Best Pittsburgh Grants for Nonprofits in Pennsylvania

The WaterSMART Cooperative Watershed Management Program offers funding to eligible entities for developing local solutions to water management issues. This initiative supports watershed group development, restoration planning, and project design, promoting stakeholder cooperation and improving water reliability. It aligns with key priorities from the Trump administration, addressing complex water challenges and enhancing federal grant oversight. By facilitating these efforts, the program aims to stretch limited water resources and foster collaborative solutions among diverse stakeholders.

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is inviting applications for the Clinical Trial Cooperative Agreement Program. This funding opportunity supports investigator-initiated, interventional clinical trials at various phases. Initial funding will facilitate the preparation needed to start trials, with successful milestones leading to further support. NIAMS emphasizes hypothesis-driven trials that promise significant clinical impact within its research mission.

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is launching a funding opportunity for Exploratory Clinical Trials Grants. This program aims to support innovative clinical trials that enhance the understanding and treatment of arthritis and other musculoskeletal and skin conditions. Research proposals should focus on early-stage trials, including first-in-human studies, dose-finding, and biomarker evaluation. The initiative encourages the translation of promising laboratory findings into effective clinical practices, ultimately improving patient outcomes.

PennDOT Behavioral Highway Safety Grants

PennDOT’s Behavioral Traffic Safety Unit offers traffic safety grants to support local communities and organizations working to make Pennsylvania’s roads safer. Eligible applicants include local governments, universities within the Pennsylvania State System of Higher Education, Pennsylvania state related universities, and nonprofit organizations.

These grants are funded through federal programs administered by the National Highway Traffic Safety Administration (NHTSA) under 23 U.S.C. §402 and §405. Funding follows the federal fiscal year, which runs from October 1 through September 30.

Grant opportunities focus on proven, data driven strategies that address the most urgent traffic safety challenges across the Commonwealth. Available funds are allocated using formulas based on crash data to ensure resources are directed where they can make the greatest impact.

Child Passenger Safety Educational Initiatives

Supplements efforts provided by the existing statewide child passenger safety project organized by the PA Traffic Injury Prevention Project (PA TIPP) by providing additional trainings for CPS technicians across the state, broaden outreach efforts, and distribute car seats to underserved communities.

PennDOT Behavioral Highway Safety Grants

PennDOT’s Behavioral Traffic Safety Unit offers traffic safety grants to support local communities and organizations working to make Pennsylvania’s roads safer. Eligible applicants include local governments, universities within the Pennsylvania State System of Higher Education, Pennsylvania state related universities, and nonprofit organizations.

These grants are funded through federal programs administered by the National Highway Traffic Safety Administration (NHTSA) under 23 U.S.C. §402 and §405. Funding follows the federal fiscal year, which runs from October 1 through September 30.

Grant opportunities focus on proven, data driven strategies that address the most urgent traffic safety challenges across the Commonwealth. Available funds are allocated using formulas based on crash data to ensure resources are directed where they can make the greatest impact.

Community Traffic Safety Project (CTSP)

Traffic safety educational outreach programs to schools and communities targeting local safety issues identified through data analysis. Provide support towards national and statewide enforcement mobilizations and other programs. Applicants for these grants must be a PA county government.

Lilly Foundation

To extend Lilly’s charitable reach and impact, the Eli Lilly and Company Foundation (Lilly Foundation) was established in 1968 and is supported by donations from Eli Lilly and Company.

The Foundation is a tax-exempt, private foundation supporting programs that align with its philanthropic priorities.

Grantmaking Approach

The Lilly Foundation’s work is guided by a charitable vision of a world where every person has an opportunity to live their healthiest life. Through grantmaking focused on Lilly Foundation’s charitable vision, grants can serve as a catalyst for closing gaps and empowering individuals and communities to thrive.

All proposals should demonstrate clear alignment with at least one focus area and include charitable outcomes that are measurable and consistent with the Foundation’s long-term charitable goals.

Global Health, K-12 STEM Education and Economic Mobility Grant

Focus Areas

Global Health

Lilly Foundation, through its charitable grants, aims to support permissible charitable efforts to improve access to quality healthcare for resource-limited communities in low- and lower-middleincome countries (L/LMICs) and in the United States. Strengthening access to care is essential for enhancing community well-being and supporting economic stability in resource-limited settings.

The Global Health focus area aims to close gaps in quality healthcare by supporting charitable solutions that improve access, bring care closer to where people live, and address the high burden of non-communicable diseases (NCDs) in resource-limited settings. To the extent permissible, the Foundation prioritizes charitable efforts related to cardiometabolic health in resource-limited settings.

K-12 STEM Education

The K-12 STEM Education focus area aims to close the gaps for students from low-income communities by supporting programs that foster new pathways and pipelines to STEM education through focused K-12 efforts, concentrating on the critical middle school years. The Foundation’s K-12 STEM Education grants are focused on initiatives that benefit Marion County, Indiana.

Economic Mobility

The Economic Mobility focus area supports charitable and educational programs that strengthen workforce readiness, postsecondary and skills-based educational pathways, and housing stability to promote long-term prosperity. This support is focused on Marion County, Indiana, with the goal of improving economic opportunity for low-income communities and advancing community well-being.

About McElhattan Foundation

Founded in 2017 following the sale of Industrial Scientific Corporation, McElhattan Foundation invites bold ideas that advance the goals of its four program areas, including Ending Death on the Job.

Zero Electrocution Challenge

Despite decades of regulations, training, and personal protective equipment, workers continue to die from electrical contact every year.

McElhattan Foundation’s Zero Electrocution Challenge seeks breakthrough solutions that present pathways to eliminate life-threatening tasks that lead to fatal electrocution on the job by the year 2050, while increasing enterprise profitability and productivity. This is the inaugural ZERO 2050 challenge, awarding two Winners up to $1 million each.

The F26AS00104 State ANS Management Plan 2026 aims to combat aquatic nuisance species through pre-proposals followed by full applications. Managed by the US Department of the Interior's Fish and Wildlife Service, this initiative requires a 25% cost-share and limits administrative costs to 5%. Applications are due by October 14, 2026, though the funding opportunity closes on December 16, 2026. The plan is crucial for maintaining biodiversity and supporting a coordinated national approach to invasive species management.

The Radiation Oncology-Biology Integration Network (ROBIN) Centers, funded by the National Cancer Institute (NCI), aims to enhance national radiation oncology infrastructure through collaborative research. This initiative supports studies on biological responses to radiation treatment in cancer patients, focusing on understanding tumor and tissue changes. By integrating various scientific disciplines and collecting comprehensive data, ROBIN intends to improve cancer care, optimize treatment strategies, and accelerate translational discoveries to enhance patient outcomes.

The Clinical Trial & Research Network Kick-Start Grant (CTRN), launched by the Department of Community and Economic Development in partnership with the Office of Transformation & Opportunity aims to create a coordinated clinical research infrastructure that will reduce the cost, time, and complexity of conducting clinical trials in the Commonwealth. Critically, the CTRN is meant to facilitate a robust partnership across healthcare and life sciences stakeholders that benefits patients, healthcare institutions, and businesses alike.

St. Ignace Area Community Foundation: CTE Technical Scholarship

The St. Ignace Community Fund annually awards scholarships assisting students with higher education, technical training, vocational training or retraining based largely on acknowledgement of student responsibility, community service, and civic involvement. These Scholarships are made possible through the generosity of donors to the various accounts within the St. Ignace Area Community Fund. Some accounts specifically are awarded to recognize higher education in the areas of special education, vocational/technical careers, teaching, law enforcement, and health care.

Each year, Pennsylvanians generate an estimated 25,000 tons of household hazardous waste such as pesticides, old paint, drain cleaners and pool chemicals. Household hazardous wastes (HHW) are those wastes produced in households that are hazardous in nature but are not regulated as hazardous waste under federal and state laws. These wastes, when not properly managed, can create environmental and public health hazards.

HHW Collection Programs give Pennsylvanians an opportunity to safely dispose of these wastes. The Pennsylvania Department of Environmental Protection (DEP) encourages HHW collection events by providing financial and technical assistance to collection programs that register with DEP. These programs provide sites for residents or small businesses to drop off their HHW. The materials collected at these sites are then reused, recycled, and, when necessary, disposed of at hazardous waste facilities.

Susan G Komen Breast Cancer Foundation

The mission of Susan G. Komen® is to save lives by meeting the most critical needs in our communities and investing in breakthrough research to prevent and cure breast cancer.

Susan G. Komen Career Catalyst Research (CCR) Grants

Susan G. Komen Career Catalyst Research (CCR) Grants foster promising breast cancer researchers who are in the early stages of their faculty careers by providing support for up to three years of “protected time” for research career development under the guidance of a Mentor Committee. We seek to support those who will emerge as the next key leaders in the fight against breast cancer.

CCR Research Focus: Research projects must be hypothesis-driven, breast cancer-focused studies. They may be considered basic, translational, clinical and/or population science in nature and should align with Komen’s research priorities and mission to save lives from breast cancer. 

Rob-See-Co is an independent seed company with regional expertise, providing customers access to leading genetics and traits through the Rob-See-Co and Innotech® seed brands. Rob-See-Co also sells Masters Choice specialty silage and forage products, as well as Streamline Ag seed-driven crop inputs. Rob-See-Co works alongside its customers, building strong relationships and helping them plant the right seed for their long-term success, while keeping the process friendly, straightforward, and simple. 

Rob-See-Co Library Grant

In recognition of National Library Day, Rob-See-Co, an independent seed company located in Elkhorn, Neb. is proud to announce the continuation of its Rural Library Grant program.

Originally launched in 2023 to commemorate the company’s 10th anniversary and honor Agnes Robinson’s dedication to the rural library in Waterloo, NE, the program continues to hold special meaning. Agnes, great-grandmother of Jim Robinson, CEO of Rob-See-Co, was a passionate advocate for rural libraries. Today, the program extends support to libraries across rural communities within the company’s footprint. 

The focus areas for grant distributions from the Rob-See-Co Rural Library Grant program will assist local libraries with expanding book collections, core educational programs for adults or children, and computer or software upgrades. Examples of this would be new books, expansion of school visits or field trips, digitizing research materials, support for funding traveling exhibits and speakers.

Rob-See-Co will award ten grants to selected rural libraries across CO, IA, KS, MD, MI, MN, ND, NE, OH, OK, PA, SD, TX and WI. Funds may be used for core educational, preservation and interpretive purposes, including collection development, facility improvements, traveling exhibits, guest speakers, staff training, programming, and publications. 

The Readiness and Recreation Initiative (RARI) by the National Park Service aims to enhance outdoor recreation and support compatible land uses near military installations. This program, funded through the Land and Water Conservation Fund, provides up to 50% of project costs, encouraging collaboration with the Department of War. Projects must involve land acquisition and align with national priorities to ensure public outdoor access in perpetuity, directly benefiting both military and civilian communities.

The Indian Housing Block Grant Competitive Program (IHBG-COMP) for FY 2026 offers competitive grants to eligible recipients under NAHASDA. This program aims to support affordable housing initiatives benefiting low-income Tribal families, enhancing their living conditions and community well-being. Funded by the US HUD's Office of Public and Indian Housing, the IHBG-COMP encourages the development of sustainable housing solutions within Native American communities.

Nonprofit Security Grant Program (NSGP) - Pennsylvania

This program provides funding for physical and cybersecurity enhancements and other security-related activities to nonprofit organizations that are at high-risk of a terrorist or other extremist attack.

The Nonprofit Security Grant Program also seeks to integrate the preparedness activities of nonprofit organizations with broader stated and local preparedness efforts,

Program Basics

• Federal program administered by PEMA
• Reimbursement based grant
• 36-month period of performance
• No cost-share requirement
• Maximum award request is $200,000 for both NSGP-UA and NSGP-S
•  Nonprofits with multiple sites (multiple locations/physical addresses) can apply for additional sites, per funding stream (NSGP-S and NSGP-UA). Each location MUST have an individual application and a unique risk assessment specific to the location. No combination of site locations can exceed $600,000 per funding stream.

What Can Funds Be Used For?

The grant program seeks to integrate preparedness activities of nonprofit organizations with broader state and local preparedness efforts.

This funding for eligible nonprofit organizations is generally limited to target hardening and physical security enhancements.

NSGP funds may be used for:

• Planning related to the protection of the facility and people within the facility.
• Equipment focused on target hardening and physical security enhancements.
• Training and Exercise for nonprofit security personnel to attend security-related training courses and programs or participate in security-related exercises.
• Contracted Security personnel are allowed under this program only as described in this NOFO. The recipient must be able to sustain this capability in future years without NSGP funding. NSGP funds may not be used to purchase equipment for contracted security.
• Construction and Renovation with pre-approval from DHS/FEMA.
• Management and Administration (M&A) for costs directly related to the administration of NSGP funds.

PADDC Community Grants Program

Our Community Grants Program brings together people, with and without disabilities, in a local community initiative to influence social change and improve the lives of everyone in the community. We support ideas that develop generic change, providing benefits to people with disabilities in settings that are the same as those available to community-at-large. If necessary, projects also change that generic community to meet the needs of people with disabilities, affirming the status of people with disabilities as full and equal members.

The Pennsylvania Developmental Disabilities Council (PADDC) uses the federal definition of developmental disabilities, as it appears in Developmental Disabilities Assistance and Bill of Rights Act of 2000 (The DD Act). This definition is based on substantial physical or mental impairment function in three or more major areas of life activity and the age of onset when the disability occurred.

Act 101, Section 901, Household Waste (HHW) Education Grants. Counties are eligible for 80 percent reimbursement for educational programs on household hazardous waste and pollution prevention.

Hogg Foundation for Mental Health

The Hogg Foundation for Mental Health was established in 1940 at The University of Texas at Austin by the children of Texas Governor James Hogg. For over a quarter of a century, the Hogg Foundation was guided by the passion and insight of the Governor’s daughter, Miss Ima Hogg, who actively promoted the foundation and encouraged its staff to pursue a bold, new vision. Today the Hogg Foundation is based at The University of Texas at Austin Steve Hicks School of Social Work and is funded through an endowment created by gifts from the Hogg family and managed by The University of Texas/Texas A&M Investment Management Company.

The Hogg Foundation is inspired by Ima Hogg’s vision for a Texas that supports and promotes mental health, resilience, and well-being. Miss Ima was ahead of her time in believing that mental health was just as important as physical health. She believed all people should have access to community-based resources to support mental well-being and live fulfilling lives, and she championed supports in everyday environments like schools, workplaces, places of worship, and homes.

Stephany June Bryan: Bold Spirit of Achievement Scholarship

The Hogg Foundation for Mental Health is offering ten $5,000 scholarships in honor of Stephany June Bryan to individuals facing personal and financial barriers to achieving their educational or career goals due to the impact of living with a mental health challenge and/or supporting a loved one with a mental health challenge.

You do not need to be enrolled in a program at the time you submit your application. However, you will need to provide enrollment verification and/or a certificate of completion when/if it is awarded.

Pennsylvania Council on the Arts

Agency Mission

Empowering, connecting, and amplifying creatives and creative industries and their contributions to Pennsylvania’s communities, economy, and workforce.

Agency Vision

Pennsylvania becomes the national leader among states for creative communities, talent, and industries.

Pennsylvania Creative Asset Program

The Pennsylvania Creative Asset Program supports small- to mid-sized creative organizations that deliver services, products, and/or programs that align with one or more of Pennsylvania Creative Industries’ strategic plan focus areas:

• Asset Development (e.g., creative organizations, entrepreneurial ecosystem, technical assistance, regional networking)
• Workforce Development (e.g., creative skills, career awareness, and employment pathways)
• Community Development (e.g., creative placemaking, engagement with local governments, and networking for practitioners)
• Visibility (e.g., promotion of creative industries, products and services, and of the contributions and opportunities within our commonwealth’s creative sector)
• Policy (e.g., creation of policies that promote and foster relevancy and opportunity for creative industries, within governmental and non-governmental agencies and businesses)

About BlackRock

We’re a global asset manager and technology provider dedicated to helping more and more people experience financial well-being. We help millions of people invest to build savings that serve them throughout their lives. The BlackRock Foundation which funds and partners with organizations that strengthen financial security for more people,

BlackRock Future Builders

BlackRock Future Builders is a $100 million philanthropic initiative funded by The BlackRock Foundation to expand economic opportunity and power the next generation of America’s skilled trades workers. Through this Request for Proposals (RFP) process, The Foundation seeks to support U.S. nonprofit organizations (i.e., registered 501(c)3 organizations) delivering or supporting high‑quality skilled trades training.

This competitive grant opportunity operates in parallel to other BlackRock Future Builders partnerships and is intended to surface additional, regionally grounded solutions across the skilled trades ecosystem. Organizations may propose direct worker training programs or capacity‑building efforts that enable systems to function more effectively and at greater scale. This first round RFP will be administered by Jobs for the Future (JFF), a national nonprofit that transforms U.S. education and workforce systems.

Focus Areas and Solutions

Applicants may propose worker training or capacity‑building solutions aligned to skilled trades workforce development.

• Worker training interventions may include direct service proposals such as pre-apprenticeship or career navigation programs, workforce training programs, apprenticeship programs, or wraparound participant supports that are supportive of training persistence and completion.
• Capacity-building interventions are organizational and system-focused, rather than in direct service of participants, and may include, but are not limited to, proposals such as ecosystem-building, demonstration projects, technology or tool adoptions, or research, among others.

PHARE was established by Act 105 of 2010 (the "PHARE Act") to provide the mechanism by which certain allocated state or federal funds, as well as funds from other outside sources, would be used to assist with the creation, rehabilitation and support of affordable housing throughout the Commonwealth. 

PennDOT provides traffic safety grants to local governments, PA state-related universities and PA State System of Higher Education universities, and nonprofit organizations to improve highway safety and reduce deaths and serious injuries due to crashes. First-time applicants must be pre approved by first submitting a letter of interest to RA-PDSHSO_GRANTS@pa.gov. Letters must be written on agency letterhead and include the organization’s FEIN, a summary of the proposed project, a budget estimate, and the specific local grant opportunity listed below that the agency intends to pursue.Statewide DUI Program coordinates technical services in support of the Commonwealth's Impaired Driving Program, including specialized training and statewide coordination of the Drug Evaluation and Classification (DEC) Program.

State Library of Pennsylvania

The Office of Commonwealth Libraries (OCL) within the Pennsylvania Department of Education (PDE) supports, develops, and provides library services for learning and advancement.

About

The Office of Commonwealth Libraries (OCL) within the Pennsylvania Departme​nt of Education (PDE) supports, develops, and provides library services for learning and advancement.​

We collect, preserve, and connect government, libraries, and residents to the information and resources they need to build a successful Pennsylvania.

Grants: Local Library

Grant Description

The Office of Commonwealth Libraries (OCL) is accepting applications for Library Services and Technology Act (LSTA) Action Grants.

Action Grants provide funding of up to $10,000 per project for high-impact initiatives that strengthen library services and create lasting community benefit. These grants support libraries in addressing pressing local needs, deepening partnerships, and building organizational capacity.

Projects may include, but are not limited to: community-focused services, professional development for library staff, trustees, or volunteers, planning studies, community-responsive collections, programming supplies and materials, outreach initiatives, accessibility upgrades, and technology enhancements.

These grants advance OCL’s priority of Libraries as Community Catalyst, supporting libraries in understanding and responding to community needs through deep engagement, effective partnerships, and strategic resource sharing. Additional information is available in the Office of Commonwealth Libraries Five Year Plan.

No specific funding amounts are set aside for particular project types. Awards will be made to the most competitive proposals that demonstrate meaningful community engagement, equitable partnerships, and responsive service design.

Funding for this opportunity is contingent upon OCL receiving its federal award from the Institute of Museum and Library Services.

This project is made possible by Library Services and Technology Act (LSTA) funds from the U.S. Institute of Museum and Library Services administered by the Pennsylvania Department of Education, Office of Commonwealth Libraries. 

PennDOT provides traffic safety grants to local governments, PA state-related universities and PA State System of Higher Education universities, and nonprofit organizations to improve highway safety and reduce deaths and serious injuries due to crashes. First-time applicants must be pre approved by first submitting a letter of interest to RA-PDSHSO_GRANTS@pa.gov. Letters must be written on agency letterhead and include the organization’s FEIN, a summary of the proposed project, a budget estimate, and the specific local grant opportunity listed below that the agency intends to pursue.This grant supports a qualified individual with expertise in traffic safety education to serve as a liaison between the Pennsylvania State Highway Safety Office (SHSO) and the traffic safety education community, particularly Community Traffic Safety Projects (CTSPs). This role will also function as the SHSO’s Public Participation and Engagement (PP&E) Coordinator. Proposals should include a budget that designates funding for sub-grants to support smaller traffic safety education projects.

AΩA is committed to preparing future leaders in medicine and health care. Leadership is about making a positive difference and can be developed through education, observation, experience, and by working with leader mentors. Service learning provides excellent opportunities for students to develop as servant leaders. Only one team from each school may be nominated.