Best Grants for New Nonprofits in Ohio

The Area Development Grant Program, managed by the Appalachian Regional Commission (ARC), supports economic growth in Appalachia through investments in critical infrastructure and workforce development. Targeting 423 counties across 13 states, the program encourages local communities to collaborate with state governments to identify and implement impactful projects. Key focus areas include enhancing utilities, promoting entrepreneurship, and strengthening local leadership. This initiative aims to uplift the 26 million residents of Appalachia, fostering sustainable economic opportunities.

CSX Charitable Investments provide essential in-kind donations to nonprofit organizations focused on supporting military members and community first responders. Through intermodal transportation services, CSX offers equipment and rail services to help reduce transportation costs for eligible organizations. The program also includes occasional donations of railroad materials and equipment based on availability. CSX prioritizes support for organizations operating within its service areas, promoting community betterment and development.

The Environmental Justice Thriving Communities Grantmaking Program, led by The Minneapolis Foundation, supports community-based nonprofits in the Great Lakes region. With a focus on underserved communities, grants will total $40 million over three years, aiming to enhance environmental health, education, and resilience. The program prioritizes applications from federally recognized tribes and organizations with limited budgets, fostering inclusive community engagement and sustainable development. Eligible projects include environmental assessments, public health initiatives, and job training.

The Amgen Foundation Inc focuses on non-healthcare donations and sponsorships that target humanitarian, social, educational, and community programs. They offer support to organizations outside the U.S. healthcare community, particularly those recognized as tax-exempt public charities. Eligible organizations must serve specific Amgen communities throughout the U.S. This initiative aims to enhance health outcomes and address critical societal needs, thereby reducing the burden of disease and improving lives.

The Penn National Gaming Foundation Grants support various community initiatives across North America, emphasizing education, health services, and cultural affairs. Launched post-Hurricane Katrina, the foundation aids local nonprofits, enhancing community development, public safety, and veteran support. The grants cater to organizations that address the needs of children, senior citizens, and disadvantaged populations, ensuring a broad impact in areas where Penn National Gaming operates. This commitment reflects the foundation's dedication to uplifting communities and fostering resilience.

The WGPF: Legends & Lore Marker Grant Program celebrates and promotes local folklore, legends, and folklife as vital aspects of cultural heritage. Targeted at 501(c)(3) organizations and government entities across 14 US states, it aims to enhance cultural tourism by commemorating community stories. Successful applications typically focus on folktales, historical legends, and community traditions, while excluding purely literary works or personal folklore that lacks broader community significance.

The Joyce Foundation's Education & Economic Mobility Grants aim to close income and race disparities in college and career success. The foundation prioritizes equitable access to high-quality education, supporting policies for effective educators, high school graduation, and affordable college credentials. Focused on racial equity and economic mobility, it addresses the needs of historically underserved young people in the Great Lakes region and invests in research, policy development, and advocacy to help them recover from the COVID-19 pandemic.

The Joyce Foundation's Journalism Grants support independent, nonpartisan reporting to address critical issues in the Great Lakes region. By investing in high-quality journalism, the Foundation aims to promote informed decision-making and strengthen community cohesion. Eligible applicants include nonprofit journalism organizations and projects that enhance local news and support early career journalists, particularly those from diverse backgrounds. The application process requires advance planning, with funding decisions made quarterly.

The Baltimore Life Community Grants Program, established by the Baltimore Life Foundation, awards grants of up to $500 to nonprofit organizations in various states, including Maryland and Virginia. This initiative aims to enhance community quality of life through projects that focus on family safety and community enhancement. Eligible applicants must be IRS-certified 501(c)(3) organizations, with priority given to those with volunteer support. This program reflects Baltimore Life's commitment to corporate citizenship and community involvement.

The American Honda Foundation provides programmatic support to nonprofit organizations and schools in the U.S., empowering impactful initiatives aligned with community needs. Funding opportunities are available through Honda corporate and Honda USA Foundation, focusing on projects that enhance education and community welfare. Eligible organizations must have nonprofit status or be recognized educational institutions. The application process opens each fall, with funding decisions announced the following spring, ensuring alignment with Honda's commitment to social responsibility.

The Programmatic Support - Education Pillar Award by Honda aims to enhance workforce readiness in the manufacturing sector. It supports nonprofit organizations and schools focused on hands-on programs in design, software/data analytics, and AI/machine learning. Eligible applicants must be US-based and have 501(c)(3) status. The initiative prioritizes projects that train individuals for manufacturing roles, develop technical skills, and introduce automation to prepare for evolving industry demands, ultimately fostering economic prosperity in local communities.

The Honda USA Foundation's Mobility Pillar Award aims to empower individuals with disabilities by funding programs that enhance access and mobility. The foundation supports nonprofit organizations and schools that provide therapeutic, adaptive, and comprehensive care programs, as well as mobility modifications and assistive technology. Applications are accepted from U.S.-based organizations with 501(c)(3) status or fiscal sponsors, ensuring that the joy of mobility is accessible to all.

The JBF Do Good Grant, established by the Joe Burrow Foundation, aims to support innovative projects that assist underprivileged children, particularly those facing mental health challenges and food insecurity. Eligible organizations include nonprofits and public charities, with proposals up to $10,000 considered. The foundation encourages creative solutions that foster lasting impacts within communities in Greater Cincinnati and Baton Rouge. By fostering these initiatives, the foundation continues Joe Burrow's commitment to community service and social responsibility.

The Woodruff Foundation Grant supports nonprofit organizations in Cuyahoga County, Ohio, focusing on behavioral health through treatment, education, resource coordination, research, and advocacy. Grants are typically awarded annually, encouraging collaboration among organizations. Key eligibility requirements include being a tax-exempt entity under IRS 501(c)(3) and having a relevant focus area. The Foundation prioritizes initiatives that enhance access to mental health care and strengthen the local behavioral health workforce.

The Kenneth A. Scott Charitable Trust offers grants aimed at enhancing the lives of animals in the Ohio/Great Lakes region. It prioritizes projects that foster animal adoption, behavior training, and humane education. Eligible organizations must be 501(c)(3) certified and demonstrate a commitment to animal welfare. The Trust seeks innovative, collaborative initiatives that significantly improve the well-being of animals, particularly in underserved communities, ensuring a high quality of life for both individual animals and larger populations.

The Elevance Health Foundation's Behavioral Health Grant aims to address significant challenges in mental health and substance use disorders. With a commitment of up to $90 million over three years, the Foundation seeks partnerships with nonprofits to enhance treatment access, promote prevention strategies, and alleviate loneliness among affected individuals. This initiative emphasizes innovative solutions and measurable outcomes, targeting both national and local programs, particularly in states with pressing health disparities.

The Toledo Rotary Club Foundation provides traditional grants to support nonprofit, 501(c)3 tax-exempt organizations focused on community and international projects. Each year, approximately 20 grants are awarded, with funding capped at $10,000, except for camperships which are limited to $750. The foundation prioritizes projects benefiting disadvantaged citizens, particularly youth, the disabled, and the elderly, within the Toledo area and Northwest Ohio.

The Community Health Foundation provides responsive grants to nonprofit organizations in Clark and Champaign Counties, Ohio, focusing on health and wellness initiatives. With a mission to preserve reproductive services and promote health equity, the foundation aims to reduce health disparities through diverse funding types, including program, project, and operating support. Grants are awarded annually to support programs addressing children's health, chronic disease management, maternal and infant health, and mental health services, fostering a healthier community for all.

The Ohio Arts Council's ArtsNEXT program offers competitive funding for innovative and experimental projects aimed at enhancing the arts in Ohio. With awards typically up to $25,000, this grant supports bold ideas that push artistic boundaries, improve accessibility, and encourage diversity in arts experiences. Projects may include collaborations, new programming strategies, or technology advancements that foster community engagement. Organizations must demonstrate a commitment to artistic evolution and meet specific eligibility criteria to apply.

The MGM Resorts Foundation Community Grant Fund supports nonprofit agencies providing essential services in areas such as affordable housing, education, and health. Grants are awarded for a one-year period and focus on regions where MGM Resorts employees live and work. Eligible applicants must comply with diversity policies and serve individuals or families. The foundation does not fund governmental agencies or projects exclusively for medical research. This initiative aims to enhance community well-being through targeted support.

The AmeriHealth Caritas Foundation Grant aims to prevent and mitigate adverse childhood experiences (ACEs) to promote healthier outcomes for children. With a focus on empowering families, healing behaviors, and access to healthcare, the foundation supports nonprofit organizations that provide comprehensive care and resources. Grants range from $100,000 to $250,000, totaling up to $1.945 million for project-specific initiatives. Eligible organizations must be 501(c)(3) nonprofits operating in states where AmeriHealth Caritas Medicaid markets exist.

The Donald C. and Laura M. Harrison Family Foundation, established in 2006, aims to enhance educational opportunities for underprivileged students in the Greater Cincinnati area. With a focus on innovative programs and scholarships, the foundation supports initiatives in primary, secondary, and adult education. Grants range from $5,000 to $15,000 annually, promoting sustainability and collaboration with other donors. Eligible applicants must be IRS-designated 501(c)(3) organizations, prioritizing local community impact.

The Elevance Health Foundation's Food as Medicine Grant aims to enhance access to nutritious foods and improve health outcomes for individuals facing diet-related conditions. This initiative invites qualified nonprofits to submit proposals focused on scalable solutions that address food insecurity and promote health equity. The foundation prioritizes programs that demonstrate measurable outcomes and support whole-person health, particularly for populations at high social risk. Grants will be awarded for a term of 1-3 years, with funding based on program needs.

The Elevance Health Foundation's Maternal and Child Health Grant supports community-based nonprofit organizations aiming to enhance maternal and infant health outcomes. The foundation prioritizes funding programs that address disparities, improve care access, and promote health throughout the pregnancy journey. Focus areas include reducing pre-term birth rates and severe maternal morbidity. This initiative encourages scalable solutions for measurable impact across various states, ensuring comprehensive support for mothers and infants alike.

Truist Foundation

The Truist Foundation is committed to Truist Financial Corporation's (NYSE: TFC) purpose to inspire and build better lives and communities. Established in 2020, the foundation makes strategic investments in nonprofit organizations to help ensure the communities it serves have more opportunities for a better quality of life. The Truist Foundation's grants and activities focus on building career pathways to economic mobility and strengthening small businesses.

Inspire Awards

This year’s Inspire Awards seeks nonprofits supporting the career navigation and workforce development needs of workers across the United States. The challenge seeks applications that help individuals gain the skills, guidance, and support needed to access quality jobs, advance in their careers, and build long-term stability in an evolving world of work.

2026 Truist Foundation Inspire Awards Challenge Question

How are nonprofits providing innovative direct services, training programs, and career navigation supports for adult workers in the age of AI?

Challenge Dimensions

Nonprofit organizations have long been critical advocates and service providers for workers in the United States. Nonprofits provide workers necessary upskilling opportunities, AI literacy training, career navigation support, and wraparound services in conjunction with career pathways programming. All necessary for the modern workforce. Meeting the moment, Truist Foundation and MIT Solve want to hear the ways in which nonprofits headquartered in the Truist operating footprint are providing innovative career pathway programming in the age of AI. Although solutions don’t need to focus on generative AI specifically, teams should demonstrate how their career pathways programming align with the following dimensions:

• Training and Upskilling Programs – Providing holistic, accessible programming that equips workers with essential skills, industry-validated credentials, and technical literacy for the modern workplace.
• AI Readiness and Literacy – Offering high-quality training that helps workers understand generative AI and agentic technologies as augmented intelligence tools, helping to build practical skills like effective prompting, domain expertise application, and ethical use.
• Additional Wraparound Services and Basic Needs Support – Supporting unemployed and underemployed workers on their journey to economic mobility through comprehensive, integrated resources including childcare, transportation support, mentorship, mental health services, benefits navigation, and more.
• Career Navigation in the AI Economy – Enabling workers to navigate career choices with clarity and confidence by providing accessible information about how AI is reshaping job roles and industries, facilitating informed decisions about high-quality career trajectories that align with individual circumstances, and connecting workers to industry-validated credentials or trainings.

Here are the grants for this challenge

• First place: $250,000
• Second place: $150,000
• Runners-up: $25,000
• Audience favorite: $75,000

The Ruth Danley and William Enoch Moore Charitable Fund Grant is a private foundation based in Pittsburgh, established in 1992. It focuses on philanthropy, specifically supporting K-12 education for Native American children living on reservations. The foundation directs its grants primarily to regions preferred by donors, including several states in the Northeast and Midwest, aiming to improve educational opportunities and foster community development in underserved populations.