Best Grants for 501(c)(3) in Ohio

The Barney Family Foundation Grant focuses on improving early education and advancing medical research, particularly in cancer and Alzheimer’s. It supports organizations that demonstrate a clear plan to enhance children's life experiences and educational opportunities for those in grades K-8. Grants typically range from $5,000 to $50,000, prioritizing established entities while welcoming startups. Eligible applicants must have 501(c)(3) status, and the Foundation does not fund individual requests or political activities.

The Educational Incentive Award Application by the Cooley’s Anemia Foundation aims to support children of individuals with severe thalassemia in pursuing their educational and career aspirations. With a total funding of $10,000 for the 2025-2026 school year, awards range from $500 for two-year programs to $1,000 for higher degree studies. Eligible applicants must be diagnosed with specific thalassemia types and provide necessary documentation, including a 250-word essay detailing their educational goals.

Funding Innovative Research

Cannonball Kids’ cancer Foundation (CKc) prioritizes funding clinical trials, research that is nearing translation to a clinical trial, and young investigator grants.

Grants funded by CKc must be innovative and provide better quality of life or symptom relief than current treatments. 

When possible, CKc will prioritize funding research:

• with a focus on cancers that are under-funded or under-researched,
• with a focus on patient populations who are traditionally underserved.

When possible, CKc will prioritize funding researchers of diverse backgrounds.

For CKc, “innovation” means the invention or application of novel methods or treatments, specifically treatments that have fewer side-effects than standard care, increase a child’s quality of life, and/or create an option for care where there otherwise were few or none (either on primary diagnosis, relapse, or for recalcitrant cancers).

Research Grants

Grant Program: Clinical Trial

$200,000 over 3 years

• PI must hold an academic appointment at the Assistant Professor level or higher
• Preclinical studies must be complete
• If an FDA Investigational New Drug (IND) application is necessary for the proposed clinical study, the IND application should already have passed FDA initial review and be active
• If the PI has recruited additional patient enrollment sites, local IRB approval must be obtained for each site.

• How many treatment options would this study provide for children?
• How accessible is this study for children and families to access?

The Dean John A. Knauss Marine Policy Fellowship offers a unique opportunity for early career professionals to engage in marine and Great Lakes science and policy within the U.S. government. This one-year, paid fellowship encourages graduate students from accredited programs to explore impactful coastal resource issues. Interested applicants should connect with their local Sea Grant program or the National Sea Grant Office for guidance, especially if they are from Massachusetts, to ensure a competitive application.

Headstream Accelerator 2026

Accelerator Application Cohort VI

The Headstream Accelerator supports entrepreneurs from all backgrounds in scaling digital solutions that improve the mental well-being of teens at risk, with a focus on the education and healthcare sectors. Our four-month, virtual-first program is designed for early-stage innovators, helping them strengthen their business models, refine their value propositions, and build the foundation for sustainable growth and meaningful impact.

Benefits:

• $30,000 non-dilutive stipend 
• Partnership with youth from Headsteam’s Youth Co-Creator Club to gain insights on cultural relevance, age-appropriateness, and user experience, ensuring your solutions resonate deeply and effectively with the next generation 
• Access to a network of expert advisors, connect with a community of founders, and engage with potential investors and capital providers 
• Access to one-on-one and group coaching sessions with our partner, FounderWell

Participant Expectations:

• Attend all activities, including virtual cohort and youth co-creation sessions, advisor calls, and an in-person kickoff event from July 28–30, 2026
• Commit 2–5 hours weekly during the program, including virtual sessions, advisor network office hours, guide calls, and more
• Embed youth voices throughout your product development

St. Mary's Bank Charitable Foundation Community Support Grants aim to enhance community welfare by providing financial support to nonprofit organizations. With a commitment to 'people helping people' since 1908, the foundation focuses on areas like youth programming, homelessness, and civic support. In 2023 alone, they donated over $200,000 to 190 organizations, reflecting their dedication to improving lives in New Hampshire. They prioritize funding for nonprofits within their service areas, ensuring impactful contributions to local communities.

Sun Life’s Health Access Grant Program aims to enhance access to health services, specifically targeting diabetes and oral health in local communities. With funding options ranging from $25,000 to $100,000, this program supports 501(c)(3) charities focused on diabetes prevention, management, and oral health care. By fostering access to essential health services, Sun Life is committed to building healthier communities and addressing health disparities faced by underprivileged populations.

The Harris and Frances Block Foundation, established in 2001, supports small grassroots organizations focused on social and environmental justice. They prioritize equitable solutions and sustainable community development, funding initiatives related to environmental education, justice, and food security. Grants are available to non-profit, tax-exempt organizations in specific geographical areas including Vermont, North Carolina, Virginia, and New York City, excluding funding for lobbying, land acquisition, and scholarships.

The Chemical Countermeasures Research Program (CCRP) Initiative aims to support vital research on the harmful effects of acute exposure to Ultra-Potent Synthetic (UPS) opioids, including fentanyl and its combinations. This funding opportunity encourages studies that enhance understanding and mitigation strategies for these substances, focusing on both immediate and long-term health impacts. Applications are due by 5:00 PM local time, with optional Letters of Intent accepted 30 days prior to the proposal deadline.

The Nicholas B. Ottaway Foundation offers grants through its Education Committee to support programs enhancing educational opportunities for economically disadvantaged students. These grants focus on initiatives like tutoring, college preparation, and internship programs. To qualify, organizations must be tax-exempt under 501(c)(3). Preference is given to projects that provide ongoing support to students post-graduation, particularly in specific geographic areas such as San Diego County and the New York Metropolitan Area.

The Thalassemia Patient Incentive Award, sponsored by the Cooley’s Anemia Foundation, aims to support thalassemia patients in pursuing their educational and career aspirations. Awards ranging from $250 to $2,000 will be granted to students at various academic levels, with applications due in March 2026. This initiative not only encourages academic growth but also fosters a positive outlook among patients living with thalassemia, underscoring the Foundation's commitment to improving their quality of life.

The Sylvania Franciscan Foundation Fund offers grants to support initiatives aimed at combating human trafficking, assisting immigrants and refugees, and promoting social justice. The fund also aligns with Pope Francis’ Laudato Si’ call for environmental stewardship. Eligible projects may include survivor support services, community engagement, and ecological education. Notably, faith-based organizations that limit service to their members or engage in lobbying are ineligible for funding. This foundation prioritizes systemic solutions that foster dignity and opportunity for underserved communities.

The Ernest F. Hollings Undergraduate Scholarship offers up to $9,500 annually for two years, alongside a paid summer internship at NOAA. This program enhances students' training in oceanic and atmospheric sciences, aiming to increase public understanding and support for environmental stewardship. Eligible students must be U.S. citizens, enrolled full-time in relevant disciplines, and maintain a minimum GPA of 3.0. The experience fosters valuable skills and networks, with 100% of alumni recommending the scholarship.

The Adtalem Global Education Foundation, established in 2010, is dedicated to enhancing education and community development. Based in Chicago, it focuses on expanding educational access, particularly for underrepresented minorities in the healthcare sector. The foundation prioritizes initiatives that promote economic growth through skills-based workforce development, address healthcare disparities, and increase access to quality education for underserved populations. Its commitment to civic engagement and equality reflects its mission to empower communities.

The Ingram-White Castle Foundation, established in 1949 by the Ingram Family, aims to support disadvantaged students through educational programs. With over $22 million awarded in grants, its mission encompasses providing essential resources for academic success, workforce preparation, and strengthening educational institutions. The Foundation prioritizes projects that foster community cooperation and encourage additional funding. Although primarily focused on education, it also addresses critical human service needs, impacting the lives of many in the central Ohio area.

The Community Connect Grants Program provides financial assistance to eligible applicants aiming to deliver broadband services in rural areas where access is limited. This initiative fosters economic growth and enhances educational, healthcare, and public safety benefits, improving the quality of life in underserved communities. By supporting projects that create better market opportunities and promote equitable access, the program plays a vital role in advancing rural development and addressing environmental justice.

The WV Central Federal Credit Union's Day of Giving Grant supports 501(c)3 organizations in Jackson, Pleasants, Ritchie, Wirt, Wood in West Virginia, and Washington in Ohio. The grant focuses on initiatives like financial education, youth programs, community development, and food insecurity. Organizations eligible for funding must address these critical areas, ensuring that their projects benefit local communities and enhance the quality of life for residents. Applications are welcomed from qualifying entities looking to make a positive impact.

The Reboot Representation Tech Coalition aims to significantly increase the number of Black, Latina, and Native American women earning computing bachelor’s degrees. They invite qualified organizations to submit grant inquiries focused on recruiting and retaining these women in tech. Programs that leverage existing resources and operate across multiple regions will be prioritized, and the Coalition seeks initiatives backed by substantial research and community trust.

The Social Impact Fund - Nationwide Grant supports innovative solutions addressing health care access, food security, and economic empowerment. Funded by the American Heart Association, this grant prioritizes community-led projects from organizations with under $10M in revenue. Eligible entities include both for-profit and nonprofit organizations based in the U.S. and Puerto Rico. Grants can provide up to $250,000 to initiatives that demonstrate measurable impact, fostering sustainable change in health and wellness.

The FY 2026 Continuation of Solicitation for the Office of Science Financial Assistance Program invites applications for research in various domains, including Advanced Scientific Computing and Biological Research. This ongoing opportunity from the Department of Energy will remain available until September 30, 2026. Eligible projects must align with SC's mission, supporting innovative research that advances scientific knowledge and energy solutions.

The Reynolds and Reynolds Associate Foundation, established in 1956, is a prominent associate-run charitable organization in the U.S. that supports various community-focused initiatives. With a commitment to health services, youth support, and education, the Foundation empowers local charities through financial assistance and volunteer efforts. It prioritizes grant requests that align with its mission, particularly favoring projects with associate involvement. The Foundation exemplifies a legacy of community service and innovation, enhancing the lives of those in need across eight counties surrounding Dayton.

The JAH Foundation, established in 2012 in Cuyahoga Falls, Ohio, is dedicated to supporting community organizations aligned with Christian principles. It provides financial assistance primarily to 501(c)(3) tax-exempt organizations that serve the poor, disabled individuals, and promote Catholic education and disaster relief, focusing on Summit County and surrounding areas. The foundation's commitment to community service reflects the founders' belief in giving back through various charitable initiatives.

Brooks Brothers, founded in 1818, is committed to social responsibility through its donation program. The company partners with local and national non-profits focused on health issues and education. They seek to enhance community well-being while maintaining a commitment to inclusivity. Notably, they do not support organizations that discriminate based on protected categories. Their donations are aimed at fostering positive change in society, reflecting their belief in the importance of community engagement.

The Harry Chapin Foundation grants support 501(c)(3) organizations in the U.S. focused on self-sufficiency. They prioritize grassroots programs in the arts, community education, and environmental sectors, with a budget cap of $750,000. Grants are typically awarded for one year, with renewals requiring a new proposal each year. Organizations using fiscal agents or applying for individuals are not eligible. The foundation is dedicated to improving lives through sustainable initiatives.

The Amcor Community Support Grants Program, administered by the Amcor Cares Foundation, provides funding for projects that benefit local communities. Grants are available to 501(c)(3) organizations and accredited educational institutions that serve Amcor Flexibles North America facility communities. Focus areas include fighting hunger, supporting disaster relief, expanding STEM education, and enhancing health and wellness. Applications are reviewed quarterly, and grant amounts typically exceed $1,000.

The Hudson Community Foundation offers competitive community grants to enhance the quality of life in Hudson, Ohio. Since 2000, over $500,000 has been awarded to support nonprofit organizations in various areas, including art, culture, historical preservation, social services, and youth education. The foundation aims to address current community needs while anticipating future challenges, making strategic investments for lasting impact.

The Conservation Practitioner Award, presented by the American Ornithological Society, recognizes dedicated professionals at any career stage who address avian conservation issues at local or regional levels. This award includes a certificate and a $1,000 honorarium, acknowledging the critical work of individuals or groups in government or non-government organizations. The AOS aims to promote ethical standards and support a diverse community of ornithologists committed to bird conservation.