Best Operating Grants for Nonprofits in Puerto Rico

The Feasibility Clinical Trials of Mind and Body Interventions grant aims to support trials that investigate complementary health approaches for high-priority conditions identified by NCCIH. This funding opportunity focuses on generating vital data necessary for planning future clinical efficacy studies. Applicants must demonstrate the feasibility and acceptability of interventions, ensure proper recruitment and retention strategies, and refine protocols to significantly impact public health. A Plan for Enhancing Diverse Perspectives is also required.

The AARP Community Challenge Grant supports innovative projects that enhance community livability for people aged 50 and older. Funded by the AARP Foundation, these demonstration grants range from $10,000 to $25,000 and aim to improve pedestrian safety, expand broadband access, and reconnect divided communities. Since 2017, AARP has awarded over $20 million in grants, fostering immediate improvements and long-term progress across the United States, including Puerto Rico and the U.S. Virgin Islands.

The AARP Community Challenge Grant: Capacity-Building Microgrant offers $2,500 to support projects that enhance community livability for residents aged 50 and older. Initiated in 2017, it has funded over 1,700 projects nationwide, focusing on immediate improvements and long-term progress. Eligible organizations include nonprofits and government entities, aiming to implement innovative programs in areas like disaster preparedness, walkability, and home modifications. This initiative fosters inclusive communities and empowers older adults.

The F26AS00104 State ANS Management Plan 2026 aims to combat aquatic nuisance species through pre-proposals followed by full applications. Managed by the US Department of the Interior's Fish and Wildlife Service, this initiative requires a 25% cost-share and limits administrative costs to 5%. Applications are due by October 14, 2026, though the funding opportunity closes on December 16, 2026. The plan is crucial for maintaining biodiversity and supporting a coordinated national approach to invasive species management.

PetSmart Charities

We’re proud to celebrate over 30 years of being the leading funder of animal welfare in communities across North America. Since 1994, we’ve granted over $600 million to change-making organizations that help transform the lives of pets and those who love them.

Our Mission: We make the world a better place for pets by investing in community partners that advocate and care for the well-being of pets and all who love them.

Adoption Growth Grants 

Purpose

Adoption Growth grants drive lifesaving outcomes by supporting successful, sustainable in-store adoption programs, events, and results in partnership with PetSmart stores.

Funding Support

Funding may be used for costs associated with building or enhancing your organization’s adoption program in partnership with PetSmart stores, including:

• Staff positions supporting in-store adoption programs and events.
• Marketing and advertising for in-store adoption programs.
• Volunteer or foster support, incentives, and recruitment related to in-store adoption events.
• Event supplies, including containment and enrichment materials.
• Shelter software and technology needs.
• Vehicle repairs or transportation to adoption events.
• Innovative in-store adoption ideas and pilot programs.
• Other costs directly associated with facilitating PetSmart adoptions and in-store events.

There are two Cohorts under this funding: Cohort 1-  Accelerating in-store adoptions; and Cohort 2: Capacity Building.

Cohort 2: Capacity Building

Applicants must have completed at least one adoption in a PetSmart store within the last 12 months.

Preference will be given to organizations seeking to build a consistent, sustainable in-store adoption program. Applications should include a clear plan, with examples, for sustaining the program over time.

Four Required Steps

Applicants must complete all four required steps below before submitting a grant application:

• Step 1 - Watch the kick-off video and complete the Adoption Accessibility Questionnaire
• Step 2 - Confirm eligibility and connect with your Adoptions Grant Manager: After completing the questionnaire, you will receive an email confirming your eligibility. Eligible partners will be invited to a call with their Adoptions Grant Manager to discuss the grant opportunity, expectations, and potential fit.
• Step 3 - Engage your PetSmart store partners: Discuss your intent to apply, align on goals, and gain their commitment to support the success of your in-store adoption program.
• Step 4-  Submit your application.

PetSmart Charities

We’re proud to celebrate over 30 years of being the leading funder of animal welfare in communities across North America. Since 1994, we’ve granted over $600 million to change-making organizations that help transform the lives of pets and those who love them.

Our Mission: We make the world a better place for pets by investing in community partners that advocate and care for the well-being of pets and all who love them.

Adoption Growth Grants 

Purpose

Adoption Growth grants drive lifesaving outcomes by supporting successful, sustainable in-store adoption programs, events, and results in partnership with PetSmart stores.

Funding Support

Funding may be used for costs associated with building or enhancing your organization’s adoption program in partnership with PetSmart stores, including:

• Staff positions supporting in-store adoption programs and events.
• Marketing and advertising for in-store adoption programs.
• Volunteer or foster support, incentives, and recruitment related to in-store adoption events.
• Event supplies, including containment and enrichment materials.
• Shelter software and technology needs.
• Vehicle repairs or transportation to adoption events.
• Innovative in-store adoption ideas and pilot programs.
• Other costs directly associated with facilitating PetSmart adoptions and in-store events.

There are two Cohorts under this funding: Cohort 1-  Accelerating in-store adoptions; and Cohort 2: Capacity Building.

Cohort 1- Accelerating in-store Adoptions

Applicants must have completed 500 or more adoptions in a PetSmart store in the U.S. within the last 12 months.

Preference will be given to organizations that demonstrate a clear plan to expand an existing in-store adoption program or introduce new in-store adoption models that will increase adoptions.

Four Required Steps

Applicants must complete all four required steps below before submitting a grant application:

• Step 1 - Watch the kick-off video and complete the Adoption Accessibility Questionnaire
• Step 2 - Confirm eligibility and connect with your Adoptions Grant Manager: After completing the questionnaire, you will receive an email confirming your eligibility. Eligible partners will be invited to a call with their Adoptions Grant Manager to discuss the grant opportunity, expectations, and potential fit.
• Step 3 - Engage your PetSmart store partners: Discuss your intent to apply, align on goals, and gain their commitment to support the success of your in-store adoption program.
• Step 4-  Submit your application.

The Microplastics Research and Resource Coordination Center aims to foster collaboration among researchers in biomedical and material sciences to understand the health impacts of micro/nanoplastics (M/NPs). This initiative will enhance research reliability by standardizing sampling, analytical practices, and data harmonization. The center will lead efforts in best practices and provide essential guidance to the M/NPs research community, ultimately advancing knowledge and methodologies in this critical area of study.

The Preschool Development Grant Birth Through Five (PDG B-5) SMART Grant aims to enhance early care and education systems in the U.S. by supporting targeted investments in technology and data analytics. This initiative, led by the Administration for Children and Families, encourages states to improve program quality, family choice, and data-driven decision-making for children from birth to five years old. The funding is designed to create measurable outcomes and strengthen coordination within the mixed-delivery system.

The NCAA Division II Degree Completion Award provides financial assistance to student-athletes who have exhausted their athletics eligibility, enabling them to complete their first undergraduate degree. Since its inception in 2001, nearly $9 million has supported approximately 1,875 athletes, with a remarkable 90 percent graduation rate among recipients. The award covers tuition costs up to $15,000 for remaining credits and may be used in the summer term or short terms surrounding the final undergraduate year.

The World Trade Center Health Program K01 Award supports early-career researchers dedicated to enhancing the health of those impacted by the September 11 attacks. This award grants up to three years of mentored research and career development, focusing on the physical and mental health effects of 9/11 exposures. It encourages studies that translate scientific findings into improved clinical care and public health practices, ultimately addressing emerging health concerns and improving long-term outcomes for affected populations.

This initiative aims to enhance clinical and public health outcomes through innovative digital health interventions. It supports research on the development and effectiveness of tools designed for underserved settings, leveraging new technologies and analytics. By fostering collaborations between U.S. and low- and middle-income country researchers, the program emphasizes reciprocal innovation to tackle common health challenges, ultimately maximizing benefits for diverse populations.

The International Research Scientist Development Award (IRSDA) supports U.S. postdoctoral researchers and junior faculty to engage in mentored research and career development in low- and middle-income countries (LMICs). This initiative promotes collaboration with local researchers, enhancing understanding of the research environment and strengthening international networks. Recipients are expected to spend significant time at LMIC sites, ultimately aiming to develop competitive NIH research proposals and become leaders in global health.

The Veterans Legacy Grants Program (VLGP) offers funding up to $400,000 to eligible entities for cemetery research related to Veterans’ interred in national, State, or Tribal cemeteries. It aims to create educational materials promoting community engagement and understanding of Veterans' histories. Administered by the Department of Veterans Affairs, the program provides resources for educational institutions to enhance public knowledge and appreciation of Veterans’ contributions and legacies.

The Tobacco Centers of Regulatory Science (TCORS) program, supported by the NIH and FDA, aims to foster research centers that enhance the scientific understanding of tobacco regulation. These centers will conduct hypothesis-driven projects on critical topics such as addiction, health effects, and marketing. By providing a multidisciplinary approach, TCORS seeks to inform public health strategies and ensure effective implementation of the Family Smoking Prevention and Tobacco Control Act.

The MPS Mathematical Sciences Research Programs (MPS MathSci) by the NSF supports diverse research initiatives in theoretical and applied mathematical sciences. Key areas include Algebra, Applied Mathematics, Combinatorics, and Mathematical Biology. The program encourages groundbreaking foundational research with flexible budgets and durations. Proposals do not need to promise immediate outcomes, allowing researchers to explore innovative concepts without the pressure of commercial viability.

This funding opportunity seeks to enhance awareness and education on viral hepatitis among high-risk populations and healthcare professionals. It focuses on two components: community education and professional training. By fostering coalitions and providing resources, the initiative aims to improve testing, treatment, and care for hepatitis B and C, ultimately reducing morbidity and mortality linked to these infections. The goal is to empower communities and healthcare providers with the knowledge and tools needed for effective prevention and intervention.

The NCAA Walter Byers Graduate Scholarship is awarded annually to one male and one female student-athlete, recognizing outstanding academic achievement and potential for success in graduate study. Each scholarship provides $24,000 for one academic year, with the possibility of renewal. Candidates must have a minimum GPA of 3.500, compete in NCAA athletics, and demonstrate strong character and leadership. The scholarship aims to support future leaders in their chosen fields, fostering excellence in academics and community engagement.

The CDC is offering FY 2027 funds for a cooperative agreement to enhance national surveillance for human prion diseases, or transmissible spongiform encephalopathies (TSEs), in the U.S. This initiative aims to confirm suspected cases and monitor emerging diseases through a specialized center utilizing advanced diagnostic techniques. Since 1997, this center has facilitated disease confirmation and trend evaluation, ensuring accurate surveillance and fostering confidence that novel prion diseases are not emerging in the country.

The Feasibility Clinical Trials of Mind and Body Interventions grant aims to support trials that examine complementary and integrative health approaches for high-priority NCCIH research topics. This opportunity seeks to gather essential data for designing future efficacy studies, focusing on aspects such as feasibility, acceptability, and recruitment strategies. The goal is to bridge gaps in scientific knowledge and enhance public health impact through rigorous clinical research. Applicants are encouraged to contact NCCIH representatives for guidance.

The NCCIH Multi-Site Feasibility Clinical Trials (R01) invites applications for clinical trials focused on mind and body interventions. This program emphasizes the need for multisite feasibility studies to gather essential data for future efficacy trials. The initiative is designed to enhance public health by addressing gaps in scientific knowledge related to the delivery, recruitment, and data collection of integrative health approaches. Deadlines for submissions range from February 2025 to October 2026.

The NIOSH Centers for Agriculture, Forestry, and Fishing Safety and Health provide critical support to enhance worker safety and health in the vital AgFF sector. With a focus on high-quality interdisciplinary research, these centers aim to translate scientific findings into practical solutions, improve health outcomes, and engage with partners to promote best practices. By addressing health hazards and improving data coordination, these centers strive for a meaningful impact on the well-being of AgFF workers across the nation.

The NIOSH National Center of Excellence for the Prevention of Childhood Agricultural Injury (U54) aims to enhance the safety and well-being of youth in the agriculture sector. This initiative will conduct vital research, improve data collection, and implement effective interventions to mitigate risks faced by young workers. By collaborating with various stakeholders, the center seeks to translate scientific findings into practical solutions that promote healthier working environments for children in agriculture, forestry, and fishing industries.

The "Opportunities for Collaborative Research with the NIH Intramural Research Program (U01 Clinical Trial Optional)" aims to foster partnerships between NIH intramural and extramural researchers. This initiative supports translational research projects that bridge basic biological discoveries and clinical applications, enhancing health outcomes. By encouraging collaborations, it seeks to accelerate the development of new therapies and prevention strategies, leveraging unique NIH resources to strengthen scientific innovation and address critical disease processes.

The TESOL Leadership Mentoring Program connects TESOL members with experienced leaders for mentorship and professional development. Participants receive free registration to the annual convention, up to $1,000 for lodging, and the opportunity to build lasting relationships within the TESOL community. This program is designed for members in good standing, with a preference for individuals from underrepresented groups, fostering inclusivity and active participation in the association's initiatives.

The TYLENOL Future Care Scholarship supports students pursuing healthcare careers, continuing a 30-year tradition of helping those dedicated to caring for others. Eligible applicants must be U.S. residents, graduate students or seniors enrolling in graduate school for the 2024-25 academic year, and provide proof of enrollment in an accredited healthcare program. Scholarships cover tuition, fees, and necessary supplies, ensuring that future healthcare professionals receive the support they need.

The Bonnycastle Fellowship for Wetland and Waterfowl Research supports graduate students in advancing conservation efforts. Offered by Ducks Unlimited, this fellowship provides up to $17,000 annually for research and personal support. The fellowship emphasizes the importance of research originality, ecological contributions, and feasibility. It is open to all North American graduate students, with a preference for doctoral candidates. The award is renewable for PhD students up to two years, and once for Master's students, contingent on satisfactory progress.

The Pratt Family Foundation Grant, established in 1999, supports initiatives in education, healthcare, and community welfare. It prioritizes organizations that aid housing assistance, support for women in crisis, and disadvantaged youth programs, particularly in North Carolina. The Foundation favors established religious and charitable organizations that are tax-exempt and have a local presence. Preference is given to areas connected to the Pratt family, such as Texas and Florida, ensuring impactful contributions to community development.