Best Operating Grants for Nonprofits in Puerto Rico

The FY 2027 Service Area Competition (SAC) funding aims to enhance health services in underserved communities across the U.S. by providing grants for comprehensive preventive and primary health care. The initiative supports health centers in delivering essential services, ensuring that vulnerable populations receive the care they need. Service areas for competition are announced periodically, and additional areas may be added if existing centers are unable to continue their services.

The FY 2027 Service Area Competition (SAC) aims to enhance health services in underserved communities across the U.S. by providing grants for comprehensive primary and preventive care. This initiative will support health centers in delivering high-quality services, addressing the needs of populations that face barriers to care. Each funding opportunity will specify service areas available for competition, ensuring effective resource allocation to improve community health outcomes.

The FY 2027 Service Area Competition (SAC) aims to enhance health services in underserved communities across the U.S. and its territories. This funding opportunity supports comprehensive preventive and primary health care delivery. Each SAC announcement details service areas available for competition, with potential additional areas announced throughout the year. This initiative is crucial for ensuring continuous access to quality health care for vulnerable populations.

The National Fund for Sacred Places Grant Program supports historic houses of worship in the U.S. through matching grants ranging from $50,000 to $250,000. This initiative, in collaboration with the National Trust for Historic Preservation, aims to enhance community engagement and preserve culturally significant buildings. Applicants are encouraged to demonstrate their historical relevance and community service, particularly those representing underrepresented groups. The program prioritizes urgent repair needs and projects that foster inclusivity and accessibility.

The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to enhance our understanding of somatic mutations and their impact on human biology and disease. This initiative will establish a Tissue Procurement Center (TPC) to collect and provide clinically relevant tissue samples from a diverse set of healthy donors. The TPC will support ongoing research by ensuring high-quality, well-characterized specimens are available for functional analyses, advancing the field of somatic mosaicism.

The FY 2027 Service Area Competition (SAC) funding aims to enhance healthcare access in underserved communities across the U.S. by providing grants for comprehensive primary and preventive health services. This initiative addresses essential health needs through competitive funding opportunities, ensuring that health centers can effectively serve their designated areas. Additional service areas may be announced as needed if current centers are unable to continue their operations, thus maintaining service continuity.

The Leadership Education in Adolescent Health (LEAH) Program, funded by the US HHS: Health Resources & Services Administration, aims to enhance the quality of care for adolescents and young adults. By establishing graduate training programs, LEAH prepares healthcare professionals to effectively address chronic disease prevention and improve access to team-based healthcare services for this population, ultimately fostering better health outcomes and empowering future leaders in adolescent health.

The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to uncover biological processes and disease mechanisms influenced by somatic mutations. Since its inception in 2023, it has produced valuable multi-omic datasets from diverse human tissues. The upcoming Stage 2 Genome Characterization Centers will focus on understanding the impact of these mutations in both healthy and clinically significant samples, enhancing our knowledge of somatic mosaicism's role in human health and disease.

The NIAID Physician-Scientist Pathway to Independence Award (K99/R00) aims to support new independent physician-scientists by facilitating their transition from postdoctoral research to tenure-track faculty positions. This program provides essential research funding to help awardees establish their careers in biomedical research, addressing the national shortage of physician-scientists. Applicants must propose research that does not lead an independent clinical trial, but may include mentorship in clinical trials.

The Medical Scientist Training Program (MSTP) aims to cultivate a diverse group of physician-scientist leaders to address the nation's biomedical research needs. This program supports institutions in creating integrated dual-degree training that results in both medical and research doctorate degrees. By combining clinical practice with scientific research, MSTP graduates will advance health-related research, focusing on improving training effectiveness, alumni retention in research careers, and workforce diversity. NIGMS emphasizes comprehensive training elements for impactful careers.

The HEAL Initiative aims to enhance therapeutic medical devices through team science research, focusing on the mechanisms that drive their effectiveness. The National Institute of Neurological Disorders and Stroke (NINDS) seeks to improve clinical outcomes by fostering interdisciplinary collaborations. This initiative invites teams with expertise in engineering, biology, and clinical care to explore innovative device-based therapies. By understanding how these devices work, the program hopes to optimize existing technologies and inspire new designs, ultimately improving patient care.

The American Bar Endowment's Opportunity Grant Program provides funding for innovative, boots-on-the-ground initiatives that address urgent legal needs of the public. This grant focuses on increasing access to justice for underserved populations, improving the justice system, and enhancing public understanding of legal rights. Eligible applicants include public charities and organizations directly impacting local communities, with a strong emphasis on projects that leverage technology and address immediate legal challenges.

The National Science Foundation (NSF) is funding initiatives to enhance the value of scientific datasets through innovative artificial intelligence (AI) methods. This program aims to facilitate interdisciplinary research and unlock new insights by applying AI for feature extraction, metadata generation, and dataset integration. Proposals should ensure data security and promote collaboration with various sectors to advance AI-driven scientific discovery. By aligning with NSF priorities, researchers can contribute to cutting-edge science and technology for broader participation in STEM.

The National Biomedical Research Centers (NBRCs) aim to enhance biomedical research by providing advanced equipment, scientific expertise, and innovative human-based models. Supported by NIH and other federal agencies, this initiative focuses on reducing reliance on live animal models through the development of New Approach Methodologies (NAMs). The program invites applications that propose actionable plans to refine and replace animal use, promoting innovative research at centers with existing nonhuman primate colonies.

The Collaborative Program Grant for Multidisciplinary Teams, funded by the US Dept. of Health & Human Services: National Institutes of Health (NIH), supports integrated teams of researchers tackling ambitious projects that individual efforts cannot achieve. This program promotes collaboration among experts with complementary skills, aiming for significant advancements in their fields. Teams are encouraged to pursue innovative objectives that have the potential to transform research landscapes.

Bureau of Justice Assistance

The Bureau of Justice Assistance (BJA) was created in 1984 to reduce violent crime, create safer communities, and reform our Nation’s criminal justice system.

BJA strengthens the Nation’s criminal justice system and helps America’s state, local, and tribal jurisdictions reduce and prevent crime, reduce recidivism, and promote a fair and safe criminal justice system. BJA focuses its programmatic and policy efforts on providing a wide range of resources, including training and technical assistance, to law enforcement, courts, corrections, treatment, reentry, justice information sharing, and community-based partners to address chronic and emerging criminal justice challenges nationwide. 

Special Attorneys Program

This program will support state, local, Tribal, and territorial prosecuting agencies in assigning or hiring qualified prosecutors to serve full time as Special Attorneys within the National Fraud Enforcement Division or the Criminal Division or as Special Assistant United States Attorneys (SAUSAs) within a United States Attorney’s Office. These cross-designated prosecutors will investigate and prosecute fraud and other crimes committed by aliens within the United States (hereafter referred to as “criminal aliens”) and will investigate and prosecute crimes involving drug or human trafficking committed within the United States.

This grant program, authorized under Public Law 119-21, Title X, Subtitle A, Part II, Section 100055 (codified at 34 U.S.C. § 61101), is intended to strengthen investigative and prosecutorial capacity, expand intergovernmental coordination, and enhance the ability of jurisdictions to investigate and prosecute fraud and other crimes committed by aliens within the United States and drug and human trafficking crimes. The program is also intended to increase the availability of cross-designated prosecutorial personnel who can pursue these matters in coordination with federal authorities and contribute to the effective enforcement of applicable criminal laws.

The Engineering Biological and Biomedical Systems (EBBS) program, funded by the National Science Foundation (NSF), aims to advance our understanding of biological systems and improve human health through innovative engineering solutions. It supports research that combines mechanistic insights with experimental techniques to develop novel biomedical technologies, enhance biomanufacturing processes, and explore therapeutic applications. Projects focusing on engineering principles for biological responses and rehabilitation are encouraged, while drug design and clinical trials are outside the program's scope.

The HDR Foundation Grant Cycle supports community organizations aligned with HDR's values, focusing on education, healthy communities, and environmental stewardship. This employee-funded initiative emphasizes the importance of employee engagement in grant proposals, requiring a clear scope of work and completion within a year. Eligible applicants include U.S.-based nonprofits, educational institutions, and tribal governments, while grants are not provided for faith-based organizations or individual support.

The Centers of Biomedical Research Excellence: Development Phase (COBRE-D) program aims to enhance biomedical research capacity in IDeA states, which historically receive low NIH funding. By providing critical support for early-career investigators and essential infrastructure, COBRE-D facilitates a long-term vision for institutions. This initiative not only supplements start-up packages for new hires but also establishes research facilities and improves administrative services, paving the way for less-resourced institutions to transition into the COBRE E/S program.

The Maximizing Investigators’ Research Award (MIRA) for Early Stage Investigators (ESI) by NIGMS aims to enhance research productivity and flexibility for early career scientists. This program consolidates funding into a single award, allowing investigators to pursue ambitious projects while reducing administrative burdens. By supporting diverse research initiatives, MIRA helps cultivate a new generation of innovative researchers, ensuring essential breakthroughs in fundamental science.

The JetBlue Foundation is dedicated to enhancing aviation-related education and STEM initiatives, aiming to inspire future aviation leaders. Offering grants up to $50,000, it supports educational organizations that focus on aviation technology, engineering, operations, and maintenance. The foundation prioritizes programs benefiting under-represented communities in aviation, including veterans, women, and diverse groups, ensuring a broader range of voices in the industry.

The National Science Foundation (NSF) Directorate for Engineering (ENG) fosters groundbreaking research in electrical, communications, and computing systems through programs like Electronic, Photonic, Magnetic, and Quantum Devices (EPMQD) and Circuits and Systems for Communications and Sensing (CSCS). These initiatives emphasize innovative foundational research, particularly in power and energy systems, while being open to transformative ideas without immediate commercial outcomes. Funding availability will shape the portfolios of ECCS awards.

The NSF Expeditions in Computing program aims to foster transformative research in computer and information science. By funding projects up to $15 million over seven years, it encourages multidisciplinary teams to tackle ambitious research agendas that redefine the future of computing. The program supports innovative areas such as new architectures for intelligence, advanced robotics, and next-generation communication, emphasizing the importance of collaboration across various fields to achieve groundbreaking advancements.

The Amgen Foundation, established in 1990, focuses on enhancing science education and strengthening communities. It supports nonprofit organizations that align with its mission, emphasizing teacher development and hands-on science experiences. Grants are awarded annually, with a commitment of $180 million to impactful programs. Eligible organizations include public schools and libraries, while ineligible requests involve individual support, religious organizations, and political activities. This approach aims to inspire the next generation of innovators through quality educational opportunities.

The Organizational Change in the Professional Formation of Engineers (ENGINEER:OC) initiative promotes innovative research and activities aimed at transforming engineering education and workforce development. Supported by the National Science Foundation (NSF), it seeks to enhance access to quality engineering programs across diverse institutions. Projects may involve implementing new curricular innovations or adapting existing models to different contexts, ultimately advancing the professional formation of engineers and fostering inclusive educational pathways.

The Medical Scientist Training Program (MSTP) aims to cultivate skilled clinician-scientist leaders to meet the nation's biomedical research demands. It supports domestic organizations in developing dual-degree training that integrates clinical and research education, leading to both a clinical degree (e.g., M.D., D.O.) and a Ph.D. Through comprehensive mentoring and career development, MSTP prepares trainees for impactful careers in health-related research, ensuring a robust pipeline of qualified scientists.

The R21 Clinical Trial Not Allowed funding opportunity invites innovative research to develop and enhance research models and biological materials vital for studying human health and diseases. It emphasizes the need for new approach methodologies (NAMs) to improve the identification of confounding factors in biomedical research. Projects should have broad applicability across multiple NIH Institutes, focusing on various body systems and disease categories, ensuring relevance to a wide range of health issues.