Best Foundation Grants for Nonprofits in Ohio

Ohio 501(c)(3) nonprofits and eligible public institutions can seek Amgen Foundation support for scalable science education and community-strengthening programs in areas where Amgen operates. The foundation prioritizes teacher professional development, inquiry-based STEM learning using educational technology, and civic engagement initiatives that deliver lasting impact in local communities; most grants are by invitation, with limited unsolicited reviews twice yearly.

Ohio 501(c)(3) nonprofits working in education, hunger relief, health, or environmental sustainability can seek US $5,000 - US $40,000 to support community programs, with priority to areas near Lubrizol facilities. Focused on SDGs for quality education, zero hunger, health, and sustainable environments, Lubrizol Foundation invites aligned organizations to apply.

Nonprofit organizations in Ohio and across North America can seek up to US $25,000 to advance health equity, cancer prevention and care, healthcare workforce diversity, crisis response, or food and medicine access. With a mission to remove barriers to quality healthcare, McKesson Foundation provides program support for U.S. and Canadian 501(c)(3)-equivalent organizations.

The Peoples Bank Foundation Grant aims to create a significant impact in local communities by providing financial support to nonprofit organizations. With over 20 years of service, the foundation has awarded more than $7.5 million in grants and scholarships across several states. It prioritizes initiatives that assist low to moderate-income individuals and families, encouraging organizations within its footprint to apply for funding to enhance their community-focused programs.

Nonprofit 501(c)(3) organizations in Ohio communities where Penn National Gaming operates can seek funding for community development, education, human services, cultural programs, health initiatives, and veteran and military support. Grants from Penn National Gaming help eligible Ohio nonprofits address broad local needs in counties such as Franklin, Lucas, Mahoning, Montgomery, and others.

Nonprofit 501(c)(3) organizations with operating budgets under $10 million running programs within 60 miles of downtown Cincinnati in Ohio can seek program and project funding of more than US $20,000. Elsa Heisel Sule Foundation supports work in areas like education, health care access, arts, community development, and environmental stewardship, not individuals or completed projects.

Nonprofit organizations working on education policy and economic mobility in Ohio and the Great Lakes region can seek support for research, policy development, advocacy, and implementation efforts. The Joyce Foundation provides funding for initiatives that advance effective educators, college and career readiness, and post-secondary success, with a focus on historically underserved young people and racial equity.

Nonprofit 501(c)(3) organizations and schools serving Ohio communities can apply for American Honda Foundation programmatic support to fund high-impact community services. Eligible applicants must be U.S.-based and serve at least one of Honda’s key states, including Ohio, with applications accepted each fall and funding decisions announced in the spring.

Nonprofit 501(c)(3) organizations and schools in Ohio offering manufacturing workforce education can apply for American Honda Motor’s Education Pillar Award, with grants of US $25,000 - US $100,000 for hands-on training programs. Eligible initiatives strengthen the manufacturing talent pipeline in areas like design, data analytics, AI, automation, and related technical skills.

Nonprofit 501(c)(3) organizations and schools running environmental programs in Ohio can apply for American Honda Motor’s Environment Pillar Award, offering US $25,000 - US $100,000 for programmatic support. Grants from American Honda Motor help Ohio sustainability initiatives focused on decarbonization, clean energy, and efficient use of natural resources that benefit communities where Honda associates live and work.

Nonprofit 501(c)(3) organizations and schools serving people with disabilities in Ohio can apply for Honda USA Foundation’s Mobility Pillar programmatic grants, with awards from US $25,000 - US $100,000 for mobility-focused services. Grants support therapeutic or adaptive programs, comprehensive care, and mobility modifications, accommodations, and assistive technology in communities where Honda associates live and work.

Nonprofit 501(c)(3) organizations in eastern Ohio can seek approximately US $15,000 to support community enrichment, education and workforce, or environmental programs. Grants from EQT Foundation help Ohio nonprofits deliver food access, STEM education, libraries, arts and music, parks, and environmental stewardship projects in Belmont County within EQT’s operating footprint.

The Andrew Jergens Foundation Grant, administered by the Greater Cincinnati Foundation, focuses on enhancing the health, education, cultural experiences, and social welfare of children in the Greater Cincinnati area. With a commitment to supporting programs for children through high school, the foundation seeks to foster vibrant communities by connecting with nonprofits dedicated to improving quality of life. The foundation emphasizes the importance of generous contributions to create lasting change in the region.

Nonprofit 501(c)(3) organizations serving Greater Cincinnati, Dayton, and Northern Kentucky with programs in education, arts, community development, and human services may be eligible for support in Ohio. Fifth Third Foundation, through multiple trustee funds, backs initiatives ranging from youth and women’s services to environmental conservation, health, and faith-based community outreach.

The JBF Do Good Grant, established by the Joe Burrow Foundation, aims to support innovative projects that assist underprivileged children, particularly those facing mental health challenges and food insecurity. Eligible organizations include nonprofits and public charities, with proposals up to $10,000 considered. The foundation encourages creative solutions that foster lasting impacts within communities in Greater Cincinnati and Baton Rouge. By fostering these initiatives, the foundation continues Joe Burrow's commitment to community service and social responsibility.

Nonprofit 501(c)(3) organizations serving children, adolescents, and young adults with disabilities or economic barriers in the Greater Cincinnati area of Ohio can seek support for education, health, cultural, social welfare, and recreation programs. Grants from Greater Cincinnati Foundation may cover capital, operating, or limited endowment needs for eligible Ohio counties.

Ohio 501(c)(3) nonprofits focused on mental health and substance use disorder treatment can seek behavioral health funding through Elevance Health Foundation. Focused on behavioral health, the foundation invites U.S. organizations, including those in Ohio, to propose scalable programs that expand treatment access, emphasize prevention and early intervention, and reduce loneliness among affected individuals.

Nonprofit organizations serving people in Northeast Ohio can seek one-year grants to support community services such as affordable housing, workforce development, K-12 education, family services, food security, health and wellness, homelessness, senior services, and support for veterans and military families. Grants from MGM Resorts Foundation help Ohio nonprofits expand direct services where MGM employees live and work.

Ohio 501(c)(3) nonprofits serving children, families in need, or advancing medical research can access funding through the Sam J Frankino Foundation; awards are typically more than US $1,000. Support covers education, youth and homeless services, health care and disease research, arts and culture, environmental initiatives, disaster relief, and veteran-focused programs in Northeast Ohio counties.

The Cyrus Eaton Foundation Grant focuses on advancing sustainable environments, social justice, cultural enrichment, and peaceful coexistence. It funds innovative and small nonprofit organizations, primarily in Northeast Ohio and Pugwash, Nova Scotia. The foundation typically distributes $160,000 annually across two funding cycles, with grants ranging from $1,000 to $5,000, and occasionally offers high-impact grants of up to $15,000 for significant projects.

Ohio 501(c)(3) nonprofits addressing the opiate epidemic, human trafficking, anti-bullying, suicide prevention, or pollinator conservation can seek up to US $30,000 for community-focused projects. Levin Family Foundation prioritizes initiatives in the Greater Dayton Area, including Montgomery, Miami, Greene, Darke, Preble, and Warren counties, with a required LOI and potential site visit before full application.

Nonprofit organizations improving health outcomes and health equity through cancer support, healthcare workforce development, or crisis response programs in Ohio and across North America can apply for McKesson Foundation grants above US $25,000. Grants support prevention, screening, financial and logistical assistance, STEM and medical education, and disaster preparedness, relief, and food and medicine access.

Ohio 501(c)(3) nonprofits addressing adverse childhood experiences and related health or family trauma can access funding through AmeriHealth Caritas Foundation for one-year, project-specific programs. Grants of US $100,000 - US $150,000 support community-led efforts focused on healing behaviors, health care access, and empowering families in Medicaid-enrolled communities within the foundation’s operating markets.

Nonprofit 501(c)(3) organizations running food-as-medicine or nutrition programs that improve clinical outcomes and food access can apply for funding, including in Ohio. Focused on food security and diet-related chronic illness, Elevance Health Foundation invites proposals that are innovative, culturally relevant, and able to demonstrate measurable, long-term health impacts.

Ohio nonprofit organizations improving maternal and infant health can apply for Elevance Health Foundation’s Maternal and Child Health Grant to support programs across the pregnancy journey, from pre-conception through postnatal care. Funding prioritizes reducing disparities in pre-term birth and severe maternal morbidity and improving measurable maternal and infant health outcomes through scalable community-based interventions.

Nonprofit 501(c)(3) organizations providing adult workforce development, career navigation, and AI-related training can apply for Truist Foundation Inspire Awards, offering US $10,000 - US $250,000. With a mission to build economic mobility, Truist Foundation provides Ohio and other eligible states’ nonprofits with funding for upskilling, AI literacy, and wraparound services that help workers access quality jobs.

Nonprofit organizations providing K-12 education for Native American children living on reservations can seek project funding that delivers direct services and measurable outcomes. The Ruth Danley and William Enoch Moore Fund provides Ohio and regional nonprofits with support for year-round, collaborative programs that address demonstrated community needs and benefit underserved populations, with awards around Approximately US $77,000.