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Best Operating Grants for Nonprofits in Puerto Rico

Find the perfect Operating grants for nonprofits in Puerto Rico on Instrumentl. 9,000+ Operating grants for nonprofits in Puerto Rico in the United States.

9,000+

Available grants

$2.55B

Total funding

$5K

Median grant

9,000+ grants
$2.55B total
$5K median

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8,931 Results based on applied filters

TESOL Award for Excellence in Research

Teachers Of English To Speakers Of Other Languages Inc
Association/Society
Algeria, American Samoa +33 more
US $3,000
The TESOL Award for Excellence in Research honors outstanding empirical research in language teaching and learning, promoting advancements in English language education. Sponsored by Dr. Deborah Short, this award includes a $1,500 grant, an additional $1,500 for conference expenses, a featured session at the TESOL convention, keynote speaking opportunity at the Graduate Student Forum, a one-year subscription to TESOL Quarterly, and a featured article in TESOL Connections.
English for Speakers of Other Languages (ESOL) Education

The Ron Chang Lee for Excellence in Classroom Technology

Teachers Of English To Speakers Of Other Languages Inc
Association/Society
Algeria, American Samoa +33 more
US $1,000
The Ron Chang Lee for Excellence in Classroom Technology award recognizes three TESOL members for their innovative use of technology in English Language Teaching. Established in 2018, the award offers prizes of $1000 for first place, $750 for second, and $500 for third. Eligible candidates must be TESOL members with at least two years of classroom experience and have designed the materials used for this award. Applications from certain countries may be ineligible due to international regulations.
English for Speakers of Other Languages (ESOL) Education

Mckesson Foundation Grant: below $25,000

McKesson Foundation
Private
Canada, United States
Up to US $25,000
The McKesson Foundation Grant provides funding up to $25,000 for organizations focused on improving health outcomes in underserved communities. Established in 1943, the foundation prioritizes health equity through strategic partnerships aimed at reducing cancer burdens, preparing healthcare professionals, and enhancing crisis response efforts. Eligible applicants include national and local nonprofits targeting specific regions in the U.S. and Canada. The foundation emphasizes projects that align with its mission and demonstrate significant community impact.
Food Access & Hunger Cancer / Oncology Disaster Relief / Humanitarian Aid +8 more

NIDCR Small Grant Program for New Investigators (R03 Clinical Trial Not Allowed) (357201)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $200,000
The NIDCR Small Grant Program for New Investigators (R03) supports early-stage scientists in dental and craniofacial research. It funds pilot studies and developmental projects aimed at generating preliminary data for future Research Project Grant (R01) applications. Key deadlines for applications include February 16, June 16, and October 16 from 2025 to 2027, addressing the need for timely submissions in this competitive funding landscape.
Dental Health

Innovative Approaches to Extend Lifetime and Minimize O&M for Nature-based Installations RFP

Water Research Foundation
Private
Countries
Up to US $250,000

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5416 - Innovative Approaches to Extend Lifetime and Minimize O&M for Nature-based Installations

Grant Information

  • Identify and evaluate innovative design, construction, and management approaches that extend the functional lifetime of nature-based installations and reduce ongoing operations and maintenance (O&M) requirements.
  • Develop practical guidance on key factors affecting nature-based solution (NbS) longevity, including hydraulic optimization, engineered media selection and replacement, plant selection, sediment management, and construction-phase best practices.
  • Survey utilities and other NbS owners to document current maintenance practices, costs, and hours, and establish benchmarks to inform targets for improvement.
Hydrology Climate Change Resilience & Equity Green Infrastructure +1 more

Adaptive Control Frameworks to Unlock Full-Scale BNR Potential RFP

Water Research Foundation
Private
Countries
Up to US $300,000

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5424 - Adaptive Control Frameworks to Unlock Full-Scale BNR Potential

Grant Information

  • Identify and categorize the dominant failure modes of current aeration and process control implementations under real-world operating conditions.
  • Develop guidance on data and instrumentation requirements for utilities to support adaptive control, including the characterization of existing sensor infrastructure and the use of soft sensors where hard sensors are limited.
  • Develop practical adaptive control frameworks and implementation guidance that utilities can deploy without dependence on proprietary black-box tools or specialized data science expertise, including hybrid approaches that augment conventional controls with data-driven models (e.g., artificial intelligence (AI)/machine learning (ML), digital twins) for variable flow and concentration conditions.
  • Benchmark control performance against biological capacity indicators across multiple full-scale facilities to quantify the gap between achievable and realized biological nutrient removal (BNR) performance.
Water Resource Management Carbon / Greenhouse Gas Reduction Hydrology

Occupational Safety and Health Research (R01) (363289)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
Up to US $680,000
The Occupational Safety and Health Research (R01) grant aims to enhance understanding of workplace hazards, develop strategies to mitigate risks, and translate research into effective prevention measures. This initiative encourages applicants to address specific occupational health challenges and articulate the anticipated outcomes of their research, contributing to the reduction of work-related illnesses and injuries. By fostering innovative solutions, this grant supports the mission of NIOSH and promotes safer working environments.
Occupational Health & Safety

Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program (UC2- Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,500,000
The Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program, funded by the NIH, aims to enhance the biomedical research landscape by supporting resource-limited organizations. It targets domestic institutions with limited research resources and few doctoral students in biomedical fields, promoting broader participation in research and boosting administrative capacities for sponsored programs. Applications are due by 5:00 PM local time of the applicant organization, ensuring timely submissions.
Biology Health & Medicine

NIOSH Support for Conferences and Scientific Meetings (U13 Clinical Trial Not Allowed) (363291)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
Up to US $30,000
The NIOSH Support for Conferences and Scientific Meetings (U13) program aims to fund high-quality scientific gatherings that advance research in occupational safety and health. By promoting collaboration among experts, this program supports workshops and conferences aligned with NIOSH mission priorities. Federal involvement is significant, ensuring guidance and coordination throughout the award process. Applications for training-only events are not eligible, emphasizing the focus on comprehensive scientific discourse.
Occupational Health & Safety

NIOSH Support for Conferences and Scientific Meetings (R13 Clinical Trial Not Allowed) (363290)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
Up to US $20,000
The NIOSH Support for Conferences and Scientific Meetings (R13) program aims to fund high-quality scientific gatherings that enhance occupational safety and health research. It supports meetings that align with NIOSH's mission and priorities, encouraging the exchange of information on relevant topics. Applications should focus on advancing research in these areas, fostering collaboration among professionals. Note that training-only events are not eligible for funding under this program.
Occupational Health & Safety

BJA FY 2026 Daniel Anderl Judicial Security and Privacy Program

Bureau of Justice Assistance
Federal Government
American Samoa, Guam +4 more
US $200,000 - US $500,000
The BJA FY 2026 Daniel Anderl Judicial Security and Privacy Program aims to enhance the safety of federal judges and their families by preventing the disclosure of sensitive information. This funding opportunity supports state and local governments, including tribal entities, in implementing protective measures. The program emphasizes collaboration between federal, state, and local agencies to ensure justice is administered without fear of personal reprisal. Grants can only be used for the designated purpose of safeguarding federal judges as outlined in the statute.
Crime & Justice

NIOSH Small Research Grant Program (R03)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
Up to US $100,000
The NIOSH Small Research Grant Program (R03) aims to enhance the understanding of occupational disease risks and develop strategies for risk reduction. This grant supports research projects that require limited resources, including pilot studies and data analysis, to effectively translate scientific findings into practice. Applicants are urged to articulate the health burdens addressed and the anticipated impacts of their research on workplace safety and health, thereby contributing to the reduction of work-related illnesses and injuries.
Occupational Health & Safety

Silcon Carbide Cladding Lead Test Rod Development-Phase 1

United States Department of Energy (DOE)
Federal Government
American Samoa, Guam +4 more
Up to US $50,000,000
The Silicon Carbide Cladding Lead Test Rod Development-Phase 1 project aims to advance the use of silicon carbide cladding for nuclear fuel rods. It focuses on the research, development, and fabrication of cladding specimens for reactors, with testing planned for both unirradiated and irradiated samples. The project is poised to provide critical performance data for future commercial lead test rods, enhancing safety and efficiency in light water reactors.
Engineering Materials Science and Engineering Emerging Technology Development +1 more

NIOSH Exploratory/Developmental Grant Program (R21) (363327)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
Up to US $300,000
The NIOSH Exploratory/Developmental Grant Program (R21) aims to enhance understanding of occupational diseases and injuries. It focuses on identifying risks, developing prevention strategies, and translating scientific discoveries into effective measures. Applicants are encouraged to describe the health burdens addressed, outline research activities, and demonstrate potential impacts on occupational safety. This initiative supports innovative concepts, model systems, and technologies that can significantly improve workplace health outcomes.
Occupational Health & Safety

Continuation or Revision of NIDCR Clinical Trial Planning and Implementation Cooperative Agreement (UH3 Clinical Trial Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIDCR is inviting applications for the continuation or revision of ongoing clinical trials through the UH3 Clinical Trial Required grant. This opportunity supports extensions for completing trials or longer follow-up periods, as well as revisions that are well justified. Key deadlines for submissions are set from March 2025 to January 2028, with optional Letters of Intent encouraged thirty days prior to application due dates. Ensure compliance with the outlined requirements to enhance your chances of funding.
Dental Health

NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) (356617)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) grant aims to facilitate high-quality conferences that align with public health and scientific missions. Key deadlines include December 12, 2024, April 12, 2025, and August 12, 2025, among others, specifically for AIDS-related applications. This funding opportunity is provided by the US Department of Health & Human Services: National Institutes of Health (NIH).
Epidemiology & Public Health

Infant-Toddler Court Program–State Awards

US HHS: Health Resources & Services Administration (HRSA)
Federal Government
American Samoa, Guam +4 more
Up to US $700,000
The Infant-Toddler Court Program State Awards empower states and communities to enhance child welfare practices by integrating courts, social services, and families. This initiative promotes safety, healthy development, and nurturing relationships for young children involved in child welfare. Awardees implement the evidence-based ITC approach, sharing lessons learned with local teams, tracking outcomes, and training to ensure effective program expansion across targeted communities.
Child Welfare Services

Gilead Medical Education Grants - Independent Medical Education Funding

Gilead Sciences Foundation
Private
American Samoa, Guam +4 more
Unspecified amount
Gilead Medical Education Grants fund innovative, data-driven programs that enhance healthcare infrastructure and support vulnerable communities globally. Focused on core therapeutic areas like HIV, liver diseases, and oncology, these grants aim to deliver impactful continuing medical education for healthcare providers. Eligible applicants include for-profit medical education companies and nonprofit organizations. Gilead prioritizes programs that demonstrate a strong capacity to achieve specific educational outcomes, ensuring that support reaches those who need it most.
Medical Education & Professional Training

Occupational Safety and Health Education and Research Centers (T42) (355417)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
US $4,500,000 - US $9,000,000
The Occupational Safety and Health Education and Research Centers (T42) program, funded by the CDC, focuses on enhancing occupational safety through targeted education and training. By fostering interdisciplinary research and collaboration among academic institutions, this initiative aims to equip professionals with the necessary skills to address workplace health challenges. The program seeks to diversify the workforce and improve worker safety and well-being through outreach and continued education efforts.
Occupational Health & Safety

World Trade Center Youth Research Coordinating Center (U54)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
Up to US $10,000,000
The World Trade Center Youth Research Coordinating Center aims to establish a research cohort to study the health impacts on youth exposed to the 9/11 events. This initiative, backed by the NIOSH, will focus on individuals aged 21 or younger at the time of exposure, including those in utero. The Center will integrate diverse expertise to assess long-term health and educational effects while enhancing community engagement and stakeholder communication throughout its activities.
Occupational Health & Safety

State Occupational Safety and Health Surveillance Program (U60) (363431)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
US $150,000 - US $685,000
The State Occupational Safety and Health Surveillance Program (U60) aims to enhance state-level occupational safety and health (OSH) surveillance capacity. Funded by NIOSH, this initiative supports various state programs, fostering partnerships among health departments and universities. By utilizing diverse data sources, these programs assess workplace health impacts and develop tailored interventions, ultimately ensuring better health and safety for workers across the U.S. This collaborative approach addresses critical gaps left by regulatory programs.
Occupational Health & Safety

Innovative Traffic Safety Enforcement (ITSE) Grant Program

US Department of Transportation: National Highway Traffic Safety Administration (NHTSA)
Federal Government
American Samoa, Guam +4 more
US $300,000 - US $20,000,000
The Innovative Traffic Safety Enforcement (ITSE) Grant Program aims to develop effective traffic safety enforcement initiatives to reduce motor vehicle crashes caused by risky driving behaviors. It encompasses three evaluation phases, with deadlines from September 2026 to September 2027. This program seeks to fund scalable and repeatable projects that align with the Department of Transportation's mission and executive priorities, enhancing safety across the United States.
Automotive Safety

U.S. National Science Foundation State and Regional Artificial Intelligence Infrastructure Hubs:

National Science Foundation (NSF)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NSF State and Regional AI Infrastructure Hubs program seeks to enhance access to computational resources essential for AI-driven scientific exploration. By forming flexible consortia among government, academia, and industry, these hubs aim to foster innovation and workforce development in AI. The initiative aligns with national R&D priorities, emphasizing the critical role of AI in advancing scientific discovery and expanding infrastructure to support this mission across various disciplines.
Artificial Intelligence (AI)

National Foundation for the Centers for Disease Control and Prevention (363484)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
US $500,000 - US $1,250,000
The National Foundation for the Centers for Disease Control and Prevention offers funding to support administrative expenses that bolster CDC's mission. This initiative enhances partnerships to address health threats both domestically and globally. Projects funded through this grant align with CDC's strategic goals, focusing on measurable outcomes such as program support and participation from various CDC Centers and Offices. Importantly, this grant only supports non-research activities.
Epidemiology & Public Health

Infant-Toddler Court Program–National Resource Center

US HHS: Health Resources & Services Administration (HRSA)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Infant-Toddler Court Program's National Resource Center (NRC) focuses on enhancing child welfare practices across the United States. By collaborating with courts, social services, and families, the NRC aims to improve the safety and healthy development of young children involved with the child welfare system. This initiative not only supports families but also fosters nurturing relationships essential for child growth and well-being, making it a crucial resource for communities.
Child Welfare Services

DoW Orthopaedic, Applied Research Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
Up to US $950,000
The DoW Orthopaedic Applied Research Award supports innovative research aimed at improving treatment and functionality for individuals with combat-related orthopaedic injuries. Applicants are required to present preliminary data and focus on applied research that evaluates new solutions, including pharmacologic agents and rehabilitation techniques. This initiative emphasizes the importance of military relevance, aiming to benefit Service Members, their families, and Veterans, while clinical research proposals are not permitted.
Orthopedics

Limited Competition: Biomedical Research Environment & Sponsored Programs Administration Development (BRE-SPAD) Program

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Limited Competition: Biomedical Research Environment & Sponsored Programs Administration Development (BRE-SPAD) Program aims to enhance the research capacity of resource-limited institutions. By focusing on essential areas like biomedical research environment and sponsored programs administration, this initiative seeks to foster rigorous and reproducible biomedical research. Eligible organizations are encouraged to submit proposals addressing their specific needs, thereby expanding the pool of qualified researchers and strengthening the settings for NIH-funded research.
Biology Health & Medicine

Operating Grants for Nonprofits in Puerto Rico Highlights

Looking for operating grants for nonprofits in Puerto Rico?


Read more about each grant below or start your 14-day free trial to see all operating grants for nonprofits in Puerto Rico recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Operating Grants for Nonprofits in Puerto Rico

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

800+ Operating grants for nonprofits in Puerto Rico grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

500+ Operating grants for nonprofits in Puerto Rico over $25K in average grant size

400+ Operating grants for nonprofits in Puerto Rico over $50K in average grant size

16 Operating grants for nonprofits in Puerto Rico supporting general operating expenses

500+ Operating grants for nonprofits in Puerto Rico supporting programs / projects

1,000+ Grants on Instrumentl focused on Workforce Preparation & Job Readiness

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Operating grants for Nonprofits in Puerto Rico?

Most grants are due in the first quarter.

Q1
31.5%
Q2
23.7%
Q3
19.8%
Q4
25.0%

Typical Funding Amounts

What's the typical grant amount funded for Operating Grants for Nonprofits in Puerto Rico?

Grants are most commonly $318,750.

$375 $375 Min.
$318,750 $318.8 K Median
$1,385,019 $1.4 M Average
$80,000,000 $80 M Max.

Average Grant Size

What's the typical amount funded for Puerto Rico?

Grants are most commonly $104,638.

$104,638

Total Number of Grants

What's the total number of grants in Operating Grants for Nonprofits in Puerto Rico year over year?

In 2024, funders in Puerto Rico awarded a total of 1,758 grants.

2022 1,942

2023 1,805

2024 1,758

Top Grant Focus Areas

Among all the Operating Grants for Nonprofits in Puerto Rico given out in Puerto Rico, the most popular focus areas that receive funding are Education, Human Services, and Human Service Organizations.

1. Education

2. Human Services

3. Human Service Organizations

Funding Over Time

How is funding for Operating Grants for Nonprofits in Puerto Rico changing over time?

Funding has increased by 15.38%.

2022 $135,836,997

2023 $159,254,276
17.24%

2024 $183,744,801
15.38%

Puerto Rico Counties That Receive the Most Funding

How does grant funding vary by county?

San Juan County, Dorado County, and Loiza County receive the most funding.

County Total Grant Funding in 2024
San Juan County $85,833,046
Dorado County $27,296,199
Loiza County $11,736,039
Bayamon County $11,338,985
Vega Alta County $9,404,211