in New York working to build women’s and children’s self-sufficiency can seek funding for programs such as homelessness services, education, job readiness, food security, health care, and anti-trafficking. The Father's Table Foundation provides grants up to US $750,000, with a preference for proven partners expanding sustainable, community-strengthening projects and, occasionally, urgent humanitarian or disaster relief efforts.

Nonprofit and community-based organizations in New York offering out-of-school academic enrichment and youth development programs can apply for New York State Education Department’s Nita M. Lowey 21st Century Community Learning Centers grants, awarding US $50,000 - US $1,200,000. Funding supports tutoring, arts, STEM, health, career pathways, and family engagement activities that complement regular school-day learning.

Nonprofit 501(c)(3) organizations in New York City’s five boroughs can seek approximately US $10,000 for general operating support or projects serving economically disadvantaged people. Grants from Venable Foundation help organizations advance human services, legal services, education, workforce development, youth programs, health, environment, and arts and culture in their local communities.

New York nonprofit organizations and research partners focused on clean water, freshwater conservation, and ecosystem health can access funding through Lake Champlain Basin Program for projects in the Lake Champlain Basin. Awards of US $25,000 - US $400,000 support research, including pilot or implementation-efficacy studies, that advance water quality, habitat restoration, and environmental stewardship goals.

New York nonprofit organizations planning sustainability projects such as renewable energy, energy efficiency, or resource conservation can apply for large grants from Green Mountain Energy, with awards ranging from US $50,000 - US $400,000. Eligible 501(c)(3), (4), (6), or (19) nonprofits must meet specific revenue and public support thresholds and serve communities in designated ZIP codes.

Undergraduate-focused higher education institutions conducting biomedical research in New York can access funding through the National Institutes of Health to support small-scale research projects and student research experiences. This U.S. Dept. of Health & Human Services program offers up to US $375,000 to institutions that award baccalaureate science degrees and have limited prior NIH support.

New York nonprofit organizations managing accredited charitable projects in humanitarian, social, science education, community, environment, or contemporary arts may be eligible for funding that supports sustainable, high-quality initiatives. La Roche prioritizes projects that leverage its expertise and logistics, engage employees, and involve early collaboration with local authorities and established partners in the same country as the affiliate office.

Soil and Water Conservation Districts in New York seeking funding for climate-smart agricultural projects can apply for New York State Department of Agriculture and Markets’ Climate Resilient Farming Program grants, awarding US $2,000,000 - US $10,000,000. Funding supports livestock waste and feed management, adaptation and resiliency, healthy soils and agroforestry, and agricultural forest management BMP systems.

McAuley Ministries provides New York nonprofit organizations with US $10,000 - US $500,000 for health, education, housing, economic development, and capacity-building programs. Eligible 501(c)(3)s or fiscally sponsored groups must align with its priorities, addressing basic needs, workforce readiness, academic success, community gardens, violence prevention, or nonprofit growth and development.

Early-career research scientists at academic or research institutions in eligible low- and middle-income countries can apply for National Institutes of Health Emerging Global Leader Awards to support mentored clinical research careers. Grants from NIH help New York nonprofits collaborating with LMIC investigators advance work in cancer, cardiovascular, neurological, mental health, environmental health, and other biomedical fields.

Municipalities and eligible public agencies in New York seeking financing for wastewater, sewer, or stormwater infrastructure can apply for the Clean Water State Revolving Fund. Grants from New York State Environmental Facilities Corporation help fund construction or restoration of sewers and treatment facilities, stormwater management, landfill closures, and habitat restoration and protection projects through interest-free or low-interest loans.

New York 501(c)(3) public charities can seek general operating or program support for arts, environmental conservation, medical research, and veterans initiatives. Grants from Cornelia T Bailey Charitable Trust help organizations serving New York residents whose projects advance the foundation’s mission; applicants start with a letter of inquiry for projects outside its main programs.

Perrigo Company Charitable Foundation Grant

The Perrigo Foundation is committed to empowering individuals and global communities by supporting programs and organizations that promote health, well-being, and education. We aim to prepare students and young adults for the workforce, providing accessible career pathways that inspire and empower individuals to reach their full potential. The Foundation is proudly funded by Perrigo Company plc.

Mission Statement

To provide financial support to non-profit organizations that promote our commitment to enhancing the health, well-being and education of individuals and families in the communities in which Perrigo operates. 

Vision Statement

To help improve and positively impact communities by improving access to quality health services, creating educational opportunities, and supporting the needs of the under-served.

Giving Back to Our Communities

Healthcare

We are providing program stability and capacity building for key community agencies, supporting local nonprofits to improve the quality and accessibility of services, and increasing the quality of mental health services, especially for children and families. 

Education

 Education, post-secondary scholarships, and support for first-generation and low-income students primarily focused on a STEM career, advancement for STEM curriculum, and resources in the K-12 classrooms. 

Supporting the Underserved

Community engagement and well-being, ensuring access to basic human necessities such as food, housing, end-of-life support, and necessary social services.

The HEP Action Agenda aims to engage communities in the NY/NJ Harbor & Estuary Program through in-person sessions this spring and summer. These sessions will gather feedback on community visions for the estuary, addressing challenges and opportunities. Small grants of $2,000-$4,000 will support NGOs in hosting these events, prioritizing collaboration and engagement with overburdened communities. This initiative seeks to develop a new Action Agenda that reflects the needs and priorities of stakeholders for the next decade.

The Fogarty Emerging Global Leader Award supports early career research scientists from low- or middle-income countries (LMIC) by providing research funding and mentored career development for three to five years. This program encourages LMIC scientists in health-related fields to develop projects aligned with their country's health priorities, fostering independent research careers within their institutions. Applications are welcomed from junior faculty members, enhancing global health research and capacity in LMICs.

The NY Environmental Quality Incentives Program (EQIP) provides vital technical and financial assistance to farmers and landowners in New York. This program supports sustainable practices on working lands, including crops and livestock, promoting soil health, water conservation, and improved wildlife habitats. By integrating conservation into agricultural operations, EQIP helps mitigate environmental challenges while enhancing productivity. Eligible participants can access tailored conservation plans and potential financial aid to implement effective practices, fostering a more sustainable agricultural future.

The Aegon Transamerica Foundation Grant supports non-profit organizations focused on enhancing financial and social empowerment in communities where Transamerica employees live and work. Established in 2000, the foundation prioritizes initiatives that foster self-reliance, financial literacy, and community engagement. Eligible organizations must be IRS 501(c)(3) non-profits operating in specific locations such as Atlanta, GA and Denver, CO. The foundation does not fund individuals or certain types of organizations, aiming to create inclusive, resilient communities.

Highmark Corporate Giving is dedicated to enhancing community health and economic resilience across its service areas. With a focus on equitable access to healthcare and support for local organizations, Highmark aims to reduce health disparities and promote well-being. Their initiatives, such as the Bright Blue Futures program, provide funding to impactful community projects, supporting a diverse range of organizations that align with their mission of fostering healthier, more vibrant communities.

The John Ben Snow Memorial Trust Grant supports educational programs and initiatives that assist individuals demonstrating financial need. Founded in 1975, it prioritizes funding for organizations that enhance educational opportunities, arts, culture, and community initiatives, particularly for youth and disadvantaged populations. The Trust encourages proposals from 501(c)(3) organizations, with grants typically ranging from $10,000 to $20,000. It also considers limited proposals in disabilities, environmental protection, and historic preservation, focusing on educational impact.