Best Corporate Grants for Nonprofits in Puerto Rico

The National Cancer Institute (NCI) invites applications for the Toward Translation of Nanotechnology Cancer Interventions (TTNCI) program. This funding opportunity focuses on advanced pre-clinical research aimed at developing nanotechnology-based cancer diagnostics and therapeutics. TTNCI awards will support the maturation of innovative nanomedicines using nanoparticles and nano-devices, enhancing cancer treatment efficacy. Successful projects will progress towards further NCI translational programs, such as the NExT initiative.

The BJA FY 2026 Upholding the Rule of Law and Preventing Wrongful Convictions Program aims to enhance justice by strengthening the capacity of entities that review wrongful convictions. By supporting partnerships among criminal justice and victims' services, the program seeks to effectively manage post-conviction claims of innocence and prevent future errors. This initiative will help identify actual perpetrators and ensure justice for victims, contributing to public safety and the integrity of the legal system.

The National Institutes of Health (NIH) is continuing support for the Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT), which focuses on clinical trials and biomarker validation studies for neurological disorders. This initiative aims to foster innovation in neurotherapeutics by providing essential infrastructure and expertise. The program encourages the establishment of Clinical Coordinating Centers (CCC) and Data Coordinating Centers (DCC) to enhance collaborative efforts. Note that applications are not currently being solicited.

The National Cancer Institute (NCI) invites applications for transformative research in cancer biology and oncology through nanotechnology. This funding opportunity aims to address significant challenges by exploring the interactions of nanomaterials with biological systems. Projects should focus on utilizing nanoparticles and devices for targeted cancer therapies and enhancing diagnostic capabilities. Successful proposals will contribute to the foundational knowledge necessary for future nanotechnology-based interventions in cancer treatment.

The National Urban Indian Health Program aims to enhance behavioral health services for Urban Indian communities by fostering awareness, advocacy, and collaboration across the nation. By providing technical assistance and training to Urban Indian Organizations, the program seeks to improve access to culturally relevant behavioral health care for American Indian and Alaska Native populations residing in urban areas, ultimately leading to better health outcomes and community support.

The NIH Science Education Partnership Award (SEPA) fosters innovative educational initiatives aimed at pre-college students, promoting their interest in STEM fields, especially in biomedical and behavioral sciences. This program supports both classroom projects and informal science education activities, such as after-school programs and library events. Emphasizing the development of quantitative and computational skills, SEPA seeks to inspire the next generation of scientists and thinkers through engaging educational experiences.

The BRAIN Initiative aims to advance innovative neurotechnologies by funding early-stage clinical studies for devices that record or stimulate the human central nervous system. This initiative encourages collaborations between clinical researchers and device manufacturers to facilitate groundbreaking studies. By addressing the challenges of obtaining safety and utility data, this program supports both non-invasive and significant risk devices, providing essential insights into their functionality and design. Applications are currently not being solicited, allowing time for meaningful project development.

The Rehabilitation Engineering Research Center on Recreational, Sport, and Exercise Technologies for People with Disabilities aims to enhance rehabilitation services through innovative technological solutions. This initiative focuses on promoting health and exercise among individuals with disabilities by addressing unique rehabilitation challenges. Funded by the US HHS Administration for Community Living, the project spans 60 months, involving advanced research and development to create effective support mechanisms and overcome environmental barriers.

The HFM Foodservice Scholarship Fund supports students in Hawaii pursuing education in Culinary Arts or Agriculture. Applicants must demonstrate financial need, maintain a minimum GPA of 2.7, and attend an accredited institution in the U.S. Preference is given to prior recipients in good academic standing. This scholarship aims to empower future leaders in the foodservice industry by providing financial assistance to deserving candidates.

The Community Heart & Soul Seed Grant Program offers $10,000 in startup funding for community-driven groups in small towns to adopt the Community Heart & Soul model. Applications are accepted until 11:59 p.m. EST on the last business day of each month, with funding decisions made the following month. This initiative aims to empower residents to engage in local development and foster community connections.

The Jay L. Smith Family Foundation provides grants to tax-exempt non-profit organizations in the United States, primarily focusing on healthcare, family values, and supporting the disadvantaged. With a strong commitment to Alzheimer's research, the foundation has funded various initiatives including elderly care, domestic violence prevention, and cancer research. Their mission is to enhance the quality of life for individuals and communities through meaningful contributions, aiming to address critical social issues and promote well-being.

The Maximizing Investigators' Research Award (MIRA) program, established by NIGMS, aims to enhance research funding efficiency by providing stable financial support to investigators. This allows for greater scientific flexibility and encourages innovative studies. MIRA is pivotal for distributing funding among promising researchers, fostering groundbreaking research. The program invites applications from eligible NIGMS-funded and NIH-defined New Investigators, as well as current MIRA grantees seeking renewal, ensuring a broad and inclusive approach to advancing science.

About Borealis Philanthropy

Borealis Philanthropy is a philanthropic social justice intermediary that works to resource grassroots leaders and social justice movements for transformative change. We help funders expand their reach and strengthen their impact through donor collaboratives that support a variety of issues, communities, and movements. Borealis is home to nine donor collaboratives, including the Disability Inclusion Fund and Disability x Tech.

DIF x Tech Fund

For the Disability Inclusion Fund at Borealis, part of our efforts for disability rights and justice includes the ways disability and technology are working towards shared goals in our movements. The DIF x Tech initiative, supported by the Ford Foundation’s Technology & Society Program and the MacArthur Foundation’s Technology in the Public Interest, invites proposals that are working to bring about transformational change at the intersections of disability, justice, and technology

About the Disability Inclusion Fund and DIF x Tech

The Disability Inclusion Fund (DIF) supports U.S.-based groups run by and for people with disabilities to lead transformational change. The Fund is supported by donors including the Presidents’ Council on Disability Inclusion in Philanthropy, which is comprised of foundation presidents who are committed to disability inclusion as part of improving diversity, equity, and inclusion within philanthropy.

Part of the efforts of disability rights and justice includes the ways disability and technology are working towards shared goals in our movements. This newly launched initiative is housed at the Disability Inclusion Fund (DIF) and supported by Ford Foundation’s Technology & Society Program and the MacArthur Foundation’s Technology in the Public Interest. 

DIF x Tech Fund Values

All Disability x Tech award decisions will align with the DIF guiding values. The DIF guiding values are:

• Participation: Movement funding accountable to the disability rights movement. Those impacted by injustice/exclusion should be involved in strategies to advance justice/inclusion.
• Intersectionality: Acknowledging that disabled people have multiple and intersecting social and political identities that can influence their ability to have access and inclusion including race, gender identity, class, sexual orientation.
• Radical inclusion: Deeply committed to removing barriers and ensuring access so that those most affected by intersecting identities can participate, valuing lived experience.
• Leadership of those most impacted by ableism: Emphasis is given to organizations led by people subject to systemic bias and impacted by underrepresentation, particularly disabled people of color, queer, gender nonconforming and women with disabilities.
• Cross-movement solidarity: Intentional focus on collaboration and bridge- building amongst disability justice activists and across movements.
• Sustainability: Resources and tools that support the growth of grassroots disabled-led organizations, and expand operational capacities for ongoing movement building. 

What we fund

We invite proposals that are at the nexus of technology, disability rights and justice. This opportunity may be a good fit for your organization, if you are doing work in any of these areas below:

• Disabled people sharing technical skills and knowledge with others in the community.
• Disabled people leading policy, rights, and disability justice activism work related to tech. 
• Disabled people participate in all stages of the design and development of new tech that will enrich lives of people with disabilities.
• Enabling collective and equitable access to digital infrastructure. 
• Expanding the participation, leadership, and thought partnership of overlooked and under-resourced people with disabilities in all areas of the technology sector.
• Partnerships between disability-focused engineering design labs and maker spaces within schools, centers for independent living, or local nonprofit organizations.
• Permissible Policy Work:
  • We may support nonpartisan policy education and advocacy related to disability and technology. Any lobbying must remain within applicable 501(c)(3) limits and Borealis grant restrictions.

The MPS Physics Research Programs, funded by the National Science Foundation (NSF), support transformative research in various fields of physics. This includes experimental and theoretical work in atomic and molecular physics, particle physics, gravitational physics, and more. The NSF aims to promote ambitious projects without the need for immediate commercialization, focusing instead on foundational advancements that push the boundaries of our understanding of the universe.

The All of Us Research Program seeks to advance its mission by enabling access to biospecimens stored in the All of Us supported Biobank for researchers to conduct assays to evaluate associations between biomarkers and chronic diseases and add data to the All of Us resource for broad use by researchers. Biomarker analysis includes, but is not limited to, biomarker discovery; biomarker validation; novel disease stratification; and multiomics integration for disease risk, diagnosis, and prognosis, in support of advancing precision medicine. The All of Us Research Program is a historic effort to enroll 1 million participants who share data to accelerate research and medical breakthroughs, and enable individualized prevention, treatment, and care. Researchers use data from the program to learn more about how individual differences in lifestyle, environment, and genetics can influence health and disease.Grant authorities that allow the All of Us Research Program to forecast this opportunity are as follows: 42 USC 241 and 284.

The DOJ FY 2026 ANGEL Grant Program aims to enhance public safety by funding state, local, and tribal government initiatives to combat violent crime committed by criminal illegal aliens. This program supports hiring law enforcement personnel, retaining critical staff, and acquiring advanced technology. The objective is to prevent harm to American citizens and support Homeland Security Task Force operations. Applications must be submitted by October 27, 2026, to qualify for funding.

The Powering Affordable Reliable Technology (PART) Energy Program, managed by the Rural Utilities Service, seeks Letters of Interest for loan applications to fund renewable energy generation and energy storage projects. With approximately $410 million available from the Inflation Reduction Act, the program offers up to 75% financing for project costs, along with potential loan forgiveness options. This initiative aims to enhance energy infrastructure in rural areas, promoting sustainable energy solutions.

The EPSCoR Centers of Research Excellence in Science and Technology initiative, led by the National Science Foundation, aims to enhance the research capabilities of EPSCoR jurisdictions. By fostering STEM capacity and promoting geographic diversity, this program invites proposals that align with its goals. The focus is on strengthening local research infrastructure and talent development to boost competitiveness in science and technology fields across the nation.

This funding opportunity announcement (FOA) invites applications for Animal and Biological Material Resource Centers (P40), aimed at enhancing biomedical research through providing essential resources such as laboratory animal colonies and informatics tools. The initiative supports both the continuation of existing resources and the development of new ones, emphasizing alignment with NIH Institutes and Centers. Applicants are encouraged to consult with NIH staff to ensure their proposals meet program priorities and competitiveness in the grant process.

The Limited Competition K12 Mentored Research Career Development Program aims to support institutions in developing innovative career pathways for later-stage postdoctoral fellows and junior faculty. This initiative encourages applicants from those with existing Clinical and Translational Science Awards (CTSA) to foster independent research careers. By creating diverse opportunities across academia, industry, and government, the program enhances engagement in clinical and translational science research, ultimately contributing to significant advancements in health outcomes.

The Level 1 Rural Outreach Grant, offered by the National Association of Realtors, aims to enhance REALTORS®' understanding of rural issues. With a maximum award of $3,000, this grant is available once per calendar year to associations. It supports educational efforts and promotes smart growth and diversity in rural communities. Grant recipients are required to complete an evaluation form for the funded activities, ensuring accountability and effectiveness in addressing rural challenges.

The Mary W. Jackson Undergraduate Scholarship, offered by the AIAA Foundation, provides $10,000 to support students pursuing studies in aerospace sciences. Honoring NASA mathematician Mary W. Jackson, this scholarship aims to enhance access to educational opportunities for underrepresented students. Applicants must maintain a minimum GPA of 2.50 and be enrolled in an accredited U.S. institution. This initiative reflects AIAA's commitment to fostering diversity and innovation in the aerospace sector.

The Alleghany Foundation, a private 501(c)(3) organization in Virginia, focuses on enhancing the quality of life in the Alleghany Highlands through strategic funding initiatives. It seeks grant applications that address key areas such as economic transformation, educational excellence, health and wellness, community capacity, and civic leadership. By prioritizing innovative projects and supporting local organizations, the Foundation aims to foster sustainable growth and community engagement, ensuring a vibrant future for the region.

The National Endowment for the Humanities invites K-12 teachers and higher education faculty to apply for the Landmarks of American History and Culture and Summer Institutes program. This initiative aims to enhance humanities education through professional development opportunities, fostering a deeper understanding of historical and cultural landmarks. Participants will engage in enriching experiences designed to improve teaching practices and student learning outcomes in the humanities.

The NCI Pathway to Independence Award (K99/R00) aims to support early-stage postdoctoral researchers transitioning to independent faculty positions. This initiative focuses on talented individuals with doctoral degrees in research or clinical fields, providing essential NCI funding during this key career juncture. Researchers engaged in cancer control, prevention, and data sciences are encouraged to apply for this opportunity, which emphasizes experimental studies with human participants, thus aligning with NIH's clinical trial definitions.

The BJA FY25 Capital Case Litigation Initiative aims to enhance the quality of legal representation in state capital cases, ensuring effective public representation and support for indigent defendants. This initiative is part of the OJP's commitment to uphold the rule of law, protect civil rights, and address public safety challenges. Through federal leadership and funding, OJP seeks to bolster law enforcement efforts and combat violent crime, thereby improving community safety and justice.

The NIDA Avenir Program aims to cultivate innovative leaders in addiction science by funding exceptional early stage investigators (ESIs) embarking on pioneering research. Launched in 2015, this initiative encourages high-risk, high-reward mechanistic studies related to Substance Use Disorders (SUDs) across diverse scientific domains. Applications from new investigators and those outside addiction research are welcomed, fostering interdisciplinary approaches that enhance understanding of SUD mechanisms. The program supports ESIs who may lack preliminary data but demonstrate potential for impactful contributions.