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Best Operating Grants for Nonprofits in Puerto Rico

Find the perfect Operating grants for nonprofits in Puerto Rico on Instrumentl. 9,000+ Operating grants for nonprofits in Puerto Rico in the United States.

9,000+

Available grants

$2.55B

Total funding

$5K

Median grant

9,000+ grants
$2.55B total
$5K median

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8,931 Results based on applied filters

RPAC Fundraising Grants

National Association Of Realtors
Private
American Samoa, Guam +4 more
US $5,000 - US $45,000
The RPAC Fundraising Grants, offered by the National Association of Realtors, support state and local associations in organizing fundraising events aimed at boosting RPAC contributions. These grants require a fundraising goal three times the amount requested, ensuring tangible results. The initiative emphasizes developing detailed fundraising plans that comply with state laws regarding corporate treasury funds. This program is vital for enhancing RPAC participation and advancing property ownership advocacy.
Real Estate & Housing Nonprofit Growth & Development

National Center for Construction Safety and Health Research and Translation (U54)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
US $3,000,000 - US $5,750,000
The National Center for Construction Safety and Health Research and Translation (U54) aims to enhance worker safety in the construction industry through innovative research and intervention strategies. By fostering partnerships and focusing on evidence-based solutions, the Center will address critical safety and health challenges faced by construction workers. The initiative aligns with NIOSH's strategic objectives, promoting collaboration among academic institutions and organizations to improve health outcomes and reduce the occupational health burden in this vital sector.
Occupational Health & Safety

Kids’ Chance of America: Emergency Grant Program

Kids’ Chance of America
Association/Society
American Samoa, Guam +4 more
Unspecified amount
The Kids’ Chance of America: Emergency Grant Program aims to provide essential support to state organizations facing unexpected challenges in funding scholarships for children of injured workers. This initiative ensures that these children can continue their education despite unforeseen financial hardships. Grants can be utilized for scholarships, room, board, and educational fees, emphasizing the importance of maintaining educational support for deserving students during the 2023-2024 academic year.
Academic Scholarship Programs Nonprofit Growth & Development

Ashland County Wildlife Conservation League David McClure Memorial Scholarship

Ashland County Community Foundation
Private
United States
Unspecified amount
The Ashland County Wildlife Conservation League David McClure Memorial Scholarship supports graduating seniors from Ashland County high schools and alternative education programs pursuing a degree in wildlife-related fields. Applicants must maintain a GPA of 3.0 or higher and be accepted into accredited colleges or vocational programs. This scholarship fosters educational growth while promoting conservation efforts, reflecting the commitment of the Ashland County Community Foundation to enhance community development and support future leaders in wildlife conservation.
Education - Higher Education Career / College Preparation Education - High School +5 more

IDeA Networks of Biomedical Research Excellence (INBRE)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
Alaska, Arkansas +22 more
Unspecified amount
The IDeA Networks of Biomedical Research Excellence (INBRE) program aims to enhance biomedical research capacity in underfunded states by fostering collaborations among research institutions. By supporting faculty research, mentoring, and student involvement, INBREs create pathways for undergraduate students to enter biomedical careers. This initiative not only promotes institutional partnerships but also strengthens research infrastructure, ultimately contributing to a more robust scientific community in IDeA states.
Biology Health & Medicine

Abbey Mural Prize

National Academy of Design
Private
American Samoa, Guam +4 more
US $10,000 - US $40,000
The Abbey Mural Prize, established in 1932, supports the creation and restoration of public murals across the United States. This prestigious award, administered by the National Academy of Design since 1940, emphasizes projects that enhance community engagement and social activism through art. Grants typically range from $10,000 to $40,000, with a total annual funding cap of $125,000. Eligible applicants include artists, architects, and nonprofit organizations committed to impactful mural projects.
Public / Community Art

NIH Collaborative International Research Project (Parent PF5 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIH Collaborative International Research Project aims to foster international research collaborations that align with the NIH mission. This grant encourages applications that incorporate at least one international subproject, offering oversight and tracking for NIH-funded international initiatives. Projects should leverage unique resources or populations abroad, contributing to advancements in health sciences relevant to NIH's objectives. This initiative underscores the importance of global partnerships in enhancing research capabilities and outcomes in the United States.
International / Foreign Affairs

Day-End Dough-Nation® Program

Panera Bread Foundation Inc
Private
United States
Unspecified amount
The Day-End Dough-Nation® Program by Panera Bread exemplifies community generosity through the donation of unsold bakery products to local charities. This impactful initiative supports various organizations that distribute food to those in need, including shelters, health centers, and youth programs. By partnering with thousands of non-profits nationwide, Panera Bread not only reduces food waste but also plays a crucial role in addressing hunger and promoting equality within communities.
Immigrant Services Military & Veterans Services Mental Health & Psychiatric Diseases +5 more

Paul B. Beeson Emerging Leaders Career Development Award in Aging (K76 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Paul B. Beeson Emerging Leaders Career Development Award in Aging is designed for early-stage physicians and health professionals committed to aging research. This initiative, supported by the NIH, aims to cultivate leadership skills and advance research in geriatrics. Eligible candidates must demonstrate prior research support and leadership in their field. While applications are not currently being accepted, this NOFO encourages potential applicants to develop collaborative and impactful projects in aging research.
Aging / Gerontology

Critical Needs List

Community Foundation Of Tampa Bay Inc
Private
United States
Up to US $250,000
The Critical Needs List by Community Foundation Tampa Bay addresses urgent, unforeseen needs of nonprofits that threaten their ability to serve the community. This innovative program allows nonprofits to submit requests for funding up to $250,000 for critical expenses such as emergency repairs and essential equipment replacement. With a focus on supporting local organizations, the program aims to match funding with community philanthropists, ensuring timely assistance to those in need.
Animal Welfare - General Art & Culture Basic Human Needs +9 more

Coordinating Center for the Claude D. Pepper Older Americans Independence Centers (OAICs)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute on Aging intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the Coordinating Center (CC) of the Claude D. Pepper Older Americans Independence Centers (OAIC) program. The CC serves as a facilitator for OAIC site interactions and as a conduit for translating OAIC objectives and findings to both scientific and general audiences. The proposed CC must demonstrate an ability to work cooperatively with all OAIC sites and possess sufficient scientific expertise in geriatrics and related areas to serve the national coordination functions of the OAIC program. Applicants should have a demonstrated ability to coordinate multi-site projects.Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U24 activity code. Investigators with expertise and insights into this area of aging research are encouraged to begin to consider applying for this new NOFO.
Aging / Gerontology

Optimizing Maternal RSV Immunization Delivery: A Systems-Based QI Initiative to Improve Uptake, Equity, and Newborn Outcomes Fund

Pfizer, Inc.
Corporate
United States
Up to US $200,000

Quality Improvement Grant Request for Proposals

Optimizing Maternal RSV Immunization Delivery: A Systems-Based Quality Improvement Initiative to Improve Uptake, Equity, and Newborn Outcomes

Pfizer, in collaboration with the Society for Maternal-Fetal Medicine (SMFM), is pleased to announce a competitive grant opportunity to support independent Quality Improvement (QI) initiatives focused on advancing maternal immunization, with a specific emphasis on Respiratory Syncytial Virus (RSV) vaccination during pregnancy.

This initiative builds upon insights generated from the Maternal Immunization Needs Assessment (MINA) project, a multi-stakeholder collaboration that identified persistent clinical, behavioral, and system-level gaps in the delivery and uptake of maternal vaccines.

We seek to fund projects that implement measurable, evidence-based interventions to improve real-world delivery of maternal RSV immunization across healthcare systems and care settings. Proposed initiatives should aim to optimize access, strengthen provider–patient communication training and tools, enhance care coordination, and address structural and behavioral barriers impacting vaccine uptake and equity.

Pfizer Global Medical Grants (GMG) supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies. Pfizer’s GMG competitive grant program involves a publicly posted Request for Proposal (RFP) that provides detail regarding a specific area of interest, sets timelines for review and approval, and uses an expert review panel (ERP) to make final grant decisions. Organizations are invited to submit an application addressing the specific gaps in clinical practice or care as outlined in the specific RFP.

For all QI grants, the applicant (and ultimately the grantee) will be solely responsible for the design, implementation, and conduct of the proposed initiative. Pfizer will have no involvement in project development, execution, or outcomes.

Obstetrics & Neonatal Care Maternal And Perinatal Health Vaccines & Immunizations +2 more

BMS Independent Medical Education Requests

Bristol Myers Squibb Foundation Inc
Private
United States
Unspecified amount
Bristol Myers Squibb Foundation Inc supports independent medical education to enhance healthcare professional competence and improve patient health outcomes. Their mission is to be a global leader in innovative medical education, focusing on evidence-based activities that address critical gaps in knowledge. By fostering excellence in healthcare, they aim to ensure measurable improvements in performance and patient outcomes across various disease areas.
Cancer / Oncology Cardiovascular Diseases & Systems Neurological Diseases & Disorders +7 more

Live Your Dream Awards

Soroptimist International Of The Americas Inc
Private
Argentina, Bolivia +18 more
Up to US $10,000
The Live Your Dream Awards, sponsored by Soroptimist International of the Americas, empower women by providing vital monetary assistance for their education and training. Each year, over $3 million is awarded to more than 2,300 women who are the primary financial support for their families. This initiative supports those overcoming significant challenges like poverty and domestic violence, ensuring they have the resources to achieve their dreams and live fulfilling lives.
Women & Girl Services

L.L.Bean Charitable Donations

L.L. Bean
Corporate
American Samoa, Guam +4 more
Unspecified amount
L.L.Bean Charitable Donations supports outdoor initiatives that bring communities together. The program encourages partnerships with inspiring individuals and organizations. To apply, ensure requests are made at least eight weeks before the event. Please note that the program does not fund individuals, advertising, specific schools, or projects outside the U.S. For more information, visit their website to learn how to get involved.
Outdoor Recreation Outdoor Equity

Union Plus Scholarship

Union Plus Education Foundation
Association/Society
American Samoa, Guam +4 more
US $500 - US $4,000
The Union Plus Scholarship, offered by the Union Plus Education Foundation, supports students from working families pursuing post-secondary education. Since its inception in 1991, over $5.6 million has been awarded to more than 4,000 beneficiaries. Scholarships range between $500 and $4,000 for studies starting in Fall 2025. Applicants must be current or retired union members, their spouses, or dependent children, ensuring access to higher education for diverse families across the U.S. and Canada.
Academic Scholarship Programs

Bear Paw Resort Scholarship

Community Foundation for the Fox Valley Region
Private
American Samoa, Guam +4 more
US $1,000
The Bear Paw Resort Scholarship, offered by the Community Foundation for the Fox Valley Region, supports graduating seniors from White Lake High School who plan to pursue post-secondary education. With over $2 million available for scholarships in 2025, this initiative aims to empower students in their educational journeys. The scholarship is designed to assist with tuition costs, payable after the completion of the first semester, thereby encouraging academic success and community development.
Education - Higher Education

Reducing Fraud and Lowering Barriers to the Production of Drugs in Shortage by Outsourcing Facilities

US Department of Health & Human Services: Food and Drug Administration (FDA)
Federal Government
American Samoa, Guam +4 more
Up to US $3,000,000
This grant aims to address drug shortages by exploring the landscape of products susceptible to health fraud and finding ways for outsourcing facilities to fulfill these needs. By funding research and development, the initiative seeks to enhance the production of critical medications, thereby stabilizing the drug supply chain and protecting public health from fraud-related risks.
Economics Health & Medicine

NIH Director's Transformative Research Award (R01 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIH Director's Transformative Research Award encourages innovative research that challenges conventional ideas. This award supports bold scientists and teams aiming to create groundbreaking technologies and new clinical approaches, ultimately transforming scientific paradigms. As part of the NIH Common Fund's High-Risk, High-Reward Research Program, it seeks to fund high-impact projects that have the potential to significantly advance science and technology.
Science Health & Medicine Emerging Technology Development

The Academy Martial Arts Leadership Scholarship

Community Foundation for the Fox Valley Region
Private
American Samoa, Guam +4 more
US $500

Our Mission

We strengthen our community for current and future generations by helping people make a difference in the lives of all.

We believe in our community’s lasting goodness. In fact, making sure our community is always a special place for us to live is why we’re here.

Scholarships

Through the generosity of our donors, we have more than $2 million in scholarships available in 2025 to students from more than 60 high schools. We offer scholarships to high school seniors, college and nontraditional students, and K-12 art and music camps and lessons.

The Academy Martial Arts Leadership Scholarship

Background

The Academy Martial Arts Leadership has been serving families in the Fox Cities since 1995. As the founders/owners, Jeff & Amanda Denu have been passionate about making our community stronger one Black Belt at a time teaching martial arts, while reinforcing respect, self-discipline, integrity, and excellence. Their passion with community involvement and creating a positive learning environment inspires others to be their personal best, and to make a difference every day.

Education - Higher Education

NIH Director's Pioneer Award (DP1 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $700,000
The NIH Director's Pioneer Award (DP1) encourages innovative research by funding exceptional scientists. This award is designed for groundbreaking projects that diverge from the investigator's current work and address significant scientific challenges relevant to the NIH mission. Applications are invited across all NIH-relevant fields, promoting high-risk, high-reward research that could transform our understanding of critical scientific areas.
Science Health & Medicine Emerging Technology Development

Pathways to Enable Secure Open-Source Ecosystems

National Science Foundation (NSF)
Federal Government
American Samoa, Guam +4 more
US $300,000 - US $1,500,000
The Pathways to Enable Secure Open-Source Ecosystems (PESOSE) program, funded by the National Science Foundation, aims to transform open-source research into sustainable ecosystems that tackle national and societal challenges. This initiative promotes innovation across various sectors, including AI and cybersecurity, by fostering strong governance and broad user engagement. PESOSE invites proposals to establish and enhance open-source ecosystems, ensuring their safety, security, and effectiveness in meeting emergent needs.
Engineering Computer Science & Engineering Emerging Technology Development

NRP Young Investigator Award

American Academy Of Pediatrics
Private
Canada, United States
Up to US $15,000
The NRP Young Investigator Award is designed to support research on optimizing newborn care during delivery using Neonatal Resuscitation Program (NRP) techniques. This grant encourages innovative projects addressing gaps in transitional physiology and resuscitation practices. Eligible applicants include researchers from Canadian and US institutions, particularly those in training or within four years of completing medical training. Awardees may receive up to $15,000 to enhance their skills and knowledge, ultimately improving neonatal outcomes.
Obstetrics & Neonatal Care Medical Education & Professional Training Human Physiology +3 more

Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement Clinical Trial Optional) (361408)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIH is announcing a funding opportunity for competitive revisions of ongoing grants to tackle unforeseen public health crises. This Urgent Competitive Revision program aims to facilitate timely responses to emerging health challenges. Once the Notice of Funding Opportunity is published, eligible applications will be directly routed to the appropriate NIH awarding component. Only submissions in response to an Urgent Guide Notice published by an NIH Institute or Center will be accepted.
Epidemiology & Public Health

Transition to Aging Research for Predoctoral Students

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute on Aging (NIA) is launching a funding opportunity for outstanding graduate students interested in aging research. The Transition to Aging Research Award for Predoctoral Students will support late-stage doctoral students in completing their dissertation projects. This two-phase award aims to ensure a smooth transition into postdoctoral positions focused on aging, promoting the recruitment and retention of new investigators in the field. Applications are currently not being solicited, allowing time for potential applicants to prepare collaborations.
Aging / Gerontology

Opportunities for Collaborative Research at the NIH Clinical Center

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Opportunities for Collaborative Research at the NIH Clinical Center aims to foster high-quality translational research partnerships between NIH intramural and extramural investigators. This program supports projects that bridge basic biological discoveries with clinical applications, ultimately enhancing patient-centric research. By facilitating collaborations, the program seeks to accelerate scientific advancements leading to improved health outcomes through innovative therapeutic interventions and diagnostic strategies.
Biology Health & Medicine

TESOL Teacher of the Year Award

Teachers Of English To Speakers Of Other Languages Inc
Association/Society
Algeria, American Samoa +33 more
US $1,000
The TESOL Teacher of the Year Award, presented by National Geographic Learning, honors exceptional English language teachers who have demonstrated outstanding dedication in the classroom for at least three consecutive years. The winner receives $1,000, a one-year TESOL membership, and free registration for the TESOL International Convention, including travel accommodations. This recognition not only highlights the importance of teaching excellence but also fosters a community of learning and collaboration among educators around the world.
English for Speakers of Other Languages (ESOL) Education

Operating Grants for Nonprofits in Puerto Rico Highlights

Looking for operating grants for nonprofits in Puerto Rico?


Read more about each grant below or start your 14-day free trial to see all operating grants for nonprofits in Puerto Rico recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Operating Grants for Nonprofits in Puerto Rico

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

800+ Operating grants for nonprofits in Puerto Rico grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

500+ Operating grants for nonprofits in Puerto Rico over $25K in average grant size

400+ Operating grants for nonprofits in Puerto Rico over $50K in average grant size

16 Operating grants for nonprofits in Puerto Rico supporting general operating expenses

500+ Operating grants for nonprofits in Puerto Rico supporting programs / projects

1,000+ Grants on Instrumentl focused on Workforce Preparation & Job Readiness

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Operating grants for Nonprofits in Puerto Rico?

Most grants are due in the first quarter.

Q1
31.5%
Q2
23.7%
Q3
19.8%
Q4
25.0%

Typical Funding Amounts

What's the typical grant amount funded for Operating Grants for Nonprofits in Puerto Rico?

Grants are most commonly $318,750.

$375 $375 Min.
$318,750 $318.8 K Median
$1,385,019 $1.4 M Average
$80,000,000 $80 M Max.

Average Grant Size

What's the typical amount funded for Puerto Rico?

Grants are most commonly $104,638.

$104,638

Total Number of Grants

What's the total number of grants in Operating Grants for Nonprofits in Puerto Rico year over year?

In 2024, funders in Puerto Rico awarded a total of 1,758 grants.

2022 1,942

2023 1,805

2024 1,758

Top Grant Focus Areas

Among all the Operating Grants for Nonprofits in Puerto Rico given out in Puerto Rico, the most popular focus areas that receive funding are Education, Human Services, and Human Service Organizations.

1. Education

2. Human Services

3. Human Service Organizations

Funding Over Time

How is funding for Operating Grants for Nonprofits in Puerto Rico changing over time?

Funding has increased by 15.38%.

2022 $135,836,997

2023 $159,254,276
17.24%

2024 $183,744,801
15.38%

Puerto Rico Counties That Receive the Most Funding

How does grant funding vary by county?

San Juan County, Dorado County, and Loiza County receive the most funding.

County Total Grant Funding in 2024
San Juan County $85,833,046
Dorado County $27,296,199
Loiza County $11,736,039
Bayamon County $11,338,985
Vega Alta County $9,404,211