Best Perkins County Grants for Nonprofits in South Dakota

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is launching a funding opportunity for Exploratory Clinical Trials Grants. This program aims to support innovative clinical trials that enhance the understanding and treatment of arthritis and other musculoskeletal and skin conditions. Research proposals should focus on early-stage trials, including first-in-human studies, dose-finding, and biomarker evaluation. The initiative encourages the translation of promising laboratory findings into effective clinical practices, ultimately improving patient outcomes.

The FY26 Bureau of Land Management Youth Conservation Corps program aims to engage youth aged 16-30, including veterans and tribal members, in hands-on conservation projects. These initiatives foster skills in natural resource management, promote public land stewardship, and enhance community involvement through trail building, habitat restoration, and cultural resource preservation. By partnering with qualified youth corps, the program supports economic growth and environmental health while preparing the next generation of public land stewards.

Lilly Foundation

To extend Lilly’s charitable reach and impact, the Eli Lilly and Company Foundation (Lilly Foundation) was established in 1968 and is supported by donations from Eli Lilly and Company.

The Foundation is a tax-exempt, private foundation supporting programs that align with its philanthropic priorities.

Grantmaking Approach

The Lilly Foundation’s work is guided by a charitable vision of a world where every person has an opportunity to live their healthiest life. Through grantmaking focused on Lilly Foundation’s charitable vision, grants can serve as a catalyst for closing gaps and empowering individuals and communities to thrive.

All proposals should demonstrate clear alignment with at least one focus area and include charitable outcomes that are measurable and consistent with the Foundation’s long-term charitable goals.

Global Health, K-12 STEM Education and Economic Mobility Grant

Focus Areas

Global Health

Lilly Foundation, through its charitable grants, aims to support permissible charitable efforts to improve access to quality healthcare for resource-limited communities in low- and lower-middleincome countries (L/LMICs) and in the United States. Strengthening access to care is essential for enhancing community well-being and supporting economic stability in resource-limited settings.

The Global Health focus area aims to close gaps in quality healthcare by supporting charitable solutions that improve access, bring care closer to where people live, and address the high burden of non-communicable diseases (NCDs) in resource-limited settings. To the extent permissible, the Foundation prioritizes charitable efforts related to cardiometabolic health in resource-limited settings.

K-12 STEM Education

The K-12 STEM Education focus area aims to close the gaps for students from low-income communities by supporting programs that foster new pathways and pipelines to STEM education through focused K-12 efforts, concentrating on the critical middle school years. The Foundation’s K-12 STEM Education grants are focused on initiatives that benefit Marion County, Indiana.

Economic Mobility

The Economic Mobility focus area supports charitable and educational programs that strengthen workforce readiness, postsecondary and skills-based educational pathways, and housing stability to promote long-term prosperity. This support is focused on Marion County, Indiana, with the goal of improving economic opportunity for low-income communities and advancing community well-being.

The DOJ FY 2026 BIDEN Program provides funding to support state and local agencies in addressing immigration-related crime. This initiative enables law enforcement to apprehend criminal illegal aliens, analyze gang activity, and enhance court operations related to trafficking crimes. The program facilitates temporary detention and transportation of offenders, promoting collaboration with Homeland Security Task Forces. Applications must be submitted via JustGrants by specified deadlines, with rounds of funding released throughout 2026.

About McElhattan Foundation

Founded in 2017 following the sale of Industrial Scientific Corporation, McElhattan Foundation invites bold ideas that advance the goals of its four program areas, including Ending Death on the Job.

Zero Electrocution Challenge

Despite decades of regulations, training, and personal protective equipment, workers continue to die from electrical contact every year.

McElhattan Foundation’s Zero Electrocution Challenge seeks breakthrough solutions that present pathways to eliminate life-threatening tasks that lead to fatal electrocution on the job by the year 2050, while increasing enterprise profitability and productivity. This is the inaugural ZERO 2050 challenge, awarding two Winners up to $1 million each.

The FY27 Communications and Networking Applied Research program aims to advance technologies essential for Naval operations. This initiative aligns with the Design for Maritime Superiority, focusing on the Naval Tactical Grid (NTG) to ensure seamless connectivity among distributed units. The technologies developed will operate under challenging conditions across multiple domains, enhancing command and control capabilities for effective decision-making in maritime and other operational theaters.

The Fair Housing Initiatives Program (FHIP) aims to combat discriminatory housing practices through funding provided to various organizations. Established by Congress in 1988 and made permanent in 1992, FHIP supports entities that educate the public and enforce fair housing rights. The program offers competitive grants across four initiatives, including the Private Enforcement Initiative, which enables national non-profit organizations to investigate violations and uphold fair housing laws effectively.

About Us

Wisconsin Sea Grant is a statewide program of basic and applied research, education, outreach and technology transfer dedicated to the stewardship and sustainable use of the nation’s Great Lakes and ocean resources.

Headquartered at the University of Wisconsin-Madison, the institute is housed in the Office of the Vice Chancellor for Research’s Aquatic Sciences Center. (See our Water and Land Acknowledgement.) Wisconsin Sea Grant is part of a national network of 34 university-based programs funded through the National Sea Grant College Program, National Oceanic and Atmospheric Administration, U.S. Department of Commerce and through matching contributions from participating states and the private sector. 

John A. Knauss Marine (and Great Lakes) Policy Fellowship

The University of Wisconsin Sea Grant College Program is accepting applications from graduate students statewide for the National Sea Grant College Program’s John A. Knauss Marine (and Great Lakes) Policy Fellowship Program. The program, established in 1979, provides a unique educational experience to applicants who have an interest in ocean, coastal and Great Lakes resources and in the national policy decisions affecting those resources. The program matches highly qualified graduate students with “hosts” in the legislative and executive branch of government located in the Washington, D.C. area, for a one year paid internship. Placement opportunities are numerous and very diverse and have typically included offices within Congress, the Executive Office of the President, the National Oceanic and Atmospheric Administration, the National Aeronautics and Space Administration, the U.S. Fish and Wildlife Service, the Environmental Protection Agency, the Federal Emergency Management Agency, the U.S. Navy, and the U.S. Departments of State, Treasury, Transportation, and Energy, in addition to others. Applicants from a variety of backgrounds including natural and social sciences, law, engineering, and communications can be competitive for this fellowship. Fellowships begin June 1, 2027.

The DoW Rare Cancers Concept Award for FY26 promotes groundbreaking ideas in rare cancer research. This award encourages innovative applications that explore novel courses of investigation without requiring preliminary data. Unique to this program is the prohibition against mentioning the Principal Investigator or collaborators in the proposal materials, ensuring an unbiased review process. This funding opportunity aims to advance scientific discovery in the rare cancer domain.

The Tribal Broadband Connectivity Program (TBCP) aims to enhance broadband access and adoption on Tribal lands, supporting initiatives for remote learning, telework, and telehealth. Administered by NTIA, this program provides vital funding to eligible entities under the Consolidated Appropriations Act of 2021 and the Infrastructure Investment and Jobs Act of 2021. This funding is crucial for fostering digital inclusion and improving connectivity in underserved Tribal communities.

The Native Entities Grant Program, initiated by NTIA under the Digital Equity Act of 2021, aims to support Indian Tribes, Alaska Native entities, and Native Hawaiian organizations. This program streamlines funding through a unified application for two significant initiatives: the State Digital Equity Capacity Grant and the Digital Equity Competitive Grant. By focusing on reducing administrative burdens, it enhances access to digital resources and equity in underserved communities.

The DoW Bone Marrow Failure Idea Development Award supports innovative, high-impact research aimed at understanding and curing bone marrow failure diseases. This grant is available to both Established Investigators and Early-Career Investigators, with no preliminary data required for applications. Reviewers assess proposals based on specific criteria tailored to the investigator's career stage. The focus is on achieving interpretable results that contribute significantly to the field.

The DoW Bone Marrow Failure Investigator-Initiated Research Award supports innovative research aimed at advancing the understanding and treatment of bone marrow failure. This funding opportunity encourages applications for translational and clinical studies, requiring preliminary data to strengthen proposals. Unique features include the ability for a partnering Principal Investigator to contribute to the research, thereby fostering collaboration while maintaining a focus on significant advancements in patient care.

South Dakota Department of Public Safety

The South Dakota Department of Public Safety includes 14 agencies with the mission to keep South Dakota a safe place in which to live, work, visit and raise a family.

Victims' Assistance Program Grants

The Victims' Assistance Program provides grant funding for agencies that provide services to victims of domestic violence, sexual assault, stalking and other violent crimes. The Victims' Assistance Program funding includes: VOCA, FVPSA, STOP, SASP and DASA Grants.

Victims of Crime Act (VOCA) Grant

Funds are awarded by the US Department of Justice, Office for Victims of Crime. The funds come entirely from fines and penalties assessed against convicted federal criminals. Funds are awarded to provide direct assistance to innocent victims of violent crime.

Agencies who are currently not funded with Victims’ Assistance grants, but who are considering applying for a grant(s) are strongly encouraged to contact the Victims’ Services Program director prior to grant announcements being released for the upcoming funding cycle.

South Dakota Department of Health

The South Dakota Department of Health (SD DOH) strives to promote, protect, and improve the health of all South Dakotans with information, licensing, and more.

Cardiovascular Disease Prevention and Treatment Funding

The South Dakota Department of Health is pleased to announce a funding opportunity, the Cardiovascular Disease Prevention and Treatment funding. This funding opportunity is intended to support strategies that have a focus on prevention, treatment and/or management of cardiovascular disease. The facilities awarded funding through this opportunity will receive funds and technical assistance to create and expand sustainable programs to help link resources that support self-management and lifestyle changes to address those at increased risk for CVD with a focus on hypertension management.

The South Dakota Department of Health (SD DOH) Heart Disease and Stroke Prevention Program (HDSPP) is offering funding to meet one or both of the following priorities: Priority 1: Self-Measured Blood Pressure (SMBP) Program; and Priority 2: Care Coordination Program.

Priority 1: Self-Measured Blood pressure (SMBP) Program

Self-Measured Blood Pressure (SMBP) Program supports the implementation and expansion of Self-Measured Blood Pressure Monitoring programs through partnerships with local healthcare facilities and clinics. These programs are designed to help individuals with hypertension manage their condition effectively by monitoring their blood pressure at home in conjunction with clinical support.

South Dakota Department of Health

The South Dakota Department of Health (SD DOH) strives to promote, protect, and improve the health of all South Dakotans with information, licensing, and more.

Cardiovascular Disease Prevention and Treatment Funding

The South Dakota Department of Health is pleased to announce a funding opportunity, the Cardiovascular Disease Prevention and Treatment funding. This funding opportunity is intended to support strategies that have a focus on prevention, treatment and/or management of cardiovascular disease. The facilities awarded funding through this opportunity will receive funds and technical assistance to create and expand sustainable programs to help link resources that support self-management and lifestyle changes to address those at increased risk for CVD with a focus on hypertension management.

The South Dakota Department of Health (SD DOH) Heart Disease and Stroke Prevention Program (HDSPP) is offering funding to meet one or both of the following priorities: Priority 1: Self-Measured Blood Pressure (SMBP) Program; and Priority 2: Care Coordination Program.

Priority 2: Care Coordination Program

Care Coordination program supports a patient-centered healthcare delivery model that provides comprehensive, proactive, and coordinated management for individuals with multiple chronic conditions, while explicitly identifying and addressing the non-medical social and environmental factors that impact their well-being.

South Dakota Department of Health

The South Dakota Department of Health (SD DOH) strives to promote, protect, and improve the health of all South Dakotans with information, licensing, and more.

‘South Dakota Walkable Communities’ Active Transportation Assessment Collaboration

The South Dakota Department of Health will provide one South Dakota community (or two communities as an inter-community project) with technical assistance (provided by South Dakota State University Landscape Architect Students) in conducting active transportation assessments and providing recommendations for improving the built environment to increase walkability and bike-ability within that community or joint communities.

Applicants are highly encouraged to consider the specific walkability needs and challenges of priority populations when completing the applications.

ASPCA Reimagining Racers: Grants for Adopting Out Retired Racehorses Grant

ASPCA Right Horse Adoption Partners, ASPCA Right Horse Industry Partners, and organizations actively participating in the warm-up ring (defined as groups that are actively working to achieve the 13 criteria for Partnership and are participating on myrighthorse.org) are invited to apply for a grant to support an increase in capacity and/or efficiency of programs aimed at adopting out retired Thoroughbred racehorses. 

Funding requests for this grant initiative should focus on:

Activities that increase capacity, decrease length of stay, reduce cost of care or increase efficiencies, and/or improve humane outcomes in other ways. Examples:

• Training programs
• Programs that engage new adopters and grow the market share for adoption
• Medical make-ready or rehabilitation with a focus on innovation and/or sustainability
• Collaborations with other equine industry organizations to increase support for retired racehorses

Proposals will be evaluated on their potential (within the 12-month grant term) to: 

• Increase capacity (the number of horses that can be rehabilitated, trained, and placed)
• Decrease length of stay
• Decrease cost of care
• Reduce risk, harm or suffering for retired racehorses

Requests may be for the creation of new programs or the expansion of existing programs. Programs that test innovative ideas are welcome.

Grant Amounts

Grants will generally range from $10,000-$40,000, with a maximum individual grant amount of $60,000. The total funding amount available for this grant opportunity is $200,000. 

Eligibility

ASPCA Right Horse Adoption Partners, ASPCA Right Horse Industry Partners, and active Warm-Up Ring participants (defined as groups that are actively working to achieve the 13 criteria for Partnership and are participating on myrighthorse.org) whose mission or operations focus significantly on serving retired Thoroughbred racehorses are eligible to apply for this grant opportunity. Adoption organizations must be up to date on reporting data biannually to the Equine Welfare Data Collective (EWDC). If you’re unsure about your eligibility, you may contact therighthorse@aspca.org to confirm before applying.   

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) was founded on the belief that animals are entitled to kind and respectful treatment by humans. We invite all voices to join us in working together to improve the lives of animals in need.

The ASPCA Right Horse Grants aim to enhance equine adoptions and support community equines by funding programs that boost shelter capacity or assist in keeping owned equines in their homes. Grants between $5,000 and $50,000 are available, with a total funding pool of up to $750,000. Eligible applicants include ASPCA Right Horse Adoption Partners and organizations committed to the welfare of retired Thoroughbred racehorses. Proposals should clearly outline the objectives and expected impacts.

Driving University Impact: Expanding the Public Exchange Network Grant

How the Public Exchange Network Works

No single university – even a large R1 – has enough faculty expertise available to meet the needs of every partner. The Public Exchange Network was designed to help universities work together seamlessly to build robust partnerships and generate more collective impact. Universities joining the network are independent but affiliated members, with full control over their own program and project portfolios. As a national network with local, on-the-ground capacity, Public Exchange Network members can also share approaches that work, scale solutions to common problems, and build cross-regional partnerships together. 

As an institutional partner in the Public Exchange Network, universities will build capacity to develop, test and implement solutions to the most urgent problems in their regions and beyond. Universities joining the Public Exchange Network get:

• The tools, templates and training they need to start right away;
• A shared brand they can plug into on day one;
• A network of faculty, past and potential partners and philanthropic relationships, benefitting everyone in the network. 

Public Exchange Network Expansion grants will cover 75-80% of the minimum estimated annual costs for two years to launch a new Public Exchange. To launch a Public Exchange, universities must have the following in place: (1) a staff executive director with experience launching and leading social impact partnerships, (2) a project seed fund, and (3) a modest operations budget. We also recommend some in-kind project management support from an existing university staff member. The grant includes a two-year Public Exchange Executive Director (ED) compensation subsidy of $300,000 to launch the Public Exchange on campus, and a 2-year license to use the Public Exchange brand. New Public Exchange Network members will also receive ongoing support and guidance from current Public Exchange leadership and staff at USC and WashU, including recruitment support and intensive training for hiring and onboarding an executive director, a sub-site on the Public Exchange website, incubation and project management support from current Public Exchange staff, and a suite of tools for developing and implementing Public Exchange projects.

The FY26 Neurofibromatosis Research Program's Synergistic Idea Award supports innovative research on neurofibromatosis (NF) through collaborative efforts of two or three Principal Investigators (PIs). By leveraging their unique perspectives, these PIs will tackle significant questions in NF research. Applicants must provide relevant preliminary or published data to support their proposals, ensuring a strong foundation for impactful research outcomes.

The DoW Neurofibromatosis Investigator-Initiated Research Award addresses critical needs in neurofibromatosis research, aiming to enhance patient care through innovative projects. It supports various research phases, excluding clinical trials, and encourages collaboration between scientists and clinicians. The funding mechanism includes two levels based on participation in optional features, such as the Open Science Initiative and collaboration with qualified partners, promoting data sharing and collaborative research efforts.

The FY26 Neurofibromatosis Research Academy – Scholar Award supports early-career independent investigators focusing on neurofibromatosis research. Scholars are required to be within 10 years of their terminal degree and must designate a Career Guide for mentorship, fostering collaboration. This initiative aims to advance impactful research and develop skilled researchers in a supportive environment, addressing critical areas of emphasis in neurofibromatosis research.

The FY26 Neurofibromatosis Research Program's Exploration-Hypothesis Development Award encourages innovative, high-risk research concepts in neurofibromatosis (NF). This award aims to support groundbreaking studies that will pave the way for future scientific inquiries. Proposals should present a well-defined, testable hypothesis grounded in sound scientific rationale. While preliminary data is encouraged, it is not a prerequisite for submission, allowing researchers to explore novel paradigms and perspectives in NF research.

The NIH Research Evaluation and Commercialization Hubs (REACH) program aims to facilitate the translation of biomedical discoveries into marketable products to enhance patient care. By funding five new academic entrepreneurship hubs, NIH will provide essential resources such as funding, mentorship, and expertise in product development. These hubs will address high-priority technologies and foster public-private partnerships, ultimately supporting the goals of federal research initiatives and addressing local health needs in underserved areas.

About Henry L. Hillman Foundation

Henry L. Hillman Foundation inspires, invests in, and leverages great ideas to improve the quality of life in Pittsburgh and southwestern Pennsylvania.

Backup Power When Your Community Needs It

The Powered & Prepared Initiative seeks proposals from nonprofit and municipal organizations in southwestern Pennsylvania for backup power solutions that allow those organizations to offer essential services during emergencies without disruption.

Southwestern Pennsylvania is increasingly impacted by severe weather events that cause widespread power outages and disruptions. The Powered & Prepared Initiative, supported by Henry L. Hillman Foundation, seeks proposals from nonprofit and municipal organizations for backup power solutions that allow those organizations to offer essential services during emergencies without disruption.

Building the Future Workforce Challenge

Awarding $5 million and the opportunity to test bold, tech‑forward solutions that strengthen the advanced manufacturing and industry technician workforce—today and for the future.

About the Challenge

Caterpillar knows preparing the workforce for the future is urgent. Communities, employers, and industry need new ways to close advancing skill gaps. The Building the Future Workforce Challenge invites fresh perspectives from all sectors to rethink training. Up to five teams will be awarded $1 million each for sustainable, tech‑forward solutions that strengthen today’s—and tomorrow’s—advanced manufacturing and industry technician talent pipelines.

What types of solutions are you looking for?

The Building the Future Workforce Challenge aims to identify, test, and scale innovative, sustainable solutions that will address today’s and tomorrow’s advanced manufacturing and industry technician skill gaps. A core requirement of any solution is that it remains relevant amid evolving technology—ensuring that breakthrough innovation and human potential rise together.

Strong proposals for Building the Future Workforce Challenge will meet four criteria outlined in the scoring rubric, and proposed solutions must focus on one or more of the following solution categories for Building the Future Workforce Challenge: